Hendrik Luesch

Also affiliated with University of Florida, Duke-NUS Medical School, Drug Discovery Laboratory (Norway)

MedicineBiochemistry, Genetics and Molecular BiologyEnergyChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 43 papers. Top paper: “Isolation and Characterization of the Cyanobacterial Macrolide Glycoside Moorenaside, an Anti-Inflammatory Analogue of Aurisides Targeting the Keap1/Nrf2 Pathway”.

Isolation and Characterization of the Cyanobacterial Macrolide Glycoside Moorenaside, an Anti-Inflammatory Analogue of Aurisides Targeting the Keap1/Nrf2 Pathway

Journal of Natural Products(2024)10.1021/acs.jnatprod.4c00420

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0.406DataRank · unranked

8 citations

Sofia Kokkaliari, Ranjala Ratnayake, Valerie J. Paul, Hendrik Luesch, Fatma H. Al‐Awadhi

Natural products as modulators of eukaryotic protein secretion

Natural Product Reports(2020)10.1039/c9np00066f

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55 citations

Ville O. Paavilainen, Hendrik Luesch

Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.9b01924

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48 citations

Ariana C. Brice‐Tutt, Shainnel O. Eans, Heather M. Stacy, Guqin Shi, Ranjala Ratnayake +7 more

Fungal Epithiodiketopiperazines Carrying α,β‐Polysulfide Bridges from Penicillium steckii YE, and Their Chemical Interconversion

ChemBioChem(2020)10.1002/cbic.202000403

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18 citations

Peilan Zhang, Ranjala Ratnayake, Guang Yang, Yi Zhang, Ran Zuo +14 more

Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115546

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25 citations

Verrill M. Norwood, Ranjala Ratnayake, Hendrik Luesch, Robert W. Huigens, Nicholas G. Paciaroni

Targeting and extending the eukaryotic druggable genome with natural products

Natural Product Reports(2020)10.1039/d0np90021d

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8 citations

John B. MacMillan, Hendrik Luesch

Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF‐1α Mediated Cancer Cell Viability and Vascularization

ChemBioChem(2020)10.1002/cbic.202000180

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27 citations

Sarath P. Gunasekera, Jiajia Ma, Long H. Dang, Thomas J. Carney, Valerie J. Paul +2 more

Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115756

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10 citations

Danmeng Luo, Gustavo Seabra, Hendrik Luesch, Qi-Yin Chen

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2021847118

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92 citations

Qi-Yin Chen, Ranjala Ratnayake, Charles S. Fermaintt, Daniel Lucena‐Agell, Francesca Bonato +9 more

Heterologous production of cyanobacterial compounds

Journal of Industrial Microbiology & Biotechnology(2021)10.1093/jimb/kuab003

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31 citations

Man‐Yun Chen, Hendrik Luesch, Yousong Ding, Dipesh Dhakal

A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00168

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34 citations

Shivani Kundra, Michaelle Chojnacki, Ke Liu, Marisa A. Fuse, Yasmeen Abouelhassan +11 more

Genomic and Targeted Approaches Unveil the Cell Membrane as a Major Target of the Antifungal Cytotoxin Amantelide A

ChemBioChem(2021)10.1002/cbic.202000685

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15 citations

James Matthews, Shinichi Nishimura, T. Nakatani, Airi Ito, Tongjun Gu +6 more

Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm

Current Research in Pharmacology and Drug Discovery(2021)10.1016/j.crphar.2021.100053

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9 citations

Ranjala Ratnayake, Mengxiong Wang, Qi-Yin Chen, Kevin P. Raisch, Long H. Dang +3 more

Function‐Oriented and Modular (+/−)‐cis‐Pseudoguaianolide Synthesis: Discovery of New Nrf2 Activators and NF‐κB Inhibitors

Chemistry - A European Journal(2021)10.1002/chem.202100038

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7 citations

Ranjala Ratnayake, Henry A. M. Schares, Katherine F. M. Jones, Emily Bevan–Smith, Hendrik Luesch +3 more

GPCR Pharmacological Profiling of Aaptamine from the Philippine Sponge Stylissa sp. Extends Its Therapeutic Potential for Noncommunicable Diseases

Molecules(2021)10.3390/molecules26185618

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5 citations

Hendrik Luesch, Mylene M. Uy, Harmie L. Basalo

Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity

ACS Infectious Diseases(2022)10.1021/acsinfecdis.2c00008

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24 citations

Laura Martin‐Sancho, Ranjala Ratnayake, Kris M. White, Laura Riva, Qi-Yin Chen +20 more

Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia

Cell Death Discovery(2022)10.1038/s41420-022-01165-4

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22 citations

Jinmai Jiang, Corey M. Perkins, Kalina R. Atanasova, Julie K. Bray, Gamze B. Bulut +11 more

Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium Caldora sp. Collected from the Reefs of Fort Lauderdale, Florida

Molecules(2022)10.3390/molecules27051717

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15 citations

Sofia Kokkaliari, Ranjala Ratnayake, Thomas Sauvage, Larissa A. H. dos Santos, Hendrik Luesch +2 more

Biosynthesis of Lyngbyastatins 1 and 3, Cytotoxic Depsipeptides from an Okeania sp. Marine Cyanobacterium

Journal of Natural Products(2022)10.1021/acs.jnatprod.2c00782

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4 citations

Sofia Kokkaliari, Garret M. Rubin, Valerie J. Paul, Yousong Ding, Hendrik Luesch +1 more

Isolation and Biological Activity of Iezoside and Iezoside B, SERCA Inhibitors from Floridian Marine Cyanobacteria

Marine Drugs(2023)10.3390/md21070378

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11 citations

Danmeng Luo, Valerie J. Paul, Hendrik Luesch, Sofia Kokkaliari

Heterologous Production of the C33–C45 Polyketide Fragment of Anticancer Apratoxins in a Cyanobacterial Host

Organic Letters(2023)10.1021/acs.orglett.3c00462

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10 citations

Dimitris Kallifidas, Man‐Yun Chen, Sofia Kokkaliari, Qi-Yin Chen, Valerie J. Paul +3 more

Targeted and functional genomics approaches to the mechanism of action of lagunamide D, a mitochondrial cytotoxin from marine cyanobacteria

Biochemical Pharmacology(2023)10.1016/j.bcp.2023.115608

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10 citations

Ranjala Ratnayake, Kalina R. Atanasova, Valerie J. Paul, Hendrik Luesch, Danmeng Luo

Chlorinated Enyne Fatty Acid Amides from a Marine Cyanobacterium: Discovery of Taveuniamides L-M and Pharmacological Characterization of Taveuniamide F as a GPCR Antagonist with CNR1 Selectivity

Marine Drugs(2023)10.3390/md22010028

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4 citations

Emma K. Ellis, Gustavo Seabra, Valerie J. Paul, Hendrik Luesch, Lobna A. Elsadek

Discovery and Anti-Inflammatory Activity of a Cyanobacterial Fatty Acid Targeting the Keap1/Nrf2 Pathway

Marine Drugs(2023)10.3390/md21110553

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9 citations

Emily F. Simon, Na Liu, Ranjala Ratnayake, Valerie J. Paul, Hendrik Luesch +1 more

Probing a distinct druggable tubulin binding site with gatorbulins 1–7, their metabolic and physicochemical properties, and pharmacological consequences

Bioorganic & Medicinal Chemistry(2023)10.1016/j.bmc.2023.117506

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4 citations

Ranjala Ratnayake, Rafael Hortigüela, Gustavo Seabra, Michael D. Cameron, J. Fernando Dı́az +3 more

Epigenetic Small-Molecule Screen for Inhibition and Reversal of Acinar Ductal Metaplasia in Mouse Pancreatic Organoids

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.27.567685

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1 citations

Corey M. Perkins, Ranjala Ratnayake, Jinmai Jiang, Qi-Yin Chen, Thomas D. Schmittgen +2 more

Morphological Profiling for Drug Discovery in the Era of Deep Learning

PubMed(2023)10.48550/arxiv.2312.07899

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1 citations

Ranjala Ratnayake, Gustavo Seabra, Zhe Jiang, Ruogu Fang, Lina Cui +7 more

Nuclear quality control of non-imported secretory proteins attenuates proteostasis decline in the cytosol

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.27.546668

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0 citations

Janine Kamps, Qi-Yin Chen, Hendrik Luesch, Konstanze F. Winklhofer, Jörg Tatzelt +1 more

Morphological profiling for drug discovery in the era of deep learning

Briefings in Bioinformatics(2024)10.1093/bib/bbae284

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41 citations

Ranjala Ratnayake, Gustavo Seabra, Zhe Jiang, Ruogu Fang, Lina Cui +7 more

Progress in the discovery and development of anticancer agents from marine cyanobacteria

