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Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100508Source: DataRank Database

Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity is a research paper published in Journal of Biological Chemistry (2021). On theSindex it has a DataRank of 0.786. It has been cited 34 times, with 20 citing works in its 1-hop citation network.

N/A

0.786DataRank · unranked

Scored on demand from live citation data

Open Access34 citations · 20 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)OA: goldTopics (14)IDs (PubMed)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 68%Citation Network 32%

Base Score Contribution

0.533

From this paper's citation signal

Citation Network Contribution

0.252

From 13 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 20 citers.

An in silico method to assess antibody fragment polyreactivity
Nature Communications202262 citations60 referencesContributes 0.069
A cationic amphiphilic peptide chaperone rescues Aβ 42 aggregation and cytotoxicity
RSC Medicinal Chemistry20224 citations50 referencesContributes 0.032
Elucidation of Amyloid-Beta’s Gambit in Oligomerization: Truncated Aβ fragments of residues Aβ1-23, Aβ1-24 and Aβ1-25 rapidly seed to form SDS-stable, LMW Aβ oligomers that impair synaptic plasticity
bioRxiv (Cold Spring Harbor Laboratory)20223 citations58 referencesContributes 0.024
Development of a human antibody fragment cross-neutralizing scorpion toxins
Molecular Immunology20233 citations59 referencesContributes 0.023
The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples
RSC Chemical Biology20252 citations51 referencesContributes 0.022

Authors (14)

Matthew D. Smith ORCID,Yulei Zhang ORCID,Emily K. Makowski ORCID,Julia E. Gerson ORCID,Edward Ionescu ORCID

Live enrichment

PubMed:19910364

National Institutes of Health

Grant: R01GM104130

National Institutes of Health

Grant: R35GM136300

National Institutes of Health

Grant: R01AG050598

National Institutes of Health

Grant: RF1AG059723

National Science Foundation

Grant: 1605266

National Science Foundation

Grant: CBET 1159943

National Science Foundation

Grant: 1813963

GOALI: Methods for designing antibodies specific for intrinsically disordered proteins

National Institutes of Health

Grant: 5R01AG050598-05

Mechanisms transducing insulin and insulin resistance in the hippocampus

National Institutes of Health

Grant: 7R01GM104130-05

Design of Antibody Fragments Specific For Amyloidogenic Aggregates

National Science Foundation

Grant: 1159943

Design of conformation-specific antibodies against unfolded and misfolded proteins

National Institutes of Health

Grant: 5R35GM136300-04

Structure-guided antibody targeting of pre-selected epitopes in amyloidogenic aggregates

National Institutes of Health

Grant: 3RF1AG059723-01S1

Design and Evolution of Polyvalent Domain Antibodies Specific for Tau Aggregates

goldLicense: cc-by

publisherhttps://doi.org/10.1016/j.jbc.2021.100508

publisherhttps://api.elsevier.com/content/article/PII:S0021925821002842?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925821002842?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8081927

http://www.jbc.org/article/S0021925821002842/pdf

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Models, MolecularAmyloidProtein ConformationAntibodies, MonoclonalBrainMiceCase-Control StudiesAnimalsHumansBinding Sites, AntibodyResearch Article

Sustainable Development Goals

SDG 3: 3. Good health

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co-cited

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Nature Communications(2022)

co-cited

10.1038/s41467-022-31457-3