Mark Chaffin

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile

2.6Author DataRank

Indexed papers

6in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 6 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Genome Medicine(2021)10.1186/s13073-021-00917-8

Top 21%

0.976DataRank

Top 21%35 citations

Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen +94 more

Papers

Driven by 53 papers — median percentile 61. Top paper: “Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics”.

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Nature Medicine(2021)10.1038/s41591-020-01227-z

N/A

8.2DataRank · unranked

378 citations

Malte D. Luecken, Gökcen Eraslan, Lisa Sikkema, Avinash Waghray, Graham Heimberg +95 more

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

Nature(2022)10.1038/s41586-022-04817-8

N/A

6.9DataRank · unranked

403 citations

Irinna Papangeli, Bridget Simonson, Amer-Denis Akkad, Matthew C. Hill, Alessandro Arduini +14 more

Clonal haematopoiesis and risk of chronic liver disease

Nature(2023)10.1038/s41586-023-05857-4

N/A

4.5DataRank · unranked

204 citations

Connor A. Emdin, Alexander G. Bick, Seyedeh M. Zekavat, Abhishek Niroula, James P. Pirruccello +95 more

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Nature Genetics(2021)10.1038/s41588-021-00935-7

N/A

4.0DataRank · unranked

191 citations

Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto +95 more

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

Nature Communications(2018)10.1038/s41467-018-04668-w

N/A

3.7DataRank · unranked

109 citations

Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan M. Bloom, Timothy Poterba +442 more

Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

Nature Communications(2018)10.1038/s41467-018-03911-8

N/A

3.1DataRank · unranked

104 citations

Amit V. Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam +43 more

Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease

Circulation(2021)10.1161/circulationaha.121.055117

N/A

2.8DataRank · unranked

95 citations

Usman A. Tahir, Alexander G. Bick, Akhil Pampana, Debby Ngo, Mark D. Benson +95 more

Genetic analysis of right heart structure and function in 40,000 people

Nature Genetics(2022)10.1038/s41588-022-01090-3

N/A

2.2DataRank · unranked

99 citations

Paolo Di Achille, Victor Nauffal, Mahan Nekoui, Sam Friedman, Marcus D. R. Klarqvist +46 more

Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta

Arteriosclerosis Thrombosis and Vascular Biology(2022)10.1161/atvbaha.122.317953

N/A

1.7DataRank · unranked

53 citations

Mark Chaffin, Bridget Simonson, James P. Pirruccello, Amer-Denis Akkad, Mahan Nekoui +11 more

Titin Truncating Variants in Adults Without Known Congestive Heart Failure

Journal of the American College of Cardiology(2020)10.1016/j.jacc.2020.01.013

N/A

1.6DataRank · unranked

28 citations

Alexander G. Bick, Mark Chaffin, Krishna G. Aragam, Seung Hoan Choi, Steven A. Lubitz +7 more

Genome sequencing unveils a regulatory landscape of platelet reactivity

Nature Communications(2021)10.1038/s41467-021-23470-9

N/A

1.5DataRank · unranked

54 citations

Ming‐Huei Chen, Benjamin A.T. Rodriguez, Lisa R. Yanek, Arunoday Bhan, Brady Gaynor +94 more

Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.11.021

N/A

1.3DataRank · unranked

70 citations

Peter Dornbos, Mark Chaffin, Dajiang J. Liu, Minxian Wang, Margaret Sunitha Selvaraj +95 more

Adjusting for common variant polygenic scores improves yield in rare variant association analyses

Nature Genetics(2023)10.1038/s41588-023-01342-w

N/A

1.2DataRank · unranked

46 citations

James P. Pirruccello, Seung Hoan Choi, Valerie N. Morrill, Mark Chaffin, Steven A. Lubitz +3 more

Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Nature Communications(2022)10.1038/s41467-022-32275-3

N/A

1.1DataRank · unranked

63 citations

Daniel H. Katz, Julián Ávila-Pacheco, Alexander G. Bick, Akhil Pampana, Jeremy Robbins +95 more

Transfer learning enables predictions in network biology

Nature(2023)10.1038/s41586-023-06139-9

N/A

1.1DataRank · unranked

1104 citations

Ling Xiao, Anant Chopra, Mark Chaffin, Zeina R. Al Sayed, Matthew C. Hill +6 more

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood

Cell(2019)10.1016/j.cell.2019.03.028

N/A

1.0DataRank · unranked

842 citations

Mark Chaffin, Kaitlin H. Wade, Sohail Zahid, Joseph Brancale, Rui Xia +14 more

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Genome Medicine(2021)10.1186/s13073-021-00917-8

Top 21%

0.976DataRank

Top 21%35 citations

Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen +94 more

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy

Nature Communications(2020)10.1038/s41467-020-15823-7

N/A

0.843DataRank · unranked

275 citations

Alexander G. Bick, Minxian Wang, Mark Chaffin, Sam Friedman, Jie Yao +14 more

Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

Nature Communications(2021)10.1038/s41467-021-23655-2

N/A

0.840DataRank · unranked

21 citations

Xiuwen Zheng, Cecelia Laurie, Stephanie M. Gogarten, Jennifer A. Brody, Matthew P. Conomos +91 more

