John Sondek

University of North Carolina at Chapel Hill

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 47 papers. Top paper: “TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death inArabidopsis”.

TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death inArabidopsis

Proceedings of the National Academy of Sciences(2017)10.1073/pnas.1620973114

N/A

5.7DataRank · unranked

166 citations

Ryan G. Anderson, Karen A. Cherkis, Terry F. Law, Qingli L. Liu, Mischa Machius +12 more

PLCG2 as a Risk Factor for Alzheimer's Disease.

Research Square (Research Square)(2020)10.21203/rs.3.rs-38216/v1

N/A

0.483DataRank · unranked

8 citations

Chuanpeng Dong, Christoph Preuß, Miguel Moutinho, Peter Bor‐Chian Lin, Nicole Hajicek +9 more

Small Molecule Inhibitors of Phospholipase C from a Novel High-throughput Screen

UNC Libraries(2020)10.17615/ev6p-yt94

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0DataRank · unranked

1 citations

John Sondek, Nicole Hajicek, Matthew O. Barrett, Qisheng Zhang, Stephanie C. Hicks +2 more

A Fluorogenic, Small Molecule Reporter for Mammalian Phospholipase C Isozymes

INDIGO (University of Illinois at Chicago)(2020)10.17615/68na-1z91

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0DataRank · unranked

1 citations

John Sondek, Weigang Huang, Stephanie N. Hicks, Qisheng Zhang

Structure and Function of Vps15 in the Endosomal G Protein Signaling Pathway ,

INDIGO (University of Illinois at Chicago)(2020)10.17615/z5ex-kt73

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0DataRank · unranked

1 citations

John Sondek, Erin J. Heenan, Brenda Temple, Janeen L. Vanhooke, Henrik Dohlman +1 more

PLCG2 as a Risk Factor for Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.19.104216

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0DataRank · unranked

5 citations

Chuanpeng Dong, Christoph Preuß, Miguel Moutinho, Peter Bor‐Chian Lin, Nicole Hajicek +9 more

The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation

UNC Libraries(2020)10.17615/web4-s082

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0DataRank · unranked

0 citations

Laurie Betts, Mariya Chhatriwala, John Sondek, David K. Worthylake

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

UNC Libraries(2020)10.17615/6wz3-eh05

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0DataRank · unranked

0 citations

Kent L. Rossman, Natalia Mitin, John Sondek, Channing J. Der, Laurie Betts +1 more

SmgGDS Is a Guanine Nucleotide Exchange Factor That Specifically Activates RhoA and RhoC

UNC Libraries(2020)10.17615/g32s-1a49

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0DataRank · unranked

0 citations

John Sondek, Daniel J. Marston, Brenda Temple, Keith Burridge, Brant Hamel +2 more

Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange

UNC Libraries(2020)10.17615/dy5d-v834

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0DataRank · unranked

0 citations

Mark R. Jezyk, David P. Siderovski, T. Kendall Harden, Francis S. Willard, Val J. Watts +7 more

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation

UNC Libraries(2020)10.17615/1v9z-yb26

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0DataRank · unranked

0 citations

John Sondek, Aaron A. Cook, Ren, Jinqi, Wolfgang Bergmeier

Prediction of Protein–Protein Interfaces on G-Protein β Subunits Reveals a Novel Phospholipase C β2 Binding Domain

UNC Libraries(2020)10.17615/7fta-7146

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0DataRank · unranked

0 citations

Erin J. Friedman, Alan M. Jones, Corbin D. Jones, Stephanie N. Hicks, John Sondek +1 more

Direct Activation of Human Phospholipase C by Its Well Known Inhibitor U73122

UNC Libraries(2020)10.17615/97f8-yz59

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0DataRank · unranked

0 citations

Chester Costales, Wendy L. White, John Sondek, Dhiren R. Thakker, Stephanie N. Hicks +4 more

AvrRpm1 Missense Mutations Weakly Activate RPS2-Mediated Immune Response in Arabidopsis thaliana

UNC Libraries(2020)10.17615/exhz-cc91

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0DataRank · unranked

0 citations

John Sondek, Jeffery L. Dangl, Karen Cherkis, Brenda Temple, Eui-Hwan Chung

Correction: Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction

UNC Libraries(2020)10.17615/b9nn-vt11

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0DataRank · unranked

0 citations

John Sondek, Alex U. Singer, Zachary L. Nimchuk, Laura W. Musselwhite, Jeffery L. Dangl +3 more

