Bryan L. Roth

University of North Carolina at Chapel Hill

NeuroscienceNursingEngineering

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 4%percentile

0.889Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search

Nature Communications(2023)10.1038/s41467-023-39905-4

Top 23%

0.889DataRank

Top 23%28 citations

Mustafa Güler, Desnor N. Chigumba, Shen Wang, Neel Mittal, Cameron Miller +12 more

Papers

Driven by 147 papers — median percentile 39. Top paper: “AlphaFold2 structures guide prospective ligand discovery”.

AlphaFold2 structures guide prospective ligand discovery

Science(2024)10.1126/science.adn6354

N/A

3.3DataRank · unranked

151 citations

Nicholas J. Kapolka, Ryan H. Gumpper, Assaf Alon, Liang Wang, Manish K. Jain +16 more

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

Cell(2020)10.1016/j.cell.2020.08.024

N/A

0.932DataRank · unranked

497 citations

Tao Che, Ouliana Panova, Jeffrey F. DiBerto, Jiankun Lyu, B. Krumm +8 more

HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search

Nature Communications(2023)10.1038/s41467-023-39905-4

Top 23%

0.889DataRank

Top 23%28 citations

Mustafa Güler, Desnor N. Chigumba, Shen Wang, Neel Mittal, Cameron Miller +12 more

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Frontiers in Pharmacology(2021)10.3389/fphar.2021.633680

N/A

0.700DataRank · unranked

105 citations

Philip Tisdall, Philip Fremont‐Smith, Yongfeng Liu, Xi‐Ping Huang, Kris M. White +20 more

Docking for EP4R antagonists active against inflammatory pain

Nature Communications(2023)10.1038/s41467-023-43506-6

N/A

0.564DataRank · unranked

42 citations

Chelsea DeLeon, João Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan +14 more

The postnatal development of VIP binding sites in rat forebrain and hindbrain

Peptides(1985)10.1016/0196-9781(85)90071-3

N/A

0.494DataRank · unranked

26 citations

Margery C. Beinfeld, Bryan L. Roth

A proximity proteomics pipeline with improved reproducibility and throughput

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.11.536358

N/A

0.486DataRank · unranked

12 citations

Qiongyu Li, Benjamin J. Polacco, Trupti Patil, Aaron Marley, Helene Foussard +10 more

A proximity proteomics pipeline with improved reproducibility and throughput

Molecular Systems Biology(2024)10.1038/s44320-024-00049-2

N/A

0.464DataRank · unranked

21 citations

Qiongyu Li, Benjamin J. Polacco, Trupti Patil, Aaron Marley, Helene Foussard +10 more

High-affinity agonists reveal recognition motifs for the MRGPRD GPCR

Cell Reports(2024)10.1016/j.celrep.2024.114942

N/A

0.367DataRank · unranked

8 citations

Yongfeng Liu, Marion Lanier, Adam R. Yeager, Isha Singh, Ryan H. Gumpper +14 more

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

INDIGO (University of Illinois at Chicago)(2021)10.17615/s98d-vh37

N/A

0.345DataRank · unranked

9 citations

Abdellah Allali‐Hassani, Victoria Korboukh, Jian Jin, Xi‐Ping Huang, Masoud Vedadi +9 more

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.22.440994

N/A

0.292DataRank · unranked

6 citations

Jeffrey F. DiBerto, Abdelfattah Faouzi, Sarah M. Bernhard, Anna M. Gutridge, Steven Ramsey +19 more

Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc

UNC Libraries(2020)10.17615/3gw8-0n78

N/A

0DataRank · unranked

6 citations

Bryan L. Roth, Xi‐Ping Huang, Seiji Sato, Wesley K. Kroeze

Inhibition of Mediodorsal Thalamus Disrupts Thalamofrontal Connectivity and Cognition

UNC Libraries(2020)10.17615/hn5k-rm82

N/A

0DataRank · unranked

3 citations

Bryan L. Roth, Scott S. Bolkan, Ryan D. Ward, Christoph Kellendonk, Peter D. Balsam +4 more

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

UNC Libraries(2020)10.17615/xksw-7k89

N/A

0DataRank · unranked

4 citations

Jian Jin, Orrin J. Stone, Xi‐Ping Huang, Xin Chen, Bryan L. Roth +2 more

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Figshare(2020)10.17615/q3bp-3c89

N/A

0DataRank · unranked

3 citations

Feng Liu, Masoud Vedadi, Kyle D. Konze, C.H. Arrowsmith, Gang Greg Wang +18 more

Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome

UNC Libraries(2020)10.17615/qvvc-ka29

N/A

0DataRank · unranked

2 citations

Jeffrey I. Everitt, Noah Sciaky, Yuna Kim, Bryan L. Roth, Yan Xiong +5 more

Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one

UNC Libraries(2020)10.17615/sk1g-tg62

N/A

0DataRank · unranked

2 citations

Eyunni V.K. Suresh Kumar, Abdul Latif Khan, Bryan L. Roth, Seth Y. Ablordeppey, Xue Y. Zhu +3 more

Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists

Figshare(2020)10.17615/6kd3-3g60

N/A

0DataRank · unranked

2 citations

Jian Jin, John D. McCorvy, Kyle V. Butler, Yudao Shen, Bryan L. Roth +2 more

Bis-spirolabdane Diterpenoids from Leonotis nepetaefolia

Figshare(2020)10.17615/4hck-7788

N/A

0DataRank · unranked

1 citations

Jordan K. Zjawiony, Bryan L. Roth, Daneel Ferreira, Jun Li

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

UNC Libraries(2020)10.17615/dj89-pm49

N/A

0DataRank · unranked

1 citations

Eyal Vardy, Daniel J. Urban, Patrick M. Giguère, Joseph E. Rittiner, Juan Song +16 more

Structure–Functional Selectivity Relationship Studies of β-Arrestin-Biased Dopamine D 2 Receptor Agonists

INDIGO (University of Illinois at Chicago)(2020)10.17615/qbdk-ee59

N/A

0DataRank · unranked

1 citations

William C. Wetsel, Jian Jin, Stephen V. Frye, Meng Chen, Maria F. Sassano +5 more

Application of Quantitative Structure–Activity Relationship Models of 5-HT 1A Receptor Binding to Virtual Screening Identifies Novel and Potent 5-HT 1A Ligands

UNC Libraries(2020)10.17615/yqtx-qp19

N/A

0DataRank · unranked

1 citations

Man Luo, Alexander Tropsha, Bryan L. Roth, Alexander Golbraikh

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

INDIGO (University of Illinois at Chicago)(2020)10.17615/f5mg-va38

N/A

0DataRank · unranked

1 citations

Zhong Zheng, Vsevolod Katritch, Raymond C. Stevens, Xi‐Ping Huang, Saheem A. Zaidi +4 more

D 4 dopamine receptor high-resolution structures enable the discovery of selective agonists

UNC Libraries(2020)10.17615/2q94-vv62

N/A

0DataRank · unranked

21 citations

Daniel Wacker, Bryan L. Roth, John D. McCorvy, Venkatakrishnan, Robin M. Betz +6 more

Erratum: VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells (Cell (2019) 178(3) (748–761.e17), (S0092867419306221), (10.1016/j.cell.2019.05.051))

UNC Libraries(2020)10.17615/p0d3-sp17

N/A

0DataRank · unranked

0 citations

R.H.J. Olsen, Bryan L. Roth, Ryan T. Strachan, Adam S. Cockrell, Katherine Lansu +5 more

Faculty Opinions recommendation of Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature(2020)10.3410/f.736929268.793575111

N/A

0DataRank · unranked

0 citations

Bryan L. Roth

Faculty Opinions recommendation of G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature(2020)10.3410/f.738475954.793578850

N/A

0DataRank · unranked

0 citations

Bryan L. Roth

Photochemical activation of TRPA1 channels in neurons and animals

UNC Libraries(2020)10.17615/8tf2-z486

N/A

0DataRank · unranked

0 citations

Randall T. Peterson, Robert Mills, Jaeda Coutinho‐Budd, Clifford J. Woolf, Jared Sprague +12 more

Automated design of ligands to polypharmacological profiles

UNC Libraries(2020)10.17615/2v9s-yz71

N/A

0DataRank · unranked

0 citations

Lauren Webster, Frederick R. C. Simeons, Ian H. Gilbert, Keren Abecassis, Suzanne Norval +16 more

Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2020)10.17615/wb9e-4z40

N/A

0DataRank · unranked

0 citations

Bryan L. Roth, Philip D. Mosier, Prabhakar R. Polepally, Krzysztof Huben, Jordan K. Zjawiony +2 more

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily

UNC Libraries(2020)10.17615/wdtb-c442

N/A

0DataRank · unranked

0 citations

Wesley K. Kroeze, Bryan L. Roth

Search for α3β2/3γ2 subtype selective ligands that are stable on human liver microsomes

UNC Libraries(2020)10.17615/v82z-qp09

N/A

0DataRank · unranked

0 citations

James M. Cook, Yun-Teng Johnson, Samarpan Majumder, Edward M. Johnson, Zdravko Varagić +8 more

Chemical informatics and target identification in a zebrafish phenotypic screen

UNC Libraries(2020)10.17615/90rb-b065

N/A

0DataRank · unranked

0 citations

Henry C. Lin, Christian Laggner, Bryan L. Roth, Vincent Setola, David Kokel +7 more

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader–Willi syndrome

UNC Libraries(2020)10.17615/05n9-rx09

N/A

0DataRank · unranked

0 citations

Robert A. Kesterson, Atheir I. Abbas, David S. Kump, Ronald B. Emeson, Michelle M. Jacobs +4 more

CoMFA analyses of C-2 position Salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity

UNC Libraries(2020)10.17615/dk44-1567

N/A

0DataRank · unranked

0 citations

Richard B. Westkaemper, Philip D. Mosier, Bryan L. Roth, Donna L. McGovern

Structure-Based Design, Synthesis, and Biochemical and Pharmacological Characterization of Novel Salvinorin A Analogues as Active State Probes of the κ-Opioid Receptor

