Alan Ashworth

UCSF Helen Diller Family Comprehensive Cancer Center

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

5in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 5 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 57 papers. Top paper: “Xist has properties of the X-chromosome inactivation centre”.

Xist has properties of the X-chromosome inactivation centre

Nature(1997)10.1038/386272a0

N/A

16.2DataRank · unranked

252 citations

Justyna T. Romer, Jacqueline M. Horn, Alan Ashworth, Laura B. K. Herzing

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.22.002386

N/A

14.3DataRank · unranked

456 citations

Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Matthew J. O’Meara +95 more

Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer(2004)10.1016/j.bbcan.2004.01.001

N/A

10.8DataRank · unranked

216 citations

Alan Ashworth, Manuela Santarosa

p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

The EMBO Reports(2006)10.1038/sj.embor.7400587

N/A

8.6DataRank · unranked

208 citations

Iciar Lazaro‐Trueba, Peter Kerr, Christopher J Lord, Tim Dexter, Marjan Iravani +3 more

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

Cancer Cell(2022)10.1016/j.ccell.2022.06.001

N/A

6.5DataRank · unranked

360 citations

Winnie Yao, Nghi Ly, Katherine A. Freitas, Yanting Chen, Quanming Shi +15 more

Biological insights and novel biomarker discovery through deep learning approaches in breast cancer histopathology

npj Breast Cancer(2023)10.1038/s41523-023-00518-1

N/A

1.9DataRank · unranked

65 citations

Jorge S. Reis‐Filho, Alan Ashworth, Divneet Mandair

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Nature(2005)10.1038/nature03445

N/A

1.3DataRank · unranked

6630 citations

Nuala McCabe, Christopher J. Lord, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa +11 more

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers

New England Journal of Medicine(2009)10.1056/nejmoa0900212

N/A

1.2DataRank · unranked

3622 citations

David S. Boss, Timothy A. Yap, Richard Turkington, Peijun Wu, Marja Mergui-Roelvink +14 more

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

EMBO Molecular Medicine(2009)10.1002/emmm.200900041

N/A

0.967DataRank · unranked

631 citations

Sarah A. Martin, Rachel Brough, Afshan McCarthy, Jessica R. Taylor, Jung‐Sik Kim +5 more

Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2

Cancer Research(2022)10.1158/0008-5472.can-21-4335

N/A

0.884DataRank · unranked

28 citations

Huadong Chen, Yagmur U. Doruk, Tess Williamson, Benjamin J. Polacco, Andrew S. McNeal +13 more

RASA2 ablation in T cells boosts antigen sensitivity and long-term function

Nature(2022)10.1038/s41586-022-05126-w

N/A

0.816DataRank · unranked

230 citations

Eric Shifrut, Nupura Kale, William A. Nyberg, Franziska Blaeschke, Yan Yi Chen +28 more

Future cancer research priorities in the USA: a Lancet Oncology Commission

The Lancet Oncology(2017)10.1016/s1470-2045(17)30698-8

N/A

0.801DataRank · unranked

208 citations

Chi Van Dang, David B. Agus, Brian M. Alexander, Kenneth C. Anderson, Alan Ashworth +64 more

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

Cancer Research(2022)10.1158/0008-5472.can-22-1123

N/A

0.635DataRank · unranked

68 citations

Shuang G. Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha +58 more

Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer

Cancer Research(2022)10.1158/0008-5472.can-22-1433

N/A

0.621DataRank · unranked

62 citations

Emily A. Egusa, Sinan Wang, Michelle L. Badura, Fei Lee, Anil P. Bidkar +22 more

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature

Science Advances(2022)10.1126/sciadv.abo5083

N/A

0.601DataRank · unranked

54 citations

Daniel W. Kneller, G.N. Phillips, Swati Pant, Silvia Russi, Aina E. Cohen +10 more

Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer

Cancer Discovery(2024)10.1158/2159-8290.cd-24-0559

N/A

0.590DataRank · unranked

50 citations

Fanny Polesso, Julie N. Graff, Jessica E. Hawley, Alexis K. Smith, Arian Lundberg +35 more

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

Nature Communications(2020)10.1038/s41467-019-14100-6

N/A

0.587DataRank · unranked

49 citations

Jean Abraham, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Alan Ashworth +95 more

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

Nature Communications(2020)10.1038/s41467-020-15047-9

N/A

0.578DataRank · unranked

46 citations

Daniel Nichol, Inmaculada Spiteri, Haider Tari, Luís Zapata, Timon Heide +7 more

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.24.393405

N/A

0.561DataRank · unranked

41 citations

G.J. Correy, Stefan Gahbauer, D. Fearon, Taiasean Wu, Roberto Efraín Díaz +47 more

Klotho and the Treatment of Human Malignancies

Cancers(2020)10.3390/cancers12061665

N/A

0.561DataRank · unranked

41 citations

Jérôme Gouge, Christos Kontovounisios, Stella Nikolaou, Alan Ashworth, Kenneth Lim +2 more

