Dwight V. Nissley

Also affiliated with Frederick Community College, Frederick National Laboratory for Cancer Research, Center for Cancer Research, Leidos Biomedical Research Inc. (United States)

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 35 papers. Top paper: “Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins”.

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2113297119

N/A

0.675DataRank · unranked

89 citations

Chris Neale, Timothy S. Carpenter, Rebika Shrestha, César A. López, Timothy H. Tran +37 more

RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling

Journal of Biological Chemistry(2020)10.1074/jbc.ra119.011080

N/A

0.622DataRank · unranked

13 citations

Thomas J. Turbyville, Srisathiyanarayanan Dharmaiah, Megan Rigby, Rendong Yang, Ting-You Wang +11 more

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00841-4

N/A

0.601DataRank · unranked

54 citations

Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing +8 more

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110331

N/A

0.540DataRank · unranked

15 citations

Albert H. Chan, Dana Rabara, Monalisa Swain, Erik K. Larsen, Marcin Dyba +11 more

Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2208960120

N/A

0.524DataRank · unranked

32 citations

Ruby Goldstein de Salazar, Sae‐Won Han, Zi Yi Stephanie Huang, Alan Merk, Matthew Drew +11 more

Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics

Journal of the American Chemical Society(2022)10.1021/jacs.2c00007

N/A

0.500DataRank · unranked

27 citations

Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, William Gillette, Dominic Esposito +6 more

The confluence of machine learning and multiscale simulations

Current Opinion in Structural Biology(2023)10.1016/j.sbi.2023.102569

N/A

0.494DataRank · unranked

26 citations

Fikret Aydin, Timothy S. Carpenter, Felice C. Lightstone, Peer‐Timo Bremer, Helgi I. Ingólfsson +3 more

Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.105650

N/A

0.464DataRank · unranked

21 citations

Jun Pei, Yue Yang, Marcin Dyba, Brian D. Smith, Dana Rabara +11 more

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements

Communications Biology(2024)10.1038/s42003-024-05959-3

N/A

0.457DataRank · unranked

20 citations

Mayukh Chakrabarti, Gülçin Gülten, Joseph Finney, Carissa Grose, Tara Fox +7 more

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.22.618529

N/A

0.391DataRank · unranked

9 citations

Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Srisathiyanarayanan Dharmaiah +24 more

Recapitulation of cell-like KRAS4b membrane dynamics on complex biomimetic membranes

iScience(2021)10.1016/j.isci.2021.103608

N/A

0.373DataRank · unranked

11 citations

De Chen, Peter Frank, Dwight V. Nissley, Thomas J. Turbyville, Rebika Shrestha

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2410766122

N/A

0.292DataRank · unranked

6 citations

Yue Yang, Alok K. Sharma, David M. Turner, Caroline J. DeHart, Hazem Abdelkarim +29 more

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.10.491335

N/A

0.241DataRank · unranked

4 citations

Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing +8 more

NMR 1H, 13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation

Biomolecular NMR Assignments(2021)10.1007/s12104-021-10050-7

N/A

0.208DataRank · unranked

3 citations

Marcin Dyba, Marco Tonelli, Brian D. Smith, William Gillette, Dominic Esposito +4 more

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.19.671159

N/A

0.104DataRank · unranked

1 citations

David Durrant, Matthew Drew, Suzanne I. Sandin, Juliana A. Martinez Fiesco, Xiaohua Zhang +21 more

Structural basis for LZTR1 recognition of RAS GTPases for degradation

Science(2025)10.1126/science.adv7088

N/A

0DataRank · unranked

11 citations

Daniel A. Bonsor, Stephanie Mo, Alvaro Fernandez-Cabrera, Albert H. Chan, Simon D. Messing +7 more

An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2508169122

N/A

0DataRank · unranked

6 citations

David Durrant, Matthew Drew, Suzanne I. Sandin, Juliana A. Martinez Fiesco, Xiao‐Hua Zhang +21 more

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

Biophysical Journal(2025)10.1016/j.bpj.2025.08.020

N/A

0DataRank · unranked

2 citations

Fikret Aydin, Chris Neale, Que N. Van, Xiaohua Zhang, Harsh Bhatia +35 more

Enhanced Exploration of Protein Conformational Space through Integration of Ultra-Coarse-Grained Models to Multiscale Workflows