UNC Libraries(2020)10.17615/h3sg-4w85

N/A

0DataRank · unranked

0 citations

Jordan K. Zjawiony, Bryan L. Roth, Feng Yan, Viorel Mocanu, William C. Wetsel +6 more

Labdane Diterpenoids from Leonotis leonurus

UNC Libraries(2020)10.17615/hgxr-8d81

N/A

0DataRank · unranked

0 citations

Charles L. Burandt, Daneel Ferreira, Bryan L. Roth, Vincent Setola, Jordan K. Zjawiony +3 more

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

UNC Libraries(2020)10.17615/9drd-2371

N/A

0DataRank · unranked

0 citations

Andrea Velenich, Giancarlo Bruni, Barbara J. Caldarone, Tama Evron, Andrew J. Rennekamp +15 more

Structure–activity relationship studies of SYA 013, a homopiperazine analog of haloperidol

UNC Libraries(2020)10.17615/dzne-3y46

N/A

0DataRank · unranked

0 citations

Seth Y. Ablordeppey, Vincent Setola, Bryan L. Roth, Xue Y. Zhu, Jagan R. Etukala +2 more

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

UNC Libraries(2020)10.17615/2ta2-f261

N/A

0DataRank · unranked

0 citations

Xiaohui Wang, Daniel J. Urban, Timothy Fabisiak, Hang Yin, Debra Berkelhammer +14 more

Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML

UNC Libraries(2020)10.17615/zvb0-bn49

N/A

0DataRank · unranked

0 citations

Mukesh K. Agarwal, Munna L. Agarwal, Bryan L. Roth, Amitabha Chakrabarti, David N. Wald +4 more

Deorphanization of Novel Peptides and Their Receptors

UNC Libraries(2020)10.17615/cfhp-hv03

N/A

0DataRank · unranked

0 citations

Wesley K. Kroeze, Bryan L. Roth, Akihiko Ozawa, Iris Lindberg

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

UNC Libraries(2020)10.17615/85jg-vv31

N/A

0DataRank · unranked

0 citations

Eleftheria Maratos–Flier, Michael J. Krashes, Andrew C. Adams, Chianping Ye, Bryan L. Roth +4 more

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine

UNC Libraries(2020)10.17615/39gt-9h56

N/A

0DataRank · unranked

0 citations

Alison I. Bernstein, Brian K. Shoichet, Bradley W. Gray, William C. Wetsel, Martilias S. Farrell +17 more

Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT 2A ) Serotonin Receptor, Thereby Modulating 5-HT 2A Signaling

UNC Libraries(2020)10.17615/4x2x-3j03

N/A

0DataRank · unranked

0 citations

Bryan L. Roth, Michael Kinter, Ryan T. Strachan, Belinda Willard, Douglas J. Sheffler +1 more

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

UNC Libraries(2020)10.17615/784j-zg92

Top 100%

0DataRank

Top 100%0 citations

Bryan L. Roth, Xi‐Ping Huang, Maria F. Sassano, Katherine Lansu, Wesley K. Kroeze +3 more

Sigma-1 receptor ligands control a switch between passive and active threat responses

UNC Libraries(2020)10.17615/bymg-p559

N/A

0DataRank · unranked

0 citations

David Kokel, Paul J. Lorello, Bryan L. Roth, Andrew J. Rennekamp, Andrew P. W. Gonzales +7 more

Chemocentric Informatics Approach to Drug Discovery: Identification and Experimental Validation of Selective Estrogen Receptor Modulators as Ligands of 5-Hydroxytryptamine-6 Receptors and as Potential Cognition Enhancers

INDIGO (University of Illinois at Chicago)(2020)10.17615/vwkf-v610

N/A

0DataRank · unranked

0 citations

Alexander Tropsha, Bryan L. Roth, Rima Hajjo, Vincent Setola

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype–targeted drugs

UNC Libraries(2020)10.17615/6vy3-9306

N/A

0DataRank · unranked

0 citations

Bryan L. Roth, Herbert Y. Meltzer

Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): A search for new dual-acting agents as potential antidepressants

UNC Libraries(2020)10.17615/jz8w-q417

N/A

0DataRank · unranked

0 citations

Xue Y. Zhu, Bryan L. Roth, Jagan R. Etukala, Vincent Setola, Seth Y. Ablordeppey +1 more

Synthesis and biological evaluation of new salvinorin A analogues incorporating natural amino acids

UNC Libraries(2020)10.17615/69pg-jt60

N/A

0DataRank · unranked

0 citations

Kevin Lewellyn, Jakub Fichna, Jordan K. Zjawiony, Yan, Feng, Bryan L. Roth

The TLQP-21 Peptide Activates the G-Protein-Coupled Receptor C3aR1 via a Folding-upon-Binding Mechanism

UNC Libraries(2020)10.17615/7s7n-b848

N/A

0DataRank · unranked

0 citations

Lucy Vulchanova, Alessandro Bartolomucci, Maria F. Sassano, Cinzia Severini, Raffaello Verardi +8 more

