Laurence J. Miller

NeuroscienceBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 19 papers. Top paper: “Structure and dynamics of the active Gs-coupled human secretin receptor”.

Structure and dynamics of the active Gs-coupled human secretin receptor

Nature Communications(2020)10.1038/s41467-020-17791-4

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0DataRank · unranked

71 citations

Giuseppe Deganutti, Sarah Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff +10 more

Rational development of a high-affinity secretin receptor antagonist

Biochemical Pharmacology(2020)10.1016/j.bcp.2020.113929

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0DataRank · unranked

12 citations

Kaleeckal G. Harikumar, Sweta R. Raval, Juliana E. Milburn, Carolyn E. Clark, Rafael Alcala‐Torano +8 more

Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial

American Journal of Physiology-Gastrointestinal and Liver Physiology(2020)10.1152/ajpgi.00371.2019

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13 citations

Laurence J. Miller, Xiao‐Jing Wang, Duane D. Burton, Irene Busciglio, Kayla Arndt +3 more

Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors

SLAS DISCOVERY(2020)10.1177/2472555220945284

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11 citations

Qing Sun, John P. Holleran, Sirkku Pollari, Jannis Beutel, Brock Brown +6 more

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

PLoS Biology(2021)10.1371/journal.pbio.3001295

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88 citations

Matthew J. Belousoff, Kaleeckal G. Harikumar, Sarah Piper, Xiaomeng Xu, Sebastian G. B. Furness +8 more

Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics

Frontiers in Endocrinology(2021)10.3389/fendo.2021.684656

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33 citations

Kaleeckal G. Harikumar, Denise Wootten, Patrick M. Sexton, Laurence J. Miller

Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors

Biochimica et Biophysica Acta (BBA) - Biomembranes(2021)10.1016/j.bbamem.2021.183557

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25 citations

Rick Sexton, Zina Al-Sahouri, Ming-Yue Lee, Eugene Chun, Kaleeckal G. Harikumar +4 more

Discovery of small molecule positive allosteric modulators of the secretin receptor

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114451

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14 citations

Kaleeckal G. Harikumar, Sirkku Pollari, Qing Sun, Brock Brown, Aki Shinoki-Iwaya +4 more

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Frontiers in Endocrinology(2021)10.3389/fendo.2021.789957

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8 citations

Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness +6 more

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins: insight into mechanisms of G protein selectivity

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.06.442871

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7 citations

Matthew J. Belousoff, Kaleeckal G. Harikumar, Sarah Piper, Xiaomeng Xu, Sebastian G. B. Furness +8 more

Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors

International Journal of Molecular Sciences(2022)10.3390/ijms23158069

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48 citations

Sarah Piper, Peishen Zhao, Laurence J. Miller, Denise Wootten, Patrick M. Sexton +1 more

Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

SLAS DISCOVERY(2022)10.1016/j.slasd.2022.07.001

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9 citations

Qing Sun, Kaleeckal G. Harikumar, Laurence J. Miller, Eduard Sergienko, Daniela G. Dengler

Secretin Amino-Terminal Structure-Activity Relationships and Complementary Mutagenesis at the Site of Docking to the Secretin Receptor

Molecular Pharmacology(2022)10.1124/molpharm.122.000502

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0DataRank · unranked

0 citations

Kaleeckal G. Harikumar, Sarah Piper, Sweta R. Raval, Arthur Christopoulos, Denise Wootten +3 more

Mechanism of Action and Structure–Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

Membranes(2023)10.3390/membranes13020150

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2 citations

Kaleeckal G. Harikumar, Alice Yen, Eduard Sergienko, Laurence J. Miller, Daniela G. Dengler

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

PLoS Biology(2024)10.1371/journal.pbio.3002673

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4 citations

Peishen Zhao, Brian P. Cary, Xiaomeng Xu, Aditya J. Desai, Maoqing Dong +9 more

Structure-activity relationships of thiadiazole agonists of the human secretin receptor

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.100176

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1 citations

Daniela G. Dengler, Kaleeckal G. Harikumar, Mathew M. Abelman, Jiwen Zou, Bryan A. Kramer +9 more

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers in live cells

Research Square(2024)10.21203/rs.3.rs-4683780/v1

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1 citations

Michael R. Stoneman, Koki Yokoi, Gabriel Biener, Thomas D. Killeen, Dhruba P. Adhikari +4 more

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells

Communications Biology(2025)10.1038/s42003-025-08374-4

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0DataRank · unranked

4 citations

Thomas D. Killeen, Koki Yokoi, Gabriel Biener, Sanam Bista, Dhruba P. Adhikari +6 more

Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor

Molecular Pharmacology(2025)10.1016/j.molpha.2025.100074

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0DataRank · unranked

0 citations

Yuanyuan Ma, Emmanuel Duarte Barbosa, Kaleeckal G. Harikumar, Denise Wootten, Patrick M. Sexton +3 more