Bradley T. Hyman

Also affiliated with Harvard NeuroDiscovery Center, Massachusetts General Hospital, MaineGeneral Medical Center, University of Southampton

MedicineNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 6%percentile

0.330Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Alzheimer DataLENS: An Open Data Analytics Portal for Alzheimer’s Disease Research

Journal of Alzheimer s Disease(2024)10.3233/jad-230884

Top 62%

0.226DataRank

Top 62%3 citations

Rojashree Jayakumar, Vaishnavi Moturi, Zhaozhi Li, Rongxin Liu, Alberto Serrano‐Pozo +3 more

Papers

Driven by 123 papers — median percentile 30. Top paper: “Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease”.

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

Cell(2020)10.1016/j.cell.2020.10.029

N/A

8.6DataRank · unranked

717 citations

Waltraud Mair, Mukesh Kumar, Christoph N. Schlaffner, Shaojun Tang, Pieter Beerepoot +18 more

Somatic genomic changes in single Alzheimer’s disease neurons

Nature(2022)10.1038/s41586-022-04640-1

N/A

4.2DataRank · unranked

224 citations

August Yue Huang, Jun‐Ho Kim, Zinan Zhou, Samantha L. Kirkham, Eduardo A. Maury +15 more

Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease

Frontiers in Neurology(2022)10.3389/fneur.2022.889647

N/A

1.6DataRank · unranked

57 citations

Robert R. Kitchen, Zoe A. Mattingly, Amanda M. Celia, Bianca A. Trombetta, Sudeshna Das +4 more

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Alzheimer's & Dementia(2011)10.1016/j.jalz.2011.03.005

N/A

1.5DataRank · unranked

18651 citations

David S. Knopman, Howard Chertkow, Bradley T. Hyman, Clifford R. Jack, Claudia H. Kawas +15 more

An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest

NeuroImage(2006)10.1016/j.neuroimage.2006.01.021

N/A

1.4DataRank · unranked

13910 citations

Florent Ségonne, Bruce Fischl, Brian T. Quinn, Bradford C. Dickerson, Deborah Blacker +9 more

Alternatives to amyloid for Alzheimer's disease therapies—a symposium report

Annals of the New York Academy of Sciences(2020)10.1111/nyas.14371

N/A

1.3DataRank · unranked

13 citations

David M. Holtzman, Bradley T. Hyman, Malú Gámez Tansey, Marco Colonna, Sharon L. R. Kardia +8 more

GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Nature Genetics(2024)10.1038/s41588-024-01939-9

N/A

1.1DataRank · unranked

66 citations

Yuriko Katsumata, Erin L. Abner, Khine Zin Aung, Steven A. Claas, Qi Qiao +91 more

Common mouse models of tauopathy reflect early but not late human disease

Molecular Neurodegeneration(2023)10.1186/s13024-023-00601-y

N/A

0.598DataRank · unranked

53 citations

Arthur Viodé, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade +11 more

Genome-wide association study and functional validation implicates JADE1 in tauopathy

Acta Neuropathologica(2021)10.1007/s00401-021-02379-z

N/A

0.553DataRank · unranked

39 citations

SoongHo Kim, Natalia Han, Megan A. Iida, Elias Gonzalez, Marcos Otero‐García +84 more

A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.04.494709

N/A

0.464DataRank · unranked

21 citations

Mariko Taga, Verena Haage, Tina Roostaei, Charles C. White, Annie Lee +22 more

Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription

Acta Neuropathologica Communications(2024)10.1186/s40478-024-01844-6

N/A

0.385DataRank · unranked

12 citations

Alexandra Melloni, Dustin P. Fykstra, Alberto Serrano‐Pozo, Leslie A. Shinobu, Bradley T. Hyman +1 more

Alzheimer DataLENS: An Open Data Analytics Portal for Alzheimer’s Disease Research

Journal of Alzheimer s Disease(2024)10.3233/jad-230884

Top 62%

0.226DataRank

Top 62%3 citations

Rojashree Jayakumar, Vaishnavi Moturi, Zhaozhi Li, Rongxin Liu, Alberto Serrano‐Pozo +3 more

A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples

10.1101/2021.12.09.471962

N/A

0.165DataRank · unranked

2 citations

Olena Ohlei, Valerija Dobricic, Derek H. Oakley, Tanja Wesse, Sanaz Sedghpour Sabet +6 more

