Channing J. Der

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Supplementary Table from Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

(2023)10.1158/1535-7163.22522299

Top 100%

0DataRank

Top 100%0 citations

Antje Schaefer, Craig M. Goodwin, Victoria V. Nguyen, Frances L. Massey, Mariaelena Pierobon +10 more

Papers

Driven by 116 papers — median percentile 0. Top paper: “Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer”.

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

Cancer Cell(2020)10.1016/j.ccell.2020.05.010

N/A

4.8DataRank · unranked

164 citations

Alex Penson, Ram Kannan, Hana Cho, Chun‐Hao Pan, Rohit K. Singh +39 more

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Nature(2024)10.1038/s41586-024-07205-6

N/A

4.2DataRank · unranked

326 citations

Bianca J. Lee, Jingjing Jiang, Aidan C.A. Tomlinson, Kyle J. Seamon, Alessia Mira +48 more

Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Nature(2024)10.1038/s41586-024-07379-z

N/A

3.9DataRank · unranked

182 citations

Jingjing Jiang, Tanner C. Dalton, Álvaro Curiel‐García, A. Cole Edwards, Yingyun Wang +61 more

Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

Cancer Research(2021)10.1158/0008-5472.can-20-4218

N/A

1.2DataRank · unranked

47 citations

Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela Herrera Loeza, Dimitri G. Trembath +20 more

RHOAL57Vdrives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

Science Signaling(2023)10.1126/scisignal.adg5289

N/A

0.575DataRank · unranked

9 citations

Richard G. Hodge, Haisheng Zhang, G. Aaron Hobbs, Julien Dilly, Minh V. Huynh +15 more

Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma

Cancer Research(2025)10.1158/0008-5472.can-25-0018

N/A

0.208DataRank · unranked

3 citations

G. Aaron Hobbs, Raven Davidson, Daniel Dorbin, J.J. Gómez Herrera, John F. Langenheim +22 more

RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress

UNC Libraries(2020)10.17615/dxmr-vy81

N/A

0DataRank · unranked

5 citations

Sarah A. Boswell, Channing J. Der, Stuart A. Aaronson, Hyung-Gu Kim, Sam W. Lee +4 more

Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration

UNC Libraries(2020)10.17615/wqac-hr42

N/A

0DataRank · unranked

4 citations

Noah Sciaky, Yung Jue Bang, Kevin D. Healy, Young Kim Tai, R. L. Juliano +1 more

The role of wild type RAS isoforms in cancer

UNC Libraries(2020)10.17615/jya5-te59

N/A

0DataRank · unranked

5 citations

Adrienne D. Cox, Channing J. Der, Bingying Zhou

A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation

UNC Libraries(2020)10.17615/x5zp-0s60

N/A

0DataRank · unranked

3 citations

Guowei Yin, Rachel Bagni, Channing J. Der, Minh Huynh, Samantha Kistler +5 more

Redundant Canonical and Noncanonical Caenorhabditis elegans p21-Activated Kinase Signaling Governs Distal Tip Cell Migrations

UNC Libraries(2020)10.17615/88j8-ps13

N/A

0DataRank · unranked

2 citations

David J. Reiner, Bob Goldstein, Channing J. Der, Eldon C. Peters, Andrea J. Gossett

Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma

UNC Libraries(2020)10.17615/gw0z-9303

N/A

0DataRank · unranked

1 citations

Daniel A. Ritt, Bingying Zhou, Adrienne D. Cox, Deborah K. Morrison, Channing J. Der

Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling

UNC Libraries(2020)10.17615/3r32-dx30

N/A

0DataRank · unranked

1 citations

Ariella B. Hanker, Natalia Mitin, Rebecca S. Wilder, Adrienne D. Cox, E. P. Henske +2 more

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

UNC Libraries(2020)10.17615/t0ce-gq36

N/A

0DataRank · unranked

1 citations

Kent L. Rossman, Dominico Vigil, Channing J. Der, Jacqueline Cherfils

Silencing of oncogenic KRAS by mutant-selective small interfering RNA

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.08.331835

N/A

0DataRank · unranked

2 citations

Salma H. Azam, Anne Y. Feng, Amanda E.D. Van Swearingen, Christina Gutierrez-Ford, Pradeep S. Pallan +5 more

