Andrew J. Aguirre

Also affiliated with Harvard University, Dana-Farber Cancer Institute, Center for Cancer Research, Center for Systems Biology

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

4.5Author DataRank

Indexed papers

5in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 5 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

Clinical Cancer Research(2020)10.1158/1078-0432.ccr-20-3141

Top 5%

4.5DataRank

Top 5%159 citations

Jinming Zhang, Chen Yuan, Juha P. Väyrynen, Andressa Dias Costa, Hannah L. Williams +24 more

Papers

Driven by 61 papers — median percentile 0. Top paper: “Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action”.

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

Nature Communications(2020)10.1038/s41467-020-17440-w

N/A

5.2DataRank · unranked

186 citations

Brenton R. Paolella, Allison C. Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg +18 more

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

Cancer Cell(2020)10.1016/j.ccell.2020.05.010

N/A

4.8DataRank · unranked

164 citations

Alex Penson, Ram Kannan, Hana Cho, Chun‐Hao Pan, Rohit K. Singh +39 more

Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

Clinical Cancer Research(2020)10.1158/1078-0432.ccr-20-3141

Top 5%

4.5DataRank

Top 5%159 citations

Jinming Zhang, Chen Yuan, Juha P. Väyrynen, Andressa Dias Costa, Hannah L. Williams +24 more

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Nature(2024)10.1038/s41586-024-07205-6

N/A

4.2DataRank · unranked

326 citations

Bianca J. Lee, Jingjing Jiang, Aidan C.A. Tomlinson, Kyle J. Seamon, Alessia Mira +48 more

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins

Cancer Discovery(2022)10.1158/2159-8290.cd-22-0043

N/A

4.2DataRank · unranked

170 citations

Maria Quiles del Rey, Kevin S. Kapner, Huan Zhang, Ajami Gikandi, Callum Malcolm +15 more

Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Nature(2024)10.1038/s41586-024-07379-z

N/A

3.9DataRank · unranked

182 citations

Jingjing Jiang, Tanner C. Dalton, Álvaro Curiel‐García, A. Cole Edwards, Yingyun Wang +61 more

Transforming Growth Factor-β Blockade in Pancreatic Cancer Enhances Sensitivity to Combination Chemotherapy

Gastroenterology(2023)10.1053/j.gastro.2023.05.038

N/A

1.8DataRank · unranked

71 citations

Megan T. Hoffman, Lestat R. Ali, Jaime I. Castillo, Lauren Kageler, Ayantu Temesgen +13 more

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.25.267336

N/A

1.6DataRank · unranked

35 citations

Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Rahul Mohan +46 more

Response and Resistance to RAS Inhibition in Cancer

Cancer Discovery(2025)10.1158/2159-8290.cd-25-0349

N/A

1.0DataRank · unranked

44 citations

Julien Dilly, Alice T. Shaw, Andrew J. Aguirre, Richard Y. Ebright

Spatially organized multicellular immune hubs in human colorectal cancer

Cell(2021)10.1016/j.cell.2021.08.003

N/A

1.0DataRank · unranked

787 citations

Matan Hofree, Siranush Sarkizova, Joshua D. Pirl, Vjola Jorgji, Alborz Bejnood +73 more

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.25.256214

N/A

0.986DataRank · unranked

10 citations

Peter Winter, Andrew W. Navia, Hannah L. Williams, Alan DenAdel, Radha L. Kalekar +36 more

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Cell(2021)10.1016/j.cell.2021.11.017

N/A

0.959DataRank · unranked

597 citations

Peter Winter, Andrew W. Navia, Hannah L. Williams, Alan DenAdel, Kristen E. Lowder +42 more

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

Cell(2020)10.1016/j.cell.2020.08.003

N/A

0.948DataRank · unranked

556 citations

Christopher S. Smillie, Nicholas Van Wittenberghe, Maria Ericsson, Gabriel K. Griffin, David S. Fischer +14 more

The enteric nervous system of the human and mouse colon at a single-cell resolution

bioRxiv (Cold Spring Harbor Laboratory)(2019)10.1101/746743

N/A

0.905DataRank · unranked

24 citations

Christopher S. Smillie, Nicholas Van Wittenberghe, Maria Ericsson, Gabriel K. Griffin, Danielle Dionne +11 more