Quantitative Analysis of Focused A-To-I RNA Editing Sites by Ultra-High-Throughput Sequencing in Psychiatric Disorders

UNC Libraries(2020)10.17615/eyrf-th35

N/A

0DataRank · unranked

0 citations

Craig A. Stockmeier, Gouri Mahajan, George Jurjus, James C. Overholser, Bryan L. Roth +10 more

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

UNC Libraries(2020)10.17615/5572-wm60

N/A

0DataRank · unranked

0 citations

Paul E. M. Phillips, Daniel Eskenazi, John F. Neumaier, Matthew J. Wanat, Yan Dong +3 more

Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents

Figshare(2020)10.17615/ms9t-0a86

N/A

0DataRank · unranked

0 citations

William C. Wetsel, Wei Lv, Bryan L. Roth, Oluseye K. Onajole, Arsen Gaisin +8 more

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Figshare(2020)10.17615/zms0-t330

N/A

0DataRank · unranked

0 citations

Laura M. Wingler, Seungkirl Ahn, Iva Navrátilová, Zhu Xiao, Kevin D. Read +13 more

Antiseizure Activity of Novel γ-Aminobutyric Acid (A) Receptor Subtype-Selective Benzodiazepine Analogues in Mice and Rat Models

Figshare(2020)10.17615/3252-n144

N/A

0DataRank · unranked

0 citations

Bryan L. Roth, Lauren J. Murphree, Chitra R. Edwankar, Subramanian Sankar, Shengming Huang +10 more

Marine Algal Toxin Azaspiracid Is an Open-State Blocker of hERG Potassium Channels

UNC Libraries(2020)10.17615/s19w-ew87

N/A

0DataRank · unranked

0 citations

Xi Huang, Michael C. Sanguinetti, Gregory J. Doucette, Andrew J. Rasky, Michael J. Twiner +1 more

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

UNC Libraries(2020)10.17615/e45z-q037

N/A

0DataRank · unranked

0 citations

Avner Schlessinger, Brian K. Shoichet, Hao Fan, Jens Carlsson, John J. Irwin +4 more

Pharmacosynthetics: Reimagining the pharmacogenetic approach

UNC Libraries(2020)10.17615/jm0j-tb27

N/A

0DataRank · unranked

0 citations

Bryan L. Roth, Martilias S. Farrell

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

UNC Libraries(2020)10.17615/0hx7-5k75

N/A

0DataRank · unranked

0 citations

Bryan L. Roth, John D. McCorvy, Jonathan S. Marchant, Pauline M. Cupit, Gihan S. Gunaratne +7 more

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

UNC Libraries(2020)10.17615/s278-v194

N/A

0DataRank · unranked

0 citations

Luo Xiao, Magdalena M. Szewczyk, Masoud Vedadi, Aiping Dong, David Smil +24 more

Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists

UNC Libraries(2020)10.17615/t8my-xj88

N/A

0DataRank · unranked

0 citations

Richard B. Westkaemper, Eyal Vardy, Bryan L. Roth, Vsevolod Katritch, Huixian Wu +4 more

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

UNC Libraries(2020)10.17615/st68-1d31

N/A

0DataRank · unranked

0 citations

Casey M. O’Connor, Kate White, Alain Milon, Kurt Wüthrich, Georges Czaplicki +4 more

Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method

UNC Libraries(2020)10.17615/72wp-4772

N/A

0DataRank · unranked

0 citations

Wesley K. Kroeze, Niels Jensen, Bryan L. Roth, Zefeng Wang, Piotr A. Mieczkowski +3 more

Identification of 6-Benzylthioinosine as a Myeloid Leukemia Differentiation-Inducing Compound

UNC Libraries(2020)10.17615/2mn6-3206

N/A

0DataRank · unranked

0 citations

William Tse, Zizhen Kang, Munna L. Agarwal, Bryan L. Roth, David N. Wald +6 more

Molecular control of δ-opioid receptor signalling

UNC Libraries(2020)10.17615/qb8y-7n16

N/A

0DataRank · unranked

0 citations

Vsevolod Katritch, Bryan L. Roth, Gustavo Fenalti, Xi‐Ping Huang, Raymond C. Stevens +3 more

Rational Drug Design Leading to the Identification of a Potent 5-HT 2C Agonist Lacking 5-HT 2B Activity

INDIGO (University of Illinois at Chicago)(2020)10.17615/5qmt-v586

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0DataRank · unranked

0 citations

Andreas Svennebring, Alan P. Kozikowski, Niels Jensen, Bryan L. Roth, Sung Jin Cho +3 more

Noradrenergic Synaptic Function in the Bed Nucleus of the Stria Terminalis Varies in Animal Models of Anxiety and Addiction

UNC Libraries(2020)10.17615/w5g0-7s02

N/A

0DataRank · unranked

0 citations

Daniel J. Urban, Bryan L. Roth, Megan E. Fox, Zoé A. McElligott, Martilias S. Ferrel +2 more