The coupling of α 6 β 4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

UNC Libraries(2020)10.17615/sffn-9r39

N/A

0DataRank · unranked

1 citations

Miroslav Blumemberg, Channing J. Der, John Westwick, Filippo G. Giancotti, Anna Maria Curatola +4 more

RAS isoforms and mutations in cancer at a glance

UNC Libraries(2020)10.17615/nn24-rr34

N/A

0DataRank · unranked

0 citations

Channing J. Der, Kent L. Rossman, G. Aaron Hobbs

Modulation of HIV-1 Replication by a Novel RhoA Effector Activity

UNC Libraries(2020)10.17615/p7ek-kr57

N/A

0DataRank · unranked

0 citations

Liping Wang, Matthew J. Hart, Patricia A. Solski, Lishan Su, Channing J. Der +1 more

Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain

UNC Libraries(2020)10.17615/m5mw-7h23

N/A

0DataRank · unranked

0 citations

Cristina E. Tognon, Lori A. Passmore, Channing J. Der, Robert J. Kay, Heather Kirk +1 more

A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma

UNC Libraries(2020)10.17615/ycwx-4c45

N/A

0DataRank · unranked

0 citations

Jeran K. Stratford, Mark S. Talamonti, Jonathan C. Samuel, David J. Bentrem, Laura S. Caskey +13 more

Drugging the undruggable RAS: Mission Possible?

UNC Libraries(2020)10.17615/2r76-yy91

N/A

0DataRank · unranked

0 citations

Adrienne D. Cox, Ji Luo, Alec Kimmelman, Channing J. Der, Stephen W. Fesik

Molecular Pathways: Targeting RAC-p21-Activated Serine-Threonine Kinase Signaling in RAS-Driven Cancers

UNC Libraries(2020)10.17615/qsek-xp46

N/A

0DataRank · unranked

0 citations

Jonathan Chernoff, Nicole M. Baker, Hoi Yee Chow, Channing J. Der

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

UNC Libraries(2020)10.17615/6wz3-eh05

N/A

0DataRank · unranked

0 citations

Kent L. Rossman, Natalia Mitin, John Sondek, Channing J. Der, Laurie Betts +1 more

Phosphorylation by Protein Kinase Cα Regulates RalB Small GTPase Protein Activation, Subcellular Localization, and Effector Utilization

UNC Libraries(2020)10.17615/1rpy-7469

N/A

0DataRank · unranked

0 citations

Adrienne D. Cox, Timothy D. Martin, Jen Jen Yeh, Channing J. Der, Natalia Mitin

Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase

UNC Libraries(2020)10.17615/9f6f-eg70

N/A

0DataRank · unranked

0 citations

Dennis Goldfarb, Tai Young Kim, Randall T. Moon, XianHua Yi, Feng Yan +6 more

Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion

UNC Libraries(2020)10.17615/gwzm-8r97

N/A

0DataRank · unranked

0 citations

David J. Reiner, Channing J. Der, Timothy D. Martin, Xiaowei Chen, Rebecca E. W. Kaplan +2 more

Mas Oncogene Signaling and Transformation Require the Small GTP-Binding Protein Rac

UNC Libraries(2020)10.17615/cqjf-6h96

N/A

0DataRank · unranked

0 citations

Marc Symons, John Westwick, Magdalena Chrzanowska‐Wodnicka, Channing J. Der, Irene E. Zohn

ROCK1 and ROCK2 Are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion

UNC Libraries(2020)10.17615/8wje-qy25

N/A

0DataRank · unranked

0 citations

Hanqing Dong, Sharon L. Campbell, Xin Chen, Linda Castaldo, Channing J. Der +6 more

Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability

UNC Libraries(2020)10.17615/395k-pt97

N/A

0DataRank · unranked

0 citations

Jeran K. Stratford, Yan Feng, Lee M. Graves, Michael B. Major, Channing J. Der +2 more

