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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles

Molecular Therapy(2020)10.1016/j.ymthe.2020.12.023Source: DataRank Database

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles is a research paper published in Molecular Therapy (2020). On theSindex it has a DataRank of 0. It has been cited 76 times.

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Open Access76 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (7 grants)OA: hybridTopics (43)IDs (PubMed, PMC)SDGs (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Jillian Caiazzi ORCID,Nicholas McHugh ORCID,Vignesh Hariharan ORCID,Manish Muhuri ORCID,Anastasia Khvorova ORCID

Live enrichment

PubMed:33348054 PMC:PMC8058398

NIH HHS

Grant: S10 OD020012

NIGMS NIH HHS

Grant: R35 GM131839

NICHD NIH HHS

Grant: R01 HD086111

National Institutes of Health

Grant: 5R35GM131839-05

Chemical engineering of therapeutic RNAs for extrahepatic delivery

National Institutes of Health

Grant: 5R01HD086111-03

Development of RNAi based sFLT1-targeting therapeutics for treatment of Preeclampsia

National Institutes of Health

Grant: 1S10OD020012-01

Mid-Scale RNA Synthesis, Purification and Quality Control System

National Institutes of Health

hybridLicense: cc-by

publisherhttp://www.cell.com/article/S152500162030681X/pdf

publisherhttps://api.elsevier.com/content/article/PII:S152500162030681X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S152500162030681X?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8058398

https://escholarship.umassmed.edu/oapubs/4514

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Muscle, SkeletalMyocardiumHeartAnimalsHumansMiceMuscular DiseasesHeart DiseasesDisease Models, AnimalFatty AcidsRNA, Small InterferingOligonucleotidesGene Transfer TechniquesMyostatin

Keywords

Heart DiseasesOligonucleotidesoligonucleotide therapeuticsTherapeuticsBiochemistryMiceMuscular Diseasescardiac musclesAnimalsHumansRNA, Small InterferingMuscle, SkeletalMyocardiumFatty AcidsGene Transfer TechniquesGenetics and GenomicsMedicinal-Pharmaceutical ChemistryHeartMyostatinsiRNAsMedicinal Chemistry and PharmaceuticsDisease Models, Animalsmall interfering RNAsgene expressionOriginal Articleskeletal muscles

Sustainable Development Goals

SDG 3: 3. Good health