Engineering GPCR signaling pathways with RASSLs

UNC Libraries(2020)10.17615/df3a-7x17

N/A

0DataRank · unranked

0 citations

Robert A. Nissenson, Joël Bockaert, John Forsayeth, Jürgen Wess, Ken D. McCarthy +9 more

Short synthesis of a novel class of salvinorin A analogs with hemiacetalic structure

UNC Libraries(2020)10.17615/pkdc-f989

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0DataRank · unranked

0 citations

Wentao Jin, R. V. Bikbulatov, Bryan L. Roth, Daneel Ferreira, Jeremy G. Stewart +2 more

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

UNC Libraries(2020)10.17615/mwkz-1n21

N/A

0DataRank · unranked

0 citations

Bryan L. Roth, Uwe Weierstall, Nilkanth Patel, Ai Zhang, Mili Kapoor +9 more

Nanobody-enabled monitoring of kappa opioid receptor states

Nature Communications(2020)10.1038/s41467-020-14889-7

N/A

0DataRank · unranked

139 citations

Justin G. English, B. Krumm, Kuglae Kim, Els Pardon, Reid H. J. Olsen +9 more

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

UNC Libraries(2020)10.17615/sjhp-f785

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0DataRank · unranked

0 citations

Jennifer M. Bossert, Bruce T. Hope, Brandon K. Harvey, Thomas E. Prisinzano, Yavin Shaham +6 more

Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands

UNC Libraries(2020)10.17615/4jp1-mb35

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0DataRank · unranked

0 citations

Kate White, Bryan L. Roth, Daneel Ferreira, Jordan K. Zjawiony, Prabhakar R. Polepally +1 more

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

UNC Libraries(2020)10.17615/pb3b-nm22

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0DataRank · unranked

0 citations

John D. McCorvy, Tim A. Day, Malcolm E. Johns, John D. Chan, Sreemoyee Acharya +2 more

In silico design of novel probes for the atypical opioid receptor MRGPRX2

UNC Libraries(2020)10.17615/w4az-cw05

N/A

0DataRank · unranked

0 citations

Tao Che, Frank I. Carroll, Wesley K. Kroeze, Hiroshi Nagase, Joel Karpiak +7 more

Development, Validation, and Use of Quantitative Structure−Activity Relationship Models of 5-Hydroxytryptamine (2B) Receptor Ligands to Identify Novel Receptor Binders and Putative Valvulopathic Compounds among Common Drugs

Figshare(2020)10.17615/34gp-xv08

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0DataRank · unranked

0 citations

Alexander Tropsha, Bryan L. Roth, Rima Hajjo, Alexander Golbraikh, Vincent Setola +2 more

Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands

UNC Libraries(2020)10.17615/k5mp-zz98

N/A

0DataRank · unranked

0 citations

Edward Ofori, Bryan L. Roth, Xi‐Ping Huang, Jagan R. Etukala, Kamanski R. Jordan +6 more

In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding

UNC Libraries(2020)10.17615/hdrf-bp38

N/A

0DataRank · unranked

0 citations

Zena Werb, Michael J. Keiser, Brian K. Shoichet, George A. Lemieux, Christian Laggner +5 more

HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data

UNC Libraries(2020)10.17615/a39s-h534

N/A

0DataRank · unranked

0 citations

Denis Fourches, Alexander Tropsha, Maria F. Sassano, Bryan L. Roth

Intestinal Epithelial Cell–Derived μ-Opioid Signaling Protects against Ischemia Reperfusion Injury through PI3K Signaling

UNC Libraries(2020)10.17615/mdr1-4c19

N/A

0DataRank · unranked

0 citations

Jason R. Goldsmith, Ernesto Peréz-Chanona, Prem N. Yadav, Bryan L. Roth, Jennifer L. Whistler +1 more

Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorin A and B

UNC Libraries(2020)10.17615/mkj7-w712

N/A

0DataRank · unranked

0 citations

R. V. Bikbulatov, Bryan L. Roth, Feng Yan, Jordan K. Zjawiony

Design and synthesis of (2-(5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a selective serotonin 2C agonist This Letter is dedicated to the lasting memory of Harry H. Wasserman, a connoisseur of heterocycles

UNC Libraries(2020)10.17615/mvqt-gd37

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0 citations

Patrick M. Giguère, Bryan L. Roth, Wei Lv, Jianjun Cheng, Alan P. Kozikowski

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism

UNC Libraries(2020)10.17615/xya2-4340

N/A

0DataRank · unranked

0 citations

C. J. Malanga, Kate White, Jeffrey F. DiBerto, Sun Hui, Vladimir I. Chefer +9 more

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

UNC Libraries(2020)10.17615/qe7c-h860

N/A

0DataRank · unranked

0 citations

Claudio Trapella, Vadim Cherezov, Vsevolod Katritch, Xi‐Ping Huang, Eugene Chun +8 more

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

UNC Libraries(2020)10.17615/n8xg-b035

N/A

0DataRank · unranked

0 citations

Thuy B. Tran, Bryan L. Roth, Xi‐Ping Huang, Herbert Y. Meltzer, Peter B. Hedlund +1 more