Nitric Oxide-Releasing Silica Nanoparticle Inhibition of Ovarian Cancer Cell Growth

UNC Libraries(2020)10.17615/kgt9-gj26

N/A

0DataRank · unranked

0 citations

Ellen V. Stevens, Jae Ho Shin, Jinsong Liu, Channing J. Der, Alexis W. Carpenter +1 more

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

UNC Libraries(2020)10.17615/r1zc-0b18

N/A

0DataRank · unranked

0 citations

Channing J. Der, Yuliya Pylayeva‐Gupta, Kirsten L. Bryant, Daniel Zeitouni

Regulation of Rnd3 Localization and Function By PKCα-Mediated Phosphorylation

UNC Libraries(2020)10.17615/z7rx-pp10

N/A

0DataRank · unranked

0 citations

Channing J. Der, Anne J. Ridley, James P. Madigan, Brian J. Dewar, Donita C. Brady +5 more

Ras Effector Switching Promotes Divergent Cell Fates in C. elegans Vulval Patterning

UNC Libraries(2020)10.17615/zjt9-sa95

N/A

0DataRank · unranked

0 citations

David J. Reiner, Channing J. Der, Tanya P. Zand

Extracellular Signal-regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration

UNC Libraries(2020)10.17615/3c6y-sj88

N/A

0DataRank · unranked

0 citations

Gerold Bepler, Santo V. Nicosia, Channing J. Der, Shengyan Xiang, Hu Chen +13 more

Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector

UNC Libraries(2020)10.17615/b25a-0815

N/A

0DataRank · unranked

0 citations

Randall J. Kimple, Xiaoyan Li, Emily A. Oestreich, Melinda D. Willard, Mark J. Zylka +8 more

The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility

UNC Libraries(2020)10.17615/d3gc-5f69

N/A

0DataRank · unranked

0 citations

James E. Bear, Victoria L. Bautch, Thomas W. Marshall, Channing J. Der, Kent L. Rossman +3 more

ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma

UNC Libraries(2020)10.17615/3w14-jx16

N/A

0DataRank · unranked

0 citations

Alexander J. Finn, Adrienne D. Cox, Channing J. Der, Katherine H. Pedone, Meagan B. Ryan +1 more

SGEF, a RhoG Guanine Nucleotide Exchange Factor that Stimulates Macropinocytosis

UNC Libraries(2020)10.17615/jpag-5y98

N/A

0DataRank · unranked

0 citations

William T. Arthur, Channing J. Der, Kris A. DeMali, Krister Wennerberg, Shawn M. Ellerbroek +3 more

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

UNC Libraries(2020)10.17615/bvfb-zp29

N/A

0DataRank · unranked

0 citations

Adrienne D. Cox, Mark R. Philips, Channing J. Der

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

UNC Libraries(2020)10.17615/a4jv-yy19

N/A

0DataRank · unranked

0 citations

Savitri Maddileti, Adam Shutes, Rudolph L. Juliano, Channing J. Der, T. Kendall Harden +5 more

Identification of a Novel Actin-Binding Domain within the Rho Guanine Nucleotide Exchange Factor TEM4

UNC Libraries(2020)10.17615/00s1-vm89

N/A

0DataRank · unranked

0 citations

Channing J. Der, Kent L. Rossman, Natalia Mitin

Rho Family GTPase Modification and Dependence on C AAX Motif-signaled Posttranslational Modification

UNC Libraries(2020)10.17615/40a3-2469

N/A

0DataRank · unranked

0 citations

Emily J. Chenette, Paul T. Kirschmeier, Oswald Wilson, Natalia Mitin, Patricia J. Keller +5 more

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

UNC Libraries(2020)10.17615/kc7j-6z87

N/A

0DataRank · unranked

0 citations

K BURRIDGE, Channing J. Der, R Khosravi-Far, Alessandra Eva, Magdalena Chrzanowska‐Wodnicka +1 more

