Andrew D. Mesecar

MedicineComputer ScienceBiochemistry, Genetics and Molecular BiologyMaterials ScienceImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 30 papers. Top paper: “Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19”.

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.12.293498

N/A

5.5DataRank · unranked

159 citations

Rhys Jones, Brandon J. Anson, Dan Arenson, Lisa Aschenbrenner, Malina A. Bakowski +44 more

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

The Journal of Infectious Diseases(2021)10.1093/infdis/jiab305

N/A

2.2DataRank · unranked

41 citations

James M. Anderson, Annaliesa S. Anderson, David Baker, Jay Bradner, Kyle R. Brimacombe +37 more

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Nature(2020)10.1038/s41586-020-2577-1

N/A

1.0DataRank · unranked

858 citations

Shuofeng Yuan, Xin Yin, Laura Martin‐Sancho, Naoko Matsunaga, Lars Pache +40 more

Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics

ChemMedChem(2020)10.1002/cmdc.202000223

N/A

0.864DataRank · unranked

316 citations

Margherita Brindisi, Dana Shahabi, Mackenzie E. Chapman, Andrew D. Mesecar, Arun K. Ghosh

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Nature Communications(2021)10.1038/s41467-021-26239-2

N/A

0.855DataRank · unranked

297 citations

Rhys Jones, Brandon J. Anson, Dan Arenson, Lisa Aschenbrenner, Malina A. Bakowski +47 more

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Nature Communications(2021)10.1038/s41467-021-20900-6

N/A

0.792DataRank · unranked

196 citations

Nobuyo Higashi‐Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut +18 more

Broad-spectrum inhibition of coronavirus main and papain-like proteases by HCV drugs

Research Square (Research Square)(2020)10.21203/rs.3.rs-26344/v1

N/A

0.568DataRank · unranked

43 citations

Mackenzie E. Chapman, Emma K. Lendy, S. Pshenychnyi, Richard T. D’Aquila, Karla J. F. Satchell +2 more

Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus

Journal of Virology(2020)10.1128/jvi.01734-19

N/A

0.500DataRank · unranked

27 citations

Yafang Chen, Anna M. Mielech, Matthew Hackbart, Kristina R. Kesely, Robert C. Mettelman +5 more

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

Molecules(2021)10.3390/molecules26195782

N/A

0.406DataRank · unranked

14 citations

Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J. Anson, Emma K. Lendy +8 more

SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late‐onset Alzheimer's disease

Alzheimer s & Dementia Translational Research & Clinical Interventions(2023)10.1002/trc2.12429

N/A

0.385DataRank · unranked

12 citations

Emily R. Mason, Shaoyou Chu, Adrian L. Oblak, June Javens‐Wolfe, Mustapha Moussaif +23 more

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF- B Signaling

UNC Libraries(2020)10.17615/7gc9-pv50

N/A

0.165DataRank · unranked

2 citations

Andrew D. Mesecar, Matthew B. Frieman, Robert E. Johnston, Ralph S. Baric, Kiira Ratia

A structure-guided taxonomicbased approach to the design of broad-spectrum coronavirus protease inhibitors

Acta Crystallographica Section A Foundations and Advances(2021)10.1107/s010876732109485x

N/A

0.104DataRank · unranked

1 citations

Sarah E. St. John, Emma K. Lendy, Brandon J. Anson, Mackenzie E. Chapman, Arun K. Ghosh +1 more

Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2′- O -methyl transfer by SARS-CoV-2 nsp16

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.31.429023

N/A

0.104DataRank · unranked

1 citations

Mónica Rosas‐Lemus, L. Shuvalova, Nicole L. Inniss, J.S. Brunzelle, Courtney M. Daczkowski +4 more

pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography

Biophysical Journal(2024)10.1016/j.bpj.2024.02.003

N/A

0DataRank · unranked

4 citations

C.N. Steussy, Anthony R. Rosales, Chandra J. Critchelow, Tim Schmidt, Paul Helquist +5 more

A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes

PLoS ONE(2024)10.1371/journal.pone.0299541

N/A

0DataRank · unranked

2 citations

Tadanobu Utsuki, Daniel E. Beck, W. Brent Clayton, Emma K. Lendy, Kuai-lin Sun +6 more

