John A. Tainer

Also affiliated with The University of Texas MD Anderson Cancer Center, Lawrence Berkeley National Laboratory

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 5%percentile

0.421Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Distinct sequence features underlie microdeletions and gross deletions in the human genome

Human Mutation(2021)10.1002/humu.24314

Top 44%

0.421DataRank

Top 44%8 citations

Peter D. Stenson, Edward V. Ball, John A. Tainer, Albino Bacolla, Hildegard Kehrer‐Sawatzki +3 more

Papers

Driven by 58 papers — median percentile 56. Top paper: “PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis”.

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Nature Cell Biology(2020)10.1038/s41556-020-0575-z

N/A

8.4DataRank · unranked

1022 citations

Rongce Zhao, Weiya Xia, Chiung-Wen Chang, Yun You, Jung-Mao Hsu +18 more

Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1

Cancer Discovery(2022)10.1158/2159-8290.cd-21-0900

N/A

3.2DataRank · unranked

133 citations

Yimin Duan, Yi Xiao, Kai Sun, Yutao Qi, Yuan Zhang +18 more

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles

Nature Communications(2023)10.1038/s41467-023-40096-1

N/A

0.974DataRank · unranked

40 citations

Sunetra Roy, Yue Chen, Karl-Heinz Tomaszowski, A.S. Arvai, Jordan T. Pepper +9 more

Mechanism of efficient double-strand break repair by a long non-coding RNA

Nucleic Acids Research(2020)10.1093/nar/gkaa784

N/A

0.596DataRank · unranked

52 citations

Jinglong Wang, Michal Hammel, Ruiqiong Ye, Ke Liang, Cheng‐Cao Sun +15 more

GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer

Nature Communications(2024)10.1038/s41467-024-46283-y

N/A

0.538DataRank · unranked

35 citations

Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy +10 more

Epigenetic–Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer

Cancer Research(2023)10.1158/0008-5472.can-22-3015

N/A

0.515DataRank · unranked

30 citations

Swagata Adhikari, Apoorva Bhattacharya, Sanjukta Chakraborty, Payel Mondal, Shalini S. Yadav +9 more

Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases

Nature Communications(2023)10.1038/s41467-023-38416-6

N/A

0.477DataRank · unranked

23 citations

Chunli Yan, Thomas Dodd, Chi-Lin Tsai, John A. Tainer, Susan E. Tsutakawa +2 more

Distinct sequence features underlie microdeletions and gross deletions in the human genome

Human Mutation(2021)10.1002/humu.24314

Top 44%

0.421DataRank

Top 44%8 citations

Peter D. Stenson, Edward V. Ball, John A. Tainer, Albino Bacolla, Hildegard Kehrer‐Sawatzki +3 more

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy

Molecular Cell(2023)10.1016/j.molcel.2023.06.011

N/A

0.406DataRank · unranked

14 citations

Luke Buerer, Ning Tsao, Albino Bacolla, Fadhel Mansoori, Timur Rusanov +17 more

Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.19.613927

N/A

0.256DataRank · unranked

4 citations

Keegan Bush, Nan Zhang, Raj K. Pandita, Chi-Lin Tsai, Charlene Smith +16 more

Two Interaction Surfaces between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.01.482439

N/A

0.241DataRank · unranked

4 citations

Hyun Suk Kim, Areetha D’Souza, Kaitlyn Gallagher, Eunwoo Jeong, Agnieszka M. Topolska‐Woś +9 more

RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stability

Nucleic Acids Research(2025)10.1093/nar/gkaf920

N/A

0.208DataRank · unranked

3 citations

Albino Bacolla, Suganya Rangaswamy, Manohar Kodavati, Joy Mitra, Issa Olakunle Yusuf +10 more

Enriched G4 forming repeats in the human genome are associated with robust well-coordinated transcription and reduced cancer transcriptome variation

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107822

N/A

0.165DataRank · unranked

2 citations

Albino Bacolla, Aleem Syed, John A. Tainer, Ruth B. De-Paula

Profiling human pathogenic repeat expansion regions by synergistic and multi-level impacts on molecular connections

