Craig W. Lindsley

Also affiliated with Discovery Laboratories (United States), Health Advances (United States), Center for Discovery

MedicineBiochemistry, Genetics and Molecular BiologyChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 41 papers. Top paper: “mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits”.

mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits

Cell Reports(2021)10.1016/j.celrep.2021.109950

N/A

0.561DataRank · unranked

41 citations

Nellie Byun, Deborah J. Luessen, Brianna Li, Robert Barry, John C. Gore +5 more

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

eLife(2023)10.7554/elife.83477

N/A

0.542DataRank · unranked

36 citations

Jinan Wang, Vi Pham, Jesse I. Mobbs, Matthew J. Belousoff, Apurba Bhattarai +19 more

A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes

JCI Insight(2021)10.1172/jci.insight.143324

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0.520DataRank · unranked

31 citations

Aqeela AlHashim, Aditi Buch, Hana Badivuku, Manar Samman, Kelly Weiss +8 more

Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102458

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0.477DataRank · unranked

23 citations

Nicole M. Fisher, Shalini Dogra, Rebecca K. Senter, Carson W. Reed, Jacob J. Kalbfleisch +6 more

Discovery of VU0467319: an M1 Positive Allosteric Modulator Candidate That Advanced into Clinical Trials

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.4c00769

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0.457DataRank · unranked

11 citations

Michael R. Wood, Changho Han, Shaun R. Stauffer, Joseph D. Panarese, Bruce J. Melancon +21 more

Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128416

N/A

0.420DataRank · unranked

8 citations

Rory A. Capstick, Paul K. Spearing, Julie L. Engers, Alison R. Gregro, Sean R. Bollinger +11 more

Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity

Bioorganic & Medicinal Chemistry Letters(2020)10.1016/j.bmcl.2020.127212

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0.330DataRank · unranked

8 citations

Matthew T. Loch, Alice L. Rodriguez, Xin Lin, Jonathan A. Javitch, P. Jeffrey Conn +3 more

Development and profiling of mGlu7 NAMs with a range of saturable inhibition of agonist responses in vitro

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128923

N/A

0.208DataRank · unranked

3 citations

Alice L. Rodriguez, Jacob J. Kalbfleisch, Mabel Seto, Matthew T. Jenkins, Anna L. Blobaum +4 more

Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors

ACS Chemical Neuroscience(2021)10.1021/acschemneuro.1c00557

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0DataRank · unranked

4 citations

Matthew T. Duvernay, Sidnee G. Mitchell, Shannon T. Smith, Jae G. Maeng, Anna L. Blobaum +5 more

Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00192

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0DataRank · unranked

23 citations

Douglas L. Orsi, Rory A. Capstick, David Whomble, Jinming Li, Trever R. Carter +21 more

VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

Molecular Pharmacology(2022)10.1124/molpharm.121.000464

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0DataRank · unranked

17 citations

Caitlin N. Kent, Sujay V. Kharade, Елена Исаева, Jade C. Williams, Changho Han +14 more

Effects of acute and repeated administration of the selective M 4 PAM VU0152099 on cocaine versus food choice in male rats

Addiction Biology(2022)10.1111/adb.13145

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0DataRank · unranked

13 citations

Jill R. Crittenden, Craig W. Lindsley, Ann M. Graybiel, Morgane Thomsen

The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on behavioral and NMDA receptor adaptations in the brain

Neuropharmacology(2022)10.1016/j.neuropharm.2022.108943

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0DataRank · unranked

18 citations

Maya N Bluitt, Julie L. Engers, Craig W. Lindsley, Joyce Besheer, Ryan E. Tyler

Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

Neurotherapeutics(2022)10.1007/s13311-022-01254-3

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0DataRank · unranked

14 citations

Bright Arthur, Jakub Cikowski, Calista Holt, Sonia Gonzalez, Nicole M. Fisher +5 more

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.27.509640

N/A

0DataRank · unranked

1 citations

Jinan Wang, Vi Pham, Jesse I. Mobbs, Matthew J. Belousoff, Apurba Bhattarai +18 more

A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2212338120

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0DataRank · unranked

39 citations

Ping Li, Juan J. Ferreira, Roman M. Lazarenko, Sujay V. Kharade, Meghan Kramer +14 more

2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01178

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0DataRank · unranked

18 citations

Lauren C. Parr, William B. Livingston, Craig W. Lindsley, W. David Merryman, Aaron M. Bender

Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen

Assay and Drug Development Technologies(2023)10.1089/adt.2022.116

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0DataRank · unranked

8 citations

Michael Valentine, Joshua A. Bauer, Emily Days, Craig W. Lindsley, W. David Merryman +1 more

Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits

Biological Psychiatry(2023)10.1016/j.biopsych.2023.11.023

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0DataRank · unranked

3 citations

Caleb Aguayo, Zixiu Xiang, Jason Putnam, J. R. Smith, Curran Johnston +5 more

Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4 Muscarinic Receptor

Molecular Pharmacology(2023)10.1124/molpharm.122.000643

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0DataRank · unranked

6 citations

Haley E. Kling, Natasha B. Billard, Alice L. Rodriguez, Peng Li, Jonathan W. Dickerson +7 more

Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS

Bioorganic & Medicinal Chemistry Letters(2023)10.1016/j.bmcl.2023.129256

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0DataRank · unranked

2 citations

Keagan S. Chronister, Upendra Rathnayake, Lauren C. Parr, Kangjun Li, Sichen Chang +9 more

Data from Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER2 Inhibitors against HER2-Overexpressing Cancer Cells

(2023)10.1158/1078-0432.c.6517720

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0DataRank · unranked

0 citations

James T. Forbes, Chirayu Shah, Shelby K. Wyatt, H. Charles Manning, Maria G. Olivares +9 more

Data from Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER2 Inhibitors against HER2-Overexpressing Cancer Cells

(2023)10.1158/1078-0432.c.6517720.v1

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0DataRank · unranked

0 citations

James T. Forbes, Chirayu Shah, Shelby K. Wyatt, H. Charles Manning, Maria G. Olivares +9 more

Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.3c00378

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0DataRank · unranked

12 citations

Jackson B. Cassada, Lukas von Bredow, Kevin Erreger, Emma M. Webb, Trevor A. Trombley +12 more

Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KATP Channels

Molecular Pharmacology(2024)10.1124/molpharm.123.000783

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0DataRank · unranked

8 citations

Samantha J. McClenahan, Changho Han, Joseph D. Bungard, Upendra Rathnayake, Olivier Boutaud +6 more

Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.4c00508

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0DataRank · unranked

8 citations

Katrina A. Bollinger, Rory A. Capstick, Madeline F. Long, Aaron M. Bender, Jonathan W. Dickerson +14 more

Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile

ACS Medicinal Chemistry Letters(2024)10.1021/acsmedchemlett.4c00249

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0DataRank · unranked

6 citations

Sean R. Bollinger, Julie L. Engers, Madeline F. Long, Sichen Chang, Vincent B. Luscombe +9 more

Discovery of VU6024578/BI02982816: An mGlu1 Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c02554

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0DataRank · unranked

3 citations

Jacob F. Kalbfleisch, Jeremy A. Turkett, Trevor A. Trombley, Anthony F. Nastase, Paul K. Spearing +17 more

Computer-Aided Design and Biological Evaluation of Diazaspirocyclic D4R Antagonists

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.4c00086

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0DataRank · unranked

6 citations

Benjamin P. Brown, Daniel Schultz, Julie L. Engers, Valerie M. Kramlinger, Jens Meiler +2 more

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR

Nature Communications(2025)10.1038/s41467-025-62212-z

N/A

0DataRank · unranked

5 citations

Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry +9 more

Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

ACS Medicinal Chemistry Letters(2025)10.1021/acsmedchemlett.5c00119

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0DataRank · unranked

2 citations

Scott H. Henderson, Rory A. Capstick, David Whomble, Aaron M. Bender, Andrew S. Felts +18 more

Further Optimization of the mGlu1 PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685

ACS Chemical Neuroscience(2025)10.1021/acschemneuro.5c00014

N/A

0DataRank · unranked

0 citations

Jacob F. Kalbfleisch, Jeremy A. Turkett, Trevor A. Trombley, Paul K. Spearing, Daniel H. Haymer +16 more

Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents

Biological Psychiatry(2020)10.1016/j.biopsych.2020.02.019

N/A

0DataRank · unranked

50 citations

Alice E. Berizzi, Nicola A. Chen, Patricia Rueda, Victoria M. Perreau, Katherine Huckstep +10 more

Discovery of VU6052254: A Novel, Potent M 1 Positive Allosteric Modulator

ACS Chemical Neuroscience(2025)10.1021/acschemneuro.5c00825

N/A

0DataRank · unranked

0 citations

Joseph D. Bungard, Christopher C. Presley, Irène Zagol-Ikapitte, Katherine J. Watson, Sichen Chang +15 more

Modulation of arousal and sleep/wake architecture by M1 PAM VU0453595 across young and aged rodents and nonhuman primates

Neuropsychopharmacology(2020)10.1038/s41386-020-00812-7

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0DataRank · unranked

20 citations

Jason K Russell, Michael T. Nedelcovych, Michael Bubser, Anna L. Blobaum, Thomas M. Bridges +6 more

Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors

Bioorganic & Medicinal Chemistry Letters(2020)10.1016/j.bmcl.2020.127418

N/A

0DataRank · unranked

8 citations

Sean R. Bollinger, Andrew S. Felts, Anish K. Vadukoot, Charles H. Williams, Anna L. Blobaum +4 more

Discovery of the first selective M 4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.12.324152

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0DataRank · unranked

1 citations

Aaron M. Bender, Jonathan W. Dickerson, Daniel J. Foster, Yuping Donsante, Weimin Peng +14 more

Activating mGlu 3 metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.27.356196

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0DataRank · unranked

1 citations

Branden J. Stansley, Zixiu Xiang, Weilun Qian, Rocco G. Gogliotti, Ferdinando Nicoletti +5 more

Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus

Biological Psychiatry(2021)10.1016/j.biopsych.2021.02.970

N/A

0DataRank · unranked

47 citations

Branden J. Stansley, Zixiu Xiang, Weilun Qian, Rocco G. Gogliotti, Ferdinando Nicoletti +5 more

Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study

British Journal of Ophthalmology(2021)10.1136/bjophthalmol-2020-318529

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0DataRank · unranked

40 citations

Jessica V. Kaczmarek, Janene Pierce, Sheau‐Chiann Chen, Kelli L. Boyd, M. Wade Calcutt +11 more

Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG

Frontiers in Neuroscience(2021)10.3389/fnins.2021.700822

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0DataRank · unranked

19 citations

Alex Lekander, Christina M. LaValley, Elizabeth G. Bedingham, Bethany Pierce, L. Paul Sands +4 more