Brain MRI signatures across sex and CSF Alzheimer’s disease biomarkers

Brain Communications(2025)10.1093/braincomms/fcaf210

Top 78%

0.104DataRank

Top 78%1 citations

Yingnan He, Karthik Gopinath, Benjamin Billot, Juan Eugenio Iglesias, Chao‐Yi Wu +95 more

Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model

Annals of Neurology(2021)10.1002/ana.26043

N/A

0DataRank · unranked

83 citations

Tien‐Phat V. Huynh, Yang Shi, Rosemary J. Jackson, Mary Beth Finn, Melissa Manis +8 more

Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease

Neurology(2021)10.1212/wnl.0000000000011883

N/A

0DataRank · unranked

72 citations

Rebecca A. Betensky, Bradley T. Hyman, Alberto Serrano‐Pozo, Jing Qian

Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss

Science Translational Medicine(2021)10.1126/scitranslmed.aaz4699

N/A

0DataRank · unranked

57 citations

Aslı Şahin, Benjamin R. Schrank, Hawra Al Lawati, Isabel Costantino, Eric Benz +13 more

Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis

Molecular Neurobiology(2021)10.1007/s12035-021-02557-w

N/A

0DataRank · unranked

53 citations

Evan A. Bordt, Alexandra N. Mills, Spencer E. Kim, Ellen Sapp, Benjamin A. Devlin +19 more

Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging

Frontiers in Neuroscience(2021)10.3389/fnins.2021.727784

N/A

0DataRank · unranked

24 citations

Chuangqi Wang, Molly J. Carroll, Douglas K. Brubaker, Bradley T. Hyman, Douglas A. Lauffenburger +1 more

Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease

Alzheimer s & Dementia(2021)10.1002/alz.12312

N/A

0DataRank · unranked

42 citations

Raibatak Das, Hafiz Mohmmad‐Abdul, Lin Lin, Bradley T. Hyman, Douglas A. Lauffenburger +8 more

Conformational fingerprinting of tau variants and strains by Raman spectroscopy

RSC Advances(2021)10.1039/d1ra00870f

N/A

0DataRank · unranked

36 citations

Anna Crisford, William J. Rice, Hilary A. Weismiller, Zhanyun Fan, Caitlin Commins +5 more

Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons

Journal of Neuroscience(2021)10.1523/jneurosci.2590-20.2021

N/A

0DataRank · unranked

21 citations

Naomi Klickstein, Caitlin Commins, Mirra Chung, Simon Dujardin, Rachel E. Bennett +3 more

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein

Cell Reports(2021)10.1016/j.celrep.2021.109189

N/A

0DataRank · unranked

13 citations

Alessandro Crimi, Anne Wiedmer, Marc Emmenegger, C. Manzoni, Sara Bandrés‐Ciga +28 more

Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD

Current Alzheimer Research(2021)10.2174/1567205018666211126113904

N/A

0DataRank · unranked

11 citations

Mary Kate Manhard, David H. Salat, Bruce R. Rosen, Bradley T. Hyman, Keith A. Johnson +4 more

Predictors of the importance of everyday preferences for older adults with cognitive impairment

International Psychogeriatrics(2021)10.1017/s1041610220003956

N/A

0DataRank · unranked

7 citations

Joseph J. Locascio, Jeanette Günther, Liang Yap, Teresa Gómez‐Isla, Bradley T. Hyman +4 more

Longitudinal differences in everyday preferences: Comparisons between people with cognitive impairment and their care partners

International Journal of Geriatric Psychiatry(2021)10.1002/gps.5620

N/A

0DataRank · unranked

5 citations

Joseph J. Locascio, Jeanette Günther, Teresa Gómez‐Isla, Bradley T. Hyman, Deborah Blacker +3 more

Drug repurposing of metformin for Alzheimer’s disease: Combining causal inference in medical records data and systems pharmacology for biomarker identification

medRxiv(2021)10.1101/2021.08.10.21261747

N/A

0DataRank · unranked

8 citations

Bella Vakulenko‐Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle E. Evans +15 more

The Co-chaperone Carboxyl Terminus of Hsp70-interacting Protein (CHIP) Mediates α-Synuclein Degradation Decisions between Proteasomal and Lysosomal Pathways

