Charis Eng

Also affiliated with Cleveland Clinic Lerner College of Medicine, Community Care, University School, Case Western Reserve University

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 4%percentile

0.803Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype

Genome biology(2021)10.1186/s13059-021-02269-3

Top 25%

0.803DataRank

Top 25%22 citations

Junfei Zhao, Jiansong Fang, William R. Martin, Lang Li, Ruth Nussinov +4 more

Papers

Driven by 59 papers — median percentile 75. Top paper: “A randomized controlled trial of everolimus for neurocognitive symptoms in PTEN hamartoma tumor syndrome”.

A randomized controlled trial of everolimus for neurocognitive symptoms in PTEN hamartoma tumor syndrome

Human Molecular Genetics(2022)10.1093/hmg/ddac111

N/A

0.908DataRank · unranked

35 citations

Booil Jo, Bo Zhang, Thomas Frazier, Anne Gallagher, Fleming Peck +13 more

My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype

Genome biology(2021)10.1186/s13059-021-02269-3

Top 25%

0.803DataRank

Top 25%22 citations

Junfei Zhao, Jiansong Fang, William R. Martin, Lang Li, Ruth Nussinov +4 more

Cross-level analysis of molecular and neurobehavioral function in a prospective series of patients with germline heterozygous PTEN mutations with and without autism

Molecular Autism(2021)10.1186/s13229-020-00406-6

N/A

0.578DataRank · unranked

16 citations

Ritika Jaini, Robyn M. Busch, Matthew Wolf, Tammy Sadler, Patricia Klaas +12 more

Embryonic stem cell factor FOXD3 (Genesis) defects in gastrointestinal stromal tumors

Endocrine Related Cancer(2023)10.1530/erc-23-0067

N/A

0.269DataRank · unranked

5 citations

Anélia Horvath, Guillaume Assié, Madson Q. Almeida, Eva Szarek, Sosipatros A. Boikos +11 more

Maternal and fetal outcomes in phaeochromocytoma and pregnancy: a multicentre retrospective cohort study and systematic review of literature

The Lancet Diabetes & Endocrinology(2020)10.1016/s2213-8587(20)30363-6

N/A

0DataRank · unranked

68 citations

Elizabeth J. Atkinson, Charis Eng, William F. Young, Hartmut P.H. Neumann, M. Yu. Yukina +95 more

Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

PLoS Computational Biology(2020)10.1371/journal.pcbi.1007701

N/A

0DataRank · unranked

52 citations

Junfei Zhao, Weiqiang Lü, Yao Dai, Jennifer Hockings, Yadi Zhou +4 more

Pharmacogenomics for immunotherapy and immune-related cardiotoxicity

Human Molecular Genetics(2020)10.1093/hmg/ddaa137

N/A

0DataRank · unranked

19 citations

Charis Eng, Feixiong Cheng, Jessica A. Castrillon

A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19

ChemRxiv(2020)10.26434/chemrxiv.12579137

N/A

0DataRank · unranked

30 citations

Yuan Hou, Jiayu Shen, Asha Kalianpur, Joe Zein, Daniel A. Culver +13 more

A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19

ChemRxiv(2020)10.26434/chemrxiv.12579137.v1

N/A

0DataRank · unranked

19 citations

Yuan Hou, Jiayu Shen, Asha Kalianpur, Joe Zein, Daniel A. Culver +13 more

Multimodal Single-Cell Omics Analysis of COVID-19 Sex Differences in Human Immune Systems

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.01.407007

N/A

0DataRank · unranked

1 citations

Yadi Zhou, Michaela U. Gack, Justin D. Lathia, Asha Kallianpur, Reena Mehra +6 more

Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.18.302588

N/A

0DataRank · unranked

0 citations

Junfei Zhao, Yang Wang, Weiqiang Lü, Zehui Liu, Yadi Zhou +19 more

Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis

UNC Libraries(2020)10.17615/v2xq-7x21

N/A

0DataRank · unranked

0 citations

Paul Law, Robert L. Findling, Rebecca Embacher, Eric A. Youngstrom, Charis Eng +3 more

Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

UNC Libraries(2020)10.17615/np0d-4636

N/A

0DataRank · unranked

0 citations

Manaswi Gupta, Anouk van Berkel, Jessica Marquard, Tobias Else, Ian T. Fiddes +95 more

A Founding Locus within the RET Proto-Oncogene May Account for a Large Proportion of Apparently Sporadic Hirschsprung Disease and a Subset of Cases of Sporadic Medullary Thyroid Carcinoma

UNC Libraries(2020)10.17615/rg45-2d02

N/A

0DataRank · unranked

0 citations

Guillermo Antiñolo, Manuel López-Alonso, Fred A. Wright, Raquel Fernandez, Charis Eng +3 more

Validation of Proposed DSM-5 Criteria for Autism Spectrum Disorder

UNC Libraries(2020)10.17615/e3js-4r86

N/A

0DataRank · unranked

0 citations

Antonio Y. Hardan, Robert L. Findling, John N. Constantino, Rebecca Embacher, Paul Law +4 more

A Twin Study of Heritable and Shared Environmental Contributions to Autism

UNC Libraries(2020)10.17615/sxey-bt17

N/A

0DataRank · unranked

0 citations

Charis Eng, Nathan Morris, Eric A. Youngstrom, Antonio Y. Hardan, L.F. Thompson +2 more

Development of an Objective Autism Risk Index Using Remote Eye Tracking

UNC Libraries(2020)10.17615/r95p-5m29

N/A

0DataRank · unranked

0 citations

Eric W. Klingemier, Michael J. Manos, Leslie Markowitz, Eric A. Youngstrom, Leslie Speer +11 more

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

iScience(2021)10.1016/j.isci.2021.102438

N/A

0DataRank · unranked

64 citations

Iris Nira Smith, Charis Eng, Ruth Nussinov, Hyunbum Jang

Multimodal single-cell omics analysis identifies epithelium–immune cell interactions and immune vulnerability associated with sex differences in COVID-19

Signal Transduction and Targeted Therapy(2021)10.1038/s41392-021-00709-x

N/A

0DataRank · unranked

30 citations

Yadi Zhou, Michaela U. Gack, Justin D. Lathia, Asha Kallianpur, Reena Mehra +6 more

A randomized double-blind controlled trial of everolimus in individuals with PTEN mutations: Study design and statistical considerations

Contemporary Clinical Trials Communications(2021)10.1016/j.conctc.2021.100733

N/A

0DataRank · unranked

19 citations

Booil Jo, Thomas Frazier, Patricia Klaas, Robyn M. Busch, Kira A. Dies +7 more

Non-canonical role of wild-type SEC23B in the cellular stress response pathway

Cell Death and Disease(2021)10.1038/s41419-021-03589-9

N/A

0DataRank · unranked

12 citations

Darren Liu, Shuai Fu, Pranav Iyer, Charis Eng, Lamis Yehia

Psychiatric Characteristics Across Individuals With PTEN Mutations

Frontiers in Psychiatry(2021)10.3389/fpsyt.2021.672070

N/A

0DataRank · unranked

17 citations

Mirko Uljarević, Gaëlle Rached, Thomas Frazier, Jennifer M. Phillips, Robin A. Libove +8 more

Brief Report: Role of Parent-Reported Executive Functioning and Anxiety in Insistence on Sameness in Individuals with Germline PTEN Mutations

Journal of Autism and Developmental Disorders(2021)10.1007/s10803-021-04881-5

N/A

0DataRank · unranked

14 citations

Thomas Frazier, Gaëlle Rached, Robyn M. Busch, Patricia Klaas, Siddharth Srivastava +5 more

The role of genetic polymorphisms in executive functioning performance in temporal lobe epilepsy

