Kim L. R. Brouwer

University of North Carolina at Chapel Hill

ORCID: 0000-0003-1945-4929

MedicinePharmacology, Toxicology and Pharmaceutics

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 76 papers. Top paper: “Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo”.

Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo

Small(2020)10.1002/smll.201906360

N/A

1.1DataRank · unranked

23 citations

Yusra B. Medik, Liantao Li, Xi Tian, Dong Fu, Kim L. R. Brouwer +6 more

Role of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions

Toxicological Sciences(2020)10.1093/toxsci/kfaa052

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0.739DataRank · unranked

23 citations

Jacqueline Bezençon, Noora Sjöstedt, John K. Fallon, Kim L. R. Brouwer, James J. Beaudoin

Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

UNC Libraries(2020)10.17615/ggm4-4r76

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0.241DataRank · unranked

4 citations

Curtis Johnston, Brian C. Ferslew, W-Y Jia, Kim L. R. Brouwer, Eleftheria Tsakalozou +4 more

Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00825

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0.241DataRank · unranked

4 citations

Abigail K. Mayo, Anirban Ghoshal, Sharon Taft-Benz, Elizabeth J. Anderson, Noah L. Morales +7 more

Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β)

Molecular Pharmacology(2021)10.1124/molpharm.121.000345

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0.208DataRank · unranked

3 citations

James J. Beaudoin, Tuomo Laitinen, Noora Sjöstedt, Melina M. Malinen, Henry Ho +4 more

Decreased Hepatic Breast Cancer Resistance Protein Expression and Function in Multidrug Resistance-Associated Protein 2-Deficient (TR-) Rats

UNC Libraries(2020)10.17615/461k-ad65

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0.165DataRank · unranked

2 citations

Kim L. R. Brouwer, Wenji Yue, Y. Sugiyama, Jiyeon Lee, K. Abe

Understanding Coproporphyrins and Their Disposition: Coproporphyrinuria is Common, of Diverse Cause, and Rarely Indicates Porphyria

The American Journal of Medicine(2025)10.1016/j.amjmed.2025.04.004

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0.165DataRank · unranked

2 citations

D. Christopher, Manuela Araque, Jacqueline B. Tiley, Kim L. R. Brouwer, Ulrich Stölzel +1 more

In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats

UNC Libraries(2020)10.17615/dcff-r207

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0.165DataRank · unranked

2 citations

D. R. Thakker, P. F. Augustijns, P. P. Annaert, D. K. Benjamin, Kim L. R. Brouwer +1 more

Risk Factors for Development of Cholestatic Drug-Induced Liver Injury: Inhibition of Hepatic Basolateral Bile Acid Transporters Multidrug Resistance-Associated Proteins 3 and 4

UNC Libraries(2020)10.17615/7aby-5937

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0.104DataRank · unranked

1 citations

K. Yang, P. W. Swaan, T. J. Urban, B. C. Ferslew, P. W. Stewart +3 more

Sex-Dependent Disposition of Acetaminophen Sulfate and Glucuronide in the in Situ Perfused Mouse Liver

UNC Libraries(2020)10.17615/f1tt-yg60

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0.104DataRank · unranked

1 citations

G. M. Pollack, N. J. Patel, Jiyeon Lee, A. S. Bridges, K. Abe +2 more

In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison with in Vivo Biliary Clearance

UNC Libraries(2020)10.17615/nxqv-4357

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0DataRank · unranked

2 citations

K. Abe, A. S. Bridges, Wenji Yue, Kim L. R. Brouwer

Hepatobiliary Disposition of Troglitazone and Metabolites in Rat and Human Sandwich-Cultured Hepatocytes: Use of Monte Carlo Simulations to Assess the Impact of Changes in Biliary Excretion on Troglitazone Sulfate Accumulation

UNC Libraries(2020)10.17615/8sqy-r564

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0DataRank · unranked

2 citations

K. Abe, Kim L. R. Brouwer, C. Lim, T. L. Marion, G. M. Pollock +1 more

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid–Mediated Troglitazone Hepatotoxicity

