David T. Scadden

Also affiliated with Massachusetts General Hospital, Harvard Stem Cell Institute

MedicineImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 43 papers. Top paper: “In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C”.

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C

Nature Cell Biology(2004)10.1038/ncb1126

N/A

10.9DataRank · unranked

264 citations

Hongmei Shen, David S. Franklin, David T. Scadden, Tao Cheng, Youzhong Yuan

Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses

Nature Communications(2023)10.1038/s41467-023-36325-2

N/A

5.9DataRank · unranked

257 citations

Shenglin Mei, Hirak Sarkar, Youmna Kfoury, Shulin Wu, Bronte Manouk Verhoeven +15 more

The haematopoietic stem cell niche at a glance

Journal of Cell Science(2011)10.1242/jcs.074112

N/A

5.3DataRank · unranked

140 citations

David T. Scadden, Cristina Lo Celso

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Blood(2023)10.1182/blood.2023020331

N/A

1.3DataRank · unranked

48 citations

Adam S. Sperling, Christina Mayerhofer, Marie McConkey, Jana M. Ellegast, Carmen Da Silva +18 more

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

Cell(2019)10.1016/j.cell.2019.04.040

N/A

1.0DataRank · unranked

905 citations

Dariusz Przybylski, Monika S. Kowalczyk, Youmna Kfoury, Nicolas Severe, Karin Gustafsson +16 more

External signals regulate continuous transcriptional states in hematopoietic stem cells

eLife(2021)10.7554/elife.66512

N/A

1.0DataRank · unranked

28 citations

Audrey Sporrij, Margot E. Manning, Edroaldo Lummertz da Rocha, Song Yang, Yi Zhou +7 more

C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

Nature(2020)10.1038/s41586-020-2288-7

N/A

0.877DataRank · unranked

344 citations

Michael F. Wells, Francesco Limone, Alexander Benavides Couto, Kevin S. Smith, James Keaney +12 more

A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia

Nature Biomedical Engineering(2020)10.1038/s41551-019-0503-3

N/A

0.723DataRank · unranked

123 citations

Alexander J. Najibi, Ting‐Yu Shih, Angelo S. Mao, Azeem Sharda, David T. Scadden +2 more

A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

Nature Communications(2022)10.1038/s41467-022-33375-w

N/A

0.673DataRank · unranked

88 citations

Shenglin Mei, Ιωάννα Τσέα, Taghreed Hirz, Youmna Kfoury, Douglas M. Dahl +10 more

Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease

Nature Cardiovascular Research(2021)10.1038/s44161-021-00002-8

N/A

0.672DataRank · unranked

87 citations

Katrien Vandoorne, I‐Hsiu Lee, Jana Grune, Shuang Zhang, Cameron S. McAlpine +37 more

Sleep exerts lasting effects on hematopoietic stem cell function and diversity

The Journal of Experimental Medicine(2022)10.1084/jem.20220081

N/A

0.661DataRank · unranked

81 citations

Máté G. Kiss, Faris M. Zuraikat, David Cheek, Giulia Schiroli, Hajera Amatullah +18 more

Chromatin-state barriers enforce an irreversible mammalian cell fate decision

Cell Reports(2021)10.1016/j.celrep.2021.109967

N/A

0.596DataRank · unranked

52 citations

David B. Sykes, Lei Gu, Mengjun Wu, Ricardo Petroni, Rahul Karnik +11 more

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Cell stem cell(2021)10.1016/j.stem.2021.08.014

N/A

0.574DataRank · unranked

45 citations

Fei Ji, Michael Mazzola, David B. Sykes, Allison K. Scherer, Anthony Anselmo +14 more

Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging

Nature Methods(2022)10.1038/s41592-022-01673-2

N/A

0.546DataRank · unranked

37 citations

Karin Gustafsson, Shenglin Mei, Shu-Chi Yeh, Dmitry Richter, Jelena Milosevic +6 more

Cell of origin epigenetic priming determines susceptibility to Tet2 mutation

Nature Communications(2024)10.1038/s41467-024-48508-6

N/A

0.488DataRank · unranked

13 citations

Vinay K. Kartha, Fabiana M. Duarte, Trine Kristiansen, Christina Mayerhofer, Rojesh Shrestha +7 more

Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing

Nature Cell Biology(2024)10.1038/s41556-024-01387-x

N/A

0.483DataRank · unranked

24 citations

Polina Iakova, Charles G. Lee, Shannon E. Moree, Xuan Lu, Gandhar Datar +15 more

Recent advances in “sickle and niche” research - Tribute to Dr. Paul S Frenette -

Stem Cell Reports(2022)10.1016/j.stemcr.2022.06.004

N/A

0.406DataRank · unranked

14 citations

Noboru Asada, Mitchell J. Weiss, Andreas Trumpp, Toshio Suda, David T. Scadden +2 more

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Blood(2024)10.1182/blood.2023023549

N/A

0.360DataRank · unranked

10 citations

Rahul Palchaudhuri, Leanne Lanieri, Sharon L. Hyzy, Megan Riddle, Jamie Panthera +17 more

Immune‐responsive biodegradable scaffolds for enhancing neutrophil regeneration

Bioengineering & Translational Medicine(2022)10.1002/btm2.10309

N/A

0.345DataRank · unranked

9 citations

David A. McBride, W. T. Johnson, Arun K. Chumber, Alexander J. Najibi, Bo Ri Seo +5 more

Cyclophilin A regulates protein phase separation and mitigates haematopoietic stem cell aging

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.24.432737

N/A

0.241DataRank · unranked

4 citations

Polina Iakova, Shannon E. Moree, Jordon King, David B. Sykes, Cedric T. Hill +8 more

Tissue architecture dynamics underlying immune development and decline in the thymus

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.28.662120

N/A

0.165DataRank · unranked

2 citations

Mirco Friedrich, Ruth Raichur, Dennis Gong, Niklas Kehl, Qiyu Gong +8 more

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

Research Square(2022)10.21203/rs.3.rs-1489967/v1

N/A

0.165DataRank · unranked

2 citations

Shenglin Mei, Hirak Sarkar, Youmna Kfoury, Shulin Wu, Bronte Manouk Verhoeven +15 more

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.12.476097

N/A

0.137DataRank · unranked

1 citations

Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani, Christian Burns +21 more

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

bioRxiv (Cold Spring Harbor Laboratory)(2019)10.1101/556845

N/A

0.104DataRank · unranked

1 citations

Monika S. Kowalczyk, Kfoury Youmna, Nicolas Severe, Mercier Francois, Lee Dongjun +13 more

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.13.439696

N/A

0.104DataRank · unranked

1 citations

Fei Ji, Michael Mazzola, David B. Sykes, Allison K. Scherer, Anthony Anselmo +13 more

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.18.484781

N/A

0.104DataRank · unranked

1 citations

Shenglin Mei, Hirak Sarkar, Youmna Kfoury, Shulin Wu, Bronte Manouk Verhoeven +15 more

Multiomic analysis of clonal development reveals new regulators of leukemic cell growth

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.29.582846

N/A

0.104DataRank · unranked

1 citations

Alexander Morris, Sharmistha Kundu, Anthony Ducasse, Grace Kirkpatrick, Nathan Elias Jeffries +13 more

Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning

Molecular Therapy — Methods & Clinical Development(2020)10.1016/j.omtm.2020.02.001

N/A

0DataRank · unranked

33 citations

Olivier Humbert, Kevin G. Haworth, Christina Ironside, Yogendra Singh Rajawat, Bruce R. Blazar +6 more

Health Consequences of Thymus Removal in Adults

New England Journal of Medicine(2023)10.1056/nejmoa2302892

N/A

0DataRank · unranked

174 citations

Brody H. Foy, David B. Sykes, Karin Gustafsson, David T. Scadden, Kameron Kooshesh