UNC Libraries(2021)10.17615/sd0g-xq98

N/A

0DataRank · unranked

0 citations

Pamela J. McLean, Bradley T. Hyman, Jochen Klucken, Cam Patterson, Youngah Shin

Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.22.436505

N/A

0DataRank · unranked

2 citations

Evan A. Bordt, Alexandra N. Mills, Spencer E. Kim, Ellen Sapp, Benjamin A. Devlin +19 more

Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

Nature Communications(2022)10.1038/s41467-022-35157-w

N/A

0DataRank · unranked

49 citations

Bella Vakulenko‐Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle E. Evans +15 more

[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Nature Communications(2022)10.1038/s41467-022-30653-5

N/A

0DataRank · unranked

40 citations

Mira Chamoun, Elad Lax, Hsiao‐Ying Wey, Monica Shin, Kok Pin Ng +32 more

Interpretable deep learning of myelin histopathology in age-related cognitive impairment

Acta Neuropathologica Communications(2022)10.1186/s40478-022-01425-5

N/A

0DataRank · unranked

36 citations

Gabriel A. Marx, Daniel Koenigsberg, Mary Sawyer, Megan A. Iida, Jamie M. Walker +59 more

Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Scientific Reports(2022)10.1038/s41598-022-09825-2

N/A

0DataRank · unranked

28 citations

John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk +94 more

Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy

Journal of Neuropathology & Experimental Neurology(2022)10.1093/jnen/nlac066

N/A

0DataRank · unranked

21 citations

Megan A. Iida, Jonathan D. Cherry, Alicia Casella, Thor D. Stein, Kevin F. Bieniek +56 more

Mapping the Spatial Distribution of Fibrillar Polymorphs in Human Brain Tissue

Frontiers in Neuroscience(2022)10.3389/fnins.2022.909542

N/A

0DataRank · unranked

9 citations

Prakash Nepal, Theresa R. Connors, Derek H. Oakley, Bradley T. Hyman, Lin Yang +2 more

A Nuclear Magnetic Resonance Spectroscopy Method in Characterization of Blood Metabolomics for Alzheimer’s Disease

Metabolites(2022)10.3390/metabo12020181

N/A

0DataRank · unranked

12 citations

Isabella H. Muti, Anya B. Zhong, Pia Kivisäkk, Bradley T. Hyman, Steven E. Arnold +2 more

Projection of Care Partners’ Preferences in the Proxy Assessments of Everyday Preferences for Persons With Cognitive Impairment

American Journal of Geriatric Psychiatry(2022)10.1016/j.jagp.2022.12.005

N/A

0DataRank · unranked

3 citations

Joseph J. Locascio, Teresa Gómez‐Isla, Bradley T. Hyman, Deborah Blacker, Brent P. Forester +2 more

Designing a quality assurance process for quality control of nuclear magnetic resonance metabolomics studies of human blood

NMR in Biomedicine(2022)10.1002/nbm.4868

N/A

0DataRank · unranked

1 citations

Matteo Gonzalez Sanchez‐Dahl, Anya B. Zhong, JianXiang Weng, Mark V. Füzesi, Pia Kivisäkk +6 more

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.03.518999

N/A

0DataRank · unranked

10 citations

Zhaozhi Li, Maya E. Woodbury, Clara Muñoz‐Castro, Astrid Wachter, Rojashree Jayakumar +18 more

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

Research Square(2022)10.21203/rs.3.rs-2261934/v1

N/A

0DataRank · unranked

4 citations

Zhaozhi Li, Maya E. Woodbury, Clara Muñoz‐Castro, Astrid Watcher, Rojashree Jayakumar +18 more

Common mouse models of tauopathy reflect early but not late human disease

Research Square(2022)10.21203/rs.3.rs-2056948/v1

N/A

0DataRank · unranked

3 citations

Arthur Viodé, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade +10 more

GABAergic LRP1 is a key link between obesity and memory function

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.17.508390

N/A

0DataRank · unranked

2 citations

Zhi-Shuai Hou, A. Aydoğan, KELLEN RODRIGUES, Jennie Young, Anthony Choi +8 more

Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.25.493465

N/A

0DataRank · unranked

1 citations

Rachel E. Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M. Lieber +3 more

Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster

medRxiv(2022)10.1101/2022.02.01.22270276

N/A

0DataRank · unranked

0 citations

Joseph J. Locascio, Idil Tuncali, Nada Laroussi, Elena Abatzis, Polina Kamenskaya +18 more