Natural Product Reports(2024)10.1039/d4np00019f

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29 citations

Emma K. Ellis, Qi-Yin Chen, Ranjala Ratnayake, Hendrik Luesch

Biosynthesis of Dolastatin 10 in Marine Cyanobacteria, a Prototype for Multiple Approved Cancer Drugs

Organic Letters(2024)10.1021/acs.orglett.3c04083

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24 citations

Dipesh Dhakal, Man‐Yun Chen, Qi-Yin Chen, Sofia Kokkaliari, Nicole A. Colon Rosa +6 more

Epigenetic small-molecule screen for inhibition and reversal of acinar ductal metaplasia in mouse pancreatic organoids

Frontiers in Pharmacology(2024)10.3389/fphar.2024.1335246

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10 citations

Corey M. Perkins, Ranjala Ratnayake, Jinmai Jiang, Qi-Yin Chen, Thomas D. Schmittgen +2 more

Isolation, Structure Elucidation, and Biological Activity of the Selective TACR2 Antagonist Tumonolide and its Aldehyde from a Marine Cyanobacterium

Chemistry - A European Journal(2024)10.1002/chem.202401393

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7 citations

Laura Grauso, Alfonso Mangoni, Gustavo Seabra, Valerie J. Paul, Hendrik Luesch +1 more

VCP/p97 mediates nuclear targeting of non-ER-imported prion protein to maintain proteostasis

Life Science Alliance(2024)10.26508/lsa.202302456

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5 citations

Koustav Ray, Janine Kamps, Qi-Yin Chen, Hendrik Luesch, Konstanze F. Winklhofer +2 more

Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response

ACS Chemical Biology(2024)10.1021/acschembio.4c00131

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4 citations

A. M. Gihan K. Athapaththu, Kalina R. Atanasova, Qi-Yin Chen, Taylor J. Corcoran, Juan Piloto +5 more

Chemical genetics in C. elegans identifies anticancer mycotoxins chaetocin and chetomin as potent inducers of a nuclear metal homeostasis response

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.15.579914

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0 citations

A. M. Gihan K. Athapaththu, Kalina R. Atanasova, Qi-Yin Chen, Taylor J. Corcoran, Juan Piloto +5 more

Small molecular weight epigenetic inhibitors modulate the extracellular matrix during pancreatic acinar ductal metaplasia

Biochemical and Biophysical Research Communications(2024)10.1016/j.bbrc.2024.150496

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0 citations

Yating Mao, Jinmai Jiang, Diana J. Wilkie, Bo Han, Qi-Yin Chen +4 more

Synthetic biology strategies for cyanobacterial systems to heterologously produce cyanobacterial natural products

Natural Product Reports(2025)10.1039/d5np00009b

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17 citations

Dipesh Dhakal, Campbell W. Eckhardt, Hendrik Luesch, Yousong Ding, Manyun Chen

Grassystatin G, a new cathepsin D inhibitor from marine cyanobacteria: discovery, synthesis, and biological characterization

RSC Medicinal Chemistry(2025)10.1039/d5md00017c

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2 citations

Gustavo Seabra, Valerie J. Paul, Hendrik Luesch, Lobna A. Elsadek

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues

Angewandte Chemie International Edition(2025)10.1002/anie.202523117

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1 citations

Lobna A. Elsadek, Max Deering, Larissa Costa de Almeida, Jasper L. Tyler, Adam Noble +5 more

Anaeic and tumoic acids, new functionalized fatty acids from marine cyanobacteria, inhibit quorum sensing in Pseudomonas aeruginosa

Medicinal Chemistry Research(2025)10.1007/s00044-025-03494-2

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0DataRank · unranked

0 citations

Sarath P. Gunasekera, Sofia Kokkaliari, Valerie J. Paul, Hendrik Luesch, Emma K. Ellis

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M

Organic & Biomolecular Chemistry(2020)10.1039/d0ob01557a

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120 citations

Ibrahim H. Eissa, Mohamed R. Oun, Mohamed Ayman El‐Zahabi, Mohammed S. Taghour, Amany Belal +8 more

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues

Angewandte Chemie(2025)10.1002/ange.202523117

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0DataRank · unranked

0 citations

Lobna A. Elsadek, Max Deering, Larissa Costa de Almeida, Jasper L. Tyler, Adam Noble +5 more