Douglas M. Fowler

Also affiliated with Brotman Baty Institute

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

4.2Author DataRank

Indexed papers

5in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 5 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays

Genome biology(2025)10.1186/s13059-025-03476-y

Top 12%

1.7DataRank

Top 12%70 citations

Jeremy Stone, Aisha Haley Bianchi, Benjamin J. Capodanno, Estelle Y. Da, Mafalda Dias +23 more

Papers

Driven by 52 papers — median percentile 82. Top paper: “Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact”.

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

eLife(2020)10.7554/elife.58026

N/A

2.2DataRank · unranked

103 citations

Nathan Rollins, Jason J. Stephany, Katherine A. Sitko, Kenneth A. Matreyek, Marta Verby +7 more

MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays

Genome biology(2025)10.1186/s13059-025-03476-y

Top 12%

1.7DataRank

Top 12%70 citations

Jeremy Stone, Aisha Haley Bianchi, Benjamin J. Capodanno, Estelle Y. Da, Mafalda Dias +23 more

Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers

Genome Medicine(2021)10.1186/s13073-021-00984-x

Top 16%

1.3DataRank

Top 16%52 citations

Jason J. Stephany, Ethan Ahler, Douglas M. Fowler, Kenneth A. Matreyek

Deciphering the impact of genomic variation on function

Nature(2024)10.1038/s41586-024-07510-0

N/A

1.1DataRank · unranked

89 citations

Jesse M. Engreitz, Heather A. Lawson, Harinder Singh, Lea M. Starita, Gary C. Hon +95 more

MaveDB v2: a curated community database with over three million variant effects from multiplexed functional assays

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.29.470445

Top 21%

0.975DataRank

Top 21%28 citations

Joseph Min, Nathan Rollins, Estelle Y. Da, Daniel Esposito, Matthew Harrington +19 more

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1915680117

N/A

0.743DataRank · unranked

141 citations

Takaya Moriyama, Kenneth A. Matreyek, Wentao Yang, Emma Rose Scaletti, Rina Nishii +27 more

Systematic misclassification of missense variants in BRCA1 and BRCA2 “coldspots”

Genetics in Medicine(2020)10.1038/s41436-019-0740-6

N/A

0.626DataRank · unranked

64 citations

Brian H. Shirts, Thomas P. Slavin, Tom Walsh, Mary‐Claire King, Douglas M. Fowler +2 more

Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning

G3 Genes|Genomes|Genetics(2019)10.1534/g3.119.400535

N/A

0.581DataRank · unranked

47 citations

Katherine Sitko, Floriane Z Ngako Kameni, Miriam Williamson, Jason J Stephany, Nicholas Hasle +2 more

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling

Nature Communications(2021)10.1038/s41467-021-27342-0

N/A

0.538DataRank · unranked

35 citations

David Nedrud, Antonio Suma, Yungui He, Kenneth A. Matreyek, Douglas M. Fowler +4 more

A chemically controlled Cas9 switch enables temporal modulation of diverse effectors

Nature Chemical Biology(2023)10.1038/s41589-023-01278-6

N/A

0.464DataRank · unranked

21 citations

Nicholas A. Popp, Omri Peleg, Rachel L. Powell, Elhanan Borenstein, Dustin J. Maly +2 more

Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff

Genetics(2024)10.1093/genetics/iyae156

N/A

0.433DataRank · unranked

12 citations

Katherine A. Sitko, Jared Galloway, Hugh K. Haddox, Aisha Haley Bianchi, Ajeya Dixon +13 more

Understanding genetic variants in context

eLife(2024)10.7554/elife.88231

N/A

0.403DataRank · unranked

10 citations

Stanley Fields, Frederick P. Roth, Lea M. Starita, Cole Trapnell, Judit Villén +3 more

Pacybara: accurate long-read sequencing for barcoded mutagenized allelic libraries

Bioinformatics(2024)10.1093/bioinformatics/btae182

N/A

0.330DataRank · unranked

8 citations

Gabrielle Ferra, Gabriel Boyle, Sriram Pendyala, Clara J. Amorosi, Chiann-Ling C Yeh +9 more

Parallel Chemoselective Profiling for Mapping Protein Structure

Cell chemical biology(2020)10.1016/j.chembiol.2020.06.014

N/A

0.330DataRank · unranked

8 citations

Ho-Tak Lau, Sujata Chakraborty, Linglan Fang, Miklos Guttman, Shao‐En Ong +3 more

Image-based identification and isolation of micronucleated cells to dissect cellular consequences

eLife(2024)10.7554/elife.101579

N/A

0.276DataRank · unranked

4 citations

Sriram Pendyala, Heather Z Huang, Douglas M. Fowler, Emily M. Hatch, Lucian DiPeso

The IGVF catalog—from genetic variation to function

Nucleic Acids Research(2025)10.1093/nar/gkaf1341

Top 63%

0.219DataRank

Top 63%3 citations

Shane Liu, Pedro Assis, Mingjie Li, Shengcheng Dong, Ian Whaling +42 more

Consultation informs strategies to improve functional evidence use in variant classification

medRxiv(2024)10.1101/2024.12.04.24318523

N/A

0.208DataRank · unranked

3 citations

Bronwyn Terrill, Emma Tudini, Maddison E. McKenzie, Corrina Cliffe, Christopher N Hahn +12 more

