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Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.16.532226Source: DataRank Database

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2023). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)OA: greenTopics (39)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (6)

Alexandr P. Kornev ORCID,Jui‐Hung Weng ORCID,Gerard Manning ORCID,Susan S. Taylor ORCID,Alexandra C. Newton ORCID

Live enrichment

PubMed:36993163 OpenAlex:https://openalex.org/W4327862345

National Institutes of Health

Grant: 5R01NS120725-03

Structural and Molecular Mechanisms for Dysregulation of Protein Kinase C Gamma in Cerebellar Ataxia

National Institutes of Health

Grant: 5T32GM007752-12

CELLULAR AND MOLECULAR PHARMACOLOGY

National Institutes of Health

Grant: 3R35GM122523-04S1

Molecular Mechanisms of Cell Signaling

National Institutes of Health

Grant: 3R35GM130389-03S1

Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches

greenLicense: CC BY

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2023/03/16/2023.03.16.532226.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2023.03.16.532226

repositoryhttp://dx.doi.org/10.1101/2023.03.16.532226

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36993163

Fields of Study

Microtubule and mitosis dynamicsCancer-related Molecular Pathways14-3-3 protein interactions0301 basic medicine03 medical and health sciences

Keywords

NeurodegenerationMutationResidue (chemistry)GeneticsCancer researchBiologyBiochemistryMedicineGeneInternal medicineDisease570Biochemistry & Molecular Biology1.1 Normal biological development and functioningBioinformatics and Computational Biology610NeurodegenerativeMedical and Health SciencesMolecular Bases of Health & DiseaseNeoplasms2.1 Biological and endogenous factorsHumansC1 domainProtein Kinase CCancerNeurosciencesNeurodegenerative DiseasesBiological Sciencesmolecular dynamicsIsoenzymesBiochemistry and cell biologyNeurologicalChemical Sciencessignaling

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being