Dario A.A. Vignali

Also affiliated with Parker Institute for Cancer Immunotherapy, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center

Immunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 66 papers. Top paper: “Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer”.

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

Immunity(2020)10.1016/j.immuni.2019.11.014

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0.975DataRank · unranked

664 citations

Cornelius Kürten, Tracy Tabib, Zengbiao Qi, Sayali Onkar, Ting Wang +11 more

Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance

Cell Reports(2020)10.1016/j.celrep.2019.12.081

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0DataRank · unranked

161 citations

Yusuke Tomita, Ewa Jankowska−Gan, Diego Lema, Matt Arvedson, Ashita Nair +12 more

Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

Nature Immunology(2020)10.1038/s41590-020-0733-2

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0DataRank · unranked

151 citations

Ashwin Somasundaram, Sasikanth Manne, Angela M. Gocher, Andrea L. Szymczak-Workman, Kate M. Vignali +9 more

Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy

Journal for ImmunoTherapy of Cancer(2020)10.1136/jitc-2020-000967

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0DataRank · unranked

146 citations

Chang Liu, Tullia C. Bruno, Creg J. Workman, Dario A.A. Vignali, Christopher A Chuckran

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

The Journal of Experimental Medicine(2020)10.1084/jem.20182232

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0DataRank · unranked

262 citations

Juhi R. Kuchroo, Peter T. Sage, Dan Liang, Loise M. Francisco, Jessica N. Buck +13 more

Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

Immunity(2020)10.1016/j.immuni.2020.10.022

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0DataRank · unranked

120 citations

Yi Yang, Yukari Zenke, Haiyue Li, Virendra K. Chaudhri, Jacinto S. De La Cruz Diaz +10 more

Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

Science Immunology(2020)10.1126/sciimmunol.abc2728

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0DataRank · unranked

86 citations

Ashwin Somasundaram, Jessica Moskovitz, Andrea L. Szymczak-Workman, Chang Liu, Anthony R. Cillo +12 more

Understanding adverse events of immunotherapy: A mechanistic perspective

The Journal of Experimental Medicine(2020)10.1084/jem.20192179

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47 citations

Stephanie Grebinoski, Arlene H. Sharpe, Dario A.A. Vignali, Kelly P. Burke

Divergent cancer etiologies drive distinct B cell signatures and tertiary lymphoid structures

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.29.123265

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5 citations

Anthony R. Cillo, Tracy Tabib, Angen Liu, Sayali Onkar, Sheryl Kunning +12 more

Systemic immune dysfunction in cancer patients driven by IL6 and IL8 induction of an inhibitory receptor module in peripheral CD8 + T cells

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.06.081471

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2 citations

Anthony R. Cillo, Caleb Lampenfeld, Lauren Oliveri, Maria A. Velez, Sonali Joyce +12 more

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

Nature(2021)10.1038/s41586-020-03045-2

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0DataRank · unranked

1257 citations

Paolo Vignali, Steven J. Mullett, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski +12 more

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

Nature Communications(2021)10.1038/s41467-021-23355-x

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362 citations

Anthony R. Cillo, Tracy Tabib, Angen Liu, Sayali Onkar, Sheryl Kunning +15 more

Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

Immunity(2021)10.1016/j.immuni.2021.11.003

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297 citations

Hannah J Bumgarner, Anthony R. Cillo, Ansen B.P. Burr, Justin T. Tometich, Amrita Bhattacharjee +4 more

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing

Nature Communications(2021)10.1038/s41467-021-27619-4

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297 citations

Aditi Kulkarni, Anthony R. Cillo, P.M.L. Santos, Anna K. Roble, Sayali Onkar +17 more

Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment

Frontiers in Immunology(2021)10.3389/fimmu.2021.702726

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0DataRank · unranked

189 citations

Angela M. Gocher, Creg J. Workman, Dario A.A. Vignali, Ellen Scott

Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

Clinical Infectious Diseases(2021)10.1093/cid/ciab072

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0DataRank · unranked

140 citations

William Bain, Jana L. Jacobs, Sham Nambulli, Urvi M. Parikh, Anthony R. Cillo +28 more

Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage

Science Immunology(2021)10.1126/sciimmunol.abe3702

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92 citations

Yuki Muroyama, Shin Foong Ngiow, Zeyu Chen, Sasikanth Manne, Zhangying Cai +23 more

A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells

Immunity(2021)10.1016/j.immuni.2021.08.029

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20 citations

Kate M. Vignali, Andrea L. Szymczak-Workman, Amanda R. Burton, Erin A. Brunazzi, Shin Foong Ngiow +7 more

People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden

Cell Reports Medicine(2021)10.1016/j.xcrm.2021.100476

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20 citations

Ashwin Somasundaram, Feng Shan, Carly Cardello, Creg J. Workman, Georgios D. Kitsios +24 more

Regulatory T Cell–Derived TRAIL Is Not Required for Peripheral Tolerance

ImmunoHorizons(2021)10.4049/immunohorizons.2000098

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6 citations

Stephanie Grebinoski, Qianxia Zhang, Erin A. Brunazzi, Amanda R. Burton, Creg J. Workman +2 more

Bifurcated monocyte states are predictive of mortality in severe COVID-19

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.10.430499

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0DataRank · unranked

9 citations

Ashwin Somasundaram, Feng Shan, Carly Cardello, Creg J. Workman, Georgios D. Kitsios +24 more

Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.27.428417

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0DataRank · unranked

3 citations

Anthony R. Cillo, Hannah J Bumgarner, Ansen B.P. Burr, Justin T. Tometich, Amrita Bhattacharjee +4 more

Therapeutic targeting of regulatory T cells in cancer

Trends in cancer(2022)10.1016/j.trecan.2022.06.008

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0DataRank · unranked

232 citations

Ashwin Somasundaram, Tullia C. Bruno, Creg J. Workman, Dario A.A. Vignali, Feng Shan

LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation

Nature Immunology(2022)10.1038/s41590-022-01176-4

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0DataRank · unranked

212 citations

Diana M. Mitrea, Po-Chien Chou, Jamshid Temirov, Kate M. Vignali, Xueyan Liu +7 more

The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes

Cancer Discovery(2022)10.1158/2159-8290.cd-22-0475

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0DataRank · unranked

206 citations

Neil Carleton, Peter C. Lucas, Tullia C. Bruno, Adrian V. Lee, Dario A.A. Vignali +2 more

Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3

Nature Immunology(2022)10.1038/s41590-022-01210-5

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0DataRank · unranked

108 citations

Qianxia Zhang, Anthony R. Cillo, Sasikanth Manne, Hanxi Xiao, Erin A. Brunazzi +10 more

Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-22-1471

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89 citations

Elina Mukherjee, Nathanael G. Bailey, Sayali Onkar, Jessica D. Daley, Cláudia Salgado +11 more

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

Nature Communications(2022)10.1038/s41467-022-29498-9

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0DataRank · unranked

72 citations

Olivia McGinn, Yang Wu, Amir Bahreini, Nolan Priedigkeit, Kai Ding +21 more

Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy

Cell Reports(2022)10.1016/j.celrep.2022.111582

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0DataRank · unranked

47 citations

Shaoxian Wu, Zhanpeng Cen, Yixin Zhang, Yuang Chen, Yixian Huang +9 more

Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells

Cancer Immunology Research(2022)10.1158/2326-6066.cir-20-0736

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0DataRank · unranked

30 citations

Anthony R. Cillo, Caleb Lampenfeld, Creg J. Workman, Sheryl Kunning, Lauren Oliveri +14 more

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

Cell Reports(2022)10.1016/j.celrep.2022.111020

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0DataRank · unranked

21 citations

Syed A. Rahman, Anthony R. Cillo, Godhev Manakkat Vijay, Ashwin Somasundaram, Creg J. Workman +14 more

Epitope Mapping of Therapeutic Antibodies Targeting Human LAG3

The Journal of Immunology(2022)10.4049/jimmunol.2200309

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0DataRank · unranked

11 citations

Arjun K. Mishra, Priyanka Agarwal, Kate M. Vignali, Creg J. Workman, Dario A.A. Vignali +2 more

Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates αPD-L1 therapy

Research Square(2022)10.21203/rs.3.rs-1633600/v1

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0DataRank · unranked

1 citations

Alex McPherson, Catherine M. Phelps, Mohit Rana, Surya Pandey, Jake Shapira +10 more

De novo identification of CD4+ T cell epitopes

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.21.517373

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0DataRank · unranked

1 citations

Stephanie Grebinoski, Jessica D. Torrey, Eduardo Zarate-Martinez, Louise Hicks, Rashi Ranjan +6 more

952 The temporal contribution of interferon-γ in driving T-cell exhaustion and response to immune checkpoint blockade

Regular and Young Investigator Award Abstracts(2022)10.1136/jitc-2022-sitc2022.0952

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0DataRank · unranked

0 citations

Chang Liu, Lawrence P. Andrews, Madhu Malinee, Carly Cardello, Creg J. Workman +2 more

Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

Cell(2023)10.1016/j.cell.2023.03.011

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0DataRank · unranked

679 citations

Alex McPherson, Catherine M. Phelps, Surya Prakash Pandey, Colin R. Laughlin, Jake H. Shapira +20 more

LAG-3 as the third checkpoint inhibitor

Nature Immunology(2023)10.1038/s41590-023-01569-z

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0DataRank · unranked

330 citations

Creg J. Workman, Dario A.A. Vignali, Vaishali Aggarwal

The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

Nature Immunology(2023)10.1038/s41590-023-01529-7

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0DataRank · unranked

87 citations

Bryan S. Yung, Farhoud Faraji, Robert Saddawi‐Konefka, Zhiyong Wang, Alexander T. Wenzel +16 more

Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment

Nature Cancer(2023)10.1038/s43018-023-00527-w

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0DataRank · unranked

76 citations

Jian Cui, Jian Zou, Carly Cardello, Anthony R. Cillo, Mostofa Rafid Uddin +12 more

IFNγ-induction of TH1-like regulatory T cells controls antiviral responses

Nature Immunology(2023)10.1038/s41590-023-01453-w

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0DataRank · unranked

60 citations

Jian Cui, Andrea L. Szymczak-Workman, Kate M. Vignali, Julianna Latini, Gwen P. Pieklo +11 more

Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells

Science Immunology(2023)10.1126/sciimmunol.adf6717

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33 citations

Anthony R. Cillo, Carly Cardello, Daniel Y. Yuan, Sheryl Kunning, Jian Cui +12 more

Pathological Tau transmission initiated by binding lymphocyte-activation gene 3

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.16.541015

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0DataRank · unranked

7 citations

Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar +20 more

Data from Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks

(2023)10.1158/1078-0432.c.6532980

N/A

0DataRank · unranked

0 citations

Elina Mukherjee, Nathanael G. Bailey, Sayali Onkar, Jessica D. Daley, Cláudia Salgado +11 more

Data from Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks

(2023)10.1158/1078-0432.c.6532980.v1

N/A

0DataRank · unranked

0 citations

Elina Mukherjee, Nathanael G. Bailey, Sayali Onkar, Jessica D. Daley, Cláudia Salgado +11 more

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

Cell(2024)10.1016/j.cell.2024.07.016

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0DataRank · unranked

244 citations

Samuel C. Butler, Jian Cui, Anthony R. Cillo, Carly Cardello, Chang Liu +15 more

Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity

Cell(2024)10.1016/j.cell.2024.06.036

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0DataRank · unranked

157 citations

Carly Cardello, Feng Shan, Lilit Karapetyan, Sheryl Kunning, Cindy Sander +9 more

LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

Cell(2024)10.1016/j.cell.2024.07.018

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0DataRank · unranked

100 citations

Sasikanth Manne, Yinghui Huang, Tarek Azar, Zeyu Chen, Divij Mathew +15 more

Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

Nature Communications(2024)10.1038/s41467-024-49016-3

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0DataRank · unranked

40 citations

Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu +37 more

Advances in LAG3 cancer immunotherapeutics

Trends in cancer(2024)10.1016/j.trecan.2024.10.009

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0DataRank · unranked

24 citations

Samuel C. Butler, Creg J. Workman, Dario A.A. Vignali, Kieran Adam

Tim-3 Is Required for Regulatory T Cell–Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection

The Journal of Immunology(2024)10.4049/jimmunol.2400119

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0DataRank · unranked

8 citations

Hridesh Banerjee, Angela Gocher-Demske, Priyanka Manandhar, Isha Mehta, Ogechukwu Ezenwa +7 more

De novo identification of CD4+ T cell epitopes

Nature Methods(2024)10.1038/s41592-024-02255-0

N/A

0DataRank · unranked

23 citations

Nishtha Trivedi, Stephanie Grebinoski, Jessica D. Torrey, Eduardo Zarate Martinez, S. Martínez +10 more