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo

PLoS Pathogens(2023)10.1371/journal.ppat.1011614

N/A

0.546DataRank · unranked

37 citations

Rahul K. Suryawanshi, Irene P. Chen, G.J. Correy, Maria McCavitt-Malvido, Patrick C. O’Leary +12 more

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

10.1101/2022.04.20.488974

N/A

0.542DataRank · unranked

36 citations

Winnie Yao, Nghi Ly, Katherine A. Freitas, Yan-Ting Chen, Quanming Shi +14 more

Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy

Cancer Discovery(2024)10.1158/2159-8290.cd-23-1459

N/A

0.483DataRank · unranked

24 citations

Martha A. Cady, Calixto‐Hope G. Lucas, Hinda Najem, Joanna J. Phillips, Brisa Palikuqi +18 more

Common Susceptibility Loci for Male Breast Cancer

JNCI Journal of the National Cancer Institute(2020)10.1093/jnci/djaa101

N/A

0.457DataRank · unranked

20 citations

Eleni Perraki, Katarzyna Tomczyk, Michael E. Jones, Olivia Fletcher, Matthew Pugh +38 more

Autoantibody Landscape in Patients with Advanced Prostate Cancer

Clinical Cancer Research(2020)10.1158/1078-0432.ccr-20-1966

N/A

0.457DataRank · unranked

20 citations

Winston Haynes, Rebecca Waitz, Kathy Kamath, Agustin Vega-Crespo, Raunak Shrestha +26 more

Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer

Nature Cancer(2024)10.1038/s43018-024-00848-4

N/A

0.396DataRank · unranked

13 citations

Michelle L. Badura, Patrick C. O’Leary, Henry M. Delavan, Troy M. Robinson, Emily A. Egusa +10 more

PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM -Deficient Tumors and Potent Synergy With PARP Inhibitors

Molecular Cancer Therapeutics(2022)10.1158/1535-7163.mct-22-0217

N/A

0.393DataRank · unranked

11 citations

Shaun D. Fontaine, Morgan E. Diolaiti, Parth Desai, Rajesh Kumar, Nobuyuki Takahashi +9 more

The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2

10.1101/2024.08.08.606661

N/A

0.385DataRank · unranked

12 citations

Priyadarshini Jaishankar, G.J. Correy, Moira Rachman, Patrick C. O’Leary, Taha Y. Taha +26 more

Extensive exploration of structure activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment merging and active learning

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.25.609621

N/A

0.345DataRank · unranked

9 citations

Moira Rachman, Takaya Togo, Stefan Gahbauer, Yagmur U. Doruk, Maisie GV Stevens +12 more

Large tandem duplications in cancer result from transcription and DNA replication collisions

medRxiv(2023)10.1101/2023.05.17.23290140

N/A

0.301DataRank · unranked

4 citations

Michelle L. Badura, Patrick C. O’Leary, Henry M. Delavan, Troy M. Robinson, Emily A. Egusa +10 more

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.18.537104

N/A

0.255DataRank · unranked

3 citations

Rahul K. Suryawanshi, Irene P. Chen, G.J. Correy, Patrick C. O’Leary, Manasi P. Jogalekar +10 more

AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid

mBio(2025)10.1128/mbio.01698-25

N/A

0.241DataRank · unranked

4 citations

Leah T. Roe, Yuping Li, Adair L. Borges, Jenny Y. Zhang, Palak Babbar +11 more

5-hydroxymethylcytosine as a liquid biopsy biomarker in mCRPC.

Journal of Clinical Oncology(2021)10.1200/jco.2021.39.6_suppl.148

N/A

0.208DataRank · unranked

3 citations

Shuang G. Zhao, Eric J. Small, Yuhong Ning, Corinne Maurice‐Dror, Adam Foye +15 more

De novo design of drug-binding proteins with predictable binding energy and specificity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.23.573178

N/A

0.208DataRank · unranked

3 citations

Xuxu Gou, Sophia K. Tan, Samuel I. Mann, Hyunjun Yang, Xiaofang Zhong +9 more

An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels

Cell chemical biology(2025)10.1016/j.chembiol.2025.10.006

N/A

0.174DataRank · unranked

2 citations

Rebecca G. Donahue, Jessica Ma, Ying Mao, Morgan E. Diolaiti, Alan Ashworth +1 more

Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.23.614494

N/A

0.115DataRank · unranked

1 citations

Letitia Sarah, Daniela Pucciarelli, Yingwei Mao, Morgan E. Diolaiti, Danica Galonić Fujimori +2 more

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

eLife(2025)10.7554/elife.103484.3

N/A

0.104DataRank · unranked

1 citations

Priyadarshini Jaishankar, G.J. Correy, Moira Rachman, Patrick C. O’Leary, Taha Y. Taha +26 more

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.27.497816

N/A

0DataRank · unranked

15 citations

G.J. Correy, M. Schuller, Matteo P. Ferla, Yagmur U. Doruk, Moira Rachman +17 more

AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.26.609590

N/A

0DataRank · unranked

0 citations

Leah T. Roe, Yuping Li, Adair L. Borges, Jenny Y. Zhang, Palak Babbar +11 more

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.07.479477

N/A

0DataRank · unranked

4 citations

Daniel W. Kneller, G.N. Phillips, Swati Pant, Silvia Russi, Aina E. Cohen +10 more

Structure-activity relationship studies on 2-thienylidene substituted 3-oxo-2,3-dihydrobenzofuran-7-carboxamides as poly (ADP-ribose) polymerase inhibitors

Bioorganic Chemistry(2025)10.1016/j.bioorg.2025.108941

N/A

0DataRank · unranked

1 citations

Ugochi A. Adiele, Griffin Coate, Morgan E. Diolaiti, Huadong Chen, Junhao Lu +11 more

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

eLife(2025)10.7554/elife.103484

N/A

0DataRank · unranked

7 citations

Priyadarshini Jaishankar, G.J. Correy, Moira Rachman, Patrick C. O’Leary, Taha Y. Taha +26 more

Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.64898/2025.12.25.696505

N/A

0DataRank · unranked

5 citations

G.J. Correy, Brendan W. Hall, Moira Rachman, Olivier Mailhot, Takaya Togo +15 more

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.11.681833

N/A

0DataRank · unranked

3 citations

G.J. Correy, Yusuke Matsui, Takaya Togo, Moira Rachman, Maisie GV Stevens +14 more

Reviewer #2 (Public review): The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2

(2025)10.7554/elife.103484.1.sa1

N/A

0DataRank · unranked

0 citations

Priyadarshini Jaishankar, Galen J Correy, Moira M Rachman, Patrick C O’Leary, Taha Y Taha +22 more

Identification and Characterization of PLUTO-201, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.21.655369

N/A

0DataRank · unranked

0 citations

Noah Younger, Bhavna Malik, Hyun Jin Shin, Chao Zhang, Yashar Niknafs +24 more

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.05.680562

N/A

0DataRank · unranked

0 citations

Stefanie Bachl, Luis R Sandoval, Carter Ching, Christopher Bowman, Nupura Kale +22 more

Macrodomain catalytic activity modulates Chikungunya virus dissemination and transmission potential in Aedes mosquitoes

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.09.681498

N/A

0DataRank · unranked

0 citations

Lena Bergmann, Annabelle Henrion Lacritick, Jared C. Nigg, G.J. Correy, Alan Ashworth +3 more

Identification of a Two-Gene Biomarker Correlated with Sensitivity to Combined PARP7 Inhibition and AHR Activation in Cancer Cells

Cancer Research Communications(2025)10.1158/2767-9764.crc-25-0173

N/A

0DataRank · unranked

0 citations

Huadong Chen, Morgan E. Diolaiti, Alan Ashworth, Xuxu Gou

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

Science Advances(2021)10.1126/sciadv.abf8711

N/A

0DataRank · unranked

209 citations

G.J. Correy, Stefan Gahbauer, D. Fearon, Taiasean Wu, Roberto Efraín Díaz +48 more

ADP‐ribosyltransferases, an update on function and nomenclature

FEBS Journal(2021)10.1111/febs.16142

N/A

0DataRank · unranked

330 citations

Ivan Ahel, Matthias Altmeyer, Alan Ashworth, Péter Bai, Paul Chang +42 more

Data from Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2

(2023)10.1158/0008-5472.c.6513989

N/A

0DataRank · unranked

0 citations

Huadong Chen, Yagmur U. Doruk, Tess Williamson, Benjamin J. Polacco, Andrew S. McNeal +13 more

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2212931120

N/A

0DataRank · unranked

132 citations

G.J. Correy, M. Schuller, Matteo P. Ferla, Yagmur U. Doruk, Moira Rachman +17 more

De novo design of drug-binding proteins with predictable binding energy and specificity

Science(2024)10.1126/science.adl5364

N/A

0DataRank · unranked

69 citations

Xuxu Gou, Sophia K. Tan, Samuel I. Mann, Hyunjun Yang, Xiaofang Zhong +9 more

Validation of Anticorrelated TGFβ Signaling and Alternative End-Joining DNA Repair Signatures that Predict Response to Genotoxic Cancer Therapy

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-21-2846

N/A

0DataRank · unranked

14 citations

Qi Liu, Miguel Ángel Pujana, Patrick Ha, Josep Piulats, Isabel Linares +8 more

Hypoxia is a dominant remodeler of the CD8 + T cell surface proteome relative to activation and regulatory T cell-mediated suppression

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.07.447379

N/A

0DataRank · unranked

0 citations

Amy M. Weeks, Eric Shifrut, Julia Carnevale, Lisa L. Kirkemo, Alan Ashworth +3 more

PARP7 Inhibitors and AHR Agonists Act Synergistically across a Wide Range of Cancer Models

Molecular Cancer Therapeutics(2024)10.1158/1535-7163.mct-24-0211

N/A

0DataRank · unranked

12 citations

Xuxu Gou, Ying Mao, Patrick C. O’Leary, Morgan E. Diolaiti, Alan Ashworth +1 more