Xufen Yu

Also affiliated with Ministry of Education, Icahn School of Medicine at Mount Sinai

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 33 papers. Top paper: “Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation”.

Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

eLife(2022)10.7554/elife.78163

N/A

0.807DataRank · unranked

27 citations

Jocelyn Fang-Yi Chen, Huacui Chen, Emily Wingrove, Sarah J. Kurley, Lok-Hei Chan +14 more

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Nature Cell Biology(2022)10.1038/s41556-022-00850-x

N/A

0.784DataRank · unranked

185 citations

Xufen Yu, Weida Gong, Xijuan Liu, Kwang‐Su Park, Anqi Ma +12 more

AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway–Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B

Cancer Discovery(2021)10.1158/2159-8290.cd-20-0815

N/A

0.631DataRank · unranked

66 citations

Xufen Yu, Tiphaine Martin, Ankita Bansal, Kakit Cheung, Abigail Lubin +15 more

Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00100

N/A

0.621DataRank · unranked

62 citations

Chris Anderson, Kwang‐Su Park, H. Ümit Kanıskan, Anqi Ma, Yudao Shen +6 more

Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01521

N/A

0.593DataRank · unranked

51 citations

Dongxu Li, Jithesh Kottur, Huen Suk Kim, Laura E. Herring, Yao Yu +9 more

Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

European Journal of Medicinal Chemistry(2024)10.1016/j.ejmech.2024.116154

N/A

0.546DataRank · unranked

37 citations

Brandon Dale, Kwang‐Su Park, H. Ümit Kanıskan, Xufen Yu, Jian Jin +1 more

Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01454

N/A

0.538DataRank · unranked

35 citations

Jia Xu, Kaitlyn M. Cahuzac, Ling Xie, Yudao Shen, Xian Chen +4 more

USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK

Journal of the American Chemical Society(2024)10.1021/jacs.4c02373

N/A

0.515DataRank · unranked

30 citations

Xiaoping Hu, Kaixiu Luo, Yan Xiong, Li Chen, Zhen Wang +11 more

Chemically induced degradation of epigenetic targets

Chemical Society Reviews(2023)10.1039/d3cs00100h

N/A

0.510DataRank · unranked

29 citations

Xufen Yu, H. Ümit Kanıskan, Jian Jin, Md Kabir

WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma

Nature Cancer(2023)10.1038/s43018-023-00609-9

N/A

0.505DataRank · unranked

28 citations

Mary E. Duffy, Alex P. Scopton, Frank Fonseca, Julia N. Zhao, Megan Schwarz +30 more

Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader

Oncogene(2023)10.1038/s41388-023-02618-5

N/A

0.494DataRank · unranked

26 citations

Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang +6 more

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation

Cell chemical biology(2023)10.1016/j.chembiol.2023.09.012

N/A

0.434DataRank · unranked

17 citations

Li Wang, Ling Xie, Feng Zhang, Bing Wu, Mei Liu +15 more

Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

iScience(2025)10.1016/j.isci.2025.112632

N/A

0.165DataRank · unranked

2 citations

Ling Xie, Xuping Xie, Feng Zhang, John A. Wrobel, Yan Xiong +11 more

Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2

Oncogenesis(2025)10.1038/s41389-025-00567-0

N/A

0.104DataRank · unranked

1 citations

Richard A Schäfer, Rui Wang, Ting-You Wang, X. Lu, Qi Liu +13 more

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.04.583415

N/A

0DataRank · unranked

0 citations

Ling Xie, Xuping Xie, Feng Zhang, John A. Wrobel, Yan Xiong +11 more

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation

UNC Libraries(2024)10.17615/144y-5d10

N/A

0DataRank · unranked

0 citations

Kanishk Jain, Ling Xie, Erik M. Lenarcic, Feng Zhang, Hongjun Song +15 more

Tumor microenvironment–targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors

Science Advances(2025)10.1126/sciadv.adu2292

N/A

0DataRank · unranked

4 citations

Magdalini Panagiotakopoulou, Mandana T. Manzari, Ana Marie Perea, Xiaoping Hu, Xufen Yu +8 more

EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of m6A autoregulation pathway

Journal of Clinical Investigation(2025)10.1172/jci195840

N/A

0DataRank · unranked

3 citations

Joshua Fry, Chaehyun Yum, Rui Wang, Siqi Wu, Sharath Narayan +20 more

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.14.382416

N/A

0DataRank · unranked

22 citations

Adil Muneer, Ling Xie, Feng Zhang, Bing Wu, Mei Liu +15 more

A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer

ACS Pharmacology & Translational Science(2025)10.1021/acsptsci.5c00402

N/A

0DataRank · unranked

0 citations

Ryan M. Kemper, Anna M. Chiarella, Stephany Gonzalez Tineo, Michael C. Carroll, Surya Tripathi +12 more

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Science Translational Medicine(2021)10.1126/scitranslmed.abj1578

N/A

0DataRank · unranked

158 citations

Dongxu Li, Jithesh Kottur, Yudao Shen, Huen Suk Kim, Kwang‐Su Park +14 more

Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01476

N/A

0DataRank · unranked

54 citations

Jia Xu, Ling Xie, Li Wang, Yudao Shen, Kaitlyn M. Cahuzac +5 more

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

Nature Communications(2021)10.1038/s41467-021-21357-3

N/A

0DataRank · unranked

42 citations

Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yi‐Hsuan Tsai, Xufen Yu +13 more

Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming

Stem Cell Research(2021)10.1016/j.scr.2021.102365

N/A

0DataRank · unranked

30 citations

Lianzhong Zhao, Xufen Yu, Jianyi Zhang, Qian Li, Jian Jin +3 more

UV-induced reduction in Polycomb repression promotes epidermal pigmentation

Developmental Cell(2021)10.1016/j.devcel.2021.08.006

N/A

0DataRank · unranked

21 citations

Pooja Flora, Hong Pu, Carmit Bar, José Silva, Idan Cohen +9 more

TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors

Journal of the American Chemical Society(2022)10.1021/jacs.2c04824

N/A

0DataRank · unranked

61 citations

Xufen Yu, He Chen, H. Ümit Kanıskan, Ling Xie, Xian Chen +3 more

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic

Oncogene(2022)10.1038/s41388-022-02340-8

N/A

0DataRank · unranked

56 citations

Xufen Yu, Jithesh Kottur, Weida Gong, Zhao Zhang, Aaron J. Storey +14 more

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformation

Nucleic Acids Research(2022)10.1093/nar/gkac861

N/A

0DataRank · unranked

41 citations

Kwang‐Su Park, Xufen Yu, Weida Gong, H. Shelton Earp, Gang Greg Wang +3 more

Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship Studies

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.1c02165

N/A

0DataRank · unranked

39 citations

Jia Xu, Yudao Shen, Kaitlyn M. Cahuzac, Kwang‐Su Park, Brandon Dale +4 more

Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00345

N/A

0DataRank · unranked

33 citations

Meng Cheng, Kaylene Lu, Yudao Shen, Yue Zhong, Jing Liu +3 more

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant promoting oncogene activation and tumorous transformation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.04.502794

N/A

0DataRank · unranked

5 citations

Kwang‐Su Park, Xufen Yu, Weida Gong, H. Shelton Earp, Gang Greg Wang +3 more

WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.30.486357

N/A

0DataRank · unranked

0 citations

Jocelyn Fang-Yi Chen, Huacui Chen, Emily Wingrove, Sarah J. Kurley, Lok-Hei Chan +13 more

Chemical Epigenetic Regulation of Adeno-Associated Virus Delivered Transgenes

Human Gene Therapy(2023)10.1089/hum.2023.005

N/A

0DataRank · unranked

6 citations

Sara R Wasserman, Liujiang Song, Arushi A. Goel, Xufen Yu, Jian Jin +2 more