Role of the C-Terminal SH3 Domain and N-Terminal Tyrosine Phosphorylation in Regulation of Tim and Related Dbl-Family Proteins †

UNC Libraries(2020)10.17615/z3ed-q261

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0DataRank · unranked

0 citations

Marielle E. Yohe, John Sondek, Kent L. Rossman

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

UNC Libraries(2020)10.17615/v2fh-k627

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0DataRank · unranked

0 citations

David P. Siderovski, David K. Worthylake, John Sondek, Jason T. Snyder, Kent L. Rossman +1 more

Gα q Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain

UNC Libraries(2020)10.17615/rgzf-en22

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0DataRank · unranked

0 citations

Tohru Kozasa, John Sondek, Rafael J. Rojas, Takeharu Kawano, Marielle E. Yohe +1 more

Crystal structure of the multifunctional Gβ5–RGS9 complex

UNC Libraries(2020)10.17615/y9kb-4m80

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0DataRank · unranked

0 citations

Svetlana Gershburg, Jason T. Snyder, Matthew L. Cheever, John Sondek, T. Kendall Harden +1 more

General and Versatile Autoinhibition of PLC Isozymes

UNC Libraries(2020)10.17615/24g1-3q92

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0DataRank · unranked

0 citations

Mark R. Jezyk, John Sondek, Svetlana Gershburg, Jason P. Seifert, T. Kendall Harden +1 more

Dual Activation of Phospholipase C-ϵ by Rho and Ras GTPases

UNC Libraries(2020)10.17615/qh8z-ct27

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0DataRank · unranked

0 citations

Jason P. Seifert, Stephanie N. Hicks, Yixing Zhou, John Sondek, T. Kendall Harden

Fluorescent Phosphatidylinositol 4,5-Bisphosphate Derivatives with Modified 6-Hydroxy Group as Novel Substrates for Phospholipase C

INDIGO (University of Illinois at Chicago)(2020)10.17615/abyj-e230

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0DataRank · unranked

0 citations

Qisheng Zhang, Matthew O. Barrett, John Sondek, Xiaoyang Wang, T. Kendall Harden

Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

UNC Libraries(2020)10.17615/xnkc-9f07

N/A

0DataRank · unranked

0 citations

Aurélie Gresset, John Sondek, Stephanie N. Hicks, T. Kendall Harden

Membrane-induced Allosteric Control of Phospholipase C-β Isozymes

UNC Libraries(2020)10.17615/m9k7-j936

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0DataRank · unranked

0 citations

Matthew O. Barrett, John Sondek, T. Kendall Harden, Gary L. Waldo, Weigang Huang +2 more

Phospholipase C isozymes as effectors of Ras superfamily GTPases

UNC Libraries(2020)10.17615/9yv7-e338

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0DataRank · unranked

0 citations

T. Kendall Harden, Stephanie N. Hicks, John Sondek

Potent and Selective Peptide-based Inhibition of the G Protein Gαq

UNC Libraries(2020)10.17615/yq12-cq22

N/A

0DataRank · unranked

0 citations

Brian D. Strahl, Krzysztof Krajewski, Gary L. Waldo, Thomas H. Charpentier, T. Kendall Harden +3 more

Designer proteins that competitively inhibit Gαq by targeting its effector site

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101348

N/A

0DataRank · unranked

10 citations

Matthew C. Cummins, Stuart Endo-Streeter, John Sondek, Brian Kuhlman, Mahmud M. Hussain

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

UNC Libraries(2021)10.17615/b9kr-6e14

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0DataRank · unranked

0 citations

Jason T. Snyder, Channing J. Der, John Sondek, Kent L. Rossman, Mark A. Baumeister +3 more

Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins

UNC Libraries(2021)10.17615/c5v7-h421

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0DataRank · unranked

0 citations

Leslie V. Parise, Cheng Yang, Alex U. Singer, John Sondek, Laurie Betts +2 more

RhoA Activates Purified Phospholipase C-ϵ by a Guanine Nucleotide-dependent Mechanism

UNC Libraries(2021)10.17615/91b8-gp61

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0DataRank · unranked

0 citations

Svetlana Gershburg, Michele R. Wing, Jason P. Seifert, Jason T. Snyder, T. Kendall Harden +1 more