Human Genetics(2022)10.1007/s00439-022-02500-6

N/A

0.104DataRank · unranked

1 citations

Ken Chen, Yukai Wang, Edward V. Ball, Peter D. Stenson, Matthew Mort +6 more

EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart

Molecular Cell(2021)10.1016/j.molcel.2021.05.027

N/A

0DataRank · unranked

48 citations

Chi-Lin Tsai, Raj K. Pandita, Albino Bacolla, Anirban Maitra, Vijay Charaka +11 more

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Molecular Cell(2021)10.1016/j.molcel.2021.09.024

N/A

0DataRank · unranked

47 citations

Joshua R. Brickner, Rebecca Rodell, Adit Ganguly, Matthew Wood, Clément Oyeniran +14 more

Target highlights in CASP14 : Analysis of models by structure providers

Proteins Structure Function and Bioinformatics(2021)10.1002/prot.26247

N/A

0DataRank · unranked

39 citations

Rosalba Lepore, Andriy Kryshtafovych, Athanassios Adamopoulos, Markus Alahuhta, Ann M. Arvin +33 more

GRB2 enforces homology-directed repair initiation by MRE11

Science Advances(2021)10.1126/sciadv.abe9254

N/A

0DataRank · unranked

38 citations

Shengfeng Xu, Yin Shi, Albino Bacolla, Aleem Syed, Davide Moiani +9 more

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

Communications Biology(2021)10.1038/s42003-021-01982-w

N/A

0DataRank · unranked

29 citations

Neus Bota‐Rabassedas, Masahiko Terajima, B. Leticia Rodriguez, Don L. Gibbons, Yulong Chen +18 more

An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation

Progress in Biophysics and Molecular Biology(2021)10.1016/j.pbiomolbio.2021.02.004

N/A

0DataRank · unranked

27 citations

Davide Moiani, Zamal Ahmed, Andy Arvai, Sarita Namjoshi, Dave S. Shin +10 more

Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication

Frontiers in Molecular Biosciences(2021)10.3389/fmolb.2021.791792

N/A

0DataRank · unranked

14 citations

Albino Bacolla, Panagiotis Katsonis, Amer Bralić, Samir M. Hamdan, Olivier Lichtarge +3 more

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100921

N/A

0DataRank · unranked

14 citations

Michal Hammel, Aleksandr Sverzhinsky, Miaw-Sheue Tsai, John M. Pascal, John A. Tainer +2 more

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

Methods in enzymology on CD-ROM/Methods in enzymology(2021)10.1016/bs.mie.2021.09.003

N/A

0DataRank · unranked

9 citations

Todd Link, Chris A. Brosey, Panagiotis Katsonis, Olivier Lichtarge, Youngchang Kim +8 more

Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2207408119

N/A

0DataRank · unranked

35 citations

Hyun-Suk Kim, Areetha D’Souza, Kaitlyn Gallagher, Eunwoo Jeong, Agnieszka M. Topolska‐Woś +9 more

Monitoring Nuclease Activity by X-Ray Scattering Interferometry Using Gold Nanoparticle-Conjugated DNA

Methods in molecular biology(2022)10.1007/978-1-0716-2063-2_12

N/A

0DataRank · unranked

7 citations

Aleem Syed, John A. Tainer, Greg L. Hura, Daniel J. Rosenberg

Applying HT-SAXS to chemical ligand screening

Methods in enzymology on CD-ROM/Methods in enzymology(2022)10.1016/bs.mie.2022.09.022

N/A

0DataRank · unranked

6 citations

Runze Shen, Davide Moiani, Darin E. Jones, Kathryn Burnett, Greg L. Hura +2 more

A condensate forming tether for lariat debranching enzyme is defective in non-photosensitive trichothiodystrophy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.03.515106

N/A

0DataRank · unranked

1 citations

Luke Buerer, Albino Bacolla, Timur Rusanov, Nicolas Schmidt, Sridhar Nonavinkere Srivatsan +13 more

HP1β Chromo Shadow Domain facilitates H2A ubiquitination for BRCA1 recruitment at DNA double-strand breaks