Efficacy and safety of anti-CD45–saporin as conditioning agent for RAG deficiency

Journal of Allergy and Clinical Immunology(2020)10.1016/j.jaci.2020.04.033

N/A

0DataRank · unranked

42 citations

Marita Bosticardo, Nicolò Sacchetti, Enrica Calzoni, Elena Fontana, Yasuhiro Yamazaki +11 more

Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction

Nature Cardiovascular Research(2023)10.1038/s44161-023-00388-7

N/A

0DataRank · unranked

22 citations

Alexandre Paccalet, David Rohde, Sebastian Cremer, Maarten Hulsmans, I‐Hsiu Lee +29 more

Clearing and replacing tissue-resident myeloid cells with an anti-CD45 antibody–drug conjugate

Blood Advances(2023)10.1182/bloodadvances.2023010561

N/A

0DataRank · unranked

11 citations

Catherine Rhee, Vanessa Frodermann, Elizabeth W. Scadden, Dan Li, Yoshiko Iwamoto +6 more

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors

Blood(2023)10.1182/blood.2023020257

N/A

0DataRank · unranked

11 citations

Elizabeth W. Scadden, Lai Ping Wong, Giulia Schiroli, Michael Mazzola, Phillip Chea +11 more

CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.05.556397

N/A

0DataRank · unranked

0 citations

Catherine Rhee, Vanessa Frodermann, Elizabeth W. Scadden, Dan Li, Yoshiko Iwamoto +6 more

A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Cell stem cell(2024)10.1016/j.stem.2024.02.004

N/A

0DataRank · unranked

60 citations

Claudia Morganti, Nick van Gastel, Kyoko Ito, Enrica Calura, Ilaria Zanolla +16 more

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

Cell Metabolism(2021)10.1016/j.cmet.2021.03.003

N/A

0DataRank · unranked

93 citations

Azeem Sharda, Shuangnian Xu, Nick van Gastel, Cheuk Him Man, Una Choi +4 more

BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate

Cell stem cell(2024)10.1016/j.stem.2024.10.014

N/A

0DataRank · unranked

16 citations

Jing Zeng, Rahul Palchaudhuri, Chuanfeng Wu, Diana M. Abraham, Taha Bartu Hayal +36 more

Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Cell Reports(2020)10.1016/j.celrep.2020.108087

N/A

0DataRank · unranked

99 citations

Qinfeng Li, Herman I. May, Chao Li, Guangyu Zhang, Gaurav Sharma +10 more

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

Cancer Cell(2021)10.1016/j.ccell.2021.09.005

N/A

0DataRank · unranked

282 citations

Ninib Baryawno, Nicolas Sévère, Shenglin Mei, Karin Gustafsson, Taghreed Hirz +13 more

Chromatin state barriers enforce an irreversible mammalian cell fate decision

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.12.443709

N/A

0DataRank · unranked

3 citations

David B. Sykes, Lei Gu, Mengjun Wu, Ricardo Petroni, Rahul Karnik +11 more

Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML

Nature Communications(2021)10.1038/s41467-020-20491-8

N/A

0DataRank · unranked

38 citations

François Mercier, Hiroki Kato, Yookyung Jung, Thomas O. McDonald, Joel A. Spencer +7 more

Human progenitor T-cell differentiation regulated by the mechanical resistance of thymus-mimetic extracellular matrices

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.27.671384

N/A

0DataRank · unranked

1 citations

Kyle T Ruark, Joshua Price, Ella M Serrano-Wu, Blake F. Hanan, Andrew Khalil +14 more

A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.28.497333

N/A

0DataRank · unranked

0 citations

Shenglin Mei, Ιωάννα Τσέα, Taghreed Hirz, Youmna Kfoury, Douglas M. Dahl +10 more