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Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?

Journal of Molecular Biology(2021)10.1016/j.jmb.2021.167123Source: DataRank Database

Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A? is a research paper published in Journal of Molecular Biology (2021). On theSindex it has a DataRank of 0. It has been cited 25 times.

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Open Access25 citations

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Enrichment:Funding (8 grants)Impact (FWCI 2.72)OA: bronzeTopics (46)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Yingjie Wang ORCID,Cristina Olivieri ORCID,Manu Veliparambil Subrahmanian ORCID,Jiali Gao ORCID,David Bernlohr ORCID

Live enrichment

PubMed:34224748 PMC:PMC8409435 OpenAlex:https://openalex.org/W3179392193

National Natural Science Foundation of China

Grant: 22007069

NIH

Grant: GM046736

NIH

Grant: S10 OD021536

NIH

Grant: GM100310

American Heart Association

Grant: 20PRE35120253

NIGMS NIH HHS

Grant: R01 GM046736

NIGMS NIH HHS

Grant: R01 GM100310

NIGMS NIH HHS

Grant: R35 GM130389

FWCI

2.72

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

bronzeLicense: cc-by-nc-nd

journalhttps://ars.els-cdn.com/content/image/1-s2.0-S0022283621003478-ga1_lrg.jpg

publisherhttps://ars.els-cdn.com/content/image/1-s2.0-S0022283621003478-ga1_lrg.jpg

publisherhttps://api.elsevier.com/content/article/PII:S0022283621003478?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0022283621003478?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jmb.2021.167123

Fields of Study

Hormonal Regulation and HypertensionPituitary Gland Disorders and TreatmentsCancer, Hypoxia, and MetabolismAllosteric RegulationCatalytic DomainCushing SyndromeCyclic AMP-Dependent Protein Kinase Catalytic SubunitsCyclic AMP-Dependent Protein KinasesHumansMutationNucleotidesPhenotypePhosphorylationProtein ConformationSubstrate Specificity

MeSH Terms

Allosteric RegulationCushing SyndromeHumansMutationNucleotidesPhenotypePhosphorylationProtein ConformationSubstrate SpecificityCyclic AMP-Dependent Protein KinasesCatalytic DomainCyclic AMP-Dependent Protein Kinase Catalytic Subunits

Keywords

Allosteric regulationCooperativityAllosteric enzymeMutationProtein subunitMutantProtein kinase ABiologyKinaseChemistryBiophysicsGeneticsBiochemistryEnzymeGeneCushing's SyndromeAllosteryBinding CooperativityCamp-dependent Protein Kinase A