Sasikanth Manne

Translational Therapeutics (United States)

Also affiliated with University of Pennsylvania

Immunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 32 papers. Top paper: “Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications”.

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Science(2020)10.1126/science.abc8511

N/A

14.5DataRank · unranked

1659 citations

Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Allison R. Greenplate, Jennifer E. Wu +50 more

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

Nature Immunology(2021)10.1038/s41590-021-00975-5

N/A

0.827DataRank · unranked

247 citations

Sasikanth Manne, Jean‐Christophe Beltra, Erietta Stelekati, Zeyu Chen, Kito Nzingha +8 more

In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

Cell(2021)10.1016/j.cell.2021.02.019

N/A

0.809DataRank · unranked

219 citations

Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan He +23 more

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

Cell Reports(2021)10.1016/j.celrep.2021.109120

N/A

0.724DataRank · unranked

124 citations

Shin Foong Ngiow, Zeyu Chen, John Attanasio, Sasikanth Manne, Gordon Ruthel +13 more

MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2106083119

N/A

0.489DataRank · unranked

25 citations

Zhangying Cai, Sasikanth Manne, Zeyu Chen, Jean‐Christophe Beltra, Lance Buchness +19 more

Deciphering the role of histone modifications in memory and exhausted CD8 T cells

Scientific Reports(2025)10.1038/s41598-025-99804-0

N/A

0.385DataRank · unranked

12 citations

Amy E. Baxter, Zhen Zhang, Charly R. Good, Katherine A. Alexander, Zeyu Chen +12 more

The identity of human tissue-emigrant CD8 + T cells

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.11.236372

N/A

0.269DataRank · unranked

5 citations

Laura A. Vella, Son Nguyen, Vincent H. Wu, Takuya Sekine, André Perez‐Potti +31 more

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.16.488552

N/A

0.269DataRank · unranked

5 citations

Sasikanth Manne, Nils Wellhausen, Derek A. Oldridge, Allison R. Greenplate, Lakshmi Chilukuri +10 more

Optimal pairing of binder and co-stimulatory domains improves dual CART cell efficacy

Molecular Therapy(2025)10.1016/j.ymthe.2025.08.002

N/A

0.247DataRank · unranked

4 citations

Sasikanth Manne, Shuguang Jiang, Marco Ruella, E. John Wherry, James L. Riley +1 more

Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways

Cell Reports Medicine(2021)10.1016/j.xcrm.2021.100262

N/A

0DataRank · unranked

56 citations

Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cécile Alanio, Bertram Bengsch +10 more

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.01.442279

N/A

0DataRank · unranked

13 citations

Amrita Sarkar, H.M. Giannini, Rishi Raj Goel, Divij Mathew, Aae Suzuki +31 more

Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics

Nature Immunology(2022)10.1038/s41590-022-01338-4

N/A

0DataRank · unranked

265 citations

Shin Foong Ngiow, Sasikanth Manne, Amy E. Baxter, Omar Khan, Ping Wang +15 more

Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3

Nature Immunology(2022)10.1038/s41590-022-01210-5

N/A

0DataRank · unranked

108 citations

Qianxia Zhang, Anthony R. Cillo, Sasikanth Manne, Hanxi Xiao, Erin A. Brunazzi +10 more

PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine

Nature Immunology(2022)10.1038/s41590-022-01274-3

N/A

0DataRank · unranked

79 citations

David A. Knorr, Laura A. Vella, Luisa Victoria Silva, Lakshmi Chilukuri, Sokratis A. Apostolidis +23 more

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19

Frontiers in Immunology(2022)10.3389/fimmu.2022.834988

N/A

0DataRank · unranked

54 citations

Amrita Sarkar, H.M. Giannini, Rishi Raj Goel, Divij Mathew, Aae Suzuki +32 more

Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

Nature Immunology(2020)10.1038/s41590-020-0733-2

N/A

0DataRank · unranked

151 citations

Ashwin Somasundaram, Sasikanth Manne, Angela M. Gocher, Andrea L. Szymczak-Workman, Kate M. Vignali +9 more

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.03.509766

N/A

0DataRank · unranked

14 citations

Mohamed S. Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Makoto Kurachi +15 more

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.27.485974

N/A

0DataRank · unranked

6 citations

Shin Foong Ngiow, Sasikanth Manne, Amy E. Baxter, Omar Khan, Ping Wang +10 more

Distinct Heterogeneity in the Naive T cell Compartments of Children and Adults

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.04.510869

N/A

0DataRank · unranked

2 citations

Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Mark-Phillip Pebworth +27 more

Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure

Immunity(2023)10.1016/j.immuni.2023.11.005

N/A

0DataRank · unranked

132 citations

Mohamed S. Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Makoto Kurachi +16 more

In vitro modeling of CD8 + T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40

Science Immunology(2023)10.1126/sciimmunol.ade3369

N/A

0DataRank · unranked

94 citations

Sasikanth Manne, Shin Foong Ngiow, Amy E. Baxter, Hua Huang, Elizabeth Freilich +10 more

Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment

Nature Immunology(2023)10.1038/s41590-023-01641-8

N/A

0DataRank · unranked

40 citations

Ziyuan He, Elliott Swanson, Katherine Henderson, Cole Phalen, Samir Rachid Zaim +29 more

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.17.537229

N/A

0DataRank · unranked

4 citations

Sasikanth Manne, Shin Foong Ngiow, Amy E. Baxter, Hua Huang, Elizabeth Freilich +10 more

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

Cell(2024)10.1016/j.cell.2024.07.016

N/A

0DataRank · unranked

244 citations

Samuel C. Butler, Jian Cui, Anthony R. Cillo, Carly Cardello, Chang Liu +15 more

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells

Cancer Cell(2024)10.1016/j.ccell.2024.08.007

N/A

0DataRank · unranked

102 citations

Paulina Coutifaris, David Brocks, Guanning Wang, Tarek Azar, Sabrina Solis +33 more

LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

Cell(2024)10.1016/j.cell.2024.07.018

N/A

0DataRank · unranked

100 citations

Sasikanth Manne, Yinghui Huang, Tarek Azar, Zeyu Chen, Divij Mathew +15 more

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 + T cells underlies distinct functional potential

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.08.669213

N/A

0DataRank · unranked

1 citations

Mark M. Painter, Sasikanth Manne, Víctor Alcalde, M. A. McLaughlin, Matthew Sullivan +28 more

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.20.087379

N/A

0DataRank · unranked

3 citations

Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan He +20 more

Deciphering the role of histone modifications in memory and exhausted CD8 T cells

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.16.649198

N/A

0DataRank · unranked

0 citations

Amy E. Baxter, Zhen Zhang, Charly R. Good, Katherine A. Alexander, Zeyu Chen +12 more

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.20.106401

N/A

0DataRank · unranked

115 citations

Josephine R. Giles, Amy E. Baxter, Allison R. Greenplate, Jennifer E. Wu, Cécile Alanio +33 more

The Identity of Human Tissue-Emigrant CD8+ T Cells

Cell(2020)10.1016/j.cell.2020.11.019

N/A

0DataRank · unranked

109 citations

Laura A. Vella, Son Nguyen, Vincent H. Wu, Zeyu Chen, Takuya Sekine +35 more

Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage

Science Immunology(2021)10.1126/sciimmunol.abe3702

N/A

0DataRank · unranked

92 citations

Yuki Muroyama, Shin Foong Ngiow, Zeyu Chen, Sasikanth Manne, Zhangying Cai +23 more