John R. Engen

Also affiliated with Universidad del Noreste

ChemistryBiochemistry, Genetics and Molecular BiologyMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 48 papers. Top paper: “The heme-regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation”.

The heme-regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.012803

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0.722DataRank · unranked

25 citations

Amanda L. Gunawan, Brent Kochert, Liu Liu, Thomas E. Wales, Maelyn C. Borowy +3 more

Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy

Trends in Biochemical Sciences(2020)10.1016/j.tibs.2020.05.005

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62 citations

Elizabeth A. Komives, John R. Engen

Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles

Communications Biology(2020)10.1038/s42003-019-0749-z

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53 citations

Dhabaleswar Patra, Christopher J. Wilson, Maria V. Fawaz, Lolita Piersimoni, Jenny Capua-Shenkar +7 more

Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization

Molecular Cell(2020)10.1016/j.molcel.2020.05.029

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53 citations

Edward P. Harvey, Catherine E. Newman, Thomas E. Wales, Joel C. Bucci, Julian Mintseris +14 more

Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.01.029

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22 citations

Meera Kumanan, Thomas E. Wales, Asanga Bandara, Marcus Fändrich, John E. Straub +3 more

Identification of a Structural Determinant for Selective Targeting of HDMX

Structure(2020)10.1016/j.str.2020.04.011

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8 citations

Hyuk‐Soo Seo, Edward P. Harvey, Zachary J. Hauseman, Thomas E. Wales, Catherine E. Newman +5 more

Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer

Nature Chemical Biology(2020)10.1038/s41589-020-0625-7

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8 citations

Gregory H. Bird, Thomas E. Wales, Henry D. Herce, Edward P. Harvey, Zachary J. Hauseman +8 more

Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering

Cell chemical biology(2020)10.1016/j.chembiol.2020.04.004

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0DataRank · unranked

37 citations

Zachary J. Hauseman, Daniel T. Cohen, T.J. Rettenmaier, Susan Lee, Annissa J. Huhn +11 more

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX

Cell Reports(2020)10.1016/j.celrep.2020.02.057

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32 citations

Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky, Daniel T. Cohen

Conformational Transitions in the Membrane Scaffold Protein of Phospholipid Bilayer Nanodiscs

UNC Libraries(2020)10.17615/76m6-d929

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0DataRank · unranked

0 citations

John R. Engen, Kasper D. Rand, Darrel W. Stafford, James W. Jorgenson, Christine M. Hebling +1 more

A Conformational Investigation of Propeptide Binding to the Integral Membrane Protein γ-Glutamyl Carboxylase Using Nanodisc Hydrogen Exchange Mass Spectrometry

Figshare(2020)10.17615/krn5-w035

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0DataRank · unranked

0 citations

Darrel W. Stafford, Christine H. Parker, John R. Engen, Kasper D. Rand, Christopher R. Morgan +1 more

Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry

Figshare(2020)10.17615/1tp2-h420

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0 citations

Kasper D. Rand, Christine M. Hebling, Christopher R. Morgan, Darrel W. Stafford, John R. Engen +1 more

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

Molecular Cell(2021)10.1016/j.molcel.2021.11.033

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81 citations

Hao Li, Daniele Peterle, Joao A. Paulo, Scott B. Ficarro, Thomas E. Wales +5 more

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core

Nature Communications(2021)10.1038/s41467-021-25200-7

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40 citations

Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen, Loren D. Walensky +1 more

A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation

Journal of Molecular Biology(2021)10.1016/j.jmb.2021.167310

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23 citations

Elena S. Klimtchuk, Thomas E. Wales, Florian Georgescauld, Lawreen H. Connors, John R. Engen +2 more

The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance

Journal of Molecular Biology(2021)10.1016/j.jmb.2021.167422

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0DataRank · unranked

9 citations

Jacques Lowe, D. Bruce Fulton, John R. Engen, Thomas E. Wales, Amy H. Andreotti +1 more

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.21.465358

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0DataRank · unranked

7 citations

Hao Li, Daniele Peterle, Joao A. Paulo, Scott B. Ficarro, Thomas E. Wales +5 more

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.16.452743

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5 citations

Sven Klumpe, Markus R. Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun +14 more

Protection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.24.449816

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0DataRank · unranked

0 citations

Bo Zhao, Roxana E. Iacob, Yuan Tian, Cameron Toohey, John R. Engen +2 more

Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102323

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30 citations

Roxana E. Iacob, Jing Li, John R. Engen, Timothy A. Springer, Yang Su

ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr

Structure(2022)10.1016/j.str.2022.08.008

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0DataRank · unranked

16 citations

John J. Alvarado, Thomas E. Wales, Jamie A. Moroco, John R. Engen, Thomas E. Smithgall +1 more

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

Nature Communications(2022)10.1038/s41467-022-28186-y

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0DataRank · unranked

42 citations

Sven Klumpe, Markus R. Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun +14 more

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker

eLife(2022)10.7554/elife.75760

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13 citations

Roxana E. Iacob, Nathan E. Hudson, Jing Li, Chafen Lu, John R. Engen +2 more

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency

Nature Communications(2022)10.1038/s41467-022-31466-2

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13 citations

Christina M. Camara, Thomas Botzanowski, Jamie A. Moroco, Noah B. Bloch, Hannah R. Levy +10 more

