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MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

Disease Models & Mechanisms(2021)10.1242/dmm.049166Source: DataRank Database

MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model is a research paper published in Disease Models & Mechanisms (2021). On theSindex it has a DataRank of 0. It has been cited 26 times.

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Open Access26 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (10 grants)OA: goldTopics (40)IDs (PubMed)SDGs (1)

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Authors (5)

Alice F. Goodwin ORCID,Yoshiko Maeda,Ophir D. Klein ORCID,Katherine A. Rauen ORCID,William E. Tidyman

Live enrichment

PubMed:34553752

National Institutes of Health

Grant: R01AR062165

National Institutes of Health

Grant: 5R35DE026602-03

Harnessing natural stem cell-based strategies for mammalian dental renewal

National Institutes of Health

Grant: 1S10OD010786-01

Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencin

National Institutes of Health

Grant: 3P30CA093373-07S2

Cancer Center Support Grant - P30

National Institutes of Health

Grant: 5R01AR062165-05

The Role of Germline Mutations of the Ras/MAPK Pathway on Skeletal Myogenesis

NCI NIH HHS

Grant: P30 CA093373

NIDCR NIH HHS

Grant: R35 DE026602

NIDCR NIH HHS

Grant: K08 DE028011

NIH HHS

Grant: S10 OD010786

NIDCR NIH HHS

Grant: F30 DE022205

goldLicense: cc-by

publisherhttps://journals.biologists.com/dmm/article-pdf/15/2/dmm049166/2120408/dmm049166.pdf

publisherhttp://journals.biologists.com/dmm/article-pdf/doi/10.1242/dmm.049166/2106353/dmm049166.pdf

repositoryhttps://doaj.org/article/95451ead71bc4f67bb310aa0bc0dee2b

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8617311

https://doi.org/10.1242/dmm.049166

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCostello SyndromeMiceMitogen-Activated Protein Kinase KinasesMuscular DiseasesMutationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins p21(ras)Quality of Life

MeSH Terms

AnimalsCostello SyndromeMiceMitogen-Activated Protein Kinase KinasesMuscular DiseasesMutationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins p21(ras)Quality of Life

Keywords

Mitogen-Activated Protein Kinase KinasesCostello SyndromeRrasopathiesProto-Oncogene Proteins p21(ras)MicePhosphatidylinositol 3-KinasesMuscular Diseasesmek inhibitorMutationPathologyQuality of LifeMedicineRB1-214Animalsras/mapkmyogenesishypotoniaResearch Article

Sustainable Development Goals

SDG 3: 3. Good health