Dimas Echeverria

University of Massachusetts Chan Medical School

Also affiliated with UMass Memorial Medical Center

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 46 papers. Top paper: “Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo”.

Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo

Nucleic Acids Research(2023)10.1093/nar/gkad1125

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0.563DataRank · unranked

17 citations

Karen Kelly, Jonathan Lee, Dimas Echeverria, David Cooper, Rebecca Panwala +13 more

Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.07.029

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41 citations

Dimas Echeverria, Jacquelyn Sousa, Anastasia Khvorova, Socheata Ly

Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.06.006

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35 citations

Dimas Echeverria, Matthew Hassler, Socheata Ly, Anastasia Khvorova, Chantal Ferguson

An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

Molecular Therapy(2021)10.1016/j.ymthe.2021.11.007

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46 citations

Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence M. Lifshitz +13 more

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

JCI Insight(2021)10.1172/jci.insight.152203

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29 citations

Bruno M.D.C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew Hassler, Dimas Echeverria +13 more

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity

Nucleic Acids Research(2021)10.1093/nar/gkab1126

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20 citations

Samuel Hildebrand, Sarah M. Davis, Rachael Miller, Faith Conroy, Ellen Sapp +10 more

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Molecular Therapy — Nucleic Acids(2022)10.1016/j.omtn.2022.06.009

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55 citations

Vignesh Hariharan, Agnes S. Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa +7 more

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models

Nature Communications(2022)10.1038/s41467-022-33061-x

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49 citations

Rachael Miller, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Bruno M.D.C. Godinho +12 more

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

Brain Communications(2022)10.1093/braincomms/fcac248

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37 citations

Marie-Cécile Didiot, Chantal Ferguson, Andrew H. Coles, Rachael Miller, Kathryn Chase +6 more

RNAi-based modulation of IFN-γ signaling in skin

Molecular Therapy(2022)10.1016/j.ymthe.2022.04.019

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34 citations

Jacquelyn Sousa, Dimas Echeverria, Xueli Fan, Ying-Chao Hsueh, Khashayar Afshari +10 more

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts

Nucleic Acids Research(2022)10.1093/nar/gkac630

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29 citations

Io Long Chan, Yuming Cao, Alisha M. Gruntman, Jonathan Lee, Jacquelyn Sousa +17 more

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

Molecular Therapy — Nucleic Acids(2022)10.1016/j.omtn.2022.06.005

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27 citations

Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy +9 more

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.29.498088

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0 citations

Rachael Miller, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Bruno M.D.C. Godinho +12 more

Di-valent siRNA Mediated Silencing of MSH3 Blocks Somatic Repeat Expansion in Mouse Models of Huntington’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.06.506795

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0DataRank · unranked

0 citations

Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh +13 more

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease

Molecular Therapy(2023)10.1016/j.ymthe.2023.05.006

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56 citations

Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh +16 more

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Nature Communications(2023)10.1038/s41467-023-42714-4

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50 citations

Hassan H. Fakih, Mohammad Zain UI Abideen, Samuel Hildebrand, Khashayar Afshari, Katherine Y. Gross +31 more

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219523120

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48 citations

Minwook Shin, Ching‐Wen Chang, Daniel O’Reilly, Annabelle Biscans, Ken Yamada +41 more

Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity

Molecular Therapy — Nucleic Acids(2023)10.1016/j.omtn.2023.102080

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20 citations

Qi Tang, Ashley Summers, Minwook Shin, Julianna Buchwald, Rosemary Gagnon +7 more

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors

Molecular Therapy — Nucleic Acids(2023)10.1016/j.omtn.2023.102088

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16 citations

Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh +7 more

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

eLife(2023)10.7554/elife.89136

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10 citations

Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz +12 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.26.542506

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0DataRank · unranked

7 citations

Vignesh Hariharan, Jillian Caiazzi, Rachael Miller, Chantal Furguson, Ellen Sapp +18 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

Research Square(2023)10.21203/rs.3.rs-2987323/v1

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4 citations

Jillian Caiazzi, Rachael Miller, Chantal Ferguson, Ellen Sapp, Hassan Fakih +18 more

Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.05.547848

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4 citations

Shauna M. Harney, Chloe DiMarzio, Mark Kelly, Kyounghee Min, Dimas Echeverria +7 more

