John E. Burke

Also affiliated with University of Victoria

Biochemistry, Genetics and Molecular BiologyMedicineChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 44 papers. Top paper: “Accurate prediction of protein structures and interactions using a three-track neural network”.

Accurate prediction of protein structures and interactions using a three-track neural network

Science(2021)10.1126/science.abj8754

N/A

1.3DataRank · unranked

5820 citations

Frank DiMaio, Ivan Anishchenko, Justas Dauparas, Sergey Ovchinnikov, Gyu Rie Lee +27 more

Structure of autoinhibited Akt1 reveals mechanism of PIP 3 -mediated activation

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2101496118

N/A

0.680DataRank · unranked

92 citations

Harald Hornegger, Dorothea Anrather, Markus Hartl, Kaelin D. Fleming, Jordan T. B. Stariha +5 more

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

Nature Communications(2023)10.1038/s41467-023-38725-w

N/A

0.606DataRank · unranked

56 citations

Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller +7 more

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

eLife(2021)10.7554/elife.64691

N/A

0.606DataRank · unranked

56 citations

Zied Gaieb, Kaelin D. Fleming, Chiara Borsari, Noah J Harris, Brandon E. Moeller +4 more

Biolayer interferometry for measuring the kinetics of protein–protein interactions and nanobody binding

Nature Protocols(2024)10.1038/s41596-024-01079-8

N/A

0.604DataRank · unranked

55 citations

Sintayehu K Gurmessa, Jules B. Weinstein, Mila Trank-Greene, Xammy Huu Wrynla, Aidan Anastas +6 more

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Journal of Clinical Investigation(2023)10.1172/jci165019

N/A

0.568DataRank · unranked

43 citations

Museer A. Lone, Winston Lee, Laura Capolupo, Sylvia Ho, Adekemi M. Adeyemi +80 more

Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition

Structure(2020)10.1016/j.str.2020.04.012

N/A

0.564DataRank · unranked

42 citations

Meredith L. Jenkins, Gregory G. Tall, John E. Burke, Alan V. Smrcka, Isaac J. Fisher

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

eLife(2023)10.7554/elife.88058

N/A

0.345DataRank · unranked

9 citations

Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad +7 more

HDX-MS optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.01.446614

N/A

0.208DataRank · unranked

3 citations

Kaelin D. Fleming, Udit Dalwadi, Els Pardon, Noah J Harris, Calvin K. Yip +3 more

Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110886

N/A

0.104DataRank · unranked

1 citations

Alexandria L Shaw, Damilola K Akintola, Martine Lunke, Sophia Doerr, Pooja Rohilla +6 more

Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.01.446612

N/A

0DataRank · unranked

0 citations

Udit Dalwadi, Kaelin D. Fleming, Carson Adams, Jordan TB Stariha, Els Pardon +8 more

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

eLife(2022)10.7554/elife.77809

N/A

0DataRank · unranked

18 citations

Jordan TB Stariha, Reece M. Hoffmann, Brenda Temple, Qisheng Zhang, Nicole Hajicek +4 more

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.17.516819

N/A

0DataRank · unranked

2 citations

Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller +7 more

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.23.481568

N/A

0DataRank · unranked

0 citations

Jordan TB Stariha, Reece M. Hoffmann, Brenda Temple, Qisheng Zhang, Nicole Hajicek +4 more

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Cell Reports(2023)10.1016/j.celrep.2023.112172

N/A

0DataRank · unranked

29 citations

Meredith L. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, Noah J Harris, John T. Evans +9 more

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

eLife(2023)10.7554/elife.91930

N/A

0DataRank · unranked

18 citations

Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka +11 more

Toxoplasma gondii mitochondrial association factor 1b interactome reveals novel binding partners including Ral GTPase accelerating protein α1

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105582

N/A

0DataRank · unranked

3 citations

Meredith L. Jenkins, Tara Hill, Matthew L. Blank, Leah F. Cabo, L. Thompson +4 more

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.16.553641

N/A

0DataRank · unranked

1 citations

Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka +11 more

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

eLife(2023)10.7554/elife.91930.1

N/A

0DataRank · unranked

1 citations

Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka +10 more

Reviewer #2 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

(2023)10.7554/elife.88058.2.sa1

N/A

0DataRank · unranked

0 citations

Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew Parson, Harish Ranga-Prasad +7 more

Novel roles of phosphoinositides in signaling, lipid transport, and disease

Current Opinion in Cell Biology(2020)10.1016/j.ceb.2019.12.007

N/A

0DataRank · unranked

208 citations

John E. Burke, Gerald Hammond

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

(2023)10.7554/elife.88058.2

N/A

0DataRank · unranked

0 citations

Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad +7 more

Author Response: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

(2023)10.7554/elife.88058.2.sa0

N/A

0DataRank · unranked

0 citations

Meredith L. Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad +7 more

Author Response: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

(2023)10.7554/elife.88058.3.sa3

N/A

0DataRank · unranked

0 citations

Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad +7 more

Reviewer #1 (Public Review): ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

