The Share of Human Genomic DNA under Selection Estimated from Human-Mouse Genomic Alignments is a research paper published in Cold Spring Harbor Symposia on Quantitative Biology (2003). On theSindex it has a DataRank of 2.9. It has been cited 63 times, with 53 citing works in its 1-hop citation network.
Draft sequences covering most euchromatic parts haverecently become available for two mammalian genomes,human (Lander et al. 2001; Venter et al. 2001) and mouse(Waterston et al. 2002). This raises the possibility of using comparative genomics to estimate what fraction ofthe human genome evolves under purifying selection.Lacking genomes of other mammals, this comparativeexercise is still in its preliminary stages. However, arough estimate has been made that ~5% of the humangenome is in short segments that appear to be under selection based on comparison with mouse (Waterston et al.2002). Here, as a basis for future refinements, we presentthe computational strategy that led to this estimate, providing details on scoring functions, data preparation, andstatistical techniques. We also describe stability analyses,control experiments, and tests for the effects of artifactsthat were performed to establish robustness of our results,and discuss possible alternate interpretations...
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.624
From this paper's citation signal
Citation Network Contribution
2.3
From 47 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 22% comes from its base citations and 78% from the citation network (47 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
Click a node to highlight its connections. Use scroll to zoom. Drag to pan.