Multifunctional Roles for the PH Domain of Dbs in Regulating Rho GTPase Activation

UNC Libraries(2021)10.17615/64r9-hp45

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0DataRank · unranked

0 citations

Jason T. Snyder, John Sondek, Rafael J. Rojas, Cheng Li, Ian P. Whitehead +2 more

Requirement For C-terminal Sequences in Regulation of Ect2 Guanine Nucleotide Exchange Specificity and Transformation

UNC Libraries(2021)10.17615/mnag-wk87

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0DataRank · unranked

0 citations

Kent L. Rossman, Patricia A. Solski, John Sondek, Sharon L. Campbell, Rhonda Wilder +2 more

Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin Cytoskeleton

UNC Libraries(2021)10.17615/hb9t-rp17

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0DataRank · unranked

0 citations

Frank B. Gertler, Margaret H. Butler, Lorenzo Pellegrini, Kent L. Rossman, Pietro De Camilli +5 more

Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif

UNC Libraries(2021)10.17615/g76g-5r61

N/A

0DataRank · unranked

0 citations

John Sondek, Antoine E. Karnoub, Jason T. Snyder, Kent L. Rossman, Marielle E. Yohe +4 more

Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis

UNC Libraries(2021)10.17615/xymg-r863

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0DataRank · unranked

0 citations

John Sondek, Darrell Desveaux, Zachary L. Nimchuk, Jeff Chang, Sarah R. Grant +3 more

Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange

UNC Libraries(2021)10.17615/9p43-sg45

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0DataRank · unranked

0 citations

John Sondek, Ian P. Whitehead, David K. Worthylake, Jason T. Snyder, Cheng Li +1 more

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

eLife(2022)10.7554/elife.77809

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0DataRank · unranked

18 citations

Jordan TB Stariha, Reece M. Hoffmann, Brenda Temple, Qisheng Zhang, Nicole Hajicek +4 more

Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.08.519685

N/A

0DataRank · unranked

4 citations

Chuanpeng Dong, Peter Bor‐Chian Lin, Adrian L. Oblak, Gonzalo Viana Di Prisco, Nian Wang +20 more

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.23.481568

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0DataRank · unranked

0 citations

Jordan TB Stariha, Reece M. Hoffmann, Brenda Temple, Qisheng Zhang, Nicole Hajicek +4 more

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease

Immunity(2023)10.1016/j.immuni.2023.08.008

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0DataRank · unranked

72 citations

Chuanpeng Dong, Peter Bor‐Chian Lin, Adrian L. Oblak, Gonzalo Viana Di Prisco, Nian Wang +20 more

De novo design of stable proteins that efficaciously inhibit oncogenic G proteins

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.28.534629

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0DataRank · unranked

0 citations

Ashutosh Tripathy, John Sondek, Brian Kuhlman, Matthew C. Cummins

Hyperactive PLCG1 drives non-canonical signaling to promote cell survival

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.12.17.628879

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0DataRank · unranked

2 citations

Xinyan Zhang, Yiwei Xiong, Kazuki Sato, Nicole Hajicek, John Sondek +2 more

Designer proteins that competitively inhibit Gαq by targeting its effector site

UNC Libraries(2024)10.17615/097x-ky07

N/A

0DataRank · unranked

0 citations

Stuart Endo-Streeter, John Sondek, Mahmud M. Hussain, Matthew C. Cummins, Brian Kuhlman

Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance

EMBO Reports(2025)10.1038/s44319-025-00546-x

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0DataRank · unranked

5 citations

Xinyan Zhang, Yiwei Xiong, K. Satoh, Nicole Hajicek, Yasunori Kogure +5 more

A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer's disease

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108356

N/A

0DataRank · unranked

4 citations

Nicole Hajicek, Andy P. Tsai, Padam P. Acharya, P. Brian Hardy, Emma Meyer +5 more

Optogenetic control of PLC-γ1 activity directs cell motility

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.09.681531

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0DataRank · unranked

0 citations

Priscila F. Siesser, Harrison H. Truscott, Nicole Hajicek, John Sondek, James E. Bear +2 more

TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis

UNC Libraries(2020)10.17615/j9hs-ax36

N/A

0DataRank · unranked

9 citations

Marc T. Nishimura, Eui-Hwan Chung, Farid El Kasmi, Michael Hyunh, Erin Osborne Nishimura +9 more