UNC Libraries(2020)10.17615/w6gf-6j96

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0DataRank · unranked

1 citations

J. L. Woodhead, Kyunghee Yang, Kim L. R. Brouwer, B. A. Howell, Paul B. Watkins

A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair

UNC Libraries(2020)10.17615/j4jc-wg15

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0DataRank · unranked

1 citations

C. N. Generaux, R. B. Goldsmith, R. R. Tidwell, C. A. Olson, M. F. Paine +5 more

Fluconazole Population Pharmacokinetics and Dosing for Prevention and Treatment of Invasive Candidiasis in Children Supported with Extracorporeal Membrane Oxygenation

UNC Libraries(2020)10.17615/hjdm-4252

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, Michael Cohen‐Wolkowiez, Kelly C. Wade, Daniel González, Daniel K. Benjamin +3 more

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

UNC Libraries(2020)10.17615/y3qj-7h58

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, Robert L. St. Claire, Tracy L. Marion, Cassandra H. Perry

Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes

UNC Libraries(2020)10.17615/f3e9-h807

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, K. K. Wolf, K. R. Brouwer, G. M. Pollack

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

UNC Libraries(2020)10.17615/np5e-wq20

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, Elaine M. Leslie, Giulia Ghibellini, Gary M. Pollack

Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

UNC Libraries(2020)10.17615/06yh-xz53

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0DataRank · unranked

0 citations

J. Li, Kim L. R. Brouwer, N. J. Patel, G. M. Pollack, P. Zhang +4 more

Relationship between Drug/Metabolite Exposure and Impairment of Excretory Transport Function

UNC Libraries(2020)10.17615/evcq-3w29

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0DataRank · unranked

0 citations

J. C. Kalvass, Maciej J. Zamek‐Gliszczynski, Kim L. R. Brouwer, G. M. Pollack

Role of Multidrug Resistance-Associated Protein 4 in the Basolateral Efflux of Hepatically Derived Enalaprilat

UNC Libraries(2020)10.17615/s6h1-v341

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, K. Kock, A. S. Bridges, B. C. Ferslew

Apparent Differences in Mechanisms of Harmol Sulfate Biliary Excretion in Mice and Rats

UNC Libraries(2020)10.17615/0ep9-hh27

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0DataRank · unranked

0 citations

K.-i. Nezasa, K. A. Hoffmaster, Maciej J. Zamek‐Gliszczynski, Kim L. R. Brouwer

Hepatocellular Exposure of Troglitazone Metabolites in Rat Sandwich-Cultured Hepatocytes Lacking Bcrp and Mrp2: Interplay between Formation and Excretion

UNC Libraries(2020)10.17615/rzs9-xh39

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, K. Yang

Toward Predicting Drug-Induced Liver Injury: Parallel Computational Approaches to Identify Multidrug Resistance Protein 4 and Bile Salt Export Pump Inhibitors

UNC Libraries(2020)10.17615/xa1t-ry39

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, T. J. Urban, M. A. Welch, K. Kock, P. W. Swaan

Mechanisms Underlying Differences in Systemic Exposure of Structurally Similar Active Metabolites: Comparison of Two Preclinical Hepatic Models

UNC Libraries(2020)10.17615/ss2t-qh31

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0DataRank · unranked

0 citations

R. R. Tidwell, M. Z. Wang, Kim L. R. Brouwer, G. M. Pollack, G. Z. Yan +2 more

Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases

UNC Libraries(2020)10.17615/crqs-3d95

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0DataRank · unranked

0 citations

Kristi Stubbert, Evan D. Kharasch, Ronald J. Falk, Melanie S. Joy, Reginald F. Frye +1 more

Methods To Evaluate Biliary Excretion of Drugs in Humans: An Updated Review

UNC Libraries(2020)10.17615/mtrq-xe23

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, Giulia Ghibellini, Elaine M. Leslie

In Vivo Alterations in Drug Metabolism and Transport Pathways in Patients with Chronic Kidney Diseases

UNC Libraries(2020)10.17615/650r-ks77

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0DataRank · unranked

0 citations

Reginald F. Frye, Melanie S. Joy, Brittney V. Roberts, Ronald J. Falk, Jinzhao Wang +4 more

Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

UNC Libraries(2020)10.17615/gf1y-8d34

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0DataRank · unranked

0 citations

Xianbin Tian, Kim L. R. Brouwer, Brandon Swift

Pharmacokinetics and Safety of Micafungin in Infants Supported With Extracorporeal Membrane Oxygenation