KRAS: feeding pancreatic cancer proliferation

UNC Libraries(2020)10.17615/6frk-np74

N/A

0DataRank · unranked

0 citations

Alec C. Kimmelman, Channing J. Der, Kirsten L. Bryant, Joseph D. Mancias

Oncogenic Activity of Ect2 Is Regulated through Protein Kinase Cι-mediated Phosphorylation

UNC Libraries(2020)10.17615/zwjj-qp24

N/A

0DataRank · unranked

0 citations

Alan P. Fields, Kent L. Rossman, Channing J. Der, Lee Jameison, Verline Justilien

Activation and Involvement of Ral GTPases in Colorectal Cancer

UNC Libraries(2020)10.17615/wzqn-jy95

N/A

0DataRank · unranked

0 citations

Jen Jen Yeh, Elizabeth D. Routh, Timothy D. Martin, Channing J. Der, Jonathan C. Samuel

Divergent Roles of C AAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases

UNC Libraries(2020)10.17615/2whv-bp72

N/A

0DataRank · unranked

0 citations

Channing J. Der, Timothy D. Martin, Motohiro Nishida, Leanna R. Gentry, Adrienne D. Cox +3 more

Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms

UNC Libraries(2020)10.17615/mh80-yc47

N/A

0DataRank · unranked

0 citations

Sharon L. Campbell, Channing J. Der, Timothy D. Martin, Jen Jen Yeh, Falina J. Williams +1 more

KRAS-dependent cancer cells promote survival by producing exosomes enriched in Survivin

Cancer Letters(2021)10.1016/j.canlet.2021.05.031

N/A

0DataRank · unranked

47 citations

Thuy‐Tien T. Nguyen, Chia‐Hsin Hsu, Kirsten L. Bryant, Han Jo Kim, Haoqiang Ying +5 more

Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen

Molecular Oncology(2021)10.1002/1878-0261.12951

N/A

0DataRank · unranked

8 citations

Craig M. Goodwin, Kotryna Seip, Bylgja Hilmarsdóttir, Solveig Pettersen, Clint A. Stalnecker +8 more

Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo

UNC Libraries(2021)10.17615/crd4-9g44

N/A

0DataRank · unranked

19 citations

Gerald A. Soff, Wolfgang Dubiel, Masuko Ushio‐Fukai, David A. Frank, Baskaran Govindarajan +9 more

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

UNC Libraries(2021)10.17615/b9kr-6e14

N/A

0DataRank · unranked

0 citations

Jason T. Snyder, Channing J. Der, John Sondek, Kent L. Rossman, Mark A. Baumeister +3 more

Vav2 Is an Activator of Cdc42, Rac1, and RhoA

UNC Libraries(2021)10.17615/0chg-c936

N/A

0DataRank · unranked

12 citations

Karon Abe, Kent L. Rossman, Derek Y. Chiang, Sharon L. Campbell, Channing J. Der +3 more

Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals

UNC Libraries(2021)10.17615/yypw-qs24

N/A

0DataRank · unranked

11 citations

A. N.Tony Kong, Rong Yu, Michael Weber, Channing J. Der, Jie Wu +2 more

Ras-mediated Loss of the Pro-apoptotic Response Protein Par-4 Is Mediated by DNA Hypermethylation through Raf-independent and Raf-dependent Signaling Cascades in Epithelial Cells

UNC Libraries(2021)10.17615/87zb-3303

N/A

0DataRank · unranked

0 citations

Vivek M. Rangnekar, Kevin Pruitt, Janiel M. Shields, Aylin S. Ülkü, Rafael J. Rojas +3 more

Role of MAP Kinases in the 1,25-Dihydroxyvitamin D 3 -induced Transactivation of the Rat Cytochrome P450C24 (CYP24) Promoter: SPECIFIC FUNCTIONS FOR ERK1/ERK2 AND ERK5

UNC Libraries(2021)10.17615/a672-mh73

N/A

0DataRank · unranked

6 citations

Prem P. Dwivedi, Channing J. Der, Joseph Tan, Brian K. May, John L. Omdahl +3 more

Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-B-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation

UNC Libraries(2021)10.17615/tpf4-td07

N/A

0DataRank · unranked

1 citations

Robert G. Oshima, Patricia A. Solski, José Javier Garcı́a-Ramı́rez, Christina K. Galang, Craig A. Hauser +3 more

Ras Inactivation of the Retinoblastoma Pathway by Distinct Mechanisms in NIH 3T3 Fibroblast and RIE-1 Epithelial Cells

UNC Libraries(2021)10.17615/pp84-dg68

N/A

0DataRank · unranked

0 citations

Kevin Pruitt, Channing J. Der, Richard G. Pestell

Transforming Activity of the Rho Family GTPase, Wrch-1, a Wnt-regulated Cdc42 Homolog, Is Dependent on a Novel Carboxyl-terminal Palmitoylation Motif

UNC Libraries(2021)10.17615/1kzf-9s07

N/A

0DataRank · unranked

0 citations

Anastacia C. Berzat, Audrey Minden, Adam Shutes, Adrienne D. Cox, Carolyn Weinbaum +3 more

Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH 2 -terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun

UNC Libraries(2021)10.17615/qpyq-4m06

N/A

0DataRank · unranked

1 citations

Richard J. Lee, Channing J. Der, Richard G. Pestell, John Westwick, Marc Symons +2 more

Defining the KRAS-regulated kinome in KRAS-mutant pancreatic cancer

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.27.441678

N/A

0DataRank · unranked

0 citations

Jennifer E. Klomp, Kayla R. Snare, Devon R. Blake, Priya S. Hibshman, Zane D. Kaiser +13 more

Overexpression of Collagenase 1 (MMP-1) Is Mediated by the ERK Pathway in Invasive Melanoma Cells: ROLE OFBRAFMUTATION AND FIBROBLAST GROWTH FACTOR SIGNALING

UNC Libraries(2021)10.17615/1tfq-h326

N/A

0DataRank · unranked

0 citations

Janiel M. Shields, Colby A. Wyatt, Craig L. Slingluff, Constance Brinckerhoff, Channing J. Der +2 more

Signaling Interplay in Ras Superfamily Function

UNC Libraries(2021)10.17615/at8v-ej73

N/A

0DataRank · unranked

0 citations

Channing J. Der, Kent L. Rossman, Natalia Mitin

Engineering threshold-based selection systems

G3 Genes Genomes Genetics(2021)10.1093/g3journal/jkab234

N/A

0DataRank · unranked

0 citations

Vanessa González‐Pérez, Luciana E. Leopold, Neal R. Rasmussen, Channing J. Der, Adrienne D. Cox +3 more

Loss of Transgelin in Breast and Colon Tumors and in RIE-1 Cells by Ras Deregulation of Gene Expression through Raf-independent Pathways

UNC Libraries(2021)10.17615/grf1-5s49

N/A

0DataRank · unranked

0 citations

Kelley Rogers-Graham, Janiel M. Shields, Channing J. Der

p68RacGAP Is a Novel GTPase-activating Protein That Interacts with Vascular Endothelial Zinc Finger-1 and Modulates Endothelial Cell Capillary Formation

UNC Libraries(2021)10.17615/d6zp-0506

N/A

0DataRank · unranked

0 citations

Vishram Kedar, Julius Aitsebaomo, Channing J. Der, Martin Moser, Cam Patterson +4 more

RhoG Signals in Parallel with Rac1 and Cdc42

UNC Libraries(2021)10.17615/2zny-w025

N/A

0DataRank · unranked

0 citations

Channing J. Der, Shawn M. Ellerbroek, Keith Burridge, Rong Yu Liu, Krister Wennerberg +1 more

The Src Homology 2 and Phosphotyrosine Binding Domains of the ShcC Adaptor Protein Function as Inhibitors of Mitogenic Signaling by the Epidermal Growth Factor Receptor

