Xian Chen

Also affiliated with University of North Carolina at Chapel Hill, Blue Cross Blue Shield of Massachusetts, Shanghai University of Engineering Science, Yunnan Institute For Drug Abuse, Wuxi Fourth People's Hospital, Segeberger Kliniken, UNC Lineberger Comprehensive Cancer Center

ChemistryBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 60 papers. Top paper: “Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy”.

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy

Cell(2020)10.1016/j.cell.2020.10.036

N/A

8.1DataRank · unranked

565 citations

Eric J. Jaehnig, Shankha Satpathy, Lili M. Blumenberg, Alla Y. Karpova, Meenakshi Anurag +85 more

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

Nature Communications(2017)10.1038/ncomms14864

N/A

4.9DataRank · unranked

155 citations

Shunqiang Li, Philipp Mertins, Song Cao, Harsha P. Gunawardena, Kelly V. Ruggles +40 more

Amino acid-coded tagging approaches in quantitative proteomics

Expert Review of Proteomics(2007)10.1586/14789450.4.1.25

N/A

4.5DataRank · unranked

86 citations

Liwei Sun, Yanbao Yu, Yan Xue, Pengyuan Yang, Xian Chen

Reversible acetylation regulates acetate and propionate metabolism in Mycobacterium smegmatis

Microbiology(2013)10.1099/mic.0.068585-0

N/A

2.4DataRank · unranked

55 citations

Lanisha R. Brown, Harsha P. Gunawardena, Ellen F. Perkowski, Xian Chen, Miriam Braunstein +1 more

Landscape of transcription in human cells

Nature(2012)10.1038/nature11233

N/A

1.3DataRank · unranked

5354 citations

Qi Dai, Angelika Merkel, Timo Lassmann, Shinichi Morishita, Andrea Tanzer +91 more

Correction: Corrigendum: Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

Nature Communications(2017)10.1038/ncomms15479

N/A

0.843DataRank · unranked

11 citations

Shunqiang Li, Philipp Mertins, Song Cao, Harsha P. Gunawardena, Kelly V. Ruggles +40 more

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets

Journal of the American Chemical Society(2022)10.1021/jacs.2c09255

N/A

0.736DataRank · unranked

134 citations

Yue Zhong, Hyerin Yim, Xiaobao Yang, Kwang‐Su Park, Ling Xie +7 more

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

UNC Libraries(2020)10.17615/0xdg-yq72

N/A

0.552DataRank · unranked

6 citations

Shunqiang Li, Philipp Mertins, Song Cao, Harsha P. Gunawardena, Kelly V. Ruggles +40 more

Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

Molecular Cell(2024)10.1016/j.molcel.2023.12.010

N/A

0.360DataRank · unranked

10 citations

Yanfeng Zhang, Lei Guo, Hua Zhong, Ling Xie, Jin Zhou +20 more

Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction

Digital Commons@Becker (Washington University School of Medicine)(2020)10.17615/b898-yw29

N/A

0.104DataRank · unranked

1 citations

Amanda G. Paulovich, R. Reid Townsend, Matthew J. Ellis, Zihao Ma, Christopher R. Kinsinger +15 more

In Vitro Phosphorylation of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase by Src Kinase

Figshare(2020)10.17615/mdk4-vm38

N/A

0DataRank · unranked

0 citations

Jennifer Cable, Sharon L. Campbell, Kirk C. Prutzman, Xian Chen, Harsha P. Gunawardena +1 more

Unambiguous Characterization of Site-specific Phosphorylation of Leucine-rich Repeat Fli-I-interacting Protein 2 (LRRFIP2) in Toll-like Receptor 4 (TLR4)-mediated Signaling

UNC Libraries(2020)10.17615/3jtt-ka77

N/A

0DataRank · unranked

0 citations

Roma Kenjale, Haiyang Wang, Ling Xie, Xian Chen, Yi Huang +1 more

Protein composition of the hepatitis A virus quasi-envelope

UNC Libraries(2020)10.17615/6zek-qc54

N/A

0DataRank · unranked

0 citations

Kevin L. McKnight, Efraín E. Rivera-Serrano, Olga González‐López, Ling Xie, Xian Chen +1 more

TF-PROTACs Enable Targeted Degradation of Transcription Factors

Journal of the American Chemical Society(2021)10.1021/jacs.1c03852

N/A

0DataRank · unranked

233 citations

He Chen, H. Ümit Kanıskan, Ling Xie, Xian Chen, Jian Jin +2 more

AIM2 in regulatory T cells restrains autoimmune diseases

Nature(2021)10.1038/s41586-021-03231-w

N/A

0DataRank · unranked

170 citations

Zengli Guo, Hao Guo, Liang Chen, Ge Zhang, Kaixin Liang +15 more

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

Journal of the American Chemical Society(2021)10.1021/jacs.1c04841

N/A

0DataRank · unranked

144 citations

Fanye Meng, Kwang‐Su Park, Hyerin Yim, Julia Velez, Prashasti Kumar +11 more

Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication

Nature Immunology(2021)10.1038/s41590-021-00898-1

N/A

0DataRank · unranked

111 citations

Qi Wang, Khader Ghneim, Li Wang, Elena Rampanelli, Elizabeth Holley-Guthrie +10 more

Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders

Nature Cancer(2021)10.1038/s43018-021-00174-z

N/A

0DataRank · unranked

73 citations

Xiaobao Yang, Yan Xiong, Ruitong Li, Takahiro Ito, Tamer A. Ahmed +14 more

Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01476

N/A

0DataRank · unranked

54 citations

Jia Xu, Ling Xie, Li Wang, Yudao Shen, Kaitlyn M. Cahuzac +5 more

Protocol for proteogenomic dissection of intronic splicing enhancer interactome for prediction of individualized cancer prognosis

STAR Protocols(2021)10.1016/j.xpro.2021.100338

N/A

0DataRank · unranked

1 citations

John A. Wrobel, Ling Xie, Xian Chen, Li Wang

Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00100

N/A

0DataRank · unranked

62 citations

Chris Anderson, Kwang‐Su Park, H. Ümit Kanıskan, Anqi Ma, Yudao Shen +6 more

TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors

Journal of the American Chemical Society(2022)10.1021/jacs.2c04824

N/A

0DataRank · unranked

61 citations

Xufen Yu, He Chen, H. Ümit Kanıskan, Ling Xie, Xian Chen +3 more

Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01505

N/A

0DataRank · unranked

38 citations

Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez +4 more

Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01454

N/A

0DataRank · unranked

35 citations

Jia Xu, Kaitlyn M. Cahuzac, Ling Xie, Yudao Shen, Xian Chen +4 more

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

PLoS Pathogens(2022)10.1371/journal.ppat.1010543

N/A

0DataRank · unranked

22 citations

Hui Feng, Helen M. E. Duyvesteyn, William G. Fusco, Kevin L. McKnight, Ling Xie +15 more

Nonlytic Quasi-Enveloped Hepatovirus Release Is Facilitated by pX Protein Interaction with the E3 Ubiquitin Ligase ITCH

Journal of Virology(2022)10.1128/jvi.01195-22

N/A

0DataRank · unranked

8 citations

Olga González‐López, Kevin L. McKnight, Ling Xie, Tomoyuki Shiota, Xian Chen +3 more

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.26.489493

N/A

0DataRank · unranked

3 citations

Hui Feng, Helen M. E. Duyvesteyn, William G. Fusco, Kevin L. McKnight, Ling Xie +15 more

Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01521

N/A

0DataRank · unranked

51 citations

Dongxu Li, Jithesh Kottur, Huen Suk Kim, Laura E. Herring, Yao Yu +9 more

Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins

Journal of the American Chemical Society(2023)10.1021/jacs.3c02783

N/A

0DataRank · unranked

30 citations

Jing Liu, He Chen, Xing Qiu, Ling Xie, H. Ümit Kanıskan +4 more

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation

Cell chemical biology(2023)10.1016/j.chembiol.2023.09.012

N/A

0DataRank · unranked

17 citations

Li Wang, Ling Xie, Feng Zhang, Bing Wu, Mei Liu +15 more

Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2

Journal of the American Chemical Society(2023)10.1021/jacs.3c06023

N/A

0DataRank · unranked

13 citations

Jing Liu, Xing Qiu, Dingpeng Zhang, Hiroyuki Inuzuka, Li Chen +7 more

Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer’s disease proteopathology for precision medication

medRxiv(2023)10.1101/2023.10.25.23297491

N/A

0DataRank · unranked

6 citations

Ryan N. Sheehy, Yan Xiong, Adil Muneer, John A. Wrobel, Kwang‐Su Park +13 more

Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer’s disease proteopathology for precision medication

Research Square(2023)10.21203/rs.3.rs-2743792/v1

N/A

0DataRank · unranked

1 citations

Ling Xie, Ryan N. Sheehy, Yan Xiong, Adil Muneer, John A. Wrobel +13 more

Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1

Journal of the American Chemical Society(2024)10.1021/jacs.3c13646

N/A

0DataRank · unranked

30 citations

Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu +8 more

USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK

Journal of the American Chemical Society(2024)10.1021/jacs.4c02373

N/A

0DataRank · unranked

29 citations

Xiaoping Hu, Kaixiu Luo, Yan Xiong, Li Chen, Zhen Wang +11 more

A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression

Science Advances(2024)10.1126/sciadv.ado1432

N/A

0DataRank · unranked

14 citations

Lihuai Qin, Hongwen Xuan, Kaixiu Luo, Mengying Huang, Ling Xie +10 more

NEAT1 repression by MED12 creates chemosensitivity in p53 wild‐type breast cancer cells

FEBS Journal(2024)10.1111/febs.17097

N/A

0DataRank · unranked

6 citations

Eui‐Jun Kim, Junfeng Huang, Peng Liu, Kristine Donahue, Qinchuan Wang +7 more

NEAT1 repression by MED12 creates chemosensitivity in p53 wild‐type breast cancer cells

UNC Libraries(2024)10.17615/f0e2-pq88

N/A

0DataRank · unranked

0 citations

Yidan Wang, Peng Liu, Junfeng Huang, Shengjie Zhang, Eui‐Jun Kim +7 more

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation

UNC Libraries(2024)10.17615/144y-5d10

N/A

0DataRank · unranked

0 citations

Kanishk Jain, Ling Xie, Erik M. Lenarcic, Feng Zhang, Hongjun Song +15 more

USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment

Journal of the American Chemical Society(2025)10.1021/jacs.5c01889

N/A

0DataRank · unranked

19 citations

C. D. Qian, Yan Xiong, Dingpeng Zhang, Hiroyuki Inuzuka, Yue Zhong +5 more

Harnessing the Deubiquitinase USP1 for Targeted Protein Stabilization

Journal of the American Chemical Society(2025)10.1021/jacs.5c01662

N/A

0DataRank · unranked

13 citations

Zhen Wang, Yan Xiong, Dingpeng Zhang, Yue Zhong, Hiroyuki Inuzuka +6 more

Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00295

N/A

0DataRank · unranked

12 citations

Jerrel L. Catlett, Youngeun Lee, Qiong Wu, Zhongli Xu, Ling Xie +5 more

Discovery of the first-in-class DOT1L PROTAC degrader

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117595

N/A

0DataRank · unranked

9 citations

Renhong Sun, Zhongli Xu, Huen Suk Kim, Min Jeong Kim, Tao Cao +5 more

Segregated supramammillary-dentate gyrus circuits modulate cognitive and affective function in healthy and Alzheimer’s disease model mice

Neuron(2025)10.1016/j.neuron.2025.09.006

N/A

0DataRank · unranked

9 citations

Longfei Li, Ze-Ka Chen, Ping Dong, Ling Xie, W. Todd Farmer +20 more

Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy

Journal of the American Chemical Society(2025)10.1021/jacs.5c06306

N/A

0DataRank · unranked

7 citations

Zhijie Deng, Yan Xiong, Jing Liu, Daoyuan Huang, Jingchao Wang +7 more

ALS-associated TDP-43 aggregates drive innate and adaptive immune cell activation

iScience(2025)10.1016/j.isci.2025.112648

N/A

0DataRank · unranked

6 citations

Joey V. Ragusa, Kyle Pellegrino, Yijia Wu, Ivana Yoseli Quiroga, Shannon R. Cahalan +14 more

Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00198

N/A

0DataRank · unranked

9 citations

Huensuk Kim, Chao Qian, Ling Xie, Xian Chen, Yan Xiong +6 more

Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology

Nature Communications(2025)10.1038/s41467-025-59128-z

N/A

0DataRank · unranked

9 citations

Ryan N. Sheehy, Adil Muneer, Yan Xiong, John A. Wrobel, Feng Zhang +20 more

Structure–Activity Relationship Studies of DNA Methyltransferase 1 Monovalent Degraders

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.4c02161

N/A

0DataRank · unranked

5 citations

Youngeun Lee, Yulin Han, Yue Zhong, Jujun Zhou, Joel Hrit +9 more

Discovery of the first-in-class Aurora B kinase selective degrader

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.118006

N/A

0DataRank · unranked

1 citations

Kevin Graciano, Jianping Hu, Chang Liu, Jiuyi Zhang, Ling Xie +5 more

Targeting kinesin family member 20A sensitizes stem-like triple-negative breast cancer cells to standard chemotherapy

UNC Libraries(2025)10.17615/wy0f-mf84

N/A

0DataRank · unranked

0 citations

Yayoi Adachi, Jin Zhou, Wang, Tao, Cheng Zhang, Masashi Takeda +17 more

Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c01609

N/A

0DataRank · unranked

42 citations

Jieli Wei, Hyerin Yim, Li Wang, Ling Xie, Margaret S. Jin +6 more

Modifications of Superoxide Dismutase (SOD1) in Human Erythrocytes: A POSSIBLE ROLE IN AMYOTROPHIC LATERAL SCLEROSIS

UNC Libraries(2020)10.17615/2v0m-zj47

N/A

0DataRank · unranked

9 citations

Yanbao Yu, Li Zhou, Joshua K. Jordon, Nikolay V. Dokholyan, Kyle C. Wilcox +4 more

CRL4 DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development

Science Advances(2020)10.1126/sciadv.abd6078

N/A

0DataRank · unranked

47 citations

Naoya Sasaki, Sarah Jackson, Pu Wang, Zhijun Li, Matthew D. Smith +6 more

Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics

UNC Libraries(2020)10.17615/nztt-2a31

N/A

0DataRank · unranked

2 citations

Linhong Jing, Maria Warren Hines, Xian Chen, Nedyalka Dicheva, Carol E. Parker +4 more

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.14.382416

N/A

0DataRank · unranked

22 citations

Adil Muneer, Ling Xie, Feng Zhang, Bing Wu, Mei Liu +15 more

Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX

UNC Libraries(2020)10.17615/mned-p064

N/A

0DataRank · unranked

0 citations

Feng Liu, Jian Jin, Nikolay V. Dokholyan, Xian Chen, Brian D. Strahl +9 more

QuantFusion: Novel Unified Methodology for Enhanced Coverage and Precision in Quantifying Global Proteomic Changes in Whole Tissues

UNC Libraries(2020)10.17615/gcj3-5y88

N/A

0DataRank · unranked

0 citations

John A. Wrobel, Shunqiang Li, Ling Xie, Sherri R. Davies, Harsha P. Gunawardena +4 more

Protein Phosphatase 2A Catalytic Subunit α Plays a MyD88-Dependent, Central Role in the Gene-Specific Regulation of Endotoxin Tolerance

UNC Libraries(2020)10.17615/7nbp-cm42

N/A

0DataRank · unranked

0 citations

Cui Liu, Ling Xie, Jing Yu, Leslie V. Parise, Yanbao Yu +10 more

DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

UNC Libraries(2020)10.17615/45c3-rw37

N/A

0DataRank · unranked

0 citations

Zengli Guo, Cui Liu, Yue Xiong, Yisong Y. Wan, Song Zhang +5 more