Michelle R. Arkin

Also affiliated with Discovery Centre, St. Mary's Medical Center, Pharmaceutical Biotechnology (Czechia)

Biochemistry, Genetics and Molecular BiologyComputer ScienceMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 39 papers. Top paper: “Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation”.

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Nature Immunology(2020)10.1038/s41590-020-0654-0

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0DataRank · unranked

202 citations

Jae Kyu Ryu, Sophia Bardehle, Anke Meyer‐Franke, Kenny Kean‐Hooi Ang, Chris Wilson +25 more

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

Molecular Neurodegeneration(2020)10.1186/s13024-019-0354-0

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110 citations

Yaqiao Li, Chao Wang, Yinyan Tang, Sue‐Ann Mok, Richard Tsai +9 more

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

Communications Biology(2020)10.1038/s42003-020-01402-5

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20 citations

Brian M. Suzuki, Jakob Dohrmann, Rahul Singh, Michelle R. Arkin, Conor R. Caffrey +1 more

Expression and purification of active human kinases using Pichia pastoris as a general-purpose host

Protein Expression and Purification(2020)10.1016/j.pep.2020.105780

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1 citations

Yao Fan, Lijun Liu, Mark M. Moasser, Haian Fu, Natalia Jura +2 more

A genetically encoded, pH-sensitive mTFP1 biosensor for probing lysosomal pH

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.04.368654

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4 citations

Anand Patwardhan, Kean-Hooi Ang, Austin L. Wang, Carolina Alquézar, Mackenzie Welch +6 more

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.20.913012

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2 citations

Susmita Khamrui, Hui Wang, Chalada Suebsuwong, Natalia S. Nemeria, Khoi Huynh +14 more

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

eLife(2021)10.7554/elife.69795

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49 citations

Han Mo, Harrison Liu, Zhihao Wu, Steven Chen, Jiashun Zheng +16 more

An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease

Pathogens(2021)10.3390/pathogens10010071

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21 citations

Christina A. Bulman, Fidelis Cho‐Ngwa, Chelsea Fischer, Chris Marcellino, Michelle R. Arkin +10 more

Reimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysis

Cell chemical biology(2021)10.1016/j.chembiol.2021.01.016

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20 citations

Jether Amos Espinosa, Grace Pohan, Sarine Markossian, Michelle R. Arkin, Marcus Y. Chin

Real‐Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer

Current Protocols(2021)10.1002/cpz1.75

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17 citations

Grace Pohan, Michelle R. Arkin, Sarine Markossian, Jether Amos Espinosa

Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.08.425912

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3 citations

Chao Wang, David Butler, Dulce Ovando Morales, Cathrine Petersen, Brian Chin +12 more

Caspase-6-cleaved tau is relevant in Alzheimer’s disease but not in other tauopathies: diagnostic and therapeutic implications

medRxiv(2021)10.1101/2021.01.28.21250322

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1 citations

Antonia M. H. Piergies, Song Hua Li, Cathrine Petersen, Alexander J. Ehrenberg, Rana Eser +10 more

Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2210247119

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34 citations

Gregory McInnes, Julia E. H. Brown, Neil Thomas, Keino Hutchinson, Marcus Y. Chin +8 more

Caspase‐6‐cleaved tau is relevant in Alzheimer's disease and marginal in four‐repeat tauopathies: Diagnostic and therapeutic implications

Neuropathology and Applied Neurobiology(2022)10.1111/nan.12819

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26 citations

Antonia M. H. Piergies, Ian Oh, Yoo Bin Lee, Song Hua Li, Felipe Luiz Pereira +14 more

Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model

ACS Chemical Neuroscience(2022)10.1021/acschemneuro.1c00804

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16 citations

Kean-Hooi Ang, Julia L. Davies, Carolina Alquézar, Virginia Garda, Brenda L. Rooney +5 more

Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein–Protein Interactions

Journal of the American Chemical Society(2022)10.1021/jacs.2c03665

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14 citations

Yu‐Hsuan Kuo, Mengqi Zhong, Jianchao Zhang, Xin Zhou, Lijuan Xing +4 more

Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine

Cell chemical biology(2022)10.1016/j.chembiol.2022.03.007

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12 citations

Priyadarshini Jaishankar, Gregory M. Lee, Markus‐Frederik Bohn, Emily J. Connelly, Kristin Wucherer +7 more

LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface

Biochemistry(2022)10.1021/acs.biochem.2c00482

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7 citations

Amber M. Kay, Ziwen Jiang, Michelle R. Arkin, Yinyan Tang

Engaging a Non-Catalytic Cysteine Residue Drives Unprecedented Selectivity of Caspase Inhibition

ChemRxiv(2022)10.26434/chemrxiv-2022-5wfm6

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0 citations

Dongju Wang, Daniel Medina-Cleghorn, Peter Lee, Clifford Bryant, Chad R. Altobelli +8 more

A Comprehensive Empirical–Computational Study of Diverse Het-eroarene Stacking under Physiological Conditions

ChemRxiv(2022)10.26434/chemrxiv-2022-359ch

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0 citations

Takaya Togo, Linh Tram, Laura Denton, Xochina ElHilali-Pollard, Jun Gu +13 more

A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers

ACS Central Science(2023)10.1021/acscentsci.2c01449

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52 citations

Emira J. Visser, Johanna M. Virta, Eline Sijbesma, Federica Centorrino, Holly R. Vickery +6 more

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

Journal of the American Chemical Society(2023)10.1021/jacs.3c05161

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39 citations

Emira J. Visser, Edmee Vandenboorn, Sheng Chen, Priyadarshini Jaishankar, Maurits Overmans +7 more

Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation

Journal of the American Chemical Society(2023)10.1021/jacs.3c05199

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28 citations

Yu-Hsuan Kuo, Michelle R. Arkin, Ziwen Jiang

Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6

Journal of the American Chemical Society(2023)10.1021/jacs.2c12240

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22 citations

Dongju Wang, Daniel Medina-Cleghorn, Peter S. Lee, Clifford Bryant, Chad R. Altobelli +8 more

The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.15.540864

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2 citations

Chad R. Altobelli, Maxwell R. Tucker, Eric Tse, Aye C. Thwin, Michelle R. Arkin +2 more

Synthetic autophagy receptor

Autophagy(2023)10.1080/15548627.2023.2278954

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0 citations

Yu-Hsuan Kuo, Michelle R. Arkin, Ziwen Jiang

Molecular glues for protein-protein interactions: Progressing toward a new dream

Cell chemical biology(2024)10.1016/j.chembiol.2024.04.002

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145 citations

Michelle R. Arkin, Markella Konstantinidou

An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis

Journal of Clinical Investigation(2024)10.1172/jci173371

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50 citations

Nabora S. Reyes, Supriya Ravishankar, Minqi Zhou, Maria Krasilnikov, Christian Ringler +9 more

Deep phenotypic profiling of neuroactive drugs in larval zebrafish

Nature Communications(2024)10.1038/s41467-024-54375-y

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23 citations

Jack C. Taylor, Douglas Myers-Turnbull, Steven Chen, Matthew N. McCarroll, Michelle R. Arkin +3 more

Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.100165

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15 citations

Johanna M. Virta, Markella Konstantinidou, Michelle R. Arkin, Holly R. Vickery

iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death

Molecular and Cellular Neuroscience(2024)10.1016/j.mcn.2024.103954

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5 citations

Chao Wang, David Butler, Dulce Ovando Morales, Cathrine Petersen, Andrew J. Ambrose +13 more

Deep phenotypic profiling of neuroactive drugs in larval zebrafish

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.22.581657

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1 citations

Jack C. Taylor, Douglas Myers-Turnbull, Steven Chen, Matthew N. McCarroll, Michelle R. Arkin +3 more

Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2023.12.31.573792

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0 citations

Johanna M. Virta, Markella Konstantinidou, Michelle R. Arkin, Holly R. Vickery

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Nature Communications(2025)10.1038/s41467-025-61176-4

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11 citations

Marios Zingiridis, Marloes Pennings, Michael Fragkiadakis, Johanna M. Virta, Jezrael L. Revalde +6 more

2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy

Neurobiology of Disease(2025)10.1016/j.nbd.2025.106861

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6 citations

Amal Dadi, Zollie Yavarow, Lindsay N. Alfano, Daniel J. Anderson, Michelle R. Arkin +36 more

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2410766122

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6 citations

Yue Yang, Alok K. Sharma, David M. Turner, Caroline J. DeHart, Hazem Abdelkarim +29 more

Stabilization of Native Protein–Protein Interactions with Molecular Glues: A 14-3-3 Case Study

Accounts of Chemical Research(2025)10.1021/acs.accounts.5c00441

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4 citations

Johanna M. Virta, Michelle R. Arkin, Markella Konstantinidou

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD

Communications Biology(2025)10.1038/s42003-025-08368-2

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2 citations

Li Fan, Rowan Saloner, Jon Iker Etchegaray, Chad R. Altobelli, Sally Salomonsson +24 more

Modulation of the 14-3-3σ/C-RAF “auto”inhibited complex by molecular glues

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.30.667769

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1 citations

Holly R. Vickery, Marloes Pennings, Johanna M. Virta, Emira J. Visser, Sean D. Bannier +9 more