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

UNC Libraries(2020)10.17615/h6h3-eh02

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0DataRank · unranked

0 citations

Peter A. DiMaggio, Dalia Barsyte-Lovejoy, Sylvie Rival‐Gervier, W. Tempel, Feng Liu +27 more

Structures of the σ2 receptor enable docking for bioactive ligand discovery

Nature(2021)10.1038/s41586-021-04175-x

N/A

0DataRank · unranked

198 citations

Jiankun Lyu, João M. Bráz, Tia A. Tummino, Veronica Craik, Matthew J. O’Meara +11 more

Biased ligands at opioid receptors: Current status and future directions

Science Signaling(2021)10.1126/scisignal.aav0320

N/A

0DataRank · unranked

114 citations

Hemlata Dwivedi‐Agnihotri, Arun K. Shukla, Bryan L. Roth, Tao Che

A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01273

N/A

0DataRank · unranked

75 citations

Jeffrey F. DiBerto, Abdelfattah Faouzi, Sarah M. Bernhard, Anna M. Gutridge, Steven Ramsey +19 more

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

eLife(2021)10.7554/elife.56519

N/A

0DataRank · unranked

66 citations

Tao Che, Saheem A. Zaidi, Steven G. Grinnell, Balázs R. Varga, Abdelfattah Faouzi +19 more

A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects

Neuropharmacology(2021)10.1016/j.neuropharm.2021.108673

N/A

0DataRank · unranked

34 citations

Hye Jin Kang, Farhana Sakloth, Yongfeng Liu, Susan Khan, Katalin Tóth +12 more

G-Protein Peptidomimetics Stabilize GPCR Active State Conformations

Trends in Pharmacological Sciences(2021)10.1016/j.tips.2021.03.009

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7 citations

Bryan L. Roth, Ryan H. Gumpper

Introduction to the Biochemistry of Pain Special Issue

Biochemistry(2021)10.1021/acs.biochem.1c00274

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0DataRank · unranked

1 citations

Bryan L. Roth

The cranial windows of perception

Neuron(2021)10.1016/j.neuron.2021.07.017

N/A

0DataRank · unranked

2 citations

Bryan L. Roth, Jeffrey F. DiBerto

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.07.430101

N/A

0DataRank · unranked

9 citations

B. Krumm, Huibing Zhang, X. Edward Zhou, Yue Wang, Xi‐Ping Huang +10 more

Crystal structures of the σ 2 receptor template large-library docking for selective chemotypes active in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.29.441652

N/A

0DataRank · unranked

7 citations

Jiankun Lyu, João M. Bráz, Tia A. Tummino, Veronica Craik, Matthew J. O’Meara +11 more

Structural insights into distinct signaling profiles of the μOR activated by diverse agonists

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.07.471645

N/A

0DataRank · unranked

6 citations

Weijiao Huang, Deniz Aydın, Joseph M. Paggi, Alpay B. Seven, Haoqing Wang +11 more

A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.24.445057

N/A

0DataRank · unranked

0 citations

Hye Jin Kang, Farhana Sakloth, Yongfeng Liu, Susan Khan, Katalin Tóth +12 more

Prevalent mouse phenotypes in the unexplored druggable genome

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.08.467777

N/A

0DataRank · unranked

0 citations

Zicheng Hu, Tudor I. Oprea, K. C. Kent Lloyd, Shawn M. Gomez, Bryan L. Roth +2 more

Faculty Opinions recommendation of Single-molecule FRET imaging of GPCR dimers in living cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature(2021)10.3410/f.739696168.793583700

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0DataRank · unranked

0 citations

Bryan L. Roth

Synthesis and evaluation of ligands for D2-like receptors: The role of common pharmacophoric groups

UNC Libraries(2021)10.17615/7wce-re35

N/A

0DataRank · unranked

0 citations

Ramazan Altundaş, Seth Y. Ablordeppey, Xue Y. Zhu, Vincent Setola, Bryan L. Roth +2 more

Modulation of the autonomic nervous system and behaviour by acute glial cell G q protein-coupled receptor activation in vivo: Glial GPCR signalling in physiology and behaviourin vivo

UNC Libraries(2021)10.17615/wsvk-jh06

N/A

0DataRank · unranked

0 citations

Ken D. McCarthy, Cendra Agulhon, Bryan L. Roth, François Friocourt, Alison Xiaoqiao Xie +1 more

Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents

UNC Libraries(2021)10.17615/gxfm-g556

N/A

0DataRank · unranked

0 citations

Vincent Setola, Kwakye Peprah, Suresh Eyunni, Bryan L. Roth, Seth Y. Ablordeppey +1 more

Structure-based design of bitopic ligands for the µ-opioid receptor

Nature(2022)10.1038/s41586-022-05588-y

N/A

0DataRank · unranked

128 citations

Haoqing Wang, Saheem A. Zaidi, Jeffrey F. DiBerto, Tao Che, Qianhui Qu +21 more

Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors

Cell Reports(2022)10.1016/j.celrep.2022.111211

N/A

0DataRank · unranked

49 citations

Jonathan F. Fay, Bryan L. Roth, Ryan H. Gumpper

Inactive and active state structures template selective tools for the human 5-HT5A receptor