Size matters - the impact of nucleus size on results from spatial transcriptomics

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.31.486657

N/A

0DataRank · unranked

0 citations

Katarzyna Chojnowska, Michał Bieńkowski, Anna Kostecka, Magdalena Koczkowska, Michał A. Żmijewski +11 more

Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment

Frontiers in Neurology(2023)10.3389/fneur.2023.1069411

N/A

0DataRank · unranked

71 citations

Becky C. Carlyle, Thadryan Sweeney, Bianca A. Trombetta, Kathryn LaCasse, Leena El‐Mufti +18 more

Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease

Journal of Neuroscience(2023)10.1523/jneurosci.0237-23.2023

N/A

0DataRank · unranked

71 citations

Zhaozhi Li, Rojashree Jayakumar, Alberto Serrano‐Pozo, Benjamin Woost, Miwei Hu +11 more

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau

Acta Neuropathologica(2023)10.1007/s00401-023-02600-1

N/A

0DataRank · unranked

49 citations

Lindsay A. Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun +3 more

Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease

Alzheimer s & Dementia(2023)10.1002/alz.13387

N/A

0DataRank · unranked

41 citations

Zhaozhi Li, Astrid Wachter, Srinija Alla, Ayush Noori, Aicha Abdourahman +8 more

LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry

Journal of Neuropathology & Experimental Neurology(2023)10.1093/jnen/nlad059

N/A

0DataRank · unranked

18 citations

David W. Fardo, Lincoln M. P. Shade, James D. Bowen, Paul K. Crane, Gail P. Jarvik +94 more

Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum

Neurology Genetics(2023)10.1212/nxg.0000000000200055

N/A

0DataRank · unranked

16 citations

Yiding Zhang, Rebecca A. Betensky, Bradley T. Hyman, Alberto Serrano‐Pozo, Jing Qian

In vivo cortical diffusion imaging relates to Alzheimer’s disease neuropathology

Alzheimer s Research & Therapy(2023)10.1186/s13195-023-01309-3

N/A

0DataRank · unranked

16 citations

Gerard R. Ridgway, Michele Valotti, Ian Hardingham, Steven A. Chance, James B. Brewer +39 more

Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging

Brain Communications(2023)10.1093/braincomms/fcad130

N/A

0DataRank · unranked

15 citations

Benjamin Woost, Joshua Bailey, Zachary Hoglund, Douglas S. Richardson, Rachel E. Bennett +2 more

Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue

eLife(2023)10.7554/elife.84112

N/A

0DataRank · unranked

12 citations

Rachel E. Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M. Lieber +3 more

Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain

Brain(2023)10.1093/brain/awad280

N/A

0DataRank · unranked

11 citations

Nichole A. Mesnard‐Hoaglin, Sarah Mays, Mercedes Priego, Joanna Dziechciowska, Sarah Morris +11 more

Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

eLife(2023)10.7554/elife.91398

N/A

0DataRank · unranked

8 citations

Henry F. J. Tregidgo, Benjamin Billot, Yaël Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse +21 more

Size matters: the impact of nucleus size on results from spatial transcriptomics

Journal of Translational Medicine(2023)10.1186/s12967-023-04129-z

N/A

0DataRank · unranked

9 citations

Katarzyna Chojnowska, Michał Bieńkowski, Anna Kostecka, Magdalena Koczkowska, Michał A. Żmijewski +11 more

Specific detection of tau seeding activity in Alzheimer’s disease using rationally designed biosensor cells

Molecular Neurodegeneration(2023)10.1186/s13024-023-00643-2

N/A

0DataRank · unranked

9 citations

Youhwa Jo, Romain Perbet, Cameron Donahue, Caitlin Commins, Noé Quittot +4 more

Cases of familial idiopathic normal pressure hydrocephalus implicate genetic factors in disease pathogenesis

Cerebral Cortex(2023)10.1093/cercor/bhad374

N/A

0DataRank · unranked

9 citations

Neel H. Mehta, Kedous Y. Mekbib, Emre Kiziltug, Hannah Smith, Bradley T. Hyman +7 more

VWA3A-derived ependyma promoter drives increased therapeutic protein secretion into the CSF

Molecular Therapy — Nucleic Acids(2023)10.1016/j.omtn.2023.07.016

N/A

0DataRank · unranked

8 citations

Yong Hong Chen, Paul T. Ranum, Stephanie L. Coffin, Larry N. Singh, Luis Tecedor +5 more

Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains

iScience(2023)10.1016/j.isci.2023.105983

N/A

0DataRank · unranked

6 citations

Simon Dujardin, Amy R. Dunn, Analiese R. Fernandes, Anita Khasnavis, Lori B. Chibnik +3 more

Lewy body dementia: Overcoming barriers and identifying solutions

Alzheimer s & Dementia(2024)10.1002/alz.13674

N/A

0DataRank · unranked

22 citations

Wendi Backler, Ece Bayram, Leah Bloom, Bradley F. Boeve, Jang‐Ho Cha +28 more

Interneuron diversity in the human dorsal striatum

Research Square(2023)10.21203/rs.3.rs-2921627/v1

N/A

0DataRank · unranked

9 citations

Lisbeth Harder, Juan M. Barba-Reyes, Mónica Díez-Salguero, Alberto Serrano‐Pozo, Bradley T. Hyman +2 more

Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer’s Disease

Portugalia : Revista de Arqueologia do Departamento de Ciências e Técnicas do Património da FLUP(2023)10.1101/2023.02.16.528825

N/A

0DataRank · unranked

7 citations

Zhaozhi Li, Rojashree Jayakumar, Alberto Serrano‐Pozo, Benjamin Woost, Miwei Hu +11 more

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.14.552850

N/A

0DataRank · unranked

7 citations

Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Alexandra Melloni +9 more

Interneuron diversity in the human dorsal striatum

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.22.533839

N/A

0DataRank · unranked

4 citations

Lisbeth Harder, Juan M. Barba-Reyes, Mónica Díez-Salguero, Alberto Serrano‐Pozo, Bradley T. Hyman +2 more

Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.08.544050

N/A

0DataRank · unranked

4 citations

Henry F. J. Tregidgo, Benjamin Billot, Yaël Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse +21 more

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.28.534418

N/A

0DataRank · unranked

3 citations

Lindsay A. Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun +3 more

Precision Brain Morphometry Using Cluster Scanning

medRxiv(2023)10.1101/2023.12.23.23300492

N/A

0DataRank · unranked

3 citations

Jared A. Nielsen, Lindsay C. Hanford, Aya Hamadeh, Tom Hilbert, Tobias Kober +6 more

Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster

Research Square(2023)10.21203/rs.3.rs-3683455/v1

N/A

0DataRank · unranked

1 citations

Joseph J. Locascio, Idil Tuncali, Nada Laroussi, Elena Abatzis, Polina Kamenskaya +18 more

Size matters - the impact of nucleus size on results from spatial transcriptomics

Research Square(2023)10.21203/rs.3.rs-2425852/v1

N/A

0DataRank · unranked

0 citations

Katarzyna Chojnowska, Michał Bieńkowski, Anna Kostecka, Magdalena Koczkowska, Michał A. Żmijewski +11 more

Potential impact of the COVID-19 pandemic on everyday preferences for persons with cognitive impairment

International Psychogeriatrics(2023)10.1017/s1041610223000650

N/A

0DataRank · unranked

0 citations

Joseph J. Locascio, Teresa Gómez‐Isla, Bradley T. Hyman, Deborah Blacker, Brent P. Forester +2 more

Multifaceted roles of APOE in Alzheimer disease

Nature Reviews Neurology(2024)10.1038/s41582-024-00988-2

N/A

0DataRank · unranked

162 citations

Bradley T. Hyman, Alberto Serrano‐Pozo, Rosemary J. Jackson

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

Nature Neuroscience(2024)10.1038/s41593-024-01791-4

N/A

0DataRank · unranked

104 citations

Huan Li, Zhaozhi Li, Clara Muñoz‐Castro, Methasit Jaisa-aad, Molly A Healey +22 more

APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

Molecular Therapy(2024)10.1016/j.ymthe.2024.03.024

N/A

0DataRank · unranked

70 citations

Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Soroush Hajizadeh +14 more

Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia

Acta Neuropathologica(2024)10.1007/s00401-024-02688-z

N/A

0DataRank · unranked

51 citations

Aaron Held, Katherine Dorfman, Joon Sung, Catherine Song, Amey S. Kavuturu +9 more

