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Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition

Structure(2020)10.1016/j.str.2020.04.012Source: DataRank Database

Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition is a research paper published in Structure (2020). On theSindex it has a DataRank of 0. It has been cited 42 times.

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Open Access42 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)Impact (FWCI 1.86)OA: bronzeTopics (69)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
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Reusable (0/3)

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Authors (5)

Meredith L. Jenkins ORCID,Gregory G. Tall ORCID,John E. Burke ORCID,Alan V. Smrcka ORCID,Isaac J. Fisher ORCID

Live enrichment

PubMed:32402248 PMC:PMC7891876 OpenAlex:https://openalex.org/W3024889382

National Institutes of Health

Grant: R35GM127303

NIGMS NIH HHS

Grant: R01 GM088242

Natural Sciences and Engineering Research Council of Canada

Grant: unidentified

unidentified

National Institutes of Health

Natural Sciences and Engineering Research Council of Canada

FWCI

1.86

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S0969212620301337/pdf

publisherhttp://www.cell.com/article/S0969212620301337/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0969212620301337?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969212620301337?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.str.2020.04.012

Fields of Study

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and SignalingMetabolism, Diabetes, and Cancer0301 basic medicine0303 health sciences03 medical and health sciencesAllosteric RegulationAnimalsBinding SitesCOS CellsChlorocebus aethiopsGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsPhospholipase C betaProtein BindingSf9 CellsSpodoptera

MeSH Terms

Allosteric RegulationAnimalsBinding SitesChlorocebus aethiopsProtein BindingSpodopteraCOS CellsGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsPhospholipase C betaSf9 Cells

Keywords

Gq alpha subunitCTDPhospholipase CChemistryG protein-coupled receptorC-terminusDiacylglycerol kinasePhospholipaseG proteinBiophysicsStereochemistryBiochemistryEnzymeReceptorBiologyProtein kinase CAmino acidLipidsSignal transductionprotein dynamicsG-protein-coupled ReceptorGpcrMembrane InteractionsHydrogen-deuterium ExchangeGαqHdx-msGβγBinding SitesGTP-Binding Protein beta SubunitsPhospholipase C betaSpodopteraAllosteric RegulationGTP-Binding Protein gamma SubunitsCOS CellsChlorocebus aethiopsSf9 CellsAnimalsGTP-Binding Protein alpha Subunits, Gq-G11Protein Binding

Sustainable Development Goals

SDG 0: Clean water and sanitation

Additional file 1 of Effect of PLC-β1/CaM signaling pathway mediated by AT1R on the occurrence and development of hepatocellular carcinoma

10.6084/m9.figshare.16921490.v1figshare

Additional file 1 of Effect of PLC-β1/CaM signaling pathway mediated by AT1R on the occurrence and development of hepatocellular carcinoma

10.6084/m9.figshare.16921490figshare

Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition

FAIR Checklist

Authors (5)

Funding (5 grants)

Impact

Open Access

Topics

Linked Datasets (2)

Annotations (Europe PMC)