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.11.475809

N/A

0DataRank · unranked

0 citations

Sharmista Chakraborty, Chi-Lin Tsai, Xiaoyan Wang, Raj K. Pandita, John A. Tainer +3 more

Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.14.503918

N/A

0DataRank · unranked

0 citations

Jianli Dai, Susan E. Tsutakawa, Brian A. MacDonald, Joseph L. Alge, Malin Sund +6 more

Dynamics of the DYNLL1–MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs

Nature Structural & Molecular Biology(2023)10.1038/s41594-023-01074-9

N/A

0DataRank · unranked

28 citations

Rui Zhou, Aleem Syed, Lisa A. Moreau, Bartłomiej Tomasik, John A. Tainer +5 more

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity

Nucleic Acids Research(2023)10.1093/nar/gkad727

N/A

0DataRank · unranked

30 citations

František Filandr, Jeffrey Patterson-Fortin, Albino Bacolla, Ramya Ravindranathan, Jia Zhou +10 more

Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish

Developmental Dynamics(2023)10.1002/dvdy.590

N/A

0DataRank · unranked

2 citations

Jianli Dai, Susan E. Tsutakawa, Brian A. MacDonald, Joseph L. Alge, Malin Sund +6 more

Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology

Nature Communications(2024)10.1038/s41467-024-46610-3

N/A

0DataRank · unranked

25 citations

Vladimir Sarpe, Shaunak Raval, D. Alex Crowder, Morgan F. Khan, Pauline Douglas +7 more

Chemical screening by time-resolved X-ray scattering to discover allosteric probes

Nature Chemical Biology(2024)10.1038/s41589-024-01609-1

N/A

0DataRank · unranked

11 citations

Todd Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L. Hura +3 more

ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107368

N/A

0DataRank · unranked

8 citations

Roopa Thapar, Andy Arvai, Altaf H. Sarker, Jennifer M. Soll, Tanmoy Paul +14 more

Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer

Nature Communications(2024)10.1038/s41467-024-47242-3

N/A

0DataRank · unranked

3 citations

Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou +26 more

Author Correction: Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology

Nature Communications(2024)10.1038/s41467-024-47157-z

N/A

0DataRank · unranked

0 citations

Vladimir Sarpe, Shaunak Raval, D. Alex Crowder, Morgan F. Khan, Pauline Douglas +7 more

NADH-bound AIF activates the mitochondrial CHCHD4/MIA40 chaperone by a substrate-mimicry mechanism

The EMBO Journal(2025)10.1038/s44318-024-00360-6

N/A

0DataRank · unranked

16 citations

Runze Shen, John A. Tainer, Chris A. Brosey

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability

Molecular Cell(2025)10.1016/j.molcel.2025.05.010

N/A

0DataRank · unranked

10 citations

Syed Moiz Ahmed, Yue Chen, Chi-Lin Tsai, Sarita Namjoshi, Runze Shen +13 more

A predictive chromatin architecture nexus regulates transcription and DNA damage repair

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108300

N/A

0DataRank · unranked

6 citations

Sonali Bhan, Aindrila Kabiraj, Raj K. Pandita, Kenneth S. Ramos, Sandhik Nandi +9 more

RNA sculpting by the primordial Helix-clasp-Helix–Strand-Loop (HcH–SL) motif enforces chemical recognition enabling diverse KH domain functions

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108474

N/A

0DataRank · unranked

3 citations

Susan E. Tsutakawa, John A. Tainer

Information theory optimization of signals from small-angle scattering measurements

Biophysical Journal(2025)10.1016/j.bpj.2025.06.031

N/A

0DataRank · unranked

2 citations

John A. Tainer, Robert P. Rambo

Huntingtin preserves mitochondrial genome integrity in neurons, which is impaired in Huntington’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.24.666629

N/A

0DataRank · unranked

1 citations

Sagar Gaikwad, Chi-Lin Tsai, Charlene Smith, Nan Zhang, Keegan Bush +14 more

Human CDK5–cyclin B1 structures uncover a conserved mitotic CDK activation mechanism

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.10.675329

N/A

0DataRank · unranked

0 citations

Ke Cong, Xiao-Feng Zheng, Amy Verway-Cohen, Miaw-Sheue Tsai, Huy Nguyen +8 more

HP1β recruits RING1A to ubiquitinate histone H2A for BRCA1-mediated resection of double-stand breaks

iScience(2025)10.1016/j.isci.2025.114582

N/A

0DataRank · unranked

0 citations

Raj K. Pandita, Chi-Lin Tsai, Xiaoyan Aria Wang, Sharmista Chakraborty, Kenneth S. Ramos +9 more

Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1921311117

N/A

0DataRank · unranked

71 citations

Altaf H. Sarker, Clifford Y. Ng, A.S. Arvai, David Shin, Brian Shih +14 more

Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease

Progress in Biophysics and Molecular Biology(2020)10.1016/j.pbiomolbio.2020.09.010

N/A

0DataRank · unranked

63 citations

Alexander Cobban, Panagiotis Katsonis, Albino Bacolla, Susan E. Tsutakawa, Michal Hammel +6 more

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells

NAR Cancer(2020)10.1093/narcan/zcaa013

N/A

0DataRank · unranked

50 citations

Albino Bacolla, Haibo Wang, Zu Ye, Erika N. Guerrero, Wei Jiang +6 more

Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM

Progress in Biophysics and Molecular Biology(2020)10.1016/j.pbiomolbio.2020.09.003

N/A

0DataRank · unranked

20 citations

Daniel J. Rosenberg, Jan C. Bierma, Gregory L. Hura, Roopa Thapar, Susan P. Lees‐Miller +2 more

Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

Progress in Biophysics and Molecular Biology(2020)10.1016/j.pbiomolbio.2020.10.005

N/A

0DataRank · unranked

39 citations

Ashley M. Deacon, Matthew A. J. Duncton, Patricia Pellicena, Millie M. Georgiadis, Andrew Yeh +5 more

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin

Nucleic Acids Research(2020)10.1093/nar/gkaa1120

N/A

0DataRank · unranked

35 citations

Shiladitya Sengupta, Zu Ye, Chunying Yang, Joy Mitra, Ruth B. De-Paula +7 more

An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

Nucleic Acids Research(2020)10.1093/nar/gkaa1188

N/A

0DataRank · unranked

32 citations

Ishtiaque Rashid, Aleksandr Sverzhinsky, Yasin Pourfarjam, Miaw-Sheue Tsai, Tom Ellenberger +5 more

Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Nature Cell Biology(2020)10.1038/s41556-020-00599-1

N/A

0DataRank · unranked

39 citations

Rongce Zhao, Weiya Xia, Chiung-Wen Chang, Yun You, Jung-Mao Hsu +18 more

Polymerase Theta Inhibition Kills Homologous Recombination Deficient Tumors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.23.111658

N/A

0DataRank · unranked

17 citations

Camille Gelot, Constantia Pantelidou, Adam Y. Li, Hatice Yücel, Rachel E. Davis +9 more

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.28.271874

N/A

0DataRank · unranked

1 citations

Ning Tsao, Rebecca Rodell, Clément Oyeniran, Valentina Lukinović, Albino Bacolla +9 more

Structural insights into NHEJ: Building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time

UNC Libraries(2020)10.17615/qbme-5s41

N/A

0DataRank · unranked

0 citations

Susan P. Lees‐Miller, John A. Tainer, Dale A. Ramsden, Sarvan Kumar Radhakrishnan

Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy

Frontiers in Immunology(2021)10.3389/fimmu.2021.797880

N/A

0DataRank · unranked

70 citations

Yin Shi, Susan P. Lees-Miller, John A. Tainer, Zu Ye

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

Progress in Biophysics and Molecular Biology(2021)10.1016/j.pbiomolbio.2021.02.002

N/A

0DataRank · unranked

63 citations

Jerry H. Houl, Panagiotis Katsonis, L.P.F. Balapiti-Modarage, Shobanbabu Bommagani, Andy Arvai +9 more

John A. Tainer

Indexed papers

Top data-sharing exemplar

Papers