The Genomics of Heart Failure: Design and Rationale of the HERMES Consortium

ESC Heart Failure(2021)10.1002/ehf2.13517

Top 24%

0.829DataRank

Top 24%22 citations

Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow +95 more

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases

Nature Genetics(2025)10.1038/s41588-024-02072-3

N/A

0.821DataRank · unranked

50 citations

Ida Surakka, Morten S. Olesen, Garðar Sveinbjörnsson, Nicholas Marston, Seung Hoan Choi +95 more

Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank

Nature Genetics(2022)10.1038/s41588-021-01011-w

N/A

0.775DataRank · unranked

174 citations

Seung Hoan Choi, Valerie N. Morrill, Mark Chaffin, James P. Pirruccello, Jennifer L. Halford +65 more

SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart

Life Science Alliance(2021)10.26508/lsa.202101048

N/A

0.743DataRank · unranked

16 citations

Avash Das, Nathan R. Tucker, Guoping Li, Ane Salvador, Mark Chaffin +19 more

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Nature Genetics(2025)10.1038/s41588-025-02074-9

N/A

0.628DataRank · unranked

28 citations

Sean J. Jurgens, Ling Xiao, Matthew C. Hill, Christopher M. Haggerty, Garðar Sveinbjörnsson +95 more

Rare coding variant analysis for human diseases across biobanks and ancestries

Nature Genetics(2024)10.1038/s41588-024-01894-5

N/A

0.614DataRank · unranked

59 citations

Xin Wang, Seung Hoan Choi, Lu‐Chen Weng, Satoshi Koyama, James P. Pirruccello +20 more

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience

Nature Genetics(2024)10.1038/s41588-024-01975-5

N/A

0.601DataRank · unranked

54 citations

Joel Rämö, Daria R. Kramarenko, Leonoor F. J. M. Wijdeveld, Jan Haas, Mark Chaffin +55 more

The Genetic Determinants of Aortic Distention

Journal of the American College of Cardiology(2023)10.1016/j.jacc.2023.01.044

N/A

0.538DataRank · unranked

35 citations

Joel Rämö, Seung Hoan Choi, Mark Chaffin, Shinwan Kany, Mahan Nekoui +11 more

Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.22.423783

N/A

0.534DataRank · unranked

11 citations

Peter Dornbos, Mark Chaffin, Dajiang J. Liu, Minxian X. Wang, Margaret Sunitha Selvaraj +95 more

Deep learning enables genetic analysis of the human thoracic aorta

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.12.091934

N/A

0.533DataRank · unranked

34 citations

Mark Chaffin, Stephen J. Fleming, Alessandro Arduini, Honghuang Lin, Shaan Khurshid +21 more

Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation

Nature Communications(2024)10.1038/s41467-024-54296-w

N/A

0.531DataRank · unranked

16 citations

Bridget Simonson, Carolina Roselli, Ling Xiao, Caroline N. Herndon, Mark Chaffin +10 more

Rare variant contribution to the heritability of coronary artery disease

Nature Communications(2024)10.1038/s41467-024-52939-6

N/A

0.513DataRank · unranked

16 citations

Shoa L. Clarke, Gaëlle Auguste, Natalie R. Hasbani, Alanna C. Morrison, Adam S. Heath +95 more

Transcriptional profile of the rat cardiovascular system at single-cell resolution

Cell Reports(2024)10.1016/j.celrep.2024.115091

Top 39%

0.495DataRank

Top 39%15 citations

Stephen J. Fleming, Ling Xiao, Amelia Weber Hall, Amer-Denis Akkad, Mark Chaffin +12 more

The impact of common and rare genetic variants on bradyarrhythmia development

Nature Genetics(2025)10.1038/s41588-024-01978-2

N/A

0.464DataRank · unranked

21 citations

Joel Rämö, Sean J. Jurgens, Shaan Khurshid, Mark Chaffin, Amelia Weber Hall +95 more

Genetic Analysis of Right Heart Structure and Function in 40,000 People

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.05.429046

N/A

0.373DataRank · unranked

11 citations

Paolo Di Achille, Victor Nauffal, Mahan Nekoui, Sam Friedman, Marcus D. R. Klarqvist +11 more

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease

PLoS Genetics(2022)10.1371/journal.pgen.1010294

N/A

0.292DataRank · unranked

6 citations

Mark Chaffin, Sohail Zahid, Scott C. Ritchie, Jerome I. Rotter, Stephen S. Rich +11 more

Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

Nature Communications(2020)10.1038/s41467-020-15236-6

Top 57%

0.275DataRank

Top 57%2 citations

Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan M. Bloom, Timothy Poterba +442 more

Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Nature Genetics(2021)10.1038/s41588-021-00979-9

N/A

0.246DataRank · unranked

4 citations

Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto +95 more

Analysis of cardiac magnetic resonance imaging traits in 29,000 individuals reveals shared genetic basis with dilated cardiomyopathy

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.02.12.946038

N/A

0.240DataRank · unranked

3 citations

Alexander G. Bick, Minxian Wang, Mark Chaffin, Steven A. Lubitz, Patrick T. Ellinor +4 more

Distinct Plasma Extracellular Vesicle Transcriptomes in Acute Decompensated Heart Failure Subtypes: A Liquid Biopsy Approach

Circulation(2024)10.1161/circulationaha.123.065513

N/A

0DataRank · unranked

15 citations

Michail Spanos, H. Immo Lehmann, Quanhu Sheng, Rodosthenis S. Rodosthenous, Mark Chaffin +12 more

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

Nature Methods(2025)10.1038/s41592-025-02919-5

N/A

0DataRank · unranked

0 citations

Yi Zhang, Xihao Li, Margaret Sunitha Selvaraj, Zilin Li, Hufeng Zhou +544 more

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

PLoS Genetics(2020)10.1371/journal.pgen.1008629

N/A

0DataRank · unranked

169 citations

Mary E. Haas, Amit V. Khera, Krishna G. Aragam, Mark Chaffin, Derek Klarin +37 more

Identification of Functional Variant Enhancers Associated With Atrial Fibrillation

Circulation Research(2020)10.1161/circresaha.119.316006

N/A

0DataRank · unranked

51 citations

Fernanda M. Bosada, Jia Liu, Juan Zhang, Karel van Duijvenboden, Mark Chaffin +7 more

Transcriptional and Cellular Diversity of the Human Heart

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.06.896076

N/A

0DataRank · unranked

54 citations

Mark Chaffin, Stephen J. Fleming, Amelia Weber Hall, Victoria A. Parsons, Kenneth Bedi +13 more

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.

Apollo (University of Cambridge)(2020)10.17863/cam.52580

N/A

0DataRank · unranked

0 citations

Mary E. Haas, Amit V. Khera, Krishna G. Aragam, Mark Chaffin, Derek Klarin +37 more

Vascular smooth muscle cell phenotype switching in carotid atherosclerosis

JVS Vascular Science(2021)10.1016/j.jvssci.2021.11.002

N/A

0DataRank · unranked

32 citations

Christian L. Lino Cardenas, Mark Chaffin, Alessandro Arduini, Dejan Juric, James R. Stone +7 more

Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling

Cardiovascular Research(2021)10.1093/cvr/cvab344

N/A

0DataRank · unranked

14 citations

Bryan T. MacDonald, Taiji Mizoguchi, Mark Chaffin, Alison Leed, Alessandro Arduini +6 more

Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure

Cell Reports(2023)10.1016/j.celrep.2023.112086

N/A

0DataRank · unranked

98 citations

Mark Chaffin, Matthew C. Hill, Ondine Atwa, Yasmine Guedira, Harshit Bhasin +8 more

Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma

EBioMedicine(2023)10.1016/j.ebiom.2023.104758

N/A

0DataRank · unranked

19 citations

Priyadarshini Kachroo, Tianxiao Huan, David Van Den Berg, Gha Young Lee, Helena Bui +95 more

Plasma extracellular vesicle transcriptome as a dynamic liquid biopsy in acute heart failure

medRxiv(2023)10.1101/2023.02.17.23285936

N/A

0DataRank · unranked

7 citations

Michail Spanos, H. Immo Lehmann, Quanhu Sheng, Rodosthenis S. Rodosthenous, Mark Chaffin +12 more

Transcriptional profile of the rat cardiovascular system at single cell resolution

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.14.567085

N/A

0DataRank · unranked

3 citations

Stephen J. Fleming, Ling Xiao, Amelia Weber Hall, Amer-Denis Akkad, Mark Chaffin +11 more

Common and Rare Variant Contributions to Bradyarrhythmias from Multi-Ancestry Meta-Analyses

medRxiv(2023)10.1101/2023.09.24.23295485

N/A

0DataRank · unranked

0 citations

Joel Rämö, Sean J. Jurgens, Shaan Khurshid, Mark Chaffin, Amelia Weber Hall +56 more

Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis

UNC Libraries(2024)10.17615/c1sy-3719

N/A

0DataRank · unranked

0 citations

Brandon K. Fornwalt, Chrissy Austin-Tse, Mark Chaffin, B.E. Cade, J Lee +43 more

HeartMap: An Integrated Cell Atlas of 2.4 million cells across 209 Individuals in Health and Disease

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.06.686995

Top 100%

0DataRank

Top 100%0 citations

Mark Chaffin, Bridget Simonson, Alex Mandia, Patrick T. Ellinor, Yesh Datar

Mark Chaffin

Indexed papers

Top data-sharing exemplar

Papers