Josephine R. Giles

Parker Institute for Cancer Immunotherapy

Also affiliated with Translational Therapeutics (United States), University of Pennsylvania

Immunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 42 papers. Top paper: “Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications”.

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Science(2020)10.1126/science.abc8511

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14.5DataRank · unranked

1659 citations

Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Allison R. Greenplate, Jennifer E. Wu +50 more

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection

Science(2025)10.1126/science.adn2337

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1.3DataRank · unranked

76 citations

John Attanasio, Christine Dien, Jaiveer Singh, Emily Kessler, Leena Abdullah +17 more

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

Science(2021)10.1126/science.abm0829

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1.0DataRank · unranked

945 citations

Mark M. Painter, Sokratis A. Apostolidis, Divij Mathew, Wenzhao Meng, Aaron M. Rosenfeld +42 more

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

Nature Immunology(2021)10.1038/s41590-021-00975-5

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0.827DataRank · unranked

247 citations

Sasikanth Manne, Jean‐Christophe Beltra, Erietta Stelekati, Zeyu Chen, Kito Nzingha +8 more

Divergent clonal differentiation trajectories of T cell exhaustion

Nature Immunology(2022)10.1038/s41590-022-01337-5

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0.818DataRank · unranked

233 citations

Kathryn E. Yost, Sunnie Hsiung, Katalin Sandor, Yu Xia, Yanyan Qi +12 more

In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

Cell(2021)10.1016/j.cell.2021.02.019

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0.809DataRank · unranked

219 citations

Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan He +23 more

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

Science Immunology(2021)10.1126/sciimmunol.abf7570

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0.800DataRank · unranked

206 citations

Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Caroline Diorio, Leticia Kuri-Cervantes +59 more

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.20.481163

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0.477DataRank · unranked

23 citations

Mark M. Painter, Kendall A. Lundgreen, Sokratis A. Apostolidis, Amy E. Baxter, Josephine R. Giles +33 more

Deciphering the role of histone modifications in memory and exhausted CD8 T cells

Scientific Reports(2025)10.1038/s41598-025-99804-0

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0.385DataRank · unranked

12 citations

Amy E. Baxter, Zhen Zhang, Charly R. Good, Katherine A. Alexander, Zeyu Chen +12 more

Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction

Nature Communications(2021)10.1038/s41467-021-27544-6

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0DataRank · unranked

80 citations

Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge +15 more

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.23.457229

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0DataRank · unranked

64 citations

Mark M. Painter, Sokratis A. Apostolidis, Divij Mathew, Wenzhao Meng, Aaron M. Rosenfeld +42 more

Rapid induction of antigen-specific CD4 + T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.21.440862

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0DataRank · unranked

27 citations

Divij Mathew, Rishi Raj Goel, Sokratis A. Apostolidis, Ajinkya Pattekar, Oliva Kuthuru +27 more

Divergent clonal differentiation trajectories of T cell exhaustion

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.16.472900

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0DataRank · unranked

20 citations

Kathryn E. Yost, Katalin Sandor, Yu Xia, Yanyan Qi, Kamir J. Hiam-Galvez +8 more

Signatures of COVID-19 severity and immune response in the respiratory tract microbiome

medRxiv(2021)10.1101/2021.04.02.21254514

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0DataRank · unranked

19 citations

Guanxiang Liang, Samantha A. Whiteside, Ana G. Cobián-Güemes, Madeline S. Merlino, Louis J. Taylor +16 more

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.01.442279

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0DataRank · unranked

13 citations

Amrita Sarkar, H.M. Giannini, Rishi Raj Goel, Divij Mathew, Aae Suzuki +31 more

Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics

Nature Immunology(2022)10.1038/s41590-022-01338-4

N/A

0DataRank · unranked

265 citations

Shin Foong Ngiow, Sasikanth Manne, Amy E. Baxter, Omar Khan, Ping Wang +15 more

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

Cell(2022)10.1016/j.cell.2022.04.009

N/A

0DataRank · unranked

217 citations

Mark M. Painter, Kendall A. Lundgreen, Sokratis A. Apostolidis, Amy E. Baxter, Josephine R. Giles +33 more

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19

Frontiers in Immunology(2022)10.3389/fimmu.2022.834988

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0DataRank · unranked

54 citations

Amrita Sarkar, H.M. Giannini, Rishi Raj Goel, Divij Mathew, Aae Suzuki +32 more

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.03.509766

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0DataRank · unranked

14 citations

Mohamed S. Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Makoto Kurachi +15 more

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.27.485974

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0DataRank · unranked

6 citations

Shin Foong Ngiow, Sasikanth Manne, Amy E. Baxter, Omar Khan, Ping Wang +10 more

Distinct Heterogeneity in the Naive T cell Compartments of Children and Adults

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.04.510869

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0DataRank · unranked

2 citations

Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Mark-Phillip Pebworth +27 more

CD8+ T cells in the cancer-immunity cycle

Immunity(2023)10.1016/j.immuni.2023.09.005

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0DataRank · unranked

410 citations

Anna-Maria Globig, Susan M. Kaech, E. John Wherry, Josephine R. Giles

Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure

Immunity(2023)10.1016/j.immuni.2023.11.005

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0DataRank · unranked

132 citations

Mohamed S. Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Makoto Kurachi +16 more

Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

Nature Immunology(2023)10.1038/s41590-023-01613-y

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0DataRank · unranked

109 citations

Timothy S. Johnston, Kendall A. Lundgreen, Jefferson Santos, Juliana S. Qin, Rishi Raj Goel +55 more

In vitro modeling of CD8 + T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40

Science Immunology(2023)10.1126/sciimmunol.ade3369

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0DataRank · unranked

94 citations

Sasikanth Manne, Shin Foong Ngiow, Amy E. Baxter, Hua Huang, Elizabeth Freilich +10 more

Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment

Nature Immunology(2023)10.1038/s41590-023-01641-8

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0DataRank · unranked

40 citations

Ziyuan He, Elliott Swanson, Katherine Henderson, Cole Phalen, Samir Rachid Zaim +29 more

The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade

Cell Reports(2023)10.1016/j.celrep.2023.112905

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0DataRank · unranked

12 citations

Oishi Bardhan, Kelly Rome, Josephine R. Giles, Amy E. Baxter, Lanwei Xu +6 more

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.05.527215

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0DataRank · unranked

8 citations

Timothy S. Johnston, Kendall A. Lundgreen, Jefferson Santos, Juliana S. Qin, Rishi Raj Goel +32 more

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.17.537229

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0DataRank · unranked

4 citations

Sasikanth Manne, Shin Foong Ngiow, Amy E. Baxter, Hua Huang, Elizabeth Freilich +10 more

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells

Cancer Cell(2024)10.1016/j.ccell.2024.08.007

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0DataRank · unranked

102 citations

Paulina Coutifaris, David Brocks, Guanning Wang, Tarek Azar, Sabrina Solis +33 more

LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

Cell(2024)10.1016/j.cell.2024.07.018

N/A

0DataRank · unranked

100 citations

Sasikanth Manne, Yinghui Huang, Tarek Azar, Zeyu Chen, Divij Mathew +15 more

Revitalizing systemic immune responses in advanced NSCLC using FLT3L and SBRT

medRxiv(2025)10.1101/2025.01.29.25321332

N/A

0DataRank · unranked

1 citations

Nitin Ohri, Shin Foong Ngiow, Balázs Halmos, Wumesh KC, Madhur Garg +16 more

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 + T cells underlies distinct functional potential

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.08.669213

N/A

0DataRank · unranked

1 citations

Mark M. Painter, Sasikanth Manne, Víctor Alcalde, M. A. McLaughlin, Matthew Sullivan +28 more

Deciphering the role of histone modifications in memory and exhausted CD8 T cells

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.16.649198

N/A

0DataRank · unranked

0 citations

Amy E. Baxter, Zhen Zhang, Charly R. Good, Katherine A. Alexander, Zeyu Chen +12 more

Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

medRxiv(2020)10.1101/2020.09.25.20201863

N/A

0DataRank · unranked

57 citations

Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Caroline Diorio, Leticia Kuri-Cervantes +33 more

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.20.106401

N/A

0DataRank · unranked

115 citations

Josephine R. Giles, Amy E. Baxter, Allison R. Greenplate, Jennifer E. Wu, Cécile Alanio +33 more

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.20.087379

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0DataRank · unranked

3 citations

Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan He +20 more

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination

Science Immunology(2021)10.1126/sciimmunol.abi6950

N/A

0DataRank · unranked

734 citations

Sokratis A. Apostolidis, Mark M. Painter, Divij Mathew, Ajinkya Pattekar, Oliva Kuthuru +26 more

Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

Immunity(2021)10.1016/j.immuni.2021.08.001

N/A

0DataRank · unranked

522 citations

Divij Mathew, Rishi Raj Goel, Sokratis A. Apostolidis, Ajinkya Pattekar, Oliva Kuthuru +27 more

CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer

Nature Medicine(2021)10.1038/s41591-021-01386-7

N/A

0DataRank · unranked

520 citations

Nicholas Han, Paul Wileyto, Justin Kim, Sigrid Gouma, James Robinson +55 more

Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome

mBio(2021)10.1128/mbio.01777-21

N/A

0DataRank · unranked

124 citations

Guanxiang Liang, Samantha A. Whiteside, Ana G. Cobián-Güemes, Madeline S. Merlino, Louis J. Taylor +16 more

Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage

Science Immunology(2021)10.1126/sciimmunol.abe3702

N/A

0DataRank · unranked

92 citations

Yuki Muroyama, Shin Foong Ngiow, Zeyu Chen, Sasikanth Manne, Zhangying Cai +23 more