Jacquelyn Sousa

University of Massachusetts Chan Medical School

Also affiliated with Rapt Therapeutics (United States)

Biochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 15 papers. Top paper: “Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection”.

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219523120

N/A

1.2DataRank · unranked

48 citations

Minwook Shin, Ching‐Wen Chang, Daniel O’Reilly, Annabelle Biscans, Ken Yamada +41 more

Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.07.029

N/A

0.561DataRank · unranked

41 citations

Dimas Echeverria, Jacquelyn Sousa, Anastasia Khvorova, Socheata Ly

RNAi-based modulation of IFN-γ signaling in skin

Molecular Therapy(2022)10.1016/j.ymthe.2022.04.019

N/A

0.533DataRank · unranked

34 citations

Jacquelyn Sousa, Dimas Echeverria, Xueli Fan, Ying-Chao Hsueh, Khashayar Afshari +10 more

Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease

Alzheimer s & Dementia(2024)10.1002/alz.13703

N/A

0.529DataRank · unranked

33 citations

Samuel Hildebrand, Bruno M.D.C. Godinho, Julianna Buchwald, Dimas Echeverria, Andrew H. Coles +10 more

A combinatorial approach for achieving CNS-selective RNAi

Nucleic Acids Research(2024)10.1093/nar/gkae100

N/A

0.385DataRank · unranked

12 citations

Bruno M.D.C. Godinho, Dimas Echeverria, Matthew Hassler, Lorenc Vangjeli, Jacquelyn Sousa +8 more

G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects

Nucleic Acids Research(2022)10.1093/nar/gkac1108

N/A

0DataRank · unranked

10 citations

Ezequiel Calvo-Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J. Kartje +6 more

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Nature Communications(2023)10.1038/s41467-023-42714-4

N/A

0DataRank · unranked

50 citations

Hassan H. Fakih, Mohammad Zain UI Abideen, Samuel Hildebrand, Khashayar Afshari, Katherine Y. Gross +31 more

Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo

Nucleic Acids Research(2024)10.1093/nar/gkae260

N/A

0DataRank · unranked

18 citations

Hassan H. Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Holly R McEachern +8 more

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy

Nucleic Acids Research(2025)10.1093/nar/gkaf479

N/A

0DataRank · unranked

15 citations

Samuel Hildebrand, Hannah J. MacMillan, Kathryn Monopoli, Julianna Buchwald, Jacquelyn Sousa +20 more

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

Nucleic Acids Research(2020)10.1093/nar/gkaa595

N/A

0DataRank · unranked

76 citations

Jillian Caiazzi, Sarah M. Davis, Nicholas McHugh, Jacquelyn Sousa, Anastasia Khvorova +1 more

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

Research Square(2025)10.21203/rs.3.rs-6465542/v1

N/A

0DataRank · unranked

0 citations

Ashley Summers, Amy E. Clipperton‐Allen, Jillian Caiazzi, Samuel Hildebrand, Daniel O’Reilly +11 more

2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.05.010

N/A

0DataRank · unranked

21 citations

Jacquelyn Sousa, Lorenc Vangjeli, Matthew Hassler, Dimas Echeverria, Emily G. Knox +4 more

An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

Molecular Therapy(2021)10.1016/j.ymthe.2021.11.007

N/A

0DataRank · unranked

46 citations

Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence M. Lifshitz +13 more

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Molecular Therapy — Nucleic Acids(2022)10.1016/j.omtn.2022.06.009

N/A

0DataRank · unranked

55 citations

Vignesh Hariharan, Agnes S. Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa +7 more

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts

Nucleic Acids Research(2022)10.1093/nar/gkac630

N/A

0DataRank · unranked

29 citations

Io Long Chan, Yuming Cao, Alisha M. Gruntman, Jonathan Lee, Jacquelyn Sousa +17 more