Changning Wang

ORCID: 0000-0002-2076-4193

Also affiliated with Lemuel Shattuck Hospital, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging

Biochemistry, Genetics and Molecular BiologyMedicineNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 39 papers. Top paper: “Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease”.

Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112265

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51 citations

Keren Wang, Ping Bai, Anguo Wu, Jian Shi, Wenmin Liu +9 more

A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging

Molecules(2020)10.3390/molecules25051018

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19 citations

Sha Bai, Michael S. Placzek, Xiaoxia Lü, Stephanie A. Fiedler, Brenda Ntaganda +3 more

Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer

European Journal of Nuclear Medicine and Molecular Imaging(2020)10.1007/s00259-020-04896-7

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12 citations

Xiashuang Wang, Xiaoshuang Yang, Yulong Xu, Yu Yang, Hao Wang +15 more

Synthesis and Characterization of Carbon-11 Labeled Iloperidone for Imaging of α1-Adrenoceptor in Brain

Frontiers in Molecular Biosciences(2020)10.3389/fmolb.2020.586327

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6 citations

Yanli Wang, Hao Wang, Changning Wang, Yulong Xu

Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins

Nuclear Medicine and Biology(2020)10.1016/j.nucmedbio.2020.04.003

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8 citations

Xiaoxia Lü, Yu Lan, Zude Chen, Debasis Patnaik, Stephanie A. Fiedler +4 more

In vivo human brain expression of histone deacetylases in bipolar disorder

Translational Psychiatry(2020)10.1038/s41398-020-00911-5

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37 citations

Tonya M. Gilbert, Mary C. Catanese, Baileigh G. Hightower, Amy T. Peters, Anjali Parmar +8 more

Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates

The Journal of Experimental Medicine(2020)10.1084/jem.20182266

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32 citations

Changning Wang, Hsiao‐Ying Wey, Yingxia Liang, Zude Chen, Se Hoon Choi +10 more

Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins

Frontiers in Molecular Biosciences(2020)10.3389/fmolb.2020.00198

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6 citations

Yu Lan, Hao Wang, Zude Chen, Stephanie A. Fiedler, Robin Striar +3 more

Epigenetic Signatures of Human Myocardium and Brown Adipose Tissue Revealed with Simultaneous Positron Emission Tomography and Magnetic Resonance of Class I Histone Deacetylases

medRxiv(2020)10.1101/2020.12.06.20244814

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2 citations

Jacob M. Hooker, Frederick A. Schroeder, Choukri Mekkaoui, Tonya M. Gilbert, Marcello Panagia +8 more

Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01477

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26 citations

Ping Bai, Yan Liu, Sepideh Afshar, Robin Striar, A Rattray +8 more

Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.127777

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23 citations

Yiming Xu, Hallie Blevins, Yu Lan, Yan Liu, Gengyang Yuan +8 more

Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I

ACS Chemical Neuroscience(2021)10.1021/acschemneuro.1c00297

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7 citations

Yiming Xu, Savannah Biby, Ping Bai, Yan Liu, Can Zhang +3 more

Molecular imaging of NAD+‐dependent deacetylase SIRT1 in the brain

Alzheimer s & Dementia(2021)10.1002/alz.12344

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5 citations

Zude Chen, Hsiao‐Ying Wey, Yingxia Liang, Rudolph E. Tanzi, Can Zhang +2 more

[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Nature Communications(2022)10.1038/s41467-022-30653-5

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40 citations

Mira Chamoun, Elad Lax, Hsiao‐Ying Wey, Monica Shin, Kok Pin Ng +32 more

Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer’s disease-related neuropathology in cell models

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.101794

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24 citations

Ping Bai, Dan Lei, Yingxia Liang, Sherri Zhen, Grisilda Bakiasi +6 more

Development of sulfonamide-based NLRP3 inhibitors: Further modifications and optimization through structure-activity relationship studies

European Journal of Medicinal Chemistry(2022)10.1016/j.ejmech.2022.114468

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24 citations

Yulong Xu, Hallie Blevins, Chunqing Guo, Savannah Biby, Xiang‐Yang Wang +3 more

Synthesis and characterization of a new Positron emission tomography probe for orexin 2 receptors neuroimaging

Bioorganic Chemistry(2022)10.1016/j.bioorg.2022.105779

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16 citations

Yan Liu, Yulong Xu, Robin Striar, Gengyang Yuan, Sepideh Afshar +4 more

Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6

Biochemistry(2022)10.1021/acs.biochem.2c00332

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10 citations

Ping Bai, Changning Wang, Abigail D. Cragin, Jacob M. Hooker, David W. Christianson +1 more

Epitope alteration by small molecules and applications in drug discovery

Chemical Science(2022)10.1039/d2sc02819k

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9 citations

Jing Yang, Richard Van, Fan Yang, Yue Yu, Astra Yu +16 more

Synthesis and Characterization of 5-(2-Fluoro-4-[ 11 C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2 H -pyrano[2,3- b ]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.1c02004

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4 citations

Maëva Dhaynaut, Yu Lan, Nicolas J. Guehl, Dalena Huynh, Suhasini M. Iyengar +13 more

Preliminary studies of an imidazole-based alcohol derivative for imaging of Heme oxygenase 1