Protection of the Prodomain α1-Helix Correlates with Latency in the Transforming Growth Factor-β Family

Journal of Molecular Biology(2022)10.1016/j.jmb.2021.167439

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0DataRank · unranked

9 citations

Roxana E. Iacob, Bo Zhao, Yang Su, Yuan Tian, Cameron Toohey +3 more

Resolving chaperone-assisted protein folding on the ribosome at the peptide level

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.23.509153

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5 citations

Aleksandra Pajak, Alžběta Roeselová, Santosh Shivakumaraswamy, Steven Howell, F. Ulrich Hartl +3 more

Von Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.13.476208

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0DataRank · unranked

0 citations

Roxana E. Iacob, Nathan E. Hudson, Jing Li, Chafen Lu, John R. Engen +2 more

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

Nature Communications(2023)10.1038/s41467-023-36956-5

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108 citations

Agatha Lyczek, YiTing Paung, Victoria R. Mingione, Roxana E. Iacob, Parker W. de Waal +5 more

Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α

Molecular Cell(2023)10.1016/j.molcel.2023.05.008

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0DataRank · unranked

64 citations

Thomas E. Wales, Haixia Zhou, Sorin-Valeriu Draga-Coletă, Christoph Gorgulla, Katherine Blackmore +17 more

Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chains

Amyloid(2023)10.1080/13506129.2023.2212397

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14 citations

Daniele Peterle, Esther Bullitt, Lawreen H. Connors, John R. Engen, Olga Gursky +1 more

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

eLife(2023)10.7554/elife.89489

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0DataRank · unranked

13 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

(2023)10.7554/elife.89489.2

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4 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.18.572223

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2 citations

Thomas E. Wales, Sandrine Jayne, Robert G. Britton, D. Bruce Fulton, John R. Engen +3 more

Role of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin κ1 Light Chains

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.01.526662

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0DataRank · unranked

1 citations

Daniele Peterle, Esther Bullitt, Lawreen H. Connors, John R. Engen, Olga Gursky +1 more

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.02.543453

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0DataRank · unranked

1 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Reviewer #2 (Public Review): Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

(2023)10.7554/elife.89489.2.sa1

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0 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Reviewer #1 (Public Review): Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

(2023)10.7554/elife.89489.2.sa2

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0 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Author Response: Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

(2023)10.7554/elife.89489.2.sa4

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0 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Covalent inhibition of pro-apoptotic BAX

Nature Chemical Biology(2024)10.1038/s41589-023-01537-6

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0DataRank · unranked

23 citations

Peiwen Shi, Christina M. Camara, Daniel T. Cohen, T.J. Rettenmaier, Utsarga Adhikary +8 more

Native Capillary Electrophoresis–Mass Spectrometry of Near 1 MDa Non‐Covalent GroEL/GroES/Substrate Protein Complexes

Advanced Science(2024)10.1002/advs.202306824

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16 citations

Florian Georgescauld, Kendall R. Johnson, Somak Ray, John R. Engen, Alexander R. Ivanov +1 more

An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.108088

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2 citations

Gabriella Gerlach, Giancarlo Gonzalez-Areizaga, Thomas E. Wales, Stephanie Y. Cui, Prema Iyer +5 more

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

eLife(2024)10.7554/elife.89489.3

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0DataRank · unranked

1 citations

Lauren E. Kueffer, Puneet Juneja, Thomas E. Wales, John R. Engen, Amy H. Andreotti +1 more

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

eLife(2024)10.7554/elife.95488

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0DataRank · unranked

8 citations

Thomas E. Wales, Sandrine Jayne, Robert G. Britton, D. Bruce Fulton, John R. Engen +3 more

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

eLife(2024)10.7554/elife.95488.1

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0DataRank · unranked

1 citations

Thomas E. Wales, Sandrine Jayne, Robert G. Britton, D. Bruce Fulton, John R. Engen +3 more

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

eLife(2024)10.7554/elife.95488.2

N/A

0DataRank · unranked

0 citations

Thomas E. Wales, Sandrine Jayne, Robert G. Britton, D. Bruce Fulton, John R. Engen +3 more

Rigorous Analysis of Multimodal HDX-MS Spectra

Journal of the American Society for Mass Spectrometry(2025)10.1021/jasms.4c00471

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0DataRank · unranked

22 citations

Ellie I. James, Florian Georgescauld, Thomas E. Wales, David D. Weis, John R. Engen +4 more

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

Scientific Reports(2020)10.1038/s41598-020-62076-x

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0DataRank · unranked

124 citations

Xiaoxi Liu, Robert S. Magin, Laura M. Doherty, Wai Cheung Chan, Scott B. Ficarro +22 more

Inhibition of oligomeric BAX by an anti-apoptotic dimer

Cell(2025)10.1016/j.cell.2025.10.037

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0DataRank · unranked

5 citations

Micah A. Gygi, Haleh Alimohamadi, Thomas M. DeAngelo, Christina M. Camara, Julian Mintseris +16 more