Epilepsy & Behavior(2021)10.1016/j.yebeh.2021.108088

N/A

0DataRank · unranked

8 citations

Tyler G. Kinzy, Lisa Ferguson, Jessica Altemus, Bruce P. Hermann, Charis Eng +3 more

Toward better characterization of restricted and repetitive behaviors in individuals with germline heterozygous PTEN mutations

American Journal of Medical Genetics Part A(2021)10.1002/ajmg.a.62458

N/A

0DataRank · unranked

7 citations

Thomas Frazier, Gaëlle Rached, Robyn M. Busch, Patricia Klaas, Siddharth Srivastava +5 more

Characterization of the colorectal cancer–associated enhancer MYC-335 at 8q24: the role of rs67491583

UNC Libraries(2021)10.17615/x90d-n159

N/A

0DataRank · unranked

0 citations

Albert de la Chapelle, Michael J. Pennison, Jian Yan, Eevi Kaasinen, Hassan Askhtorab +21 more

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.06.425565

N/A

0DataRank · unranked

2 citations

Iris Nira Smith, Charis Eng, Ruth Nussinov, Hyunbum Jang

Targeting the Cx26/NANOG/Focal Adhesion Kinase Complex via Cell-Penetrating Peptides in Triple-Negative Breast Cancers

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.09.459689

N/A

0DataRank · unranked

0 citations

Emily Esakov Rhoades, Salma Ben‐Salem, Rashmi Bharti, Nicole Hajdari, Sadie Johnson +8 more

Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer’s disease

Cell Reports(2022)10.1016/j.celrep.2022.111717

N/A

0DataRank · unranked

106 citations

Chengsheng Mao, Yuan Hou, Yuan Luo, Jessica Binder, Yadi Zhou +12 more

Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from human non-coding genomes

Human Molecular Genetics(2022)10.1093/hmg/ddac208

N/A

0DataRank · unranked

24 citations

Yuan Hou, Charis Eng, Feixiong Cheng, M. Bykova

Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation

Journal of Chemical Information and Modeling(2022)10.1021/acs.jcim.2c00441

N/A

0DataRank · unranked

19 citations

Jennifer E. Dawson, James Krieger, Stetson Thacker, İvet Bahar, Charis Eng +1 more

Distinct metabolic profiles associated with autism spectrum disorder versus cancer in individuals with germline PTEN mutations

npj Genomic Medicine(2022)10.1038/s41525-022-00289-x

N/A

0DataRank · unranked

14 citations

Ying Ni, Tammy Sadler, Thomas Frazier, Charis Eng, Lamis Yehia

Shape shifting: The multiple conformational substates of the PTEN N‐terminal PIP2‐binding domain

Protein Science(2022)10.1002/pro.4308

N/A

0DataRank · unranked

13 citations

Iris Nira Smith, William R. Martin, Krishnendu Khan, Feixiong Cheng, Charis Eng +1 more

Genetic and molecular features of seizure-freedom following surgical resections for focal epilepsy: A pilot study

Frontiers in Neurology(2022)10.3389/fneur.2022.942643

N/A

0DataRank · unranked

10 citations

Robyn M. Busch, Dennis Lal, Jennifer Hockings, Olivia Hogue, Marcia Morita‐Sherman +8 more

Characterizing dermatologic findings among patients with PTEN hamartoma tumor syndrome: Results of a multicenter cohort study

Journal of the American Academy of Dermatology(2022)10.1016/j.jaad.2022.01.045

N/A

0DataRank · unranked

8 citations

Lamis Yehia, Christine M. McDonald, Julián A. Martínez-Agosto, Antonio Y. Hardan, Joan Tamburro +4 more

Structural and Dynamic Effects of PTEN C-terminal Tail Phosphorylation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.16.488508

N/A

0DataRank · unranked

1 citations

Jennifer E. Dawson, James Krieger, Stetson Thacker, İvet Bahar, Charis Eng +1 more