UNC Libraries(2021)10.17615/hsnq-cv96

N/A

0DataRank · unranked

0 citations

John P. O’Bryan, Channing J. Der, Que T. Lambert

Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation

UNC Libraries(2021)10.17615/3gn3-qd72

N/A

0DataRank · unranked

0 citations

John Westwick, Wendy M. Pruitt, Channing J. Der, Graham K. Bilter, Kevin Pruitt

Inhibition of Ras for cancer treatment: the search continues

UNC Libraries(2021)10.17615/6rwh-2111

N/A

0DataRank · unranked

0 citations

Antonio T. Baines, Channing J. Der, Dapeng Xu

A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells

UNC Libraries(2021)10.17615/atzr-9x17

N/A

0DataRank · unranked

0 citations

Ramona Graves‐Deal, Sean Oldham, Robert J. Coffey, Nywana Sizemore, Channing J. Der +1 more

Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation

UNC Libraries(2021)10.17615/n2kr-db22

N/A

0DataRank · unranked

0 citations

Channing J. Der, Roya Khosravi‐Far, Jonelle K. Drugan, Michael A. White, Yu Wen Hwan +2 more

Requirement For C-terminal Sequences in Regulation of Ect2 Guanine Nucleotide Exchange Specificity and Transformation

UNC Libraries(2021)10.17615/mnag-wk87

N/A

0DataRank · unranked

0 citations

Kent L. Rossman, Patricia A. Solski, John Sondek, Sharon L. Campbell, Rhonda Wilder +2 more

Identification of a Novel RalGDS-related Protein as a Candidate Effector for Ras and Rap1

UNC Libraries(2021)10.17615/mkbd-zw57

N/A

0DataRank · unranked

0 citations

Teresa R. Brtva, Thomas Fischer, Daniel L. Altschuler, Paola Martelli, Channing J. Der +4 more

RasGRP4 Is a Novel Ras Activator Isolated from Acute Myeloid Leukemia

UNC Libraries(2021)10.17615/tke4-fd93

N/A

0DataRank · unranked

0 citations

John F. Rebhun, Gary W. Reuther, Channing J. Der, Lawrence A. QUILLIAM, Que T. Lambert +1 more

Two Distinct Raf Domains Mediate Interaction with Ras

UNC Libraries(2021)10.17615/p3vv-gt11

N/A

0DataRank · unranked

0 citations

Sujoy Ghosh, Channing J. Der, Sharon L. Campbell, Robert M. Bell, Regina S. Terrell +2 more

Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif

UNC Libraries(2021)10.17615/g76g-5r61

N/A

0DataRank · unranked

0 citations

John Sondek, Antoine E. Karnoub, Jason T. Snyder, Kent L. Rossman, Marielle E. Yohe +4 more

Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.

UNC Libraries(2021)10.17615/1x3v-cf90

N/A

0DataRank · unranked

0 citations

Andrew B. Sparks, Lawrence A. QUILLIAM, Channing J. Der, Judith M. Thorn, Brian K. Kay

Divergent Roles for RalA and RalB in Malignant Growth of Human Pancreatic Carcinoma Cells

UNC Libraries(2021)10.17615/68xg-tf12

N/A

0DataRank · unranked

0 citations

Paul M. Campbell, Kevin O’Hayer, Christopher M. Counter, Kian‐Huat Lim, Stacey J. Adam +2 more

p120 GAP Modulates Ras Activation of Jun Kinases and Transformation

UNC Libraries(2021)10.17615/kpkx-5223

N/A

0DataRank · unranked

0 citations

Geoffrey Clark, Channing J. Der, John Westwick

RERG Is a Novel ras -related, Estrogen-regulated and Growth-inhibitory Gene in Breast Cancer

UNC Libraries(2021)10.17615/44zm-xv81

N/A

0DataRank · unranked

0 citations

David Botstein, Robert S. Seitz, Chia Ling Gau, Douglas Andres, Fuyuhiko Tamanoi +8 more

Critical Role of the Pleckstrin Homology and Cysteine-rich Domains in Vav Signaling and Transforming Activity

