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FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

10.7554/elife.94605.1Source: DataRank Database

FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation is a research paper. On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)OA: goldTopics (45)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (10)

Huaibin Ge ORCID,Shih-Fan Kuan,Chunhui Cai ORCID,Xinghua Lu ORCID,Farzad Esni ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W4393910677

National Institutes of Health

Grant: 1R01CA236965-01A1

Targeting PYK2 for the treatment of PDAC

National Institutes of Health

Grant: 5R01DK120698-04

Chemical pancreatectomy for chronic pancreatitis and pancreatic cancer

National Institutes of Health

Grant: 5R21AI158824-02

Evaluation of the Effect of Autoimmunity on Acinar-Derived Insulin Producing Cells

goldLicense: cc-by

journalhttps://doi.org/10.7554/elife.94605.1

publisherhttps://doi.org/10.7554/elife.94605.1

publisherhttps://cdn.elifesciences.org/preprints/94605/elife-preprint-94605-v1.pdf

publisherhttps://cdn.elifesciences.org/preprints/94605/elife-preprint-94605-v1.xml

publisherhttps://elifesciences.org/reviewed-preprints/94605v1/pdf

Fields of Study

Melanoma and MAPK PathwaysColorectal Cancer Treatments and StudiesCellular Mechanics and Interactions0301 basic medicine03 medical and health sciences

Keywords

MAPK/ERK pathwayCancer researchV600EPhosphorylationFocal adhesionCarcinogenesisKinaseDownregulation and upregulationSignal transductionTumor progressionBiologyCell biologyChemistryMutationCancerBiochemistryGeneticsProto-Oncogene Proteins B-rafMaleQH301-705.5MAP Kinase Signaling SystemEGFRScienceCecal NeoplasmsArticleReceptors, G-Protein-CoupledMiceBRAFV600EAnimalsHumansBiology (General)Extracellular Signal-Regulated MAP KinasesCancer BiologyFAKQRErbB ReceptorsERKFocal Adhesion Kinase 1Medicine

Sustainable Development Goals

SDG 0: Good health and well-being

FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

FAIR Checklist

Authors (10)

Funding (3 grants)

Open Access

Topics