Development of informant‐report neurobehavioral survey scales for PTEN hamartoma tumor syndrome and related neurodevelopmental genetic syndromes

American Journal of Medical Genetics Part A(2023)10.1002/ajmg.a.63195

N/A

0DataRank · unranked

16 citations

Robyn M. Busch, Patricia Klaas, Katherine Lachlan, Shafali Jeste, A lexander Kolevzon +15 more

Targeting NANOG and FAK via Cx26-derived Cell-penetrating Peptides in Triple-negative Breast Cancer

Molecular Cancer Therapeutics(2023)10.1158/1535-7163.mct-21-0783

N/A

0DataRank · unranked

12 citations

Emily Esakov Rhoades, Salma Ben‐Salem, Rashmi Bharti, Nicole Hajdari, Sadie Johnson +8 more

Longitudinal neurobehavioral profiles in children and young adults with PTEN hamartoma tumor syndrome and reliable methods for assessing neurobehavioral change

Journal of Neurodevelopmental Disorders(2023)10.1186/s11689-022-09468-4

N/A

0DataRank · unranked

11 citations

Thomas Frazier, Claire Sonneborn, Olivia Hogue, Patricia Klaas, Siddharth Srivastava +5 more

Molecular subtypes of epilepsy associated with post-surgical seizure recurrence

Brain Communications(2023)10.1093/braincomms/fcad251

N/A

0DataRank · unranked

10 citations

Shreya Louis, Robyn M. Busch, Deborah Vegh, Imad Najm, Peter Bazeley +4 more

Hemizygous variants in protein phosphatase 1 regulatory subunit 3F (PPP1R3F) are associated with a neurodevelopmental disorder characterized by developmental delay, intellectual disability and autistic features

Human Molecular Genetics(2023)10.1093/hmg/ddad124

N/A

0DataRank · unranked

7 citations

Baozhong Xin, Iris Nira Smith, Valerie Sency, Julia Szekely, Anna Alkelai +49 more

The mitochondrial genome as a modifier of autism versus cancer phenotypes in PTEN hamartoma tumor syndrome

Human Genetics and Genomics Advances(2023)10.1016/j.xhgg.2023.100199

N/A

0DataRank · unranked

5 citations

Lamis Yehia, Ying Ni, Charis Eng, Ruipeng Wei

Data from Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

(2023)10.1158/0008-5472.c.6497130

N/A

0DataRank · unranked

0 citations

Koichi Fukino, Alain de Bruin, Wei Guo, Lei Shen, Stephan M. Tanner +7 more

Update on Pediatric Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome, DICER1- Related Tumor Predisposition, and Tuberous Sclerosis Complex

Clinical Cancer Research(2024)10.1158/1078-0432.ccr-24-1947

N/A

0DataRank · unranked

30 citations

Suzanne P. MacFarland, Melissa R. Perrino, Sarah G. Mitchell, Junne Kamihara, Alexander T. Nelson +18 more

Characterization of immunomodulating agents from Staphylococcus aureus for priming immunotherapy in triple-negative breast cancers

Scientific Reports(2024)10.1038/s41598-024-51361-8

N/A

0DataRank · unranked

11 citations

Matthew Wolf, Ruth Ortego, Dennis J. Grencewicz, Tammy Sadler, Charis Eng +1 more

Exploring the neurological features of individuals with germline PTEN variants: A multicenter study

Annals of Clinical and Translational Neurology(2024)10.1002/acn3.52046

N/A

0DataRank · unranked

13 citations

Sarah Baitamouni, Darren Liu, Robyn M. Busch, Patricia Klaas, Thomas Frazier +10 more

The Genomic Landscape of Benign and Malignant Thyroid Tumors from Individuals Carrying Germline PTEN Variants Is Distinct from Sporadic Thyroid Cancers