UNC Libraries(2021)10.17615/0sz4-8585

N/A

0DataRank · unranked

0 citations

Todd R. Palmby, Karon Abe, Channing J. Der

The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity

OAKTRUST (Texas A&M University)(2021)10.17615/m8mc-xs37

N/A

0DataRank · unranked

0 citations

Adrienne D. Cox, David J. Reiner, Vanessa Muniz‐Medina, Channing J. Der, Ambrose R. Kidd

M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6

UNC Libraries(2021)10.17615/6dhg-v775

N/A

0DataRank · unranked

0 citations

Channing J. Der, Bi Chen, Carol B. Martin, Kelley Rogers-Graham, Ariel F. Castro +1 more

Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame

UNC Libraries(2021)10.17615/zwr7-gg07

N/A

0DataRank · unranked

0 citations

David Reiner, Channing J. Der, Leanna R. Gentry, Timothy J. Martin

Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases

UNC Libraries(2021)10.17615/gspe-vj92

N/A

0DataRank · unranked

0 citations

Bertrand Leblond, Adam Shutes, Cercina Onesto, Channing J. Der, Virginie Picard +1 more

Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function

UNC Libraries(2021)10.17615/c9m5-6187

N/A

0DataRank · unranked

0 citations

Regina Terrell, Geoffrey A. Clark, Channing J. Der, Cynthia A. Bradham, Jonelle K. Drugan +2 more

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS- Mutant Pancreatic Cancer

Cancer Research(2022)10.1158/0008-5472.can-22-0391

N/A

0DataRank · unranked

163 citations

Andrew M. Waters, Jennifer E. Klomp, Sehrish Javaid, Kirsten L. Bryant, Clint A. Stalnecker +19 more

Characterization of TR ‐107, a novel chemical activator of the human mitochondrial protease ClpP

Pharmacology Research & Perspectives(2022)10.1002/prp2.993

N/A

0DataRank · unranked

43 citations

Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer +12 more

Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation

Nature Communications(2022)10.1038/s41467-022-34402-6

N/A

0DataRank · unranked

20 citations

Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi +18 more

Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

Molecular Cancer Therapeutics(2022)10.1158/1535-7163.mct-21-0142

N/A

0DataRank · unranked

18 citations

Antje Schaefer, Craig M. Goodwin, Victoria V. Nguyen, Frances L. Massey, Mariaelena Pierobon +10 more

Phase I study of hydroxychloroquine plus binimetinib in patients with metastatic pancreatic cancer (the HOPE trial).

Journal of Clinical Oncology(2022)10.1200/jco.2022.40.4_suppl.tps634

N/A

0DataRank · unranked

5 citations

J. Jack Lee, Brandon G. Smaglo, Dan Zhao, Michael Sangmin Lee, Robert A. Wolff +5 more

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.14.480426

N/A

0DataRank · unranked

1 citations

Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer +12 more

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS -Mutant Cancers

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.17.508384

N/A

0DataRank · unranked

1 citations

Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Justine C. Rutter, Christian Cerda-Smith +14 more

VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer

Genes & Cancer(2023)10.18632/genesandcancer.231

N/A

0DataRank · unranked

9 citations

Jennifer E. Klomp, Clint A. Stalnecker, Craig M. Goodwin, Yanzhe Gao, Gaith N. Droby +5 more

Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.03.569791

N/A

0DataRank · unranked

11 citations

Jingjing Jiang, Alvaro Curiel-Garcia, Yingyun Wang, Bianca J. Lee, Margo Orlen +42 more

Data from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

(2023)10.1158/0008-5472.c.6513543.v1

N/A

0DataRank · unranked

0 citations

Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza, Dimitri G. Trembath +20 more

Supplementary Table from Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

(2023)10.1158/1535-7163.22522299

Top 100%

0DataRank

Top 100%0 citations

Antje Schaefer, Craig M. Goodwin, Victoria V. Nguyen, Frances L. Massey, Mariaelena Pierobon +10 more

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers

Research Square(2023)10.21203/rs.3.rs-3511242/v1

N/A

0DataRank · unranked

0 citations

Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Justine C. Rutter +13 more

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

UNC Libraries(2024)10.17615/2caa-2659

N/A

0DataRank · unranked

24 citations

Daniel Zeitouni, Clint A. Stalnecker, Haoqiang Ying, Erik S. Knudsen, Guofang Zhang +26 more

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer.

