Xi‐Ping Huang

University of North Carolina at Chapel Hill

Also affiliated with University of North Carolina Health Care

Biochemistry, Genetics and Molecular BiologyNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

UNC Libraries(2020)10.17615/784j-zg92

Top 100%

0DataRank

Top 100%0 citations

Bryan L. Roth, Xi‐Ping Huang, Maria F. Sassano, Katherine Lansu, Wesley K. Kroeze +3 more

Papers

Driven by 51 papers — median percentile 0. Top paper: “A SARS-CoV-2 protein interaction map reveals targets for drug repurposing”.

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Nature(2020)10.1038/s41586-020-2286-9

N/A

1.3DataRank · unranked

4829 citations

Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White +95 more

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Frontiers in Pharmacology(2021)10.3389/fphar.2021.633680

N/A

0.700DataRank · unranked

105 citations

Philip Tisdall, Philip Fremont‐Smith, Yongfeng Liu, Xi‐Ping Huang, Kris M. White +20 more

Novel Molecular Targets of Dezocine and Their Clinical Implications

UNC Libraries(2020)10.17615/bay1-yh63

N/A

0DataRank · unranked

14 citations

Jin Xi, Alexei Yeliseev, Bryan L. Roth, Renyu Liu, Xi‐Ping Huang

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

UNC Libraries(2020)10.17615/kvmf-ds60

N/A

0DataRank · unranked

12 citations

Dan Urban, Marc G. Caron, Raymond C. Stevens, Huixian Wu, Tama Evron +9 more

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

UNC Libraries(2020)10.17615/x7yw-fx68

N/A

0DataRank · unranked

12 citations

Alice Jiang, Jian Jin, Sheng Wang, Wesley K. Kroeze, Bryan L. Roth +14 more

Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

UNC Libraries(2020)10.17615/7qf1-hv19

N/A

0DataRank · unranked

8 citations

R. B. Mailman, Seonjoo Lee, Xi‐Ping Huang, Y. Truong, Suman Sen +3 more

Structure of the human smoothened receptor bound to an antitumour agent

UNC Libraries(2020)10.17615/9b29-5258

N/A

0DataRank · unranked

12 citations

Vsevolod Katritch, Bryan L. Roth, Chong Wang, Raymond C. Stevens, Fai Siu +5 more

Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc

UNC Libraries(2020)10.17615/3gw8-0n78

N/A

0DataRank · unranked

6 citations

Bryan L. Roth, Xi‐Ping Huang, Seiji Sato, Wesley K. Kroeze

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

UNC Libraries(2020)10.17615/xksw-7k89

N/A

0DataRank · unranked

4 citations

Jian Jin, Orrin J. Stone, Xi‐Ping Huang, Xin Chen, Bryan L. Roth +2 more

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Figshare(2020)10.17615/q3bp-3c89

N/A

0DataRank · unranked

3 citations

Feng Liu, Masoud Vedadi, Kyle D. Konze, C.H. Arrowsmith, Gang Greg Wang +18 more

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

UNC Libraries(2020)10.17615/dj89-pm49

N/A

0DataRank · unranked

1 citations

Eyal Vardy, Daniel J. Urban, Patrick M. Giguère, Joseph E. Rittiner, Juan Song +16 more

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

INDIGO (University of Illinois at Chicago)(2020)10.17615/f5mg-va38

N/A

0DataRank · unranked

1 citations

Zhong Zheng, Vsevolod Katritch, Raymond C. Stevens, Xi‐Ping Huang, Saheem A. Zaidi +4 more

D 4 dopamine receptor high-resolution structures enable the discovery of selective agonists

UNC Libraries(2020)10.17615/2q94-vv62

N/A

0DataRank · unranked

21 citations

Daniel Wacker, Bryan L. Roth, John D. McCorvy, Venkatakrishnan, Robin M. Betz +6 more

Photochemical activation of TRPA1 channels in neurons and animals

UNC Libraries(2020)10.17615/8tf2-z486

N/A

0DataRank · unranked

0 citations

Randall T. Peterson, Robert Mills, Jaeda Coutinho‐Budd, Clifford J. Woolf, Jared Sprague +12 more

Automated design of ligands to polypharmacological profiles

UNC Libraries(2020)10.17615/2v9s-yz71

N/A

0DataRank · unranked

0 citations

Lauren Webster, Frederick R. C. Simeons, Ian H. Gilbert, Keren Abecassis, Suzanne Norval +16 more

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

UNC Libraries(2020)10.17615/9drd-2371

N/A

0DataRank · unranked

0 citations

Andrea Velenich, Giancarlo Bruni, Barbara J. Caldarone, Tama Evron, Andrew J. Rennekamp +15 more

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine

UNC Libraries(2020)10.17615/39gt-9h56

N/A

0DataRank · unranked

0 citations

Alison I. Bernstein, Brian K. Shoichet, Bradley W. Gray, William C. Wetsel, Martilias S. Farrell +17 more

