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The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

Nucleic Acids Research(2020)10.1093/nar/gkaa595Source: DataRank Database

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy is a research paper published in Nucleic Acids Research (2020). On theSindex it has a DataRank of 0. It has been cited 76 times.

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Open Access76 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 2.36)OA: goldTopics (58)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Jillian Caiazzi ORCID,Sarah M. Davis ORCID,Nicholas McHugh ORCID,Jacquelyn Sousa ORCID,Anastasia Khvorova ORCID

Live enrichment

PubMed:32672813 PMC:PMC7430635 OpenAlex:https://openalex.org/W3042395889

National Institutes of Health

Grant: R01 HD086111

National Institutes of Health

Grant: S10 OD020012

National Institutes of Health

Grant: R35 GM131839

National Institutes of Health

Grant: 5R01HD086111-03

Development of RNAi based sFLT1-targeting therapeutics for treatment of Preeclampsia

National Institutes of Health

Grant: 5R35GM131839-05

Chemical engineering of therapeutic RNAs for extrahepatic delivery

National Institutes of Health

Grant: 1S10OD020012-01

Mid-Scale RNA Synthesis, Purification and Quality Control System

FWCI

2.36

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

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2026

goldLicense: cc-by

journalhttps://doi.org/10.1093/nar/gkaa595

publisherhttps://doi.org/10.1093/nar/gkaa595

publisherhttp://academic.oup.com/nar/article-pdf/48/14/7665/34131419/gkaa595.pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32672813

repositoryhttps://escholarship.umassmed.edu/oapubs/4337

Fields of Study

RNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesMicroRNA in disease regulation0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsFemaleHydrophobic and Hydrophilic InteractionsMicePhosphorothioate OligonucleotidesRNA InterferenceRNA, Small InterferingTissue Distribution

MeSH Terms

AnimalsFemaleTissue DistributionRNA InterferenceRNA, Small InterferingMicePhosphorothioate OligonucleotidesHydrophobic and Hydrophilic Interactions

Keywords

Small interfering RNABiologyLinkerGene silencingEndosomeIn vivoRNA interferenceIntracellularDistribution (mathematics)Cell biologyBiophysicsRNABiochemistryGene570liver diseasesDigestive System DiseasesPhosphorothioate OligonucleotidesMiceChemical Biology and Nucleic Acid ChemistryStructural BiologyNucleic AcidsAnimalsSmall interfering RNAsTissue DistributionRNA, Small InterferingMolecular BiologyNucleotides540and NucleosidessiRNAsChemistrychemical structureFemaledeliveryHydrophobic and Hydrophilic Interactions

Sustainable Development Goals

SDG 3: 3. Good healthSDG 16: 16. Peace & justice