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Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100921Source: DataRank Database

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 14 times.

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Open Access14 citations

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Enrichment:Funding (10 grants)Impact (FWCI 0.52)OA: goldTopics (72)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Michal Hammel ORCID,Aleksandr Sverzhinsky ORCID,Miaw-Sheue Tsai ORCID,John M. Pascal ORCID,John A. Tainer ORCID

Live enrichment

PubMed:34181949 PMC:PMC8318918 OpenAlex:https://openalex.org/W3173379961

Cancer Prevention and Research Institute of Texas

Grant: RP180813

National Institutes of Health

Grant: R01 ES012512

National Institutes of Health

Grant: R35 CA220430

National Institutes of Health

Grant: P01 CA092584

US Department of Energy

Grant: DE-AC02-05BH11231

National Institutes of Health

Grant: 3P01CA092584-19S1

Structural Cell Biology of DNA Repair Machines

National Institutes of Health

Grant: 5R35CA220430-02

Mesocale And Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)

National Institutes of Health

Grant: 5R01ES012512-03

"Roles of LIG3 and XRCC1 genes in genome stability".

Natural Sciences and Engineering Research Council of Canada

Grant: unidentified

unidentified

Natural Sciences and Engineering Research Council of Canada

FWCI

0.52

Citation Percentile

0.6%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: CC BY NC ND

journalhttp://www.jbc.org/article/S0021925821007213/pdf

publisherhttp://www.jbc.org/article/S0021925821007213/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925821007213?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925821007213?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2021.100921

Fields of Study

Cancer therapeutics and mechanismsAntibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in Bacteria0301 basic medicine03 medical and health sciences0303 health sciencesPhosphoric Diester HydrolasesDNA Ligase ATPPhosphorylationHumansDNA RepairCatalytic DomainX-ray Repair Cross Complementing Protein 1AnimalsDNA-Binding ProteinsMiceDNA Breaks, Single-StrandedProtein Binding

MeSH Terms

DNA Ligase ATPPoly-ADP-Ribose Binding ProteinsX-ray Repair Cross Complementing Protein 1AnimalsDNA DamageDNA RepairDNA-Binding ProteinsHumansPhosphoric Diester HydrolasesPhosphorylationProtein BindingCatalytic DomainMiceDNA Breaks, Single-Stranded

Keywords

DNA ligaseDNA repairDNA clampDNAAP siteBiochemistryDNA damageBiologyChemistryMolecular biologyElectron microscopyPhosphorylationSmall angle X-ray scatteringTopoisomeraseDNA ligationprotein structure570Biochemistry & Molecular BiologyBiomedical and clinical sciences1.1 Normal biological development and functioningMedical and Health SciencesDNA Ligase ATPMiceSingle-StrandedCatalytic DomainGenetics2.1 Biological and endogenous factorsHumansAnimalsDNA Breaks, Single-StrandedCancerPhosphoric Diester HydrolasesDNA BreaksBiological SciencesDNA-Binding ProteinsX-ray Repair Cross Complementing Protein 1Chemical sciencesBiochemistry and Cell BiologyResearch ArticleProtein Binding

Sustainable Development Goals

SDG 3: 3. Good health

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

FAIR Checklist

Authors (7)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)