High-resolution genomic profiles of human lung cancer

Proceedings of the National Academy of Sciences(2005)10.1073/pnas.0504126102

N/A

0.897DataRank · unranked

395 citations

Gautam Maulik, Cameron Brennan, Bin Feng, Yunyu Zhang, Deepak B. Khatry +12 more

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

Cell(2021)10.1016/j.cell.2021.11.031

N/A

0.871DataRank · unranked

332 citations

Cherie’ R. Scurrah, Eliot T. McKinley, Alan J. Simmons, Marisol A. Ramirez-Solano, Xiangzhu Zhu +48 more

Insulin-Like Growth Factor-1 Receptor Expression and Disease Recurrence and Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma

Cancer Epidemiology Biomarkers & Prevention(2020)10.1158/1055-9965.epi-19-1315

N/A

0.802DataRank · unranked

15 citations

Annacarolina da Silva, Vicente Morales‐Oyarvide, Andressa Dias Costa, Margaret M. Kozak, Richard F. Dunne +23 more

Massively parallel phenotyping of variant impact in cancer with Perturb-seq reveals a shift in the spectrum of cell states induced by somatic mutations

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.16.383307

N/A

0.673DataRank · unranked

12 citations

James T. Neal, Emily Shea, Pratiksha I. Thakore, Livnat Jerby-Arnon, Danielle Dionne +15 more

Clinical outcomes and ctDNA correlates for CAPOX BETR: a phase II trial of capecitabine, oxaliplatin, bevacizumab, trastuzumab in previously untreated advanced HER2+ gastroesophageal adenocarcinoma

Nature Communications(2024)10.1038/s41467-024-51271-3

N/A

0.654DataRank · unranked

17 citations

Kristen E. Lowder, Kevin S. Kapner, Ronan J. Kelly, Hui Zheng, Nadine J. McCleary +20 more

Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-22-3930

N/A

0.581DataRank · unranked

47 citations

Rachel B. Keller, Kevin S. Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan +27 more

RHOAL57Vdrives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

Science Signaling(2023)10.1126/scisignal.adg5289

N/A

0.575DataRank · unranked

9 citations

Richard G. Hodge, Haisheng Zhang, G. Aaron Hobbs, Julien Dilly, Minh V. Huynh +15 more

A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-23-2005

N/A

0.503DataRank · unranked

14 citations

Hanrong Feng, Kalindi Parmar, Junning Wang, Kevin S. Kapner, Bose Kochupurakkal +23 more

Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies

Nature Communications(2025)10.1038/s41467-025-65148-6

N/A

0.472DataRank · unranked

15 citations

Keiko Takahashi, Naoya Sakamoto, Martina De Vizio, Micaela Morgado, Shahryar Khoshtinat Nikkhoi +17 more

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

bioRxiv (Cold Spring Harbor Laboratory)(2019)10.1101/868752

N/A

0.353DataRank · unranked

5 citations

Brenton R. Paolella, Allison C. Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg +18 more

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.30.426796

N/A

0.297DataRank · unranked

4 citations

Matan Hofree, Jonathan Chen, Siranush Sarkizova, Joshua D. Pirl, Vjola Jorgji +71 more

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

The Journal of Immunology(2021)10.4049/jimmunol.206.supp.68.13

N/A

0.262DataRank · unranked

3 citations

Karin Pelka, Matan Hofree, Marios Giannakis, Genevieve M. Boland, Andrew J. Aguirre +5 more

Author Correction: Massively parallel phenotyping of coding variants in cancer with Perturb-seq

Nature Biotechnology(2022)10.1038/s41587-022-01495-9

N/A

0.133DataRank · unranked

1 citations

James T. Neal, Emily Shea, Pratiksha I. Thakore, Livnat Jerby-Arnon, Danielle Dionne +17 more

Sotorasib Is a Pan- RAS G12C Inhibitor Capable of Driving Clinical Response in NRAS G12C Cancers

Cancer Discovery(2024)10.1158/2159-8290.cd-23-1138

N/A

0DataRank · unranked

43 citations

Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S. Kapner, Michael H. Rosenthal, Bryanna L. Norden +8 more

Cancer tissue of origin constrains the growth and metabolism of metastases

Nature Metabolism(2024)10.1038/s42255-024-01105-9

N/A

0DataRank · unranked

34 citations

Yetiş Gültekin, Peter Winter, Sidney Y. Vermeulen, Konstantine Tchourine, Keene L. Abbott +22 more