The Journal of Physical Chemistry B(2025)10.1021/acs.jpcb.4c08622

N/A

0DataRank · unranked

2 citations

Konstantia Georgouli, Loïc Pottier, Tomas Oppelstrup, Timothy S. Carpenter, Jeremy O. B. Tempkin +6 more

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

Cancer Research(2020)10.1158/0008-5472.can-19-1363

N/A

0DataRank · unranked

315 citations

Debanjan Goswami, Pavan P. Adiseshaiah, William Burgan, Ming Yi, Theresa M. Guerin +4 more

NMR 1H, 13C, and 15N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation

Biomolecular NMR Assignments(2025)10.1007/s12104-025-10236-3

N/A

0DataRank · unranked

0 citations

Marco Tonelli, Marcin Dyba, William Gillette, Dominic Esposito, Dwight V. Nissley +3 more

ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications

Scientific Reports(2020)10.1038/s41598-020-66986-8

N/A

0DataRank · unranked

260 citations

Dwight V. Nissley, Frank McCormick, Robert M. Stephens, Ming Yi

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

Cell Reports(2020)10.1016/j.celrep.2020.107909

N/A

0DataRank · unranked

69 citations

Evan Markegard, Srisathiyanarayanan Dharmaiah, Anatoly Urisman, Matthew Drew, Dominic Esposito +5 more

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2006504117

N/A

0DataRank · unranked

58 citations

César A. López, Marco Tonelli, Troy Taylor, Ben Niu, Christopher B. Stanley +24 more

Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

eLife(2020)10.7554/elife.47654

N/A

0DataRank · unranked

29 citations

De Chen, Yue Yang, Prabhakar R. Gudla, John Columbus, Karen M. Worthy +13 more

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature Communications(2021)10.1038/s41467-021-21422-x

N/A

0DataRank · unranked

253 citations

Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing +9 more

Exploring CRD mobility during RAS/RAF engagement at the membrane

Biophysical Journal(2022)10.1016/j.bpj.2022.06.035

N/A

0DataRank · unranked

28 citations

César A. López, Chris Neale, Que N. Van, Timothy S. Carpenter, Francesco Di Natale +25 more

RAS at 40: Update from the RAS Initiative

Cancer Discovery(2022)10.1158/2159-8290.cd-21-1554

N/A

0DataRank · unranked

24 citations

Frank McCormick, Dwight V. Nissley

Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D

Communications Biology(2023)10.1038/s42003-023-04960-6

N/A

0DataRank · unranked

16 citations

Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor +7 more

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

Science Advances(2024)10.1126/sciadv.adj4137

N/A

0DataRank · unranked

38 citations

Timothy H. Tran, Megan Rigby, Ming Yi, Srisathiyanarayanan Dharmaiah, Timothy J. Waybright +12 more

Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

Communications Biology(2024)10.1038/s42003-024-05916-0

N/A

0DataRank · unranked

13 citations

Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin +15 more

Generating Protein Structures for Pathway Discovery Using Deep Learning

Journal of Chemical Theory and Computation(2024)10.1021/acs.jctc.4c00816

N/A

0DataRank · unranked

6 citations

Robert Stephany, Jeremy O. B. Tempkin, Cláudio Santiago, Fikret Aydin, Mark Heimann +10 more

Natural Product Graveoline Modulates Kirsten Rat Sarcoma Viral Oncogene Homologue (KRAS) Membrane Association: Insights from Advanced Spectroscopic Studies

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.4c00075

N/A

0DataRank · unranked

5 citations

Lakshman Bindu, Louise M. Sternicki, Fa-An Chao, William Gillette, Nicole Fer +13 more

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations

Scientific Reports(2024)10.1038/s41598-024-76591-8

N/A

0DataRank · unranked

2 citations

Daniel Soppet, Frank McCormick, Dwight V. Nissley, Ming Yi

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation

Nature Communications(2025)10.1038/s41467-024-55766-x

N/A

0DataRank · unranked

32 citations

Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji, Mitsuhiro Yamaguchi +7 more