UNC Libraries(2020)10.17615/03zr-gd38

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0DataRank · unranked

0 citations

Daniel K. Benjamin, Kim L. R. Brouwer, Christoph P. Hornik, Susan R. Hupp, Julie Autmizguine +2 more

Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity

UNC Libraries(2020)10.17615/y0pw-g729

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0DataRank · unranked

0 citations

Jin Kyung Lee, Kim L. R. Brouwer, Maciej J. Zamek‐Gliszczynski, Elaine M. Leslie

Differential Disposition of Chenodeoxycholic Acid versus Taurocholic Acid in Response to Acute Troglitazone Exposure in Rat Hepatocytes

UNC Libraries(2020)10.17615/gmwa-aa94

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0DataRank · unranked

0 citations

Robert L. St. Claire, Tracy L. Marion, Cassandra H. Perry, Yue, Wei, Kim L. R. Brouwer

Evaluation of 99mTechnetium-Mebrofenin and 99mTechnetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes

UNC Libraries(2020)10.17615/e0ct-y043

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0DataRank · unranked

0 citations

Yue, Wei, Kim L. R. Brouwer, Brandon Swift

A novel method for the determination of biliary clearance in humans

UNC Libraries(2020)10.17615/jh3a-3191

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0DataRank · unranked

0 citations

Richard J. Kowalsky, Kim L. R. Brouwer, Guilia Ghibellini, Brendan M. Johnson, William D. Heizer

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis

UNC Libraries(2020)10.17615/8nec-th10

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0DataRank · unranked

0 citations

Fred B. Lih, A. Sidney Barritt, Weibin Zha, Darryl C. Zeldin, Craig R. Lee +8 more

Combination Lopinavir and Ritonavir Alter Exogenous and Endogenous Bile Acid Disposition in Sandwich-Cultured Rat Hepatocytes

UNC Libraries(2020)10.17615/s5pd-1z21

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0DataRank · unranked

0 citations

P. B. Watkins, C. H. Perry, R. L. St. Claire, Kim L. R. Brouwer, L. M. Griffin

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids

INDIGO (University of Illinois at Chicago)(2020)10.17615/8fee-2694

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0DataRank · unranked

0 citations

Mingming Su, Guoxiang Xie, Brian C. Ferslew, Cynthia Rajani, Changxiao Liu +3 more

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

UNC Libraries(2020)10.17615/3yv9-0837

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0DataRank · unranked

0 citations

Kristina Wolf, Joseph W. Polli, Sapana Vora, Grant T. Generaux, Kim L. R. Brouwer +1 more

Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis

UNC Libraries(2020)10.17615/jd3t-gf64

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0DataRank · unranked

0 citations

Joyce A. Goldstein, Mary K. La, Ronald J. Falk, Reginald F. Frye, Mary Anne Dooley +7 more

A Perspective on Efflux Transport Proteins in the Liver

UNC Libraries(2020)10.17615/fv56-2554

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0DataRank · unranked

0 citations

Kathleen Köck, Kim L. R. Brouwer

Multidrug Resistance-Associated Protein 2 Is Primarily Responsible for the Biliary Excretion of Fexofenadine in Mice

UNC Libraries(2020)10.17615/71s9-mb98

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0DataRank · unranked

0 citations

N. J. Patel, Maciej J. Zamek‐Gliszczynski, Xiaojin Tian, T. J. Raub, J. Li +3 more

Sulindac and Its Metabolites Inhibit Multiple Transport Proteins in Rat and Human Hepatocytes

UNC Libraries(2020)10.17615/6nff-as11

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, M. F. Paine, Jiyeon Lee

Knocking Down Breast Cancer Resistance Protein (Bcrp) by Adenoviral Vector-Mediated RNA Interference (RNAi) in Sandwich-Cultured Rat Hepatocytes: A Novel Tool To Assess the Contribution of Bcrp to Drug Biliary Excretion

UNC Libraries(2020)10.17615/wdqq-rz98

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, Kōji Abe, Yue, Wei

Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in Freshly Isolated Rat Hepatocytes

UNC Libraries(2020)10.17615/y6nz-0b32

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0DataRank · unranked

0 citations

D. A. J. Bow, Kim L. R. Brouwer, D. S. Miller, James B. Pritchard, J. L. Perry

Influence of Seeding Density and Extracellular Matrix on Bile Acid Transport and Mrp4 Expression in Sandwich-Cultured Mouse Hepatocytes

