Anton Simeonov

Also affiliated with National Center for Advancing Translational Sciences

Computer SciencePharmacology, Toxicology and PharmaceuticsBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

19.9Author DataRank

Indexed papers

8in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 8 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.0c00264

Top 4%

5.0DataRank

Top 4%314 citations

Ruili Huang, Suramya Waidyanatha, Paul Shinn, Bradley J. Collins, Inthirany Thillainadarajah +19 more

Papers

Driven by 125 papers — median percentile 90. Top paper: “The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology”.

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.0c00264

Top 4%

5.0DataRank

Top 4%314 citations

Ruili Huang, Suramya Waidyanatha, Paul Shinn, Bradley J. Collins, Inthirany Thillainadarajah +19 more

CATMoS: Collaborative Acute Toxicity Modeling Suite

Environmental Health Perspectives(2021)10.1289/ehp8495

Top 4%

4.9DataRank

Top 4%142 citations

Agnes L. Karmaus, Jeremy Fitzpatrick, Grace Patlewicz, Prachi Pradeep, Domenico Alberga +95 more

TCRD and Pharos 2021: mining the human proteome for disease biology

Nucleic Acids Research(2020)10.1093/nar/gkaa993

Top 5%

4.2DataRank

Top 5%177 citations

Stephen L. Mathias, Keith J. Kelleher, Vishal B. Siramshetty, Ðắc-Trung Nguyễn, Cristian Bologa +14 more

Real-time sharing of drug screening data on the NCATS OpenData Portal accelerates translational research

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.04.135046

Top 7%

3.3DataRank

Top 7%108 citations

Tongan Zhao, Richard T. Eastman, Xin Hu, Ke Wang, Mark Backus +31 more

Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00193

N/A

3.1DataRank · unranked

90 citations

Gregory J. Tawa, Mark J. Henderson, Carina Danchik, Suiyang Liu, Pranav Shah +10 more

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00916

N/A

1.7DataRank · unranked

63 citations

Daniel J. Urban, Bryan T. Mott, Xin Hu, Shyh‐Ming Yang, Gloria A. Benavides +40 more

High-Throughput Screening to Predict Chemical-Assay Interference

Scientific Reports(2020)10.1038/s41598-020-60747-3

Top 13%

1.6DataRank

Top 13%43 citations

Ruili Huang, Srilatha Sakamuru, Menghang Xia, Anton Simeonov, Kamel Mansouri +4 more

Small molecule antiviral compound collection (SMACC): A comprehensive, highly curated database to support the discovery of broad-spectrum antiviral drug molecules

Antiviral Research(2023)10.1016/j.antiviral.2023.105620

Top 35%

0.564DataRank

Top 35%14 citations

Cleber C. Melo‐Filho, Daniel Korn, Richard T. Eastman, Ