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Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence

Frontiers in Immunology(2021)10.3389/fimmu.2021.738958Source: DataRank Database

Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence is a research paper published in Frontiers in Immunology (2021). On theSindex it has a DataRank of 0.416. It has been cited 15 times.

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0.416DataRank · unranked

Scored on demand from live citation data

Open Access15 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 0.44)OA: goldTopics (100)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.416

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (11)

Ngoc T. Ha ORCID,Ngan K. Tran,Andrew G. Newman ORCID,Katharine M. Esselen ORCID,John L. Dalrymple ORCID

Live enrichment

PubMed:34721405 PMC:PMC8549513 OpenAlex:https://openalex.org/W3147850708

National Institutes of Health

Grant: 1R56AI099012-01

Regulation of chromatin modifications by miRNAs to control cytokine expression

National Institutes of Health

Grant: 1R21CA198263-01A1

Cbx-3/HP-1gamma deficiency confers anti-tumor immunity

FWCI

0.44

Citation Percentile

0.6%

Citation Trend

2023

2024

2025

goldLicense: cc-by

journalhttps://doi.org/10.3389/fimmu.2021.738958

publisherhttps://doi.org/10.3389/fimmu.2021.738958

publisherhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.738958/full

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34721405

repositoryhttp://europepmc.org/pmc/articles/PMC8549513

Fields of Study

Immune Cell Function and InteractionCAR-T cell therapy researchCancer Immunotherapy and Biomarkers0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsCD8-Positive T-LymphocytesCell DifferentiationCell Line, TumorChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneCoculture TechniquesFemaleGene Expression Regulation, NeoplasticImmunotherapy, AdoptiveInterleukin-21 Receptor alpha SubunitLymphocyte ActivationLymphocytes, Tumor-InfiltratingLymphoid Enhancer-Binding Factor 1Melanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeuroblastomaOvarian NeoplasmsSignal TransductionT-Lymphocytes, RegulatoryTumor BurdenTumor Microenvironment

MeSH Terms

Chromobox Protein Homolog 5AnimalsCell DifferentiationChromosomal Proteins, Non-HistoneFemaleLymphocyte ActivationMelanoma, ExperimentalMice, Inbred C57BLMice, TransgenicNeuroblastomaOvarian NeoplasmsSignal TransductionGene Expression Regulation, NeoplasticImmunotherapy, AdoptiveLymphocytes, Tumor-InfiltratingMice, KnockoutCD8-Positive T-LymphocytesCoculture TechniquesCell Line, TumorTumor BurdenT-Lymphocytes, RegulatoryMiceLymphoid Enhancer-Binding Factor 1Interleukin-21 Receptor alpha SubunitTumor Microenvironment

Keywords

EffectorCD8Cancer researchCytotoxic T cellBiologyChromatin remodelingCell biologyT cellImmune checkpointChromatinImmunologyImmune systemImmunotherapyGeneticsMelanomaOvarian cancerlef-1Il-21 ReceptorCbx3/hp1γCd8+ T-Cell PersistenceChromosomal Proteins, Non-HistoneLymphoid Enhancer-Binding Factor 1Melanoma, ExperimentalMice, TransgenicCD8-Positive T-LymphocytesLymphocyte ActivationImmunotherapy, AdoptiveMiceNeuroblastomaLymphocytes, Tumor-InfiltratingCell Line, TumorAnimalsCbx3/HP1 gammaMice, KnockoutInterleukin-21 Receptor alpha SubunitCell DifferentiationRC581-607Coculture TechniquesGene Expression Regulation, NeoplasticMice, Inbred C57BLChromobox Protein Homolog 5CD8+T-cell persistenceFemaleImmunologic diseases. Allergy

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being