UNC Libraries(2020)10.17615/w09p-kz24

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0DataRank · unranked

0 citations

Brandon Swift, Kim L. R. Brouwer

Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

UNC Libraries(2020)10.17615/yw8y-pb88

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, LaToya M. Griffin, Pieter Annaert

Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors

UNC Libraries(2020)10.17615/j5xn-n435

N/A

0DataRank · unranked

0 citations

K. Abe, Kim L. R. Brouwer, A. S. Bridges

Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury

Toxicological Sciences(2021)10.1093/toxsci/kfab069

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0DataRank · unranked

40 citations

Kim L. R. Brouwer, Darren J. Creek, Thomas Kralj

Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

Frontiers in Pharmacology(2021)10.3389/fphar.2021.655320

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0DataRank · unranked

33 citations

John K. Fallon, Craig Sykes, Natasha Kulick, Rebecca J.B. Rementer, Taryn A. Miner +7 more

Impact of Basolateral Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 on the Hepatobiliary Disposition of Fexofenadine in Perfused Mouse Livers

UNC Libraries(2021)10.17615/np68-c226

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0DataRank · unranked

1 citations

Brandon Swift, Gary D. Kruh, Martin G. Belinsky, Xianbin Tian, Maciej J. Zamek‐Gliszczynski +1 more

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

Clinical Pharmacology & Therapeutics(2022)10.1002/cpt.2605

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0DataRank · unranked

66 citations

Raymond Evers, Elizabeth R. Hayden, Shuiying Hu, Cindy Yanfei Li, Henriette E. Meyer zu Schwabedissen +9 more

A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity

Scientific Reports(2022)10.1038/s41598-022-18174-z

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0DataRank · unranked

16 citations

Dong Fu, Henry Ho, A K Klein, John K. Fallon, Paavo Honkakoski +2 more

Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences

PLoS ONE(2022)10.1371/journal.pone.0278297

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0DataRank · unranked

3 citations

Rebekah L. Layton, Paul B. Watkins, Robert A. Nicholas, Kim L. R. Brouwer, Jacqueline E. McLaughlin

Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity

Toxicologic Pathology(2023)10.1177/01926233231212255

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0DataRank · unranked

23 citations

Kim L. R. Brouwer, Chitra Saran

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro

Frontiers in Pharmacology(2023)10.3389/fphar.2023.1147495

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0DataRank · unranked

8 citations

Henry Ho, Paavo Honkakoski, Kim L. R. Brouwer, Chitra Saran

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Pharmaceutical Research(2023)10.1007/s11095-023-03549-2

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0DataRank · unranked

0 citations

Catherine M. Pastor, Kim L. R. Brouwer, Angela Jeong

Effects of PFAS on human liver transporters: implications for health outcomes

Toxicological Sciences(2024)10.1093/toxsci/kfae061

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0DataRank · unranked

61 citations

Stephen Ferguson, Kim L. R. Brouwer, Ena Vujic

Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo

UNC Libraries(2024)10.17615/f4zv-7624

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0DataRank · unranked

0 citations

Yusra B. Medik, Liantao Li, Andrew Z. Wang, Kyle Wagner, Kim L. R. Brouwer +6 more

Effects of PFAS on human liver transporters: implications for health outcomes

UNC Libraries(2024)10.17615/mvw2-jc29

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0DataRank · unranked

0 citations

Kim L. R. Brouwer, Stephen Ferguson, Ena Vujic

Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability‐Limited Multicompartment Liver Model

CPT Pharmacometrics & Systems Pharmacology(2025)10.1002/psp4.70138

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0DataRank · unranked

1 citations

Noora Sjöstedt, Maïlys De Sousa Mendes, Mattie Hartauer, Kim L. R. Brouwer, Sibylle Neuhoff +1 more

Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with in Vivo Anti-alphaviral Activity

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.13.632788

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0DataRank · unranked

0 citations

Abigail K. Mayo, Anirban Ghoshal, Sharon Taft-Benz, Elizabeth J. Anderson, Noah L. Morales +7 more

Integrated transporter elucidation center: Identifying the SLC and ABC proteome in human placenta