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.22.618529

N/A

0DataRank · unranked

9 citations

Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Srisathiyanarayanan Dharmaiah +24 more

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

UNC Libraries(2024)10.17615/1fr6-tv06

N/A

0DataRank · unranked

0 citations

Nicole Nasholm, Chiara Ambrogio, Anthony N. Milin, Yang Liu, Elsa Quintana +48 more

CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer

Cancer Research(2025)10.1158/0008-5472.can-25-1835

N/A

0DataRank · unranked

5 citations

Haley Todd, Grace Goodhart, Wen-Hsuan Chang, Amber M. Amparo, Rachel Bridgens +20 more

VEGFR2 blockade overcomes acquired KRAS G12D inhibitor resistance driven by PI3Kγ activation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.16.676456

N/A

0DataRank · unranked

0 citations

Mingyun Bae, Ji‐Won Kim, Seung Hyup Hyun, Kui‐Jin Kim, Joshua H. Choe +20 more

641 Spatially organized multicellular immune hubs in MMRd and MMRp colorectal cancer

Regular and Young Investigator Award Abstracts(2021)10.1136/jitc-2021-sitc2021.641

N/A

0DataRank · unranked

0 citations

Karin Pelka, Matan Hofree, Marios Giannakis, Prisca Liberali, Nir Hacohen +5 more

RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

UNC Libraries(2025)10.17615/4cr5-sf81

N/A

0DataRank · unranked

0 citations

Channing J. Der, J. Nathaniel Diehl, Huynh, Minh V, Rashid, Naim U, Adam J. Bass +15 more

HTAPP_Dissociation of human primary colorectal cancer resection specimens into single cell suspension for single cell RNA-seq v2

(2021)10.17504/protocols.io.busfnwbn

N/A

0DataRank · unranked

0 citations

Matan Hofree, Tabea Moll, SusannahPhillips not provided, Danielle Dionne, Julia Waldman +18 more

HTAPP_Dissociation of human primary colorectal cancer resection specimens into single cell suspension for single cell RNA-seq v1

(2019)10.17504/protocols.io.batcieiw

N/A

0DataRank · unranked

0 citations

Matan Hofree, Tabea Moll, SusannahPhillips not provided, Danielle Dionne, Julia Waldman +18 more

Single-nucleus RNA-seq of frozen archival primary pancreatic ductal adenocarcinoma uncovers multi-compartment intratumoral heterogeneity associated with neoadjuvant treatment.

Journal of Clinical Oncology(2020)10.1200/jco.2020.38.15_suppl.4633

N/A

0DataRank · unranked

0 citations

Hannah I. Hoffman, Orr Ashenberg, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Samouil Farhi +18 more

Biomarker-Guided Development of DNA Repair Inhibitors

Molecular Cell(2020)10.1016/j.molcel.2020.04.035

N/A

0DataRank · unranked

230 citations

Andrew J. Aguirre, Geoffrey I. Shapiro, Alan D. D’Andrea, James M. Cleary

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

Cell Metabolism(2020)10.1016/j.cmet.2020.10.018

N/A

0DataRank · unranked

81 citations

Kevin S. Kapner, Keisuke Yamamoto, Robert S. Banh, Jasper E. Neggers, Albert S.W. Sohn +7 more

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors

Science Signaling(2020)10.1126/scisignal.aay1451

N/A

0DataRank · unranked

69 citations

Eman Y. Ahmed, Jennifer L. Guerriero, Ewa Sicińska, Emily Su, Elizaveta Lavrova +14 more

Implementation of systematic genetic counseling (GC) and multigene germline testing (MGT) for pancreatic cancer (PC) patients (pts).

Journal of Clinical Oncology(2020)10.1200/jco.2020.38.4_suppl.678

N/A

0DataRank · unranked

2 citations

Anu Chittenden, Chinedu Ukaegbu, Kimberly Perez, Audrey Madigan, Shraddha Gaonkar +5 more

Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma

Clinical Cancer Research(2021)10.1158/1078-0432.ccr-21-1367

N/A

0DataRank · unranked

14 citations

Brian M. Wolpin, Stephanie K. Dougan, Srivatsan Raghavan, Harshabad Singh, Brandon M. Huffman +6 more

Durable clinical benefit from PARP inhibition in a platinum-sensitive, BRCA2-mutated pancreatic cancer patient after earlier progression on placebo treatment on the POLO trial: a case report