Lymphocyte‐Activation Gene 3 Facilitates Pathological Tau Neuron‐to‐Neuron Transmission

Advanced Science(2024)10.1002/advs.202303775

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13 citations

Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar +25 more

Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells

The Journal of Immunology(2024)10.4049/jimmunol.2300216

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0DataRank · unranked

11 citations

Gwenyth Pieklo, Qianxia Zhang, Anabelle Visperas, Jian Cui, J. R. Goulet +8 more

Ebi3 Binding to IFN-γ and IL-10 Limits Their Function

The Journal of Immunology(2024)10.4049/jimmunol.2400236

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0DataRank · unranked

7 citations

Ye Cheng, Hiroshi Yano, Zhanna Lipatova, Erin A. Brunazzi, Kate M. Vignali +3 more

Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer

npj Precision Oncology(2024)10.1038/s41698-024-00746-z

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0DataRank · unranked

3 citations

Sayali Onkar, Jian Zou, Yujia Li, Haley Arbore, Sai Maley +9 more

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.09.588752

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0DataRank · unranked

1 citations

Xiaoran Zhang, Anthony R. Cillo, Jonathan Sussman, Poorva Sandlesh, Antonio Corral Tarbay +25 more

Immune Infiltration Correlates with Transcriptomic Subtypes in Primary ER+ Invasive Lobular Breast Cancer

Research Square(2024)10.21203/rs.3.rs-4579052/v1

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0DataRank · unranked

0 citations

Sayali Onkar, Jian Zou, Yujia Li, Haley Arbore, Sai Maley +9 more

Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs

Cell(2025)10.1016/j.cell.2025.02.014

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0DataRank · unranked

63 citations

Anran Dai, Yuwei Huang, Hua Li, Jian Cui, Haochen Yang +27 more

Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies

Cancer Cell(2025)10.1016/j.ccell.2025.02.026

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0DataRank · unranked

61 citations

Dan P. Zandberg, Aditi Kulkarni, Simion I. Chiosea, Patricia M. Santos, Brian R. Isett +19 more

Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

Nature Immunology(2025)10.1038/s41590-025-02218-3

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0DataRank · unranked

11 citations

Eleni Phung, Xutong Gong, Pilar Baldominos, Silvia Galván-Peña, Ian Magill +93 more

Regulatory T cells in the tumor microenvironment display a unique chromatin accessibility profile

ImmunoHorizons(2025)10.1093/immhor/vlae014

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0DataRank · unranked

2 citations

Jian Cui, Dhivyaa Rajasundaram, Hiroshi Yano, Chang Liu, Jonathan Cohen +5 more

Single-cell profiling of peripheral and local immune compartments reveal unique genotype-independent prognostic immune signatures across isocitrate dehydrogenase-stratified glioma

Neuro-Oncology(2025)10.1093/neuonc/noaf206

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0DataRank · unranked

1 citations

Anthony R. Cillo, Sajeev Kohli, Carly Cardello, Jonathan Patterson, Ebrar Akca +18 more

Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.03.631221

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0DataRank · unranked

7 citations

Deok Jeong, Graziella Madeo, Ramhari Kumbhar, Ning Wang, Lili Niu +13 more

Lead-in therapy targeting PD1 and/or LAG3 imposes distinct immune phenotypes in first-line treatment of metastatic melanoma

medRxiv(2025)10.1101/2025.11.04.25339499

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0DataRank · unranked

2 citations

Anthony R. Cillo, Shuaichao Wang, Arivarasan Karunamurthy, Ryan Massa, Anjali Rohatgi +16 more

Genomic specificity of anti-mouse TCR mAbs determined by single-cell RNAseq

The Journal of Immunology(2025)10.1093/jimmun/vkaf094

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0DataRank · unranked

0 citations

Val Piekarsa, Sofia Kossida, Joshua Croteau, Amy Huei‐Yi Lee, Robert Balderas +85 more

1340 Lead-in therapy targeting PD1 and/or LAG3 distinguishes differential impacts upon the immune response in first-line treatment of metastatic melanoma

(2025)10.1136/jitc-2025-sitc2025.1340

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0 citations

Anthony R. Cillo, Shuaichao Wang, Arivarasan Karunamurthy, Ryan Massa, Anjali Rohatgi +15 more