Patrick M. Sexton

Biochemistry, Genetics and Molecular BiologyNeuroscienceMedicineArts and HumanitiesDecision Sciences

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 24 papers. Top paper: “Structure and dynamics of the active Gs-coupled human secretin receptor”.

Structure and dynamics of the active Gs-coupled human secretin receptor

Nature Communications(2020)10.1038/s41467-020-17791-4

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0DataRank · unranked

71 citations

Giuseppe Deganutti, Sarah Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff +10 more

Rational development of a high-affinity secretin receptor antagonist

Biochemical Pharmacology(2020)10.1016/j.bcp.2020.113929

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12 citations

Kaleeckal G. Harikumar, Sweta R. Raval, Juliana E. Milburn, Carolyn E. Clark, Rafael Alcala‐Torano +8 more

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

PLoS Biology(2021)10.1371/journal.pbio.3001295

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88 citations

Matthew J. Belousoff, Kaleeckal G. Harikumar, Sarah Piper, Xiaomeng Xu, Sebastian G. B. Furness +8 more

Structural and functional diversity among agonist-bound states of the GLP-1 receptor

Nature Chemical Biology(2021)10.1038/s41589-021-00945-w

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0DataRank · unranked

60 citations

Giuseppe Deganutti, Peishen Zhao, Tin T. Truong, Sarah Piper, Xinyu Liu +6 more

Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

Frontiers in Endocrinology(2021)10.3389/fendo.2021.684656

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33 citations

Kaleeckal G. Harikumar, Denise Wootten, Patrick M. Sexton, Laurence J. Miller

Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114715

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10 citations

Wijnand J. C. van der Velden, Viktorija Labroska, Antao Dai, Fenghui Zhao, Sanaz Darbalaei +9 more

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Frontiers in Endocrinology(2021)10.3389/fendo.2021.789957

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8 citations

Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness +6 more

RAMPs regulate signalling bias and internalisation of the GIPR

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.08.436756

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20 citations

Duncan I. Mackie, John B. Pawlak, Sabrina do Espirito Santo Carvalho, Tin T. Truong, Dewi Safitri +16 more

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins: insight into mechanisms of G protein selectivity

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.06.442871

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7 citations

Matthew J. Belousoff, Kaleeckal G. Harikumar, Sarah Piper, Xiaomeng Xu, Sebastian G. B. Furness +8 more

New Insights into the Structure and Function of Class B1 GPCRs

Endocrine Reviews(2022)10.1210/endrev/bnac033

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66 citations

Xin Zhang, Jianjun Cao, Rachel M. Johnson, Sarah Piper, Elliot Gerrard +3 more

Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors

International Journal of Molecular Sciences(2022)10.3390/ijms23158069

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48 citations

Sarah Piper, Peishen Zhao, Laurence J. Miller, Denise Wootten, Patrick M. Sexton +1 more

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.27.509640

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1 citations

Jinan Wang, Vi Pham, Jesse I. Mobbs, Matthew J. Belousoff, Apurba Bhattarai +18 more

Secretin Amino-Terminal Structure-Activity Relationships and Complementary Mutagenesis at the Site of Docking to the Secretin Receptor

Molecular Pharmacology(2022)10.1124/molpharm.122.000502

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0 citations

Kaleeckal G. Harikumar, Sarah Piper, Sweta R. Raval, Arthur Christopoulos, Denise Wootten +3 more

Structure-based insight into development of selective and non-selective amylin and calcitonin receptor agonists

Research Square(2022)10.21203/rs.3.rs-2268316/v1

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0 citations

Matthew J. Belousoff, Radostin Danev, Madeleine M. Fletcher, Emma Dal Maso, Herman Schreuder +9 more

Structural basis of efficacy-driven ligand selectivity at GPCRs

Nature Chemical Biology(2023)10.1038/s41589-022-01247-5

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56 citations

Vi Pham, Wessel A. C. Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W. Barnes +8 more

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

Nature Communications(2023)10.1038/s41467-023-41199-5

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37 citations

Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Yianni Laloudakis +12 more

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

eLife(2023)10.7554/elife.83477

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35 citations

Jinan Wang, Vi Pham, Jesse I. Mobbs, Matthew J. Belousoff, Apurba Bhattarai +19 more

Isoquinoline small molecule ligands are agonists and probe-dependent allosteric modulators of the glucagon subfamily of GPCRs

Biochemical Pharmacology(2024)10.1016/j.bcp.2024.116483

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3 citations

Phuc N. H. Trinh, Caroline A. Hick, Rebecca Ebenhoch, Herbert Nar, Dietmar Weichert +4 more

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

PLoS Biology(2024)10.1371/journal.pbio.3002673

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4 citations

Peishen Zhao, Brian P. Cary, Xiaomeng Xu, Aditya J. Desai, Maoqing Dong +9 more

Prolonged signaling of backbone-modified glucagon-like peptide-1 analogues with diverse receptor trafficking

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.17.589632

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0DataRank · unranked

0 citations

Marlies V. Hager, Rylie K. Morris, Matthew J. Belousoff, Patrick M. Sexton, Denise Wootten +2 more

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors

Nature Communications(2025)10.1038/s41467-025-58680-y

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13 citations

Matthew J. Belousoff, Rachel M. Johnson, Peter Keov, Zamara Mariam, Giuseppe Deganutti +10 more

Prolonged signaling of backbone-modified glucagon‐like peptide‐ 1 analogues with diverse receptor trafficking

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2407574122

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7 citations

Marlies V. Hager, Zamara Mariam, Rylie K. Morris, Matthew J. Belousoff, Giuseppe Deganutti +4 more

Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.16.649181

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0 citations

Abigail M Keith, Wenjuan Ye, Xin Hu, Noel Southall, Juan J. Marugan +6 more

Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor

Molecular Pharmacology(2025)10.1016/j.molpha.2025.100074

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0DataRank · unranked

0 citations

Yuanyuan Ma, Emmanuel Duarte Barbosa, Kaleeckal G. Harikumar, Denise Wootten, Patrick M. Sexton +3 more