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128674

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0 citations

Yan Liu, Robin Striar, Amelia G. Langan, Anna Kate Rattray, Sepideh Afshar +2 more

Blood tau‐PT217 contributes to the anesthesia/surgery‐induced delirium‐like behavior in aged mice

Alzheimer s & Dementia(2023)10.1002/alz.13118

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49 citations

Feng Liang, Ping Bai, Chenghao Liu, Miao Xu, Zhengwang Sun +13 more

In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer’s disease models

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2310131120

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34 citations

Carly Wickizer, Weihua Ding, Richard Van, Liuyue Yang, Biyue Zhu +10 more

The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption

Nature Communications(2023)10.1038/s41467-023-42283-6

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26 citations

Liuyue Yang, Eleanor Shi, Bowon Kim, Sarah Low, Kun Hu +16 more

Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice

Journal of Clinical Investigation(2023)10.1172/jci166408

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22 citations

Lukas Fischer, Qian Chen, Ziyi Li, Liuyue Yang, Zerong You +20 more

Foramen lacerum impingement of trigeminal nerve root as a rodent model for trigeminal neuralgia

JCI Insight(2023)10.1172/jci.insight.168046

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15 citations

Liuyue Yang, Qian Chen, Kun Hu, Yan Liu, Eric Bao +4 more

Design and Discovery of Novel NLRP3 Inhibitors and PET Imaging Radiotracers Based on a 1,2,3-Triazole-Bearing Scaffold

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01782

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14 citations

Yulong Xu, Savannah Biby, Baljit Kaur, Yan Liu, Frederick A. Bagdasarian +6 more

Noninvasive Positron Emission Tomography Imaging of SIRT1 in a Model of Early-Stage Alcoholic Liver Disease

Molecular Pharmaceutics(2023)10.1021/acs.molpharmaceut.2c00904

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5 citations

Zude Chen, Yanli Wang, Madelyn Rose Hallisey, Breanna Lizeth Varela, Anne Siewko +4 more

Synthesis and Characterization of a New Carbon-11 Labeled Positron Emission Tomography Radiotracer for Orexin 2 Receptors Neuroimaging

Drug Design Development and Therapy(2024)10.2147/dddt.s404992

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11 citations

Yongle Wang, Yan Liu, Cheng Hua, Tewodros Mulugeta Dagnew, Yulong Xu +2 more

Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.4c00512

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6 citations

Prasenjit Mondal, Yiming Xu, Ashley Gomm, Baljit Kaur, Jannatun Nayem Namme +5 more

Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study

iScience(2024)10.1016/j.isci.2024.110159

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5 citations

Chieh-En Jane Tseng, Chi‐Hyeon Yoo, Meena M. Makary, Anna E. Goodheart, Robin Striar +21 more

Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds

Drug Design Development and Therapy(2024)10.2147/dddt.s439589

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3 citations

Yan Liu, Yongle Wang, Ping Bai, Madelyn Rose Hallisey, Breanna Lizeth Varela +4 more

HDAC11 displays neuropathological alterations and offers as a novel drug target for Alzheimer's disease

Alzheimer s & Dementia(2025)10.1002/alz.14616

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7 citations

Prasenjit Mondal, Yan Liu, Ashley Gomm, Claire Suen, Liuyue Yang +8 more

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science(2025)10.1002/advs.202414827

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4 citations

Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Lobo, Hui Meng +8 more

Development of a Novel PET Radioligand Targeting PKM2 for Brain Imaging and Alzheimer’s Disease Characterization

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c02549

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1 citations

Yongle Wang, Wei Zhang, Yulong Xu, Nilay S. Narayan, Hua Cheng +5 more

Syntheses and preclinical evaluations of 11 C-labeled radioligands for imaging brain orexin-1 and orexin-2 receptors with positron emission tomography

RSC Medicinal Chemistry(2025)10.1039/d5md00382b

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2 citations

Pooyeh Ahmadi, Xuefeng Yan, Ping Bai, Jeih-San Liow, Adrian E. Jenson +8 more

Characterization of a novel PET radioligand for mitochondrial complex I in nonhuman primate

Nuclear Medicine and Biology(2025)10.1016/j.nucmedbio.2025.108993

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1 citations

Yiming Xu, Frederick A. Bagdasarian, Tewodros Mulugeta Dagnew, Hua Cheng, Yanli Wang +7 more

18 F-FPP-RGD 2 PET Imaging for Interrogating Target Engagement and Antifibrotic Activity of an Integrin Antagonist in a Mouse Model of Metabolic Dysfunction–Associated Steatohepatitis

Journal of Nuclear Medicine(2025)10.2967/jnumed.125.270047

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0 citations

Caiyuan Zhang, Mozhdeh Sojoodi, Nicholas J. Rotile, Yu Lan, Stephen C. Barrett +7 more

Cannabinoid 1 receptor occupancy and neurovascular responses induced by agonist, antagonist/inverse-agonist and potential modulator in non-human primate brains: PET/fMRI study

Journal of Cerebral Blood Flow & Metabolism(2025)10.1177/0271678x251389042

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0 citations

Yulong Xu, Frederick A. Bagdasarian, Yu-Shiuan Lin, Changning Wang, Hsiao‐Ying Wey +1 more