A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states

Nature Neuroscience(2024)10.1038/s41593-024-01764-7

N/A

0DataRank · unranked

51 citations

Mariko Taga, Verena Haage, Victoria Marshe, Tina Roostaei, Charles C. White +25 more

Interneuron diversity in the human dorsal striatum

Nature Communications(2024)10.1038/s41467-024-50414-w

N/A

0DataRank · unranked

42 citations

Lisbeth Harder, Juan M. Barba-Reyes, Sergio Marco Salas, Mónica Díez-Salguero, Mats Nilsson +4 more

Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology

Cell Reports(2024)10.1016/j.celrep.2024.114574

N/A

0DataRank · unranked

35 citations

Eric del Sastre, Nina Wolf, Nancy E. Ruiz‐Uribe, Benjamin Woost, Zachary Hoglund +8 more

Pathways to personalized medicine—Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer's disease

Alzheimer s & Dementia(2024)10.1002/alz.14063

N/A

0DataRank · unranked

31 citations

Bradley T. Hyman, Rebecca A. Betensky, Hiroko H. Dodge, Steven E. Arnold

TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model

Nature Neuroscience(2024)10.1038/s41593-024-01777-2

N/A

0DataRank · unranked

24 citations

Bakhos Tadros, Yan Hong Wei Liang, Young Doo Kim, Cristian A. Lasagna‐Reeves, Jun Young Sonn +5 more

SORL1 is a receptor for tau that promotes tau seeding

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107313

N/A

0DataRank · unranked

23 citations

Aurélien Lathuilière, Enming J. Su, Yuyu Song, Daniel Torrente, Youhwa Jo +8 more

Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments

Brain(2024)10.1093/brain/awad378

N/A

0DataRank · unranked

18 citations

Noé Quittot, Simon Dujardin, Christoph N. Schlaffner, Arthur Viodé, Anne Wiedmer +8 more

Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau

Acta Neuropathologica(2024)10.1007/s00401-024-02704-2

N/A

0DataRank · unranked

18 citations

Maya E. Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily J. McGlame +24 more

Amyloid-β predominant Alzheimer’s disease neuropathologic change

Brain(2024)10.1093/brain/awae325

N/A

0DataRank · unranked

15 citations

Yuriko Katsumata, Xian Wu, Khine Zin Aung, David W. Fardo, Shelley L. Forrest +95 more

Tau, synapse loss and gliosis progress in an Alzheimer’s mouse model after amyloid-β immunotherapy

Brain(2024)10.1093/brain/awae345

N/A

0DataRank · unranked

14 citations

Anastasie Maté de Gérando, Anita Khasnavis, Harshil Bhavsar, Jonah C Meltzer, Luc Buée +4 more

Precision brain morphometry using cluster scanning

Imaging Neuroscience(2024)10.1162/imag_a_00175

N/A

0DataRank · unranked

11 citations

Jared A. Nielsen, Lindsay C. Hanford, Aya Hamadeh, Tom Hilbert, Tobias Kober +6 more

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease

Acta Neuropathologica(2024)10.1007/s00401-024-02751-9

N/A

0DataRank · unranked

15 citations

Nancy E. Ruiz‐Uribe, Eric del Sastre, Benjamin Woost, Elizabeth Bader, Joshua Bailey +4 more

The structural line between prion and “prion-like”: Insights from prion protein and tau

Current Opinion in Neurobiology(2024)10.1016/j.conb.2024.102857

N/A

0DataRank · unranked

11 citations

José A. Rodríguez, Bradley T. Hyman, Calina Glynn

Aqueous extractable nonfibrillar and sarkosyl extractable fibrillar Alzheimer’s disease tau seeds have distinct properties

Acta Neuropathologica Communications(2024)10.1186/s40478-024-01849-1

N/A

0DataRank · unranked

6 citations

Anita Khasnavis, Lindsay A. Welikovitch, Harshil Bhavsar, Calina Glynn, Noé Quittot +3 more

Utility of cortical tissue analysis in normal pressure hydrocephalus

Cerebral Cortex(2024)10.1093/cercor/bhae001

N/A

0DataRank · unranked

8 citations

Kedous Y. Mekbib, Neel H. Mehta, Emre Kiziltug, Phan Q. Duy, Hannah Smith +10 more

In situ seeding assay: A novel technique for direct tissue localization of bioactive tau

Journal of Neuropathology & Experimental Neurology(2024)10.1093/jnen/nlae059

N/A

0DataRank · unranked

2 citations

Anastasie Maté de Gérando, Calina Glynn, Cameron Donahue, Angelica Gaona, Raquel N. Taddei +4 more

Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

eLife(2024)10.7554/elife.91398.4

N/A

0DataRank · unranked

1 citations

Henry F. J. Tregidgo, Benjamin Billot, Yaël Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse +21 more

Differential regulation of brain microvessel transcriptome and brain metabolome by western and heart-healthy dietary patterns in Ossabaw pigs

Scientific Reports(2024)10.1038/s41598-024-81321-1

N/A

0DataRank · unranked

1 citations

Gregory Matuszek, Nirupa R. Matthan, Alice H. Lichtenstein, Xuedi Wang, Sukla Lakshman +7 more

Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.27.577088

N/A

0DataRank · unranked

4 citations

Nancy E. Ruiz‐Uribe, Eric del Sastre, Benjamin Woost, Joshua Bailey, Bradley T. Hyman +3 more

Reviewer #1 (Public Review): Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

(2024)10.7554/elife.91398.2.sa1

N/A

0DataRank · unranked

0 citations

Henry F. J. Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan William-Ramirez, Rogeny Herisse +21 more

Reviewer #2 (Public Review): Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

(2024)10.7554/elife.91398.3.sa0

N/A

0DataRank · unranked

0 citations

Henry F. J. Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan William-Ramirez, Rogeny Herisse +21 more

Amyloid removal and the appearance of brain volume loss

The Lancet Neurology(2024)10.1016/s1474-4422(24)00370-3

N/A

0DataRank · unranked

0 citations

Bradley T. Hyman

Pseudo-rendering for Resolution and Topology-Invariant Cortical Parcellation

Lecture notes in computer science(2024)10.1007/978-3-031-73290-4_8

N/A

0DataRank · unranked

0 citations

Karthik Gopinath, John Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Dina Zemlyanker +7 more

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

Cell(2025)10.1016/j.cell.2025.04.006

N/A

0DataRank · unranked

34 citations

Robert Ellingford, J. Hartmann, Debanjan Dasgupta, Marten Kehring, Rikesh M. Rajani +14 more

CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer’s disease risk

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2416885122

N/A

0DataRank · unranked

7 citations

Ramadan Ajredini, Shu Guo, Lisa E. L. Romano, Rodrigo F. Tomas, Logan Bell +25 more

Alzheimer disease-associated tau post-translational modification mimics impact tau propagation and uptake

Journal of Neuropathology & Experimental Neurology(2025)10.1093/jnen/nlaf007

N/A

0DataRank · unranked

5 citations

Robert G R Sobolewski, Analiese R. Fernandes, Joanna M. Cooper, Zhanyun Fan, Mirra Chung +5 more

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Cell Reports(2025)10.1016/j.celrep.2025.115801

N/A

0DataRank · unranked

5 citations

Rikesh M. Rajani, Jana Zünkler, Robert Ellingford, Mengke Yang, James M Rowland +14 more

Relationship between cerebral small vessel disease and proteinopathies in the medial temporal lobe

Acta Neuropathologica Communications(2025)10.1186/s40478-025-02076-y

N/A

0DataRank · unranked

5 citations

Jan Oltmer, Francesco Bax, Maarten L van den Berg, Corinne A. Auger, Johanna Rotta +8 more

Cell-death pathways and tau-associated neuronal vulnerability in Alzheimer’s disease

Cell Reports(2025)10.1016/j.celrep.2025.115758

N/A

0DataRank · unranked

4 citations

Sarah E. Chancellor, Taekyung Kwon, Maya E. Woodbury, A. Doering, Aicha Abdourahman +21 more

Distinct inflammatory profiles in young‐onset versus late‐onset Alzheimer's disease

Alzheimer s & Dementia(2025)10.1002/alz.70509

N/A

0DataRank · unranked

5 citations

Chloe Anastassiadis, Anna Vasilevskaya, Foad Taghdiri, Igor Jurišica, Mohsen Hadian +11 more

PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease

Acta Neuropathologica(2025)10.1007/s00401-025-02954-8

N/A

0DataRank · unranked

1 citations

Rodrigo F. Tomas, Cemal Akmese, Ana Mijares, Isabella M. Gerstin, Shu Guo +16 more

Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.26.656152

N/A

0DataRank · unranked

4 citations

Katherine Sun-Mi Brown, Denis S. Smirnov, S. T. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey +11 more

APP family is a regulator of endo-lysosomal membrane vulnerability

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110774

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0DataRank · unranked

0 citations

Natalia Wieckiewicz, Midori Yokomizo, Michael Sadek, Desmond Owusu Kwarteng, John R. Dickson +8 more

Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

eLife(2024)10.7554/elife.91398.2

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0DataRank · unranked

0 citations

Henry F. J. Tregidgo, Benjamin Billot, Yaël Balbastre, Jonathan William-Ramirez, Rogeny Herisse +21 more

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease

Frontiers in Neurology(2020)10.3389/fneur.2020.575953

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0DataRank · unranked

83 citations

Miwei Hu, Becky C. Carlyle, Steven E. Arnold, Matthew P. Frosch, Sudeshna Das +3 more

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies

Brain Communications(2020)10.1093/braincomms/fcaa010

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0DataRank · unranked

49 citations

Suman De, Haiyang Jiang, Matteo Rovere, Ming Jin, Ludovica Zaccagnini +12 more

A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease

Acta Neuropathologica(2020)10.1007/s00401-020-02249-0

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0DataRank · unranked

54 citations

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The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue

Journal of Neuropathology & Experimental Neurology(2020)10.1093/jnen/nlaa025

N/A

0DataRank · unranked

16 citations

Mirra Chung, Naomi Klickstein, Caitlin Commins, Bradley T. Hyman, Matthew P. Frosch +1 more

Differences in Assessment of Everyday Preferences Between People With Cognitive Impairment and Their Care Partners: The Role of Neuropsychiatric Symptoms

American Journal of Geriatric Psychiatry(2020)10.1016/j.jagp.2020.01.189

N/A

0DataRank · unranked

15 citations

Joseph J. Locascio, Jeanette Günther, Liang Yap, Bradley T. Hyman, Deborah Blacker +3 more

Tau reduction in aged mice does not impact Microangiopathy

Acta Neuropathologica Communications(2020)10.1186/s40478-020-01014-4

N/A

0DataRank · unranked

11 citations

Miwei Hu, Analiese R. Fernandes, Marta Pérez-Rando, Ashley B. Robbins, Tarun Kamath +3 more

Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

Journal of Neuropathology & Experimental Neurology(2020)10.1093/jnen/nlaa109

N/A

0DataRank · unranked

34 citations

Ermias D. Belay, Eileen H. Bigio, Sebastian Brandner, Scott A. Brubaker, Byron Caughey +20 more

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.31.230680

N/A

0DataRank · unranked

4 citations

Savannah E. Kandigian, Johannes Kreuzer, Sudeshna Das, Bianca A. Trombetta, Yikai Kuo +10 more

Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly: POEM: Odor Memory Biomarker in Normal Elderly

UNC Libraries(2020)10.17615/984h-ka78

N/A

0DataRank · unranked

0 citations

Keith A. Johnson, Bradley T. Hyman, Josephine Asafu‐Adjei, Teresa Gómez‐Isla, Deborah Blacker +7 more

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

UNC Libraries(2020)10.17615/pbds-w495

N/A

0DataRank · unranked

0 citations

David Craig, Liming Qu, Jonathan L. Haines, Taniesha Morgan, Mark A. Sager +95 more

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

Nature Communications(2021)10.1038/s41467-021-22501-9

N/A

0DataRank · unranked

217 citations

Mathieu Bourdenx, Enrique Luengo, Antonio Díaz, Peter Sohn, Xu Chen +16 more

In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

Science Advances(2021)10.1126/sciadv.abh1448

N/A

0DataRank · unranked

133 citations

Eric Hidari, Kieren Allinson, Timothy Rittman, Sarah L. DeVos, Justin S. Sanchez +8 more

Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100715

N/A

0DataRank · unranked

127 citations

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