Journal of Gastrointestinal Oncology(2021)10.21037/jgo-21-197

N/A

0DataRank · unranked

4 citations

Brian M. Wolpin, Ilana S. Warsofsky, David P. Ryan, Kimberly Perez, Osama E. Rahma +7 more

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

Cancer Research(2022)10.1158/0008-5472.can-22-3050

N/A

0DataRank · unranked

92 citations

Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter Winter, Kevin S. Kapner +34 more

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS–MAPK Pathway Inhibition in Pancreatic Cancer

Cancer Discovery(2022)10.1158/2159-8290.cd-22-0044

N/A

0DataRank · unranked

77 citations

Jingjie Hu, Charles Cai, Nathan P. Ward, Anthony Venida, Callum Foakes +15 more

Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-22-1125

N/A

0DataRank · unranked

77 citations

Sara A. Väyrynen, Akhil Chawla, Jinming Zhang, Juha P. Väyrynen, Mai Chan Lau +26 more

Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma

Cancers(2022)10.3390/cancers14246223

N/A

0DataRank · unranked

32 citations

Haley Ellis, Alexander C. Jordan, William A. Freed-Pastor, Kimberly Perez, Douglas A. Rubinson +7 more

Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer

Nature Communications(2023)10.1038/s41467-023-40024-3

N/A

0DataRank · unranked

68 citations

Michael H. Rosenthal, Tilak Sundaresan, Natalia Khalaf, Valerie Lee, Lauren K. Brais +20 more

Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias

Nature Cancer(2023)10.1038/s43018-023-00550-x

N/A

0DataRank · unranked

41 citations

Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta +36 more

RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Nature Communications(2023)10.1038/s41467-023-37096-6

N/A

0DataRank · unranked

22 citations

Heta Jadhav, Constantia Pantelidou, Tin Phan, Carter Grochala, Anita K. Mehta +9 more

Phase Ib and Expansion Study of Gemcitabine,Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer

The Oncologist(2023)10.1093/oncolo/oyad002

N/A

0DataRank · unranked

7 citations

Anna M. Chiarella, James M. Cleary, Nora Horick, Colin D. Weekes, Thomas A. Abrams +21 more

Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.03.569791

N/A

0DataRank · unranked

11 citations

Jingjing Jiang, Alvaro Curiel-Garcia, Yingyun Wang, Bianca J. Lee, Margo Orlen +42 more

798 TGFβ blockade in pancreatic cancer enhances sensitivity to combination chemotherapy

Regular and Young Investigator Award Abstracts(2023)10.1136/jitc-2023-sitc2023.0798

N/A

0DataRank · unranked

2 citations

Megan T. Hoffman, Lestat R. Ali, Jaime Ivan Castillo Silva, Ayantu Temesgen, Patrick J. Lenehan +13 more

Data from Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

(2023)10.1158/0008-5472.c.6514341.v1

N/A

0DataRank · unranked

0 citations

Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter Winter, Kevin S. Kapner +34 more

Data from Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

(2023)10.1158/0008-5472.c.6514341

N/A

0DataRank · unranked

0 citations

Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter Winter, Kevin S. Kapner +34 more

Data from Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

(2023)10.1158/1078-0432.c.6530165

Top 100%

0DataRank

Top 100%0 citations

Jinming Zhang, Chen Yuan, Juha P. Väyrynen, Andressa Dias Costa, Hannah L. Williams +24 more

Data from Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors

(2023)10.1158/1078-0432.c.6530100

Top 100%

0DataRank

Top 100%0 citations

Victoria Wang, Rebecca S. Heist, Scott Kopetz, Edith P. Mitchell, James A. Zwiebel +19 more

Data from Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

(2023)10.1158/1078-0432.c.6530165.v1

Top 100%

0DataRank

Top 100%0 citations

Jinming Zhang, Chen Yuan, Juha P. Väyrynen, Andressa Dias Costa, Hannah L. Williams +24 more

Data from Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors

(2023)10.1158/1078-0432.c.6530100.v1

Top 100%

0DataRank

Top 100%0 citations

Victoria Wang, Rebecca S. Heist, Scott Kopetz, Edith P. Mitchell, James A. Zwiebel +19 more

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Cancer Discovery(2024)10.1158/2159-8290.cd-24-0177

N/A

0DataRank · unranked

243 citations

Megan T. Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Brendan D. Parent +50 more

Andrew J. Aguirre

Indexed papers

Top data-sharing exemplar

Papers