A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.19.572404

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4 citations

Qi Tang, Sam Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria +11 more

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

叙説(2023)10.1101/2023.05.03.539244

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3 citations

Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz +12 more

Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.20.533459

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0DataRank · unranked

1 citations

Karen Kelly, Jonathan Lee, Dimas Echeverria, David Cooper, Rebecca Panwala +11 more

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.20.558641

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0DataRank · unranked

0 citations

Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh +7 more

Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease

Alzheimer s & Dementia(2024)10.1002/alz.13703

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33 citations

Samuel Hildebrand, Bruno M.D.C. Godinho, Julianna Buchwald, Dimas Echeverria, Andrew H. Coles +10 more

A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system

Nucleic Acids Research(2024)10.1093/nar/gkae368

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26 citations

Qi Tang, Samuel Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria +11 more

Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo

Nucleic Acids Research(2024)10.1093/nar/gkae260

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18 citations

Hassan H. Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Holly R McEachern +8 more

A combinatorial approach for achieving CNS-selective RNAi

Nucleic Acids Research(2024)10.1093/nar/gkae100

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11 citations

Bruno M.D.C. Godinho, Dimas Echeverria, Matthew Hassler, Lorenc Vangjeli, Jacquelyn Sousa +8 more

mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs)

Nucleic Acids Research(2024)10.1093/nar/gkae624

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0DataRank · unranked

10 citations

Dimas Echeverria, Anastasia Khvorova, Andrei A. Korostelev, Denis Susorov

Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs

Molecular Therapy — Nucleic Acids(2024)10.1016/j.omtn.2024.102291

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0DataRank · unranked

9 citations

Zachary Kennedy, Bruno M.D.C. Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria +10 more

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo

Nucleic Acid Therapeutics(2024)10.1089/nat.2024.0027

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8 citations

Daniel O’Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, Joseph Paquette +8 more

Near Sequence Homology Does Not Guarantee siRNA Cross-Species Efficacy

Nucleic Acid Therapeutics(2024)10.1089/nat.2024.0030

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4 citations

Kathryn Monopoli, Samuel Jackson, Dimas Echeverria, Daniel O’Reilly, Robert H. Brown +2 more

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

eLife(2024)10.7554/elife.89136.3

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3 citations

Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz +12 more

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.20.599943

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6 citations

James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal Ferguson, Elif O. Dogan +18 more

mRNA nuclear clustering leads to a difference in mutant huntingtin mRNA and protein silencing by siRNAs in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.24.590997

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0DataRank · unranked

2 citations

Daniel O’Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, Joseph Paquette +8 more

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy

Nucleic Acids Research(2025)10.1093/nar/gkaf479

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15 citations

Samuel Hildebrand, Hannah J. MacMillan, Kathryn Monopoli, Julianna Buchwald, Jacquelyn Sousa +20 more

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

Molecular Therapy(2025)10.1016/j.ymthe.2025.05.010

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8 citations

James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal Ferguson, Elif O. Dogan +19 more

Optimized chemical structure extends silencing duration of therapeutic siRNAs in dividing cancer and immune cells

Molecular Therapy(2025)10.1016/j.ymthe.2025.08.017

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1 citations

Tatyana Ryaykenen, Xavier Segarra-Visent, Melanie Sauer, Leon Breuer, Yi‐Ying Wu +8 more

Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.29.667434

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1 citations

Julianna Buchwald, Christopher D Dahlke, Hassan H. Fakih, Jennifer Morgan, Ashley Summers +10 more

A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases

ACS Pharmacology & Translational Science(2025)10.1021/acsptsci.4c00594

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0DataRank · unranked

0 citations

Hassan H. Fakih, Katherine Y. Gross, Sarah J. Winter, Brianna Bramato, Ümmügülsüm Yıldız-Altay +13 more

miRNA Mimic Optimization: Chemical Structure – Activity – Targetome Relationship to Engineer Selective Anti-Tumor Immunity in T cells

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.16.649059

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0 citations

Tatyana Ryaykenen, Anastasia Kremer, Melanie Sauer, Samuel Jackson, David Cooper +3 more

2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.05.010

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21 citations

Jacquelyn Sousa, Lorenc Vangjeli, Matthew Hassler, Dimas Echeverria, Emily G. Knox +4 more

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

Research Square(2025)10.21203/rs.3.rs-6465542/v1

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0DataRank · unranked

0 citations

Ashley Summers, Amy E. Clipperton‐Allen, Jillian Caiazzi, Samuel Hildebrand, Daniel O’Reilly +11 more