Cancer Research(2024)10.1158/0008-5472.can-23-2216

N/A

0DataRank · unranked

8 citations

Takae Brewer, Lamis Yehia, Laura Rabinowitz, Christopher C. Griffith, Charis Eng +1 more

Quantitative evaluation of DNA damage repair dynamics to elucidate predictors of autism vs. cancer in individuals with germline PTEN variants

PLoS Computational Biology(2024)10.1371/journal.pcbi.1012449

N/A

0DataRank · unranked

5 citations

Masahiro Hitomi, Tammy Sadler, Lamis Yehia, Daniela Calvetti, Jacob G. Scott +2 more

Remote monitoring of social attention in neurogenetic syndromes and idiopathic neurodevelopmental disability

Autism Research(2024)10.1002/aur.3290

N/A

0DataRank · unranked

4 citations

Robyn M. Busch, Patricia Klaas, Katherine Lachlan, Shafali Jeste, A lexander Kolevzon +16 more

A Computational Approach in the Systematic Search of the Interaction Partners of Alternatively Spliced TREM2 Isoforms

International Journal of Molecular Sciences(2024)10.3390/ijms25179667

N/A

0DataRank · unranked

1 citations

Aditya Menon, Taylor Tomco, Nisha Bhattarai, Iris Nira Smith, Maria Khrestian +5 more

The new microbiome on the block: challenges and opportunities of using human tumor sequencing data to study microbes

Nature Methods(2025)10.1038/s41592-025-02807-y

N/A

0DataRank · unranked

15 citations

Anjun Ma, Evan Johnson, Charis Eng, Subhajyoti De, Sizun Jiang +4 more

Which Score for What? Operationalizing Standardized Cognitive Test Performance for the Assessment of Change

American Journal on Intellectual and Developmental Disabilities(2025)10.1352/1944-7558-130.5.344

N/A

0DataRank · unranked

3 citations

Audrey Thurm, Tanvi Das, E. Martina Bebin, Jonathan A. Bernstein, Elizabeth Berry‐Kravis +14 more

Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction

Structure(2025)10.1016/j.str.2025.06.002

N/A

0DataRank · unranked

1 citations

Iris Nira Smith, Ann M. Tushar, Charis Eng, Jennifer E. Dawson

Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder

Autism Research(2025)10.1002/aur.70119

N/A

0DataRank · unranked

1 citations

Nick Sarn, Charis Eng, Kevin M. Wright, Alejandra Fernandez

A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

PLoS Biology(2020)10.1371/journal.pbio.3000970

N/A

0DataRank · unranked

186 citations

Yuan Hou, Jiayu Shen, Reena Mehra, Asha Kallianpur, Daniel A. Culver +13 more

Neurobehavioral Signatures in Overgrowth Intellectual Disability Syndromes: Dissecting Genotype-Phenotype Relationships in the PI3K-AKT-MTOR Pathway

medRxiv(2025)10.1101/2025.08.19.25333388

N/A

0DataRank · unranked

1 citations

Gerhard Hellemann, Irma Gutierrez-Mejia, Dzung C. Nguyen, Joshua Sadik, Veronica I. Gandara +7 more

New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis

BMC Medicine(2020)10.1186/s12916-020-01673-z

N/A

0DataRank · unranked

456 citations

Junfei Zhao, William R. Martin, Asha Kallianpur, Mina K. Chung, Lara Jehi +5 more

Target identification among known drugs by deep learning from heterogeneous networks

Chemical Science(2020)10.1039/c9sc04336e

N/A

0DataRank · unranked

354 citations

Siyi Zhu, Weiqiang Lü, Zehui Liu, Jin Huang, Yadi Zhou +10 more

WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition

New England Journal of Medicine(2020)10.1056/nejmoa1914919

N/A

0DataRank · unranked

79 citations

Lamis Yehia, Takahiro Kishikawa, Ying Ni, Brandie Heald, Jinfang Zhang +6 more

Charis Eng

Indexed papers

Top data-sharing exemplar

Papers