Anastasia Khvorova

University of Massachusetts Chan Medical School

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 67 papers. Top paper: “Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference”.

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Alzheimer s & Dementia(2024)10.1002/alz.13877

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1.1DataRank · unranked

33 citations

Michaël E. Belloy, Elizabeth Blue, Gregory R. Bowman, María C. Carrillo, Xiaoying Chen +55 more

Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo

Nucleic Acids Research(2023)10.1093/nar/gkad1125

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0.563DataRank · unranked

17 citations

Karen Kelly, Jonathan Lee, Dimas Echeverria, David Cooper, Rebecca Panwala +13 more

Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.05.547848

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0.241DataRank · unranked

4 citations

Shauna M. Harney, Chloe DiMarzio, Mark Kelly, Kyounghee Min, Dimas Echeverria +7 more

Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors

RNA(2023)10.1261/rna.079521.122

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0.104DataRank · unranked

1 citations

Adam K. Hedger, Ken Yamada, Jonathan K. Watts, Anastasia Khvorova, Samuel Hildebrand

Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.06.006

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0DataRank · unranked

35 citations

Dimas Echeverria, Matthew Hassler, Socheata Ly, Anastasia Khvorova, Chantal Ferguson

Data on enrichment of chitosan nanoparticles for intranasal delivery of oligonucleotides to the brain

Data in Brief(2020)10.1016/j.dib.2019.105093

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0DataRank · unranked

7 citations

Oksana Fihurka, Anastasia Khvorova, Juan Sanchez‐Ramos, Vasyl Sava

The NIH Somatic Cell Genome Editing program

Nature(2021)10.1038/s41586-021-03191-1

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0DataRank · unranked

132 citations

Erik J. Sontheimer, Philip J. Brooks, Melinda R. Dwinell, Charles A. Gersbach, David R. Liu +70 more

AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma

The Journal of Experimental Medicine(2021)10.1084/jem.20200962

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0DataRank · unranked

70 citations

Ken Okamura, Rebecca L. Riding, Xueli Fan, Khashayar Afshari, Nazgol‐Sadat Haddadi +10 more

An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

Molecular Therapy(2021)10.1016/j.ymthe.2021.11.007

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0DataRank · unranked

46 citations

Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence M. Lifshitz +13 more

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

JCI Insight(2021)10.1172/jci.insight.152203

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0DataRank · unranked

29 citations

Bruno M.D.C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew Hassler, Dimas Echeverria +13 more

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity

Nucleic Acids Research(2021)10.1093/nar/gkab1126

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0DataRank · unranked

20 citations

Samuel Hildebrand, Sarah M. Davis, Rachael Miller, Faith Conroy, Ellen Sapp +10 more

Kinetics of HTT lowering in brain of YAC 128 mice following single and repetitive intranasal dosing of siRNA packaged in chitosan-based nanoparticles

Journal of Drug Delivery Science and Technology(2021)10.1016/j.jddst.2021.102517

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0DataRank · unranked

15 citations

Oksana Fihurka, Anastasia Khvorova, Juan Sanchez‐Ramos, V. Sava

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Molecular Therapy — Nucleic Acids(2022)10.1016/j.omtn.2022.06.009

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0DataRank · unranked

55 citations

Vignesh Hariharan, Agnes S. Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa +7 more

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models

Nature Communications(2022)10.1038/s41467-022-33061-x

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0DataRank · unranked

49 citations

Rachael Miller, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Bruno M.D.C. Godinho +12 more

Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo

Journal of Controlled Release(2022)10.1016/j.jconrel.2022.07.041

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0DataRank · unranked

44 citations

Socheata Ly, Nicholas McHugh, David Cooper, Anastasia Khvorova, Annabelle Biscans

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

Brain Communications(2022)10.1093/braincomms/fcac248

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0DataRank · unranked

37 citations

Marie-Cécile Didiot, Chantal Ferguson, Andrew H. Coles, Rachael Miller, Kathryn Chase +6 more

RNAi-based modulation of IFN-γ signaling in skin

Molecular Therapy(2022)10.1016/j.ymthe.2022.04.019

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0DataRank · unranked

34 citations

Jacquelyn Sousa, Dimas Echeverria, Xueli Fan, Ying-Chao Hsueh, Khashayar Afshari +10 more

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts

Nucleic Acids Research(2022)10.1093/nar/gkac630

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0DataRank · unranked

29 citations

Io Long Chan, Yuming Cao, Alisha M. Gruntman, Jonathan Lee, Jacquelyn Sousa +17 more

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

Molecular Therapy — Nucleic Acids(2022)10.1016/j.omtn.2022.06.005

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0DataRank · unranked

27 citations

Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy +9 more

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.29.498088

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0DataRank · unranked

0 citations

Rachael Miller, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Bruno M.D.C. Godinho +12 more

Asymmetric trichotomous data partitioning enables development of predictive machine learning models using limited siRNA efficacy datasets