SHIP1 phosphatase as a Late‐Onset Alzheimer’s Disease therapeutic target

Alzheimer s & Dementia(2024)10.1002/alz.095377

N/A

0DataRank · unranked

0 citations

Adam K Hamdani, Cynthia D. Jesudason, Daniel E. Beck, Brent Clayton, Timothy I. Richardson +2 more

One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.25.650714

N/A

0DataRank · unranked

1 citations

Kratika Singhal, Nicolás M. Morato, Yunfei Feng, Gaoyuan Meng, Makayla N. Marlin +6 more

Catalytic function and substrate specificity of alpha and beta coronavirus papain-like proteases: targeting human NL63, SARS-CoV and SARS-CoV-2 (Covid-19) with designed inhibitors

Biophysical Journal(2022)10.1016/j.bpj.2021.11.1792

N/A

0DataRank · unranked

0 citations

Courtney M. Daczkowski, Arun K. Ghosh, Andrew D. Mesecar, Mackenzie E. Chapman

A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2020)10.17615/dwgs-ep23

N/A

0DataRank · unranked

3 citations

Eric Donaldson, Arun K. Ghosh, Robin Gopal, Trevor Scobey, Maria Zambon +14 more

A Chimeric Virus-Mouse Model System for Evaluating the Function and Inhibition of Papain-Like Proteases of Emerging Coronaviruses

UNC Libraries(2020)10.17615/aftx-3z93

N/A

0DataRank · unranked

0 citations

Deborah J. Lenschow, Scott D. Larsen, Ralph S. Baric, Sarah E. St. John, Daniel Brian Nichols +6 more

Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2′- O -methyl transfer by SARS-CoV-2 nsp16

Science Signaling(2021)10.1126/scisignal.abh2071

N/A

0DataRank · unranked

31 citations

Mónica Rosas‐Lemus, L. Shuvalova, Nicole L. Inniss, J.S. Brunzelle, Courtney M. Daczkowski +4 more

Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.13.452223

N/A

0DataRank · unranked

0 citations

Srinivas Govindan, Courtney M. Daczkowski, Andrew D. Mesecar, Srinivas Chakravarthy, Nicholas Noinaj +1 more

Desorption Electrospray Ionization Mass Spectrometry Assay for Label‐Free Characterization of SULT2B1b Enzyme Kinetics

ChemMedChem(2022)10.1002/cmdc.202200043

N/A

0DataRank · unranked

29 citations

Nicolás M. Morato, Qing Zhou, R. Graham Cooks, Andrew D. Mesecar, Samadhi C. Kulathunga

Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.08.519685

N/A

0DataRank · unranked

4 citations

Chuanpeng Dong, Peter Bor‐Chian Lin, Adrian L. Oblak, Gonzalo Viana Di Prisco, Nian Wang +20 more

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease

Immunity(2023)10.1016/j.immuni.2023.08.008

N/A

0DataRank · unranked

72 citations

Chuanpeng Dong, Peter Bor‐Chian Lin, Adrian L. Oblak, Gonzalo Viana Di Prisco, Nian Wang +20 more

SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads

Bioorganic & Medicinal Chemistry Letters(2023)10.1016/j.bmcl.2023.129489

N/A

0DataRank · unranked

12 citations

Dana Shahabi, Mackenzie E.C. Imhoff, Satish Kovela, Ashish Sharma, Shin-ichiro Hattori +4 more

Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor

Communications Biology(2023)10.1038/s42003-023-04639-y

N/A

0DataRank · unranked

12 citations

C.N. Steussy, Daneli López‐Pérez, Tim Schmidt, Samadhi C. Kulathunga, Mohamed N. Seleem +5 more

A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease

SLAS DISCOVERY(2023)10.1016/j.slasd.2023.03.003

N/A

0DataRank · unranked

3 citations

Tadanobu Utsuki, Daniel E. Beck, Emma K. Lendy, Kuai-lin Sun, Yinghui Liu +5 more

Development of a sensitive microplate assay for characterizing RNA methyltransferase activity: Implications for epitranscriptomics and drug development

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105257

N/A

0DataRank · unranked

1 citations

Allison B. Norvil, Ming He, Emma K. Lendy, Nicole M Hjortland, Hern Tan +4 more

Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors

European Journal of Medicinal Chemistry(2024)10.1016/j.ejmech.2024.116132

N/A

0DataRank · unranked

15 citations

Monika Yadav, Iddum Satyanarayana, Somayeh Ghazi, Emma K. Lendy, Uttara Jayashankar +8 more