The biophysical basis of protein domain compatibility

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.09.418442

N/A

0.196DataRank · unranked

2 citations

David Nedrud, Antonio Suma, Yungui He, Kenneth A. Matreyek, Douglas M. Fowler +4 more

Defining and Reducing Variant Classification Disparities

medRxiv(2024)10.1101/2024.04.11.24305690

N/A

0.165DataRank · unranked

2 citations

Shawn Fayer, Sriram Pendyala, Mason Post, Divya Kalra, Karynne Patterson +13 more

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KCNH2 : Deep mutational scan of KCNH2 trafficking

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.02.17.952606

N/A

0DataRank · unranked

0 citations

Andrew M. Glazer, Chai-Ann Ng, Daniel Blackwell, Christian L. Egly, Loren R. Vanags +9 more

CRaTER enrichment for on-target gene editing enables generation of variant libraries in hiPSCs

Journal of Molecular and Cellular Cardiology(2023)10.1016/j.yjmcc.2023.03.017

N/A

0DataRank · unranked

11 citations

Shawn Fayer, Sriram Pendyala, Wei‐Ming Chien, Alexander Loiben, Linda Tran +10 more

Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning

Protein Science(2023)10.1002/pro.4656

N/A

0DataRank · unranked

11 citations

Ethan Ahler, Katherine A. Sitko, Jason J. Stephany, Dustin J. Maly, Douglas M. Fowler +1 more

CRaTER enrichment for on-target gene-editing enables generation of variant libraries in hiPSCs

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.25.525582

N/A

0DataRank · unranked

2 citations

Shawn Fayer, Sriram Pendyala, Wei‐Ming Chien, Linda Tran, Leslie S. Chao +9 more

Pacybara: Accurate long-read sequencing for barcoded mutagenized allelic libraries

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.22.529427

N/A

0DataRank · unranked

0 citations

Gabrielle Ferra, Gabriel Boyle, Sriram Pendyala, Clara J. Amorosi, Chiann-Ling C Yeh +9 more

Multiplexed functional assessments of MYH7 variants in human cardiomyocytes at scale

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.28.551073

N/A

0DataRank · unranked

0 citations

Shawn Fayer, Sriram Pendyala, Wei‐Ming Chien, Linda Tran, Leslie S. Chao +11 more

Pseudotime analysis for time-series single-cell sequencing and imaging data

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.03.565575

N/A

0DataRank · unranked

0 citations

Hyeonjin Kim, Sriram Pendyala, Ran Zhang, Christine M. Distèche, Jean‐Philippe Vert +4 more

Calibration of variant effect predictors on genome-wide data masks heterogeneous performance across genes

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2024.07.018

N/A

0DataRank · unranked

34 citations

Shawn Fayer, Abbye E. McEwen, Jake Flynn, Lea M. Starita, Douglas M. Fowler +1 more

Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes

Circulation Genomic and Precision Medicine(2024)10.1161/circgen.123.004377

N/A

0DataRank · unranked

13 citations

Shawn Fayer, Sriram Pendyala, Wei‐Ming Chien, Alexander Loiben, Linda Tran +11 more

A missense variant effect map for the human tumor-suppressor protein CHK2

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2024.10.013

N/A

0DataRank · unranked

15 citations

Daniel Zimmerman, Rosanna Jiang, Maria Nguyen, Jochen Weile, Roujia Li +14 more

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.10.087312

N/A

0DataRank · unranked

2 citations

Nathan Rollins, Jason J. Stephany, Katherine A. Sitko, Kenneth A. Matreyek, Marta Verby +7 more

Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.28.317040

N/A

0DataRank · unranked

5 citations

Kristoffer E. Johansson, Audronė Valančiūtė, Sofie V. Nielsen, Rasmus Hartmann‐Petersen, Jun J. Yang +4 more

MaveRegistry: a collaboration platform for multiplexed assays of variant effect

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.14.339499

N/A

0DataRank · unranked

6 citations

Jochen Weile, Nishka Kishore, Alan F. Rubin, Stanley Fields, Douglas M. Fowler +2 more

Multiplexed profiling of intracellular protein abundance, activity, interactions and druggability with LABEL-seq

Nature Methods(2024)10.1038/s41592-024-02456-7

N/A

0DataRank · unranked

8 citations

Douglas M. Fowler, Dustin J. Maly, Jessica J. Simon

Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.19.590094

N/A

0DataRank · unranked

2 citations

Douglas M. Fowler, Dustin J. Maly, Jessica J. Simon

A missense variant effect map for the human tumour suppressor protein CHK2

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.13.579700

N/A

0DataRank · unranked

1 citations

Daniel Zimmerman, Rosanna Jiang, Maria Nguyen, Jochen Weile, Roujia Li +12 more

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

Nature Communications(2020)10.1038/s41467-020-16542-9

N/A

0DataRank · unranked

59 citations

Nicholas A. Popp, Chris D. Richardson, Jason J. Stephany, Julie Mathieu, Cindy T. Wei +4 more