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00796-6

N/A

0DataRank · unranked

29 citations

He Chen, Chengwei Zhang, Yang Ying, Petr Popov, Jing Liu +10 more

Agonist and antagonist TRUPATH assays for G protein-coupled receptors

STAR Protocols(2022)10.1016/j.xpro.2022.101259

N/A

0DataRank · unranked

22 citations

Katie Smart, Reid H. J. Olsen, Bryan L. Roth, Jeffrey F. DiBerto

Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.26.521971

N/A

0DataRank · unranked

6 citations

Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang +9 more

Structures of the entire human opioid receptor family

Cell(2023)10.1016/j.cell.2022.12.026

N/A

0DataRank · unranked

194 citations

Youwen Zhuang, Jeffrey F. DiBerto, X. Edward Zhou, Gavin P. Schmitz, Qingning Yuan +7 more

Molecular basis of opioid receptor signaling

Cell(2023)10.1016/j.cell.2023.10.029

N/A

0DataRank · unranked

117 citations

Bryan L. Roth, Tao Che

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter

Cell(2023)10.1016/j.cell.2023.04.010

N/A

0DataRank · unranked

97 citations

Anubha Seth, Christian B. Billesbølle, João M. Bráz, Ramona M. Rodriguiz, Kasturi Roy +16 more

The structure, function, and pharmacology of MRGPRs

Trends in Pharmacological Sciences(2023)10.1016/j.tips.2023.02.002

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0DataRank · unranked

46 citations

Bryan L. Roth, Can Cao

Catalytic site mutations confer multiple states of G protein activation

Science Signaling(2023)10.1126/scisignal.abq7842

N/A

0DataRank · unranked

22 citations

Ning Ma, Nadia Arang, Sarah A. Martin, Ajit Prakash, Jeffrey F. DiBerto +9 more

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework

Journal of Chemical Information and Modeling(2023)10.1021/acs.jcim.3c00651

N/A

0DataRank · unranked

22 citations

Davide Provasi, Xing Qiu, H. Ümit Kanıskan, Xi‐Ping Huang, Jeffrey F. DiBerto +5 more

CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps

Cell chemical biology(2023)10.1016/j.chembiol.2023.10.014

N/A

0DataRank · unranked

2 citations

Bryan L. Roth, B. Krumm

AlphaFold2 structures template ligand discovery

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.20.572662

N/A

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19 citations

Nicholas J. Kapolka, Ryan H. Gumpper, Assaf Alon, Liang Wang, Manish K. Jain +15 more

A suite of engineered mice for interrogating psychedelic drug actions

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.25.559347

N/A

0DataRank · unranked

15 citations

Ariel Y. Deutch, Wei Wang, Gavin P. Schmitz, Karen Huang, D. Dewran Koçak +17 more

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.23.563088

N/A

0DataRank · unranked

4 citations

Radda Rusinova, Karl F. Herold, Xi‐Ping Huang, Patricia Dranchak, Ty C. Voss +9 more

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.25.537995

N/A

0DataRank · unranked

1 citations

Davide Provasi, Xing Qui, H. Ümit Kanıskan, Xi‐Ping Huang, Jeffrey F. DiBerto +5 more

Bitter taste receptor activation by cholesterol and an intracellular tastant

Nature(2024)10.1038/s41586-024-07253-y

N/A

0DataRank · unranked

91 citations

Ryan H. Gumpper, Yongfeng Liu, D. Dewran Koçak, Yan Xiong, Can Cao +7 more

Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism

Addiction Neuroscience(2024)10.1016/j.addicn.2024.100155

N/A

0DataRank · unranked

57 citations

Xi‐Ping Huang, J. G. Murray, Alexandra C. Nowlan, Sara Y. Conley, Sarah E. Mott +8 more

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

Nature Communications(2024)10.1038/s41467-024-50964-z

N/A

0DataRank · unranked

17 citations

B. Krumm, Nicholas J. Kapolka, W.H. Ludlam, Meng Cui, Sepehr Mani +15 more

Molecular glues as potential GPCR therapeutics

Biochemical Pharmacology(2024)10.1016/j.bcp.2024.116402

N/A

0DataRank · unranked

14 citations

B. Krumm, Bryan L. Roth

Structure-guided design of a peripherally restricted chemogenetic system

Cell(2024)10.1016/j.cell.2024.11.001

N/A

0DataRank · unranked

10 citations

B. Krumm, Adrien Tassou, Matan Geron, Jeffrey F. DiBerto, Nicholas J. Kapolka +15 more

Ligand recognition and allosteric modulation of the human MRGPRX1 receptor

UNC Libraries(2024)10.17615/db9p-0f56

N/A

0DataRank · unranked

1 citations

John F. Fay, Yushi Liu, B.E Krumm, Bryan L. Roth, Can Cao +6 more

Structures of the σ2 receptor enable docking for bioactive ligand discovery

UNC Libraries(2024)10.17615/r2a5-2908

N/A

0DataRank · unranked

0 citations

Jinhao Lyu, B.K. Shoichet, X.-P Huang, J.J. Irwin, João Braz +11 more

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter

UNC Libraries(2024)10.17615/xxye-0e30

N/A

0DataRank · unranked

0 citations

Parnian Lak, A. K. Seth, Gary Rudnick, Kasturi Roy, Juliana de Vasconcelos Cerqueira Braz +16 more

Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia

UNC Libraries(2024)10.17615/t3ne-yr91

N/A

0DataRank · unranked

0 citations

Eva Gil‐Iturbe, Marta Galán-Díez, Florence Borot, Bryan L. Roth, Azra Raza +14 more

Structural insights into the human D1 and D2 dopamine receptor signaling complexes

UNC Libraries(2024)10.17615/bn2v-te63

N/A

0DataRank · unranked

0 citations

Die Shen, H.E Xu, Yuheng Zhang, Yuchen Liu, Xu Cheng +17 more

Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation

Translational Psychiatry(2025)10.1038/s41398-025-03611-0

N/A

0DataRank · unranked

13 citations

Yi-Ting Chiu, Mia L. Foglesong, Sarah N. Magee, Martin MacKinnon, Gabriele M. König +6 more

Intracellular GPCR modulators enable precision pharmacology

npj Drug Discovery.(2025)10.1038/s44386-025-00011-8

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0DataRank · unranked

7 citations

Bryan L. Roth, B. Krumm

Molecular glues as potential GPCR therapeutics

UNC Libraries(2025)10.17615/d8rx-5f82

N/A

0DataRank · unranked

0 citations

Bryan L. Roth, B. Krumm

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

UNC Libraries(2025)10.17615/p1he-g624

N/A

0DataRank · unranked

0 citations

Tyler J. Lefevre, Ning Ma, Kevin M. Knight, Alan V. Smrcka, Sepehr Mani +15 more

Docking for EP4R antagonists active against inflammatory pain

UNC Libraries(2025)10.17615/545v-9x45

N/A

0DataRank · unranked

0 citations

Chelsea DeLeon, Bryan L. Roth, Brian K. Shoichet, Christian B. Billesbølle, Stefan Gahbauer +14 more

Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

UNC Libraries(2020)10.17615/fvc2-w539

N/A

0DataRank · unranked

0 citations

Brenda Temple, Stefan Knapp, A.K. Roos, Francis S. Willard, Bryan L. Roth +6 more

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

Nature Chemical Biology(2020)10.1038/s41589-020-0535-8

N/A

0DataRank · unranked

579 citations

Jeffrey F. DiBerto, Justin G. English, Alexis M. Glaudin, B. Krumm, Samuel T. Slocum +6 more

The activities of drug inactive ingredients on biological targets

Science(2020)10.1126/science.aaz9906

N/A

0DataRank · unranked

88 citations

Duncan Armstrong, Ling Zou, Alexander Fekete, Xi‐Ping Huang, Hayarpi Torosyan +15 more

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

UNC Libraries(2020)10.17615/fxr6-kq37

N/A

0DataRank · unranked

15 citations

Jayalakshmi Miriyala, Hsien‐Sung Huang, Benjamin D. Philpot, J. Walter Dutton, Xin Chen +10 more

DREADDs for Neuroscientists

UNC Libraries(2020)10.17615/2nt8-nh04

N/A

0DataRank · unranked

5 citations

Bryan L. Roth

Novel Molecular Targets of Dezocine and Their Clinical Implications

UNC Libraries(2020)10.17615/bay1-yh63

N/A

0DataRank · unranked

14 citations

Jin Xi, Alexei Yeliseev, Bryan L. Roth, Renyu Liu, Xi‐Ping Huang

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

UNC Libraries(2020)10.17615/kvmf-ds60

N/A

0DataRank · unranked

12 citations

Dan Urban, Marc G. Caron, Raymond C. Stevens, Huixian Wu, Tama Evron +9 more

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

UNC Libraries(2020)10.17615/x7yw-fx68

N/A

0DataRank · unranked

12 citations

Alice Jiang, Jian Jin, Sheng Wang, Wesley K. Kroeze, Bryan L. Roth +14 more

A Structural Understanding of Class B GPCR Selectivity and Activation Revealed

Structure(2020)10.1016/j.str.2020.02.004

N/A

0DataRank · unranked

27 citations

Bryan L. Roth, B. Krumm

A pharmacological organization of G protein–coupled receptors

UNC Libraries(2020)10.17615/670m-tf47

N/A

0DataRank · unranked

4 citations

Maria F. Sassano, Bryan L. Roth, Brian K. Shoichet, Henry C. Lin

Structure of the human smoothened receptor bound to an antitumour agent

UNC Libraries(2020)10.17615/9b29-5258

N/A

0DataRank · unranked

12 citations

Vsevolod Katritch, Bryan L. Roth, Chong Wang, Raymond C. Stevens, Fai Siu +5 more

Bryan L. Roth

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