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Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential

European Journal of Medicinal Chemistry(2022)10.1016/j.ejmech.2022.115035Source: DataRank Database

Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential is a research paper published in European Journal of Medicinal Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 0.23)OA: hybridTopics (48)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

M.G. Cuypers ORCID,Mary Ashley Rimmer ORCID,Alireza Abdolvahabi ORCID,Trushar Jeevan,Gyanendra Kumar ORCID

Live enrichment

PubMed:36603507 OpenAlex:https://openalex.org/W4312081413

Comprehensive Cancer Center, City of Hope

Grant: CA021765

Howard Hughes Medical Institute

Grant: DE-AC02-05CH11231

National Institutes of Health

Grant: S10OD021832

National Institutes of Health

Grant: P30 GM124169

Basic Energy Sciences

Grant: W\u201031\u2010109\u2010Eng\u201038

Basic Energy Sciences

Grant: S10_RR028976

Basic Energy Sciences

Grant: S10_RR25528

Basic Energy Sciences

Grant: W‐31‐109‐Eng‐38

American Lebanese Syrian Associated Charities

Comprehensive Cancer Center, City of Hope

U.S. Department of Energy

Argonne National Laboratory

National Institute of General Medical Sciences

Office of Science

FWCI

0.23

Citation Percentile

0.5%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.ejmech.2022.115035

publisherhttps://doi.org/10.1016/j.ejmech.2022.115035

publisherhttps://api.elsevier.com/content/article/PII:S0223523422009370?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0223523422009370?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36603507

Fields of Study

RNA and protein synthesis mechanismsHIV Research and TreatmentInfluenza Virus Research StudiesHumansHIV Integrase InhibitorsRNA-Dependent RNA PolymeraseOrthomyxoviridaePyridonesInfluenza, HumanDibenzothiepinsEndonucleasesTriazinesAntiviral AgentsMorpholines

MeSH Terms

Antiviral AgentsDibenzothiepinsEndonucleasesHumansInfluenza, HumanMorpholinesOrthomyxoviridaePyridonesRNA-Dependent RNA PolymeraseTriazinesHIV Integrase Inhibitors

Keywords

IntegrasePolymeraseEndonucleaseRNAChemistryVirusActive siteVirologyRNA polymeraseRNA-dependent RNA polymeraseInfluenza A virusEnzymeDNABiochemistryBiologyGeneDrug resistanceMass spectrometryInfluenzaX-ray crystallographydrug discoveryRaltegravirPa(n) Endonuclease

Sustainable Development Goals

SDG 0: Good health and well-being