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.08.499317

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0DataRank · unranked

0 citations

Dmitry Korkin, Anastasia Khvorova, Kathryn Monopoli

Di-valent siRNA Mediated Silencing of MSH3 Blocks Somatic Repeat Expansion in Mouse Models of Huntington’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.06.506795

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0DataRank · unranked

0 citations

Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh +13 more

Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.16.516815

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0DataRank · unranked

0 citations

Adam K. Hedger, Jonathan K. Watts, Anastasia Khvorova, Samuel Hildebrand

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease

Molecular Therapy(2023)10.1016/j.ymthe.2023.05.006

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0DataRank · unranked

56 citations

Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh +16 more

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Nature Communications(2023)10.1038/s41467-023-42714-4

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0DataRank · unranked

50 citations

Hassan H. Fakih, Mohammad Zain UI Abideen, Samuel Hildebrand, Khashayar Afshari, Katherine Y. Gross +31 more

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219523120

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0DataRank · unranked

48 citations

Minwook Shin, Ching‐Wen Chang, Daniel O’Reilly, Annabelle Biscans, Ken Yamada +41 more

Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy

Molecular Therapy — Nucleic Acids(2023)10.1016/j.omtn.2023.06.010

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0DataRank · unranked

25 citations

Dmitry Korkin, Anastasia Khvorova, Kathryn R. Monopoli

Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity

Molecular Therapy — Nucleic Acids(2023)10.1016/j.omtn.2023.102080

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0DataRank · unranked

20 citations

Qi Tang, Ashley Summers, Minwook Shin, Julianna Buchwald, Rosemary Gagnon +7 more

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors

Molecular Therapy — Nucleic Acids(2023)10.1016/j.omtn.2023.102088

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0DataRank · unranked

16 citations

Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh +7 more

Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy

Nucleic Acid Therapeutics(2023)10.1089/nat.2023.0038

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0DataRank · unranked

14 citations

Daniel O’Reilly, David van de Vijver, Ingrid E.C. Verhaart, Maaike van Putten, Vignesh Hariharan +5 more

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

eLife(2023)10.7554/elife.89136

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0DataRank · unranked

10 citations

Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz +12 more

Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model

Molecular Therapy — Methods & Clinical Development(2023)10.1016/j.omtm.2023.101122

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0DataRank · unranked

3 citations

Rachel Prestigiacomo, Toloo Taghian, Rachael Miller, R King, Matthew J. Gounis +13 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.26.542506

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0DataRank · unranked

7 citations

Vignesh Hariharan, Jillian Caiazzi, Rachael Miller, Chantal Furguson, Ellen Sapp +18 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

Research Square(2023)10.21203/rs.3.rs-2987323/v1

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0DataRank · unranked

4 citations

Jillian Caiazzi, Rachael Miller, Chantal Ferguson, Ellen Sapp, Hassan Fakih +18 more

A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.19.572404

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0DataRank · unranked

4 citations

Qi Tang, Sam Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria +11 more

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

叙説(2023)10.1101/2023.05.03.539244

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0DataRank · unranked

3 citations

Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz +12 more

Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.20.533459

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0DataRank · unranked

1 citations

Karen Kelly, Jonathan Lee, Dimas Echeverria, David Cooper, Rebecca Panwala +11 more

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.20.558641

N/A

0DataRank · unranked

0 citations

Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh +7 more

RNAi-based drug design: considerations and future directions

Nature Reviews Drug Discovery(2024)10.1038/s41573-024-00912-9

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0DataRank · unranked

252 citations

Anastasia Khvorova, Qi Tang

Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease

Alzheimer s & Dementia(2024)10.1002/alz.13703

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0DataRank · unranked

33 citations

Samuel Hildebrand, Bruno M.D.C. Godinho, Julianna Buchwald, Dimas Echeverria, Andrew H. Coles +10 more

A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system

Nucleic Acids Research(2024)10.1093/nar/gkae368

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0DataRank · unranked

26 citations

Qi Tang, Samuel Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria +11 more

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation

Molecular Therapy — Nucleic Acids(2024)10.1016/j.omtn.2024.102359

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0DataRank · unranked

20 citations

Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Brianna Bramato +10 more

Multispecies-targeting siRNAs for the modulation of JAK1 in the skin

Molecular Therapy — Nucleic Acids(2024)10.1016/j.omtn.2024.102117

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0DataRank · unranked

18 citations

Katherine Y. Gross, Hassan H. Fakih, Samuel O. Jackson, Mohammad Zain UI Abideen, Kathryn Monopoli +7 more

Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo

Nucleic Acids Research(2024)10.1093/nar/gkae260

N/A

0DataRank · unranked

18 citations

Hassan H. Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Holly R McEachern +8 more

A combinatorial approach for achieving CNS-selective RNAi

Nucleic Acids Research(2024)10.1093/nar/gkae100

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0DataRank · unranked

11 citations

Bruno M.D.C. Godinho, Dimas Echeverria, Matthew Hassler, Lorenc Vangjeli, Jacquelyn Sousa +8 more