The quantitative impact of 3′UTRs on gene expression

Nucleic Acids Research(2025)10.1093/nar/gkaf568

N/A

0DataRank · unranked

11 citations

H. Jesse Smith, Luyen Tien Vu, Elizabeth A. Fogarty, Kenneth A. Matreyek, Douglas M. Fowler +2 more

Insights on improving accessibility and usability of functional data to unlock their potential for variant interpretation

The American Journal of Human Genetics(2025)10.1016/j.ajhg.2025.04.009

N/A

0DataRank · unranked

12 citations

Runjun D. Kumar, Cristian Ovadiuc, Andrew Folta, Abbye E. McEwen, Ashley Snyder +8 more

Sceptic: pseudotime analysis for time-series single-cell sequencing and imaging data

Genome biology(2025)10.1186/s13059-025-03679-3

N/A

0DataRank · unranked

5 citations

Hyeonjin Kim, Sriram Pendyala, Ran Zhang, Jean‐Philippe Vert, Christine M. Distèche +4 more

Imprecision medicine: Systematic gaps in reporting variants of uncertain significance (VUS) and their reclassifications

Genetics in Medicine(2025)10.1016/j.gim.2025.101501

N/A

0DataRank · unranked

1 citations

Adriana E Sedeño Cortés, Pankhuri Gupta, Abbye E. McEwen, Eric Y. Kao, Martha Horike‐Pyne +8 more

Gene-based calibration of high-throughput functional assays for clinical variant classification

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.29.651326

N/A

0DataRank · unranked

6 citations

Ross Stewart, Shantanu Jain, Malvika Tejura, Abbye E. McEwen, Shawn Fayer +9 more

MaveMD: A functional data resource for genomic medicine

medRxiv(2025)10.1101/2025.11.15.25336228

N/A

0DataRank · unranked

4 citations

Jeremy Stone, Malvika Tejura, Pankhuri Gupta, Benjamin J. Capodanno, Estelle Y. Da +9 more

Insights on improving accessibility and usability of functional data to unlock its potential for variant interpretation

medRxiv(2025)10.1101/2025.01.25.25321117

N/A

0DataRank · unranked

2 citations

Runjun D. Kumar, Cristian Ovadiuc, Andrew Folta, Abbye E. McEwen, Ashley Snyder +6 more

Multiplex design and discovery of proximity handles for programmable proteome editing

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.13.681693

N/A

0DataRank · unranked

2 citations

Green Ahn, Melodie Chiu, Yi Fu, Shayan Sadre, Jessica J. Simon +6 more

Evidence for G6PD variant classification from multiplexed functional assays

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.11.669723

N/A

0DataRank · unranked

1 citations

Melinda Wheelock, Rachel L. Powell, Ziyu R. Wang, Daniel L. Holmes, Shawn Fayer +9 more

Identification of affinity-optimized peptide binders of a viral protease for chemical genetic applications

Bioorganic & Medicinal Chemistry Letters(2025)10.1016/j.bmcl.2025.130463

N/A

0DataRank · unranked

0 citations

Emily M. Dieter, Kyler J Radmall, Glenna Foight, Douglas M. Fowler, Dustin J. Maly +1 more

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.07.001

N/A

0DataRank · unranked

117 citations

Melissa A. Chiasson, Matthew G. McDonald, Lai Hong Wong, Katherine A. Sitko, Gabriel Boyle +5 more

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Heart Rhythm(2020)10.1016/j.hrthm.2020.05.041

N/A

0DataRank · unranked

66 citations

Andrew M. Glazer, Chai‐Ann Ng, Daniel J. Blackwell, Christian Egly, Loren Vanags +9 more

Closing the gap: Systematic integration of multiplexed functional data resolves variants of uncertain significance in BRCA1, TP53, and PTEN

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.11.001

N/A

0DataRank · unranked

128 citations

Carolyn Horton, Jennifer N. Dines, Alan F. Rubin, Marcy E. Richardson, Kelly McGoldrick +7 more

MaveRegistry: a collaboration platform for multiplexed assays of variant effect

Bioinformatics(2021)10.1093/bioinformatics/btab215

N/A

0DataRank · unranked

27 citations

Jochen Weile, Nishka Kishore, Maria Nguyen, Alan F. Rubin, Stanley Fields +3 more

Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance

Molecular Biology and Evolution(2021)10.1093/molbev/msab095

N/A

0DataRank · unranked

136 citations

Kristoffer E. Johansson, Audronė Valančiūtė, Sofie V. Nielsen, Rasmus Hartmann‐Petersen, Jun J. Yang +4 more

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.12.435209

N/A

0DataRank · unranked

11 citations

Melissa A. Chiasson, Matthew G. McDonald, Lai Hong Wong, Katherine A. Sitko, Gabriel Boyle +5 more

Douglas M. Fowler

Indexed papers

Top data-sharing exemplar

Papers