Larry H. Matherly

Also affiliated with The Barbara Ann Karmanos Cancer Institute

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 18 papers. Top paper: “FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis”.

FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis

Nature Communications(2022)10.1038/s41467-022-34239-z

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0.574DataRank · unranked

45 citations

Ling Wu, Christoph Block, Mu Zhang, Justin Hackett, Douglas B. Craig +15 more

Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro

Biochemical Pharmacology(2023)10.1016/j.bcp.2023.115981

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0.442DataRank · unranked

18 citations

Yongwei Su, Shraddha Patel, Cassandra L. Ramage, Jianlei Zhao, Brianna R. Temby +24 more

Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and purine biosynthesis

Research Square(2023)10.21203/rs.3.rs-2843025/v1

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0.165DataRank · unranked

2 citations

Katie Hege-Hurrish, Yongwei Su, Shraddha Patel, Cassandra L. Ramage, Jenna L. Carter +22 more

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Bioorganic & Medicinal Chemistry(2021)10.1016/j.bmc.2021.116093

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0DataRank · unranked

12 citations

Nian Tong, Jennifer Wong-Roushar, Carrie O’Connor, Xilin Zhou, Zhanjun Hou +8 more

Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data

Proteomes(2022)10.3390/proteomes10020018

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0DataRank · unranked

16 citations

Nicholas J. Carruthers, Zhanjun Hou, Larry H. Matherly, Paul M. Stemmer, Jordan B. Burton

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

Scientific Reports(2022)10.1038/s41598-022-14788-5

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0DataRank · unranked

15 citations

Lisa Rubinsak, Agnes Malysa, Sijana H. Dzinic, Manasa Ravindra, Mathew Schneider +11 more

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00763

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0DataRank · unranked

17 citations

Jade M. Katinas, Tejashree Magdum, Khushbu Shah, Jennifer E. Wong, Carrie O’Connor +7 more

Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism

ACS Pharmacology & Translational Science(2023)10.1021/acsptsci.3c00020

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0DataRank · unranked

6 citations

Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha V. Shah, Morgan C. Nyman, Jade M. Katinas +10 more

Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer

Molecular Cancer Therapeutics(2024)10.1158/1535-7163.mct-23-0550

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0DataRank · unranked

15 citations

Carrie O’Connor, Aamod S. Dekhne, Xun Bao, Md. Junayed Nayeen, Mathew Schneider +11 more

Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates

Molecular Pharmacology(2024)10.1124/molpharm.124.000912

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0DataRank · unranked

12 citations

Mathew Schneider, Jade M. Katinas, Md. Junayed Nayeen, Khushbu Shah, Tejashree Magdum +9 more

Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2

Biochemistry(2024)10.1021/acs.biochem.3c00613

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0DataRank · unranked

6 citations

Md. Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N. Fifer, Lily M. Klapper +8 more

Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydroxymethyltransferase inhibition in human tumors

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100120

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0DataRank · unranked

2 citations

Carrie O’Connor, Xun Bao, Md. Junayed Nayeen, Tejashree Magdum, Abhishekh Sharma +7 more

One-Carbon Metabolism Inhibition Depletes Purines and Results in Profound and Prolonged Ewing Sarcoma Growth Suppression

Cancer Research Communications(2025)10.1158/2767-9764.crc-25-0218

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0DataRank · unranked

2 citations

Noah Copperman, Shrey Patel, A.R.W. Forrest, Zhanjun Hou, Larry H. Matherly +3 more

Inhibition Of One-Carbon Metabolism In Ewing Sarcoma Results In Profound And Prolonged Growth Suppression Associated With Purine Depletion

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.13.647987

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0DataRank · unranked

0 citations

Noah Copperman, Shrey Patel, A.R.W. Forrest, Zhanjun Hou, Larry H. Matherly +3 more

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

Molecular Cancer Therapeutics(2020)10.1158/1535-7163.mct-20-0423

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0DataRank · unranked

76 citations

Zhanjun Hou, Aleem Gangjee, Larry H. Matherly, Aamod S. Dekhne

Determination of the pyrrolo[2,3-d] pyrimidine antifolate AGF94 from a preclinical murine study using a simple UHPLC-MS/MS assay

Journal of Chromatography B(2025)10.1016/j.jchromb.2025.124833

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0DataRank · unranked

0 citations

Robynne Ashe, Alexander Duncan, Ethan C. Wilner, Keith T. Schmidt, Kristbjorn O. Gudmundsson +6 more

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

British Journal of Cancer(2020)10.1038/s41416-020-0912-9

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0DataRank · unranked

42 citations

Btissame El Hassouni, Rocco Sciarrillo, Niccola Funel, Giulia Mantini, Eveline A. Zeeuw van der Laan +20 more

Lipid metabolism reprogramming in renal cell carcinoma

Cancer and Metastasis Reviews(2021)10.1007/s10555-021-09996-w

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0DataRank · unranked

100 citations

Omid Yazdanpanah, Izabela Podgorski, Larry H. Matherly, Wanqing Liu, Gioia Heravi