Drug Metabolism and Pharmacokinetics(2025)10.1016/j.dmpk.2025.101423

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0DataRank · unranked

0 citations

Jacqueline B. Tiley, Nicole Chang, Madison A. Kalk, Michael J. Campbell, Kim L. R. Brouwer +3 more

Development of an in vitro Metabolic Dysfunction-Associated Steatohepatitis (MASH) model to study hepatic transporters

Drug Metabolism and Pharmacokinetics(2025)10.1016/j.dmpk.2025.101123

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0DataRank · unranked

0 citations

William A. Murphy, Thomas Kralj, John K. Fallon, Jacqueline B. Tiley, Kim L. R. Brouwer +1 more

Application of a permeability-limited multi-compartment liver (PerMCL) model to predict zonal hepatocellular statin concentrations in metabolic dysfunction-associated steatohepatitis (MASH)

Drug Metabolism and Pharmacokinetics(2025)10.1016/j.dmpk.2025.101404

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0DataRank · unranked

0 citations

Noora Sjöstedt, Mattie Hartauer, Kim L. R. Brouwer, Sibylle Neuhoff, William A. Murphy

Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure

CPT Pharmacometrics & Systems Pharmacology(2025)10.1002/psp4.70136

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0DataRank · unranked

0 citations

Mattie Hartauer, Tajhia L. Whigham, Maïlys De Sousa Mendes, Kim L. R. Brouwer, Mary F. Hébert +1 more

Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR−) Rats

Journal of Pharmaceutical Sciences(2020)10.1016/j.xphs.2020.10.017

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0DataRank · unranked

18 citations

Chitra Saran, Janine Hußner, James J. Beaudoin, Yueping Zhang, Hong Shen +5 more

Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters

Cellular and Molecular Life Sciences(2025)10.1007/s00018-025-05996-z

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0DataRank · unranked

0 citations

Henry Ho, Meimei Wan, William A. Murphy, Jacqueline B. Tiley, John K. Fallon +3 more

Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential

UNC Libraries(2020)10.17615/qgja-gr20

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10 citations

Christina Lourdes Mayer, Michael Fried, Julie C. Lauffenburger, Kim L. R. Brouwer, Joel F. Farley +1 more

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

UNC Libraries(2020)10.17615/fd7t-ns43

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18 citations

Brandon Swift, Nathan D. Pfeifer, Kim L. R. Brouwer

Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression

Journal of Pharmaceutical Sciences(2020)10.1016/j.xphs.2020.09.013

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0DataRank · unranked

31 citations

Natasha Kulick, Rebecca J.B. Rementer, John K. Fallon, Craig Sykes, Amanda P. Schauer +9 more

Hepatic Metabolism and Biliary Excretion of Silymarin Flavonolignans in Isolated Perfused Rat Livers: Role of Multidrug Resistance-Associated Protein 2 (Abcc2)

UNC Libraries(2020)10.17615/vwhc-pp44

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0DataRank · unranked

6 citations

Jiyeon Lee, Zhenhao Wen, R. L. Hawke, P. C. Smith, S. R. Miranda +1 more

Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk

Journal of Pharmacology and Experimental Therapeutics(2020)10.1124/jpet.119.263459

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4 citations

Noora Sjöstedt, Melina M. Malinen, Cen Guo, Kim L. R. Brouwer, Katsuaki Ito

An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

UNC Libraries(2020)10.17615/m9vs-7z94

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0DataRank · unranked

4 citations

Kyunghee Yang, Alexander Tropsha, Alexander Sedykh, Kim L. R. Brouwer, Kathleen Köck

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

UNC Libraries(2020)10.17615/ynge-h550

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4 citations

A. Moss, G. R. Rosania, J. P.F. Bai, J. W. Polli, Xintong Chu +9 more

Interaction of Silymarin Flavonolignans with Organic Anion-Transporting Polypeptides

UNC Libraries(2020)10.17615/hv57-3405

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3 citations

K. Kock, Y. Xie, Kim L. R. Brouwer, N. H. Oberlies, R. L. Hawke

Organic Cation Transporter 1 (OCT1/mOct1) Is Localized in the Apical Membrane of Caco-2 Cell Monolayers and Enterocytes

UNC Libraries(2020)10.17615/y1jz-9h48

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4 citations

W. R. Proctor, C. M. Ng, Kim L. R. Brouwer, C. L. Costales, R. S. Everett +2 more