UNC Libraries(2024)10.17615/s0p7-tg86

N/A

0DataRank · unranked

12 citations

Jennifer E. Klomp, Bjoern Papke, Craig M. Goodwin, Andrew P. Beelen, Clint A. Stalnecker +19 more

Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers

npj Precision Oncology(2024)10.1038/s41698-024-00615-9

N/A

0DataRank · unranked

6 citations

Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Annie Liu, Justine C. Rutter +15 more

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

UNC Libraries(2024)10.17615/1fr6-tv06

N/A

0DataRank · unranked

0 citations

Nicole Nasholm, Chiara Ambrogio, Anthony N. Milin, Yang Liu, Elsa Quintana +48 more

Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer

UNC Libraries(2024)10.17615/90en-6z38

N/A

0DataRank · unranked

0 citations

Richard G. Hodge, Jacob E. Larson, Michael J. Emanuele, Stephen V. Frye, McKenzie P. Kline +12 more

Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma.

UNC Libraries(2024)10.17615/rpkf-j691

N/A

0DataRank · unranked

0 citations

Sehrish Javaid, Adrienne D. Cox, Andrew M. Waters, Antje Schaefer, Da'Jhnae Gambrell-Sanders +10 more

An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer

Science Translational Medicine(2025)10.1126/scitranslmed.adt5511

N/A

0DataRank · unranked

10 citations

Francesca Paradiso, Clint A. Stalnecker, Benson Chellakkan Selvanesan, Fredrik I. Thege, David H. Peng +40 more

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

NAR Cancer(2025)10.1093/narcan/zcaf009

N/A

0DataRank · unranked

6 citations

Gaith N. Droby, Sayali Joseph, Urvi Patel, Xingyuan Zhang, Jeffrey A. Klomp +6 more

CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer

Cancer Research(2025)10.1158/0008-5472.can-25-1835

N/A

0DataRank · unranked

5 citations

Haley Todd, Grace Goodhart, Wen-Hsuan Chang, Amber M. Amparo, Rachel Bridgens +20 more

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.26.634889

N/A

0DataRank · unranked

0 citations

Gaith N. Droby, Sayali Joseph, Urvi Patel, Xingyuan Zhang, Jeffrey A. Klomp +6 more

RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

UNC Libraries(2025)10.17615/4cr5-sf81

N/A

0DataRank · unranked

0 citations

Channing J. Der, J. Nathaniel Diehl, Huynh, Minh V, Rashid, Naim U, Adam J. Bass +15 more

VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer

UNC Libraries(2025)10.17615/j33x-8959

N/A

0DataRank · unranked

0 citations

Channing J. Der, Kirsten L. Bryant, Jennifer E. Klomp, Yanzhe Gao, Clint A. Stalnecker +5 more

Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice

Gut(2020)10.1136/gutjnl-2020-320742

N/A

0DataRank · unranked

50 citations

Woosook Kim, Ermanno Malagola, Tuo Ruan, Giovanni Valenti, Moritz Middelhoff +5 more

Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers

Trends in Biochemical Sciences(2020)10.1016/j.tibs.2020.02.009

N/A

0DataRank · unranked

13 citations

Channing J. Der, G. Aaron Hobbs

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

UNC Libraries(2020)10.17615/rhn3-nh69

N/A

0DataRank · unranked

10 citations

Danielle Cook, Kent L. Rossman, Channing J. Der

p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities

UNC Libraries(2020)10.17615/a09f-gs95

N/A

0DataRank · unranked

5 citations

Dominico Vigil, N. C. Popescu, Channing J. Der, M. Guan, D. R. Lowy +1 more

Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform

UNC Libraries(2020)10.17615/zagr-k882

N/A

0DataRank · unranked

5 citations

Channing J. Der, Y. Jiyoung, Savitri Maddileti, Natalia Mitin, T. Kendall Harden

Channing J. Der

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