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

UNC Libraries(2020)10.17615/784j-zg92

Top 100%

0DataRank

Top 100%0 citations

Bryan L. Roth, Xi‐Ping Huang, Maria F. Sassano, Katherine Lansu, Wesley K. Kroeze +3 more

Sigma-1 receptor ligands control a switch between passive and active threat responses

UNC Libraries(2020)10.17615/bymg-p559

N/A

0DataRank · unranked

0 citations

David Kokel, Paul J. Lorello, Bryan L. Roth, Andrew J. Rennekamp, Andrew P. W. Gonzales +7 more

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2020)10.17615/wfvq-kk18

N/A

0DataRank · unranked

0 citations

Peixiong Yuan, Yuhong Fang, Cheryl L. Mayo, Xi‐Ping Huang, Todd D. Gould +15 more

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

UNC Libraries(2020)10.17615/s278-v194

N/A

0DataRank · unranked

0 citations

Luo Xiao, Magdalena M. Szewczyk, Masoud Vedadi, Aiping Dong, David Smil +24 more

Molecular control of δ-opioid receptor signalling

UNC Libraries(2020)10.17615/qb8y-7n16

N/A

0DataRank · unranked

0 citations

Vsevolod Katritch, Bryan L. Roth, Gustavo Fenalti, Xi‐Ping Huang, Raymond C. Stevens +3 more

Rational Drug Design Leading to the Identification of a Potent 5-HT 2C Agonist Lacking 5-HT 2B Activity

INDIGO (University of Illinois at Chicago)(2020)10.17615/5qmt-v586

N/A

0DataRank · unranked

0 citations

Andreas Svennebring, Alan P. Kozikowski, Niels Jensen, Bryan L. Roth, Sung Jin Cho +3 more

In silico design of novel probes for the atypical opioid receptor MRGPRX2

UNC Libraries(2020)10.17615/w4az-cw05

N/A

0DataRank · unranked

0 citations

Tao Che, Frank I. Carroll, Wesley K. Kroeze, Hiroshi Nagase, Joel Karpiak +7 more

Development, Validation, and Use of Quantitative Structure−Activity Relationship Models of 5-Hydroxytryptamine (2B) Receptor Ligands to Identify Novel Receptor Binders and Putative Valvulopathic Compounds among Common Drugs

Figshare(2020)10.17615/34gp-xv08

N/A

0DataRank · unranked

0 citations

Alexander Tropsha, Bryan L. Roth, Rima Hajjo, Alexander Golbraikh, Vincent Setola +2 more

Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands

UNC Libraries(2020)10.17615/k5mp-zz98

N/A

0DataRank · unranked

0 citations

Edward Ofori, Bryan L. Roth, Xi‐Ping Huang, Jagan R. Etukala, Kamanski R. Jordan +6 more

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

UNC Libraries(2020)10.17615/17wc-xm97

N/A

0DataRank · unranked

0 citations

Christopher J. MacNevin, Stephen V. Frye, William P. Janzen, Dalia Barsyte-Lovejoy, Xi‐Ping Huang +19 more

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

UNC Libraries(2020)10.17615/qe7c-h860

N/A

0DataRank · unranked

0 citations

Claudio Trapella, Vadim Cherezov, Vsevolod Katritch, Xi‐Ping Huang, Eugene Chun +8 more

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

UNC Libraries(2020)10.17615/n8xg-b035

N/A

0DataRank · unranked

0 citations

Thuy B. Tran, Bryan L. Roth, Xi‐Ping Huang, Herbert Y. Meltzer, Peter B. Hedlund +1 more

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

UNC Libraries(2020)10.17615/h6h3-eh02

N/A

0DataRank · unranked

0 citations

Peter A. DiMaggio, Dalia Barsyte-Lovejoy, Sylvie Rival‐Gervier, W. Tempel, Feng Liu +27 more

Structures of the σ2 receptor enable docking for bioactive ligand discovery

Nature(2021)10.1038/s41586-021-04175-x

N/A

0DataRank · unranked

198 citations

Jiankun Lyu, João M. Bráz, Tia A. Tummino, Veronica Craik, Matthew J. O’Meara +11 more

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

INDIGO (University of Illinois at Chicago)(2021)10.17615/s98d-vh37

N/A

0DataRank · unranked

9 citations

Abdellah Allali‐Hassani, Victoria Korboukh, Jian Jin, Xi‐Ping Huang, Masoud Vedadi +9 more

Allostery of atypical modulators at oligomeric G protein-coupled receptors

Scientific Reports(2021)10.1038/s41598-021-88399-x

N/A

0DataRank · unranked

1 citations

Brendan Kelly, Gwendolynne Elmslie, Xi‐Ping Huang, Dong Yue, Margaret Seidenberg +3 more

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.07.430101

N/A

0DataRank · unranked

9 citations

B. Krumm, Huibing Zhang, X. Edward Zhou, Yue Wang, Xi‐Ping Huang +10 more

Crystal structures of the σ 2 receptor template large-library docking for selective chemotypes active in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.29.441652

N/A

0DataRank · unranked

7 citations

Jiankun Lyu, João M. Bráz, Tia A. Tummino, Veronica Craik, Matthew J. O’Meara +11 more

Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor

Science(2022)10.1126/science.abn7065

N/A

0DataRank · unranked

154 citations

Jun Xu, Harald Hübner, João M. Bráz, Philipp Seemann, Charlotte Avet +19 more

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter

Cell(2023)10.1016/j.cell.2023.04.010

N/A

0DataRank · unranked

97 citations

Anubha Seth, Christian B. Billesbølle, João M. Bráz, Ramona M. Rodriguiz, Kasturi Roy +16 more

Docking for EP4R antagonists active against inflammatory pain

Nature Communications(2023)10.1038/s41467-023-43506-6

N/A

0DataRank · unranked

39 citations

Chelsea DeLeon, João Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan +14 more

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework

Journal of Chemical Information and Modeling(2023)10.1021/acs.jcim.3c00651

N/A

0DataRank · unranked

22 citations

Davide Provasi, Xing Qiu, H. Ümit Kanıskan, Xi‐Ping Huang, Jeffrey F. DiBerto +5 more

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.23.563088

N/A

0DataRank · unranked

4 citations

Radda Rusinova, Karl F. Herold, Xi‐Ping Huang, Patricia Dranchak, Ty C. Voss +9 more

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.25.537995

N/A

0DataRank · unranked

1 citations

Davide Provasi, Xing Qui, H. Ümit Kanıskan, Xi‐Ping Huang, Jeffrey F. DiBerto +5 more

Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism

Addiction Neuroscience(2024)10.1016/j.addicn.2024.100155

N/A

0DataRank · unranked

57 citations

Xi‐Ping Huang, J. G. Murray, Alexandra C. Nowlan, Sara Y. Conley, Sarah E. Mott +8 more

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

Nature Communications(2024)10.1038/s41467-024-50964-z

N/A

0DataRank · unranked

17 citations

B. Krumm, Nicholas J. Kapolka, W.H. Ludlam, Meng Cui, Sepehr Mani +15 more

Structure-guided design of a peripherally restricted chemogenetic system

Cell(2024)10.1016/j.cell.2024.11.001

N/A

0DataRank · unranked

10 citations

B. Krumm, Adrien Tassou, Matan Geron, Jeffrey F. DiBerto, Nicholas J. Kapolka +15 more

Molecular basis of proton-sensing by G protein-coupled receptors

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.17.590000

N/A

0DataRank · unranked

13 citations

Nick Hoppe, Xi‐Ping Huang, Christian B. Macdonald, Eshan Mehrota, Patrick Rockefeller Grimes +6 more

Molecular basis of proton sensing by G protein-coupled receptors

Cell(2025)10.1016/j.cell.2024.11.036

N/A

0DataRank · unranked

56 citations

Nick Hoppe, Xi‐Ping Huang, Darko Mitrovic, Christian B. Billesbølle, Christian B. Macdonald +8 more

Structure-guided design of partial agonists at an opioid receptor

Nature Communications(2025)10.1038/s41467-025-57734-5

N/A

0DataRank · unranked

14 citations

Sarah M. Bernhard, Amal El Daibani, Saheem A. Zaidi, Jordy Homing Lam, Jhoan Aguilar +16 more

Total synthesis and biological activity of “carbamorphine”: O-to-CH 2 replacement in the E-ring of the morphine core structure

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2425438122

N/A

0DataRank · unranked

3 citations

Rohini S. Ople, Alexander Kremsmair, Nokomis Ramos‐Gonzalez, Thomas Nedungadan, Brandon J. Kennedy +9 more

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

UNC Libraries(2025)10.17615/p1he-g624

N/A

0DataRank · unranked

0 citations

Tyler J. Lefevre, Ning Ma, Kevin M. Knight, Alan V. Smrcka, Sepehr Mani +15 more

Docking for EP4R antagonists active against inflammatory pain

UNC Libraries(2025)10.17615/545v-9x45

N/A

0DataRank · unranked

0 citations

Chelsea DeLeon, Bryan L. Roth, Brian K. Shoichet, Christian B. Billesbølle, Stefan Gahbauer +14 more

The activities of drug inactive ingredients on biological targets

Science(2020)10.1126/science.aaz9906

N/A

0DataRank · unranked

88 citations

Duncan Armstrong, Ling Zou, Alexander Fekete, Xi‐Ping Huang, Hayarpi Torosyan +15 more

Xi‐Ping Huang

Indexed papers

Top data-sharing exemplar

Papers