More than 185 CAG repeats: a point of no return in Huntington’s disease biology

Brain(2024)10.1093/brain/awae105

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0DataRank · unranked

11 citations

Anastasia Khvorova, Jillian Belgrad

mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs)

Nucleic Acids Research(2024)10.1093/nar/gkae624

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0DataRank · unranked

10 citations

Dimas Echeverria, Anastasia Khvorova, Andrei A. Korostelev, Denis Susorov

Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs

Molecular Therapy — Nucleic Acids(2024)10.1016/j.omtn.2024.102291

N/A

0DataRank · unranked

9 citations

Zachary Kennedy, Bruno M.D.C. Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria +10 more

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo

Nucleic Acid Therapeutics(2024)10.1089/nat.2024.0027

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0DataRank · unranked

8 citations

Daniel O’Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, Joseph Paquette +8 more

Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA

Molecular Therapy — Nucleic Acids(2024)10.1016/j.omtn.2024.102230

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0DataRank · unranked

5 citations

Takahiro Nakamura, Minwook Shin, Qi Tang, Vyankat A. Sontakke, Jillian Caiazzi +4 more

Near Sequence Homology Does Not Guarantee siRNA Cross-Species Efficacy

Nucleic Acid Therapeutics(2024)10.1089/nat.2024.0030

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0DataRank · unranked

4 citations

Kathryn Monopoli, Samuel Jackson, Dimas Echeverria, Daniel O’Reilly, Robert H. Brown +2 more

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

eLife(2024)10.7554/elife.89136.3

N/A

0DataRank · unranked

3 citations

Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz +12 more

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.20.599943

N/A

0DataRank · unranked

6 citations

James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal Ferguson, Elif O. Dogan +18 more

mRNA nuclear clustering leads to a difference in mutant huntingtin mRNA and protein silencing by siRNAs in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.24.590997

N/A

0DataRank · unranked

2 citations

Daniel O’Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, Joseph Paquette +8 more

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.06.597639

N/A

0DataRank · unranked

1 citations

Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Brianna Bramato +10 more

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy

Nucleic Acids Research(2025)10.1093/nar/gkaf479

N/A

0DataRank · unranked

15 citations

Samuel Hildebrand, Hannah J. MacMillan, Kathryn Monopoli, Julianna Buchwald, Jacquelyn Sousa +20 more

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

Molecular Therapy(2025)10.1016/j.ymthe.2025.05.010

N/A

0DataRank · unranked

8 citations

James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal Ferguson, Elif O. Dogan +19 more

Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation

Brain Communications(2025)10.1093/braincomms/fcaf314

N/A

0DataRank · unranked

5 citations

Adel Boudi, Andrew Iwanowicz, Jillian Belgrad, Rachael Miller, R. Meldrum Robertson +11 more

Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs

Nucleic Acids Research(2025)10.1093/nar/gkaf1374

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0DataRank · unranked

1 citations

Clemens Lochmann, Rosemary Gagnon, Ashley Summers, Jillian Caiazzi, Julianna Buchwald +15 more

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington’s disease pathogenesis in mice

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.24.661398

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0DataRank · unranked

7 citations

Ashley Summers, Christian Landles, Jonathan Greene, Samuel Hildebrand, Emily G. Knox +21 more

Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.29.667434

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0DataRank · unranked

1 citations

Julianna Buchwald, Christopher D Dahlke, Hassan H. Fakih, Jennifer Morgan, Ashley Summers +10 more

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

Research Square(2025)10.21203/rs.3.rs-6465542/v1

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0DataRank · unranked

0 citations

Ashley Summers, Amy E. Clipperton‐Allen, Jillian Caiazzi, Samuel Hildebrand, Daniel O’Reilly +11 more

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

Nucleic Acids Research(2020)10.1093/nar/gkaa595

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0DataRank · unranked

76 citations

Jillian Caiazzi, Sarah M. Davis, Nicholas McHugh, Jacquelyn Sousa, Anastasia Khvorova +1 more

Presence of phosphodiester backbone, but not nucleobases, in the guide’s 3′ terminal region is necessary for RISC loading and target cleavage in vitro and in vivo

Nucleic Acids Research(2025)10.1093/nar/gkaf1438

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0DataRank · unranked

0 citations

Raymond Furgal, Vella M Ross, Eric Luu, Katherine Y. Gross, Vignesh Hariharan +12 more

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles

Molecular Therapy(2020)10.1016/j.ymthe.2020.12.023

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0DataRank · unranked

76 citations

Jillian Caiazzi, Nicholas McHugh, Vignesh Hariharan, Manish Muhuri, Anastasia Khvorova +1 more

2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.05.010

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0DataRank · unranked

21 citations

Jacquelyn Sousa, Lorenc Vangjeli, Matthew Hassler, Dimas Echeverria, Emily G. Knox +4 more

Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.07.029

N/A

0DataRank · unranked

41 citations

Dimas Echeverria, Jacquelyn Sousa, Anastasia Khvorova, Socheata Ly