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NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

eLife(2020)10.7554/elife.54993Source: DataRank Database

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency is a research paper published in eLife (2020). On theSindex it has a DataRank of 1.4. It has been cited 64 times, with 57 citing works in its 1-hop citation network.

N/A

1.4DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access64 citations · 57 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE140115 GSE155861 GSE83728 GSE116344

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 2.61)OA: goldTopics (53)IDs (PubMed, OpenAlex)SDGs (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 44%Citation Network 56%

Base Score Contribution

0.626

From this paper's citation signal

Citation Network Contribution

0.782

From 41 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 57 citers.

Epigenetics and Cancer
Learning materials in biosciences20216 citations32 referencesContributes 0.061
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression
Nature Communications202344 citations67 referencesContributes 0.057
CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents
PLoS ONE202127 citations62 referencesContributes 0.054
m6A is required for resolving progenitor identity during planarian stem cell differentiation
The EMBO Journal202236 citations88 referencesContributes 0.041
RNAi Screen Identifies MTA1 as an Epigenetic Modifier of Differentiation Commitment in Human HSPCs
Experimental Hematology20223 citations35 referencesContributes 0.040

Authors (13)

Berkley E. Gryder ORCID,Blaz Pavlovic ORCID,Yeonjoo Chung,Quy A. Ngo ORCID,Fabian Frommelt ORCID

Live enrichment

PubMed:32744500 OpenAlex:https://openalex.org/W3046671200

Swiss National Science Foundation

Grant: 310030_156923

Cancer League Switzerland

Grant: KLS-3868-02-2016

Innovative Medicines Initiative ULTRA-DD

Grant: 115766

Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery

Swiss National Science Foundation

Grant: 31003A_175558

Swiss National Science Foundation

Grant: 175558

Mechanisms of rhabdomyosarcoma progression

Swiss National Science Foundation

Grant: 156923

Towards a specific therapy for rhabdoymosarcoma: approaches to target PAX3/FOXO1 and the cancer stem cell compartment

FWCI

2.61

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://elifesciences.org/articles/54993.bib

GOLDhttps://elifesciences.org/articles/54993.bib

publisherhttps://elifesciences.org/articles/54993.bib

publisherhttps://cdn.elifesciences.org/articles/54993/elife-54993-v2.pdf

publisherhttps://cdn.elifesciences.org/articles/54993/elife-54993-v2.xml

Fields of Study

Genomics and Chromatin DynamicsProtein Degradation and InhibitorsChromatin Remodeling and CancerBiologyMedicine0301 basic medicine03 medical and health sciences

MeSH Terms

HumansRhabdomyosarcomaGene Expression Regulation, NeoplasticCell Line, TumorMi-2 Nucleosome Remodeling and Deacetylase Complex

Keywords

ChromatinEnhancerBiologyChromatin remodelingCell biologyTranscription (linguistics)RNA polymerase IITranscription factorCancer researchPromoterGeneticsDNAGene expressionGeneQH301-705.5ScienceDNA accessibility610 Medicine & healthGeneral Biochemistry, Genetics and Molecular Biology1300 General Biochemistry, Genetics and Molecular Biology2400 General Immunology and MicrobiologyNuRDsuper-enhancerCell Line, TumorRhabdomyosarcomaHumanshumanBiology (General)610 Medicine & healthcancer biologyGeneral Immunology and MicrobiologyGeneral NeuroscienceQR2800 General NeuroscienceGeneral MedicineCHD4Gene Expression Regulation, Neoplastic10036 Medical ClinicMedicineMi-2 Nucleosome Remodeling and Deacetylase Complex

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 3: 3. Good healthSDG 7: 7. Clean energySDG 0: Good health and well-being