Brian O’Rourke

Also affiliated with Johns Hopkins Medicine

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 35 papers. Top paper: “Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs”.

Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs

Genome Medicine(2020)10.1186/s13073-020-00778-7

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122 citations

Ryan J. Longchamps, Jason A. Sumpter, Charles Newcomb, John Lane, Megan L. Grove +19 more

Mitochondrial Ca2+ in heart failure: Not enough or too much?

Journal of Molecular and Cellular Cardiology(2020)10.1016/j.yjmcc.2020.11.014

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54 citations

Deepthi Ashok, Ting Liu, Brian O’Rourke

Diabetes Increases the Vulnerability of the Cardiac Mitochondrial Network to Criticality

Frontiers in Physiology(2020)10.3389/fphys.2020.00175

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14 citations

Sonia Cortassa, Brian O’Rourke, Antonis A. Armoundas, Djahida Bedja, Johann M. E. Jende +6 more

Mitochondrial DNA copy number and incident atrial fibrillation

BMC Medicine(2020)10.1186/s12916-020-01715-6

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40 citations

Traci M. Bartz, Nona Sotoodehnia, Wendy S. Post, Susan R. Heckbert, Álvaro Alonso +12 more

Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP

Journal of Molecular and Cellular Cardiology(2020)10.1016/j.yjmcc.2020.01.010

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35 citations

Deepthi Ashok, Ting Liu, Tyler M. Bauer, Junhui Sun, Zhen Li +9 more

Nuclear-mitochondrial communication involving miR-181c plays an important role in cardiac dysfunction during obesity

Journal of Molecular and Cellular Cardiology(2020)10.1016/j.yjmcc.2020.05.009

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32 citations

Pawandeep Kaur, Deepthi Ashok, Mark J. Kohr, Roopa Biswas, Brian O’Rourke +3 more

TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2001692117

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30 citations

Meera Viswanathan, Kathleen C. Woulfe, William M. Schmidt, Agnes Sidor, Ting Liu +10 more

Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells

Scientific Reports(2020)10.1038/s41598-020-67039-w

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26 citations

Natalie Vaninov, Matthew Li, Sunny Nguyen, Maneet Singh, Peter Igo +6 more

Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.17.209023

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13 citations

Christina A. Castellani, Ryan J. Longchamps, Vamsee Pillalamarri, Brian O’Rourke, Eliseo Güallar +2 more

Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy

Science Translational Medicine(2021)10.1126/scitranslmed.abf0891

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92 citations

Gizem Keceli, Andrea Carpi, Nunzianna Doti, Jacopo Agrimi, Angeliki Asimaki +21 more

MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca 2+ Leak

Circulation Research(2021)10.1161/circresaha.120.318562

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91 citations

Ni Yang, Agnieszka Sidor, Brian O’Rourke, Ting Liu

Cardiac retinoic acid levels decline in heart failure

JCI Insight(2021)10.1172/jci.insight.137593

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35 citations

Lauren E. Parker, Jianshi Yu, Jace W. Jones, Ting Liu, Kyriakos N. Papanicolaou +6 more

The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure

FEBS Letters(2021)10.1002/1873-3468.14228

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20 citations

Kazutaka Ueda, Masaki Hashimoto, Manling Zhang, Masayuki Sasaki, Taro Kariya +14 more

PDE1 Inhibition Modulates Ca v 1.2 Channel to Stimulate Cardiomyocyte Contraction

Circulation Research(2021)10.1161/circresaha.121.319828

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21 citations

Joy Song, Vivek Jani, Yuejin Wu, Ting Liu, William P.D. Jeffreys +4 more

MitoWave: Spatiotemporal analysis of mitochondrial membrane potential fluctuations during I/R

Biophysical Journal(2021)10.1016/j.bpj.2021.05.033

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10 citations

Brian O’Rourke, Deepthi Ashok

Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

Genome Research(2021)10.1101/gr.269381.120

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107 citations

Christina A. Castellani, Ryan J. Longchamps, Vamsee Pillalamarri, Brian O’Rourke, Eliseo Güallar +2 more

Myocardial BDNF regulates cardiac bioenergetics through the transcription factor Yin Yang 1

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.19.427213

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0 citations

Manling Zhang, Bingxian Xie, Raymond J. Zimmerman, Qin Wang, An‐Chi Wei +15 more

Myocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 1

Cardiovascular Research(2022)10.1093/cvr/cvac096

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49 citations

Manling Zhang, Bingxian Xie, Zishan Peng, Janet R. Manning, Raymond J. Zimmerman +17 more

Hydropersulfides (RSSH) Outperform Post-Conditioning and Other Reactive Sulfur Species in Limiting Ischemia–Reperfusion Injury in the Isolated Mouse Heart

Antioxidants(2022)10.3390/antiox11051010

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25 citations

Vinayak S. Khodade, Alexander Eremiev, Eric Bao, Ting Liu, Brian O’Rourke +3 more

Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102780

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12 citations

Ting Liu, Agnieszka Sidor, Dong I. Lee, Brian O’Rourke, Charles Steenbergen +1 more

Multiscale Modeling of the Mitochondrial Origin of Cardiac Reentrant and Fibrillatory Arrhythmias

Methods in molecular biology(2022)10.1007/978-1-0716-1831-8_11

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2 citations

Seulhee Kim, Gernot Plank, Brian O’Rourke, Lufang Zhou, Soroosh Solhjoo

Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial Ca2+ uptake

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104708

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27 citations

Kyriakos N. Papanicolaou, Agnieszka Sidor, Michelle Y. Wang, Soroosh Solhjoo, Ting Liu +2 more

Growth Differentiation Factor‐15 Predicts Mortality and Heart Failure Exacerbation But Not Ventricular Arrhythmias in Patients With Cardiomyopathy

Journal of the American Heart Association(2023)10.1161/jaha.122.026003

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21 citations

Lisa R. Yanek, Wanjun Yang, Barbara Butcher, Sanaz Norgard, Joseph E. Marine +9 more

Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.102907

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19 citations

Jessica Jung, Deepthi Ashok, Wenxi Zhang, Amir Modaressanavi, Eddie Avila +4 more

Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity

Cell chemical biology(2023)10.1016/j.chembiol.2023.09.017

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16 citations

Balamurugan Ramatchandirin, Ting Liu, Risa M. Wolf, Arisa Ikeda, Sally Radovick +5 more

Distinct Effects of Mitochondrial Na + /Ca 2+ Exchanger Inhibition and Ca 2+ Uniporter Activation on Ca 2+ Sparks and Arrhythmogenesis in Diabetic Rats

Journal of the American Heart Association(2023)10.1161/jaha.123.029997

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9 citations

Ting Liu, Kuey C. Chen, Florin Despa, Brian O’Rourke, Sanda Despa +1 more

Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors

Journal of the American Heart Association(2023)10.1161/jaha.123.030791

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5 citations

Simion Kreimer, Alma I. Plaza‐Rodriguez, Pablo A. Iglesias, C. Conover Talbot, Helmy M. Siragy +8 more

Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotection

JTCVS Open(2023)10.1016/j.xjon.2023.06.004

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3 citations

Kyriakos N. Papanicolaou, Robert C. Tryon, Janelle Sangalang, Ben Salazar, Alejandro Suarez‐Pierre +8 more

Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling

Biophysical Journal(2023)10.1016/j.bpj.2023.03.011

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2 citations

Miguel A. Aon, Heinz‐Peter Schlemmer, Johann M. E. Jende, Brian O’Rourke, Antonis A. Armoundas +1 more

Cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.29.526082

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1 citations

Pooja Joshi, Brian O’Rourke, Shanea Estes, Deeptankar DeMazumder, Swati Dey

Sex-dependent phosphorylation of Argonaute 2 reduces the mitochondrial translocation of miR-181c and induces cardioprotection in females

Journal of Molecular and Cellular Cardiology(2024)10.1016/j.yjmcc.2024.06.006

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1 citations

Bárbara Román, Marwan Salih, W.N. Daccarett-Bojanini, Haley Garbus, Obialunanma V. Ebenebe +5 more

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.05.574280

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2 citations

Ting Liu, Joseph Criscione, Meghana Prakash, Byunggik Kim, Julian Chow +9 more

Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19

JCI Insight(2025)10.1172/jci.insight.193164

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3 citations

Ting Liu, Misato Nakanishi-Koakutsu, Joseph Criscione, Meghana Prakash, Alexis Tensfeldt +15 more

Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression

ACS Omega(2025)10.1021/acsomega.5c03687

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1 citations

Ting Liu, Robert N. O’Meally, Robert N. Cole, Brian O’Rourke, D. Brian Foster +1 more

Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110818

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1 citations

Wenxi Zhang, Aidan Dunphy, Justin C. Zhong, C. Cho, Dan R. Turner +5 more