(2023)10.7554/elife.91930.1.sa2

N/A

0DataRank · unranked

0 citations

Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu Gurmessa, Ilaria R Merutka +10 more

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

Cell(2024)10.1016/j.cell.2024.08.017

N/A

0DataRank · unranked

56 citations

Victoria Bowcut, Micah C. Fernando, Yue Yang, Lawrence Zhu, Meredith L. Jenkins +12 more

Molecular basis for plasma membrane recruitment of PI4KA by EFR3

Science Advances(2024)10.1126/sciadv.adp6660

N/A

0DataRank · unranked

16 citations

Alexandria L Shaw, Joshua G. Pemberton, Mackenzie K. Scott, Noah J Harris, Matthew AH Parson +7 more

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

eLife(2024)10.7554/elife.91930.3

N/A

0DataRank · unranked

14 citations

Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka +11 more

An effective method of measuring nanobody binding kinetics and competition-based epitope mapping using biolayer interferometry

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.03.616354

N/A

0DataRank · unranked

2 citations

Sintayehu K Gurmessa, Jules B. Weinstein, Mila Trank-Greene, Xammy Huu Wrynla, Aidan Anastas +6 more

Reviewer #3 (Public Review): ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

(2024)10.7554/elife.91930.2.sa0

N/A

0DataRank · unranked

0 citations

Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka +11 more

An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate

The Journal of Cell Biology(2025)10.1083/jcb.202408158

N/A

0DataRank · unranked

12 citations

Isobel Barlow-Busch, Meredith L. Jenkins, Matthew AH Parson, Farkas Sarnyai, Seyma Nur Bektas +5 more

SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110788

N/A

0DataRank · unranked

6 citations

Hunter G. Nyvall, Matthew AH Parson, Reed K. Talus, John E. Burke, Scott D. Hansen +1 more

Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity

Nature Communications(2025)10.1038/s41467-025-55828-8

N/A

0DataRank · unranked

5 citations

Kha M. Nguyen, Sung-Eun Nam, Alexandria L Shaw, Matthew AH Parson, Hannah R. Shariati +6 more

Selective inhibition of MR1-restricted T cell activation by a novel MR1-targeting nanobody

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.11.659204

N/A

0DataRank · unranked

0 citations

Corinna A. Kulicke, Sintayehu K Gurmessa, Se-Jin Kim, Sushant Suresh, Jules B. Weinstein +5 more

Reviewer #1 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

(2023)10.7554/elife.88058.2.sa2

N/A

0DataRank · unranked

0 citations

Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew Parson, Harish Ranga-Prasad +7 more

Crystal structure of a lipin/Pah phosphatidic acid phosphatase

Nature Communications(2020)10.1038/s41467-020-15124-z

N/A

0DataRank · unranked

47 citations

Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue +2 more

Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function

Structure(2020)10.1016/j.str.2020.04.020

N/A

0DataRank · unranked

37 citations

Georg Kuenze, Reece M. Hoffmann, Brandon E. Moeller, John E. Burke, Jens Meiler +2 more

Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveals a path to selective inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.01.406264

N/A

0DataRank · unranked

0 citations

Zied Gaieb, Kaelin D. Fleming, Chiara Borsari, Noah J Harris, Brandon E. Moeller +4 more

Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

Science Advances(2021)10.1126/sciadv.abj4282

N/A

0DataRank · unranked

64 citations

Udit Dalwadi, Kaelin D. Fleming, Carson Adams, Jordan TB Stariha, Els Pardon +8 more

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane

Nature Communications(2021)10.1038/s41467-021-26326-4

N/A

0DataRank · unranked

50 citations

Matthew AH Parson, Meredith L. Jenkins, Jagoree Roy, Alexis Z.L. Shih, Nicole St‐Denis +8 more

The middle lipin domain adopts a membrane-binding dimeric protein fold

Nature Communications(2021)10.1038/s41467-021-24929-5

N/A

0DataRank · unranked

23 citations

Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang +6 more

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Nature Communications(2021)10.1038/s41467-021-26163-5

N/A

0DataRank · unranked

21 citations

Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke +5 more

Palmitoylation targets the Calcineurin phosphatase to the Phosphatidylinositol 4-kinase complex at the plasma membrane

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.14.451536

N/A

0DataRank · unranked

4 citations

Matthew AH Parson, Meredith L. Jenkins, Jagoree Roy, Alexis Z.L. Shih, Nicole St‐Denis +8 more

The middle lipin (M-Lip) domain is a new dimeric protein fold that binds membranes

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.19.436211

N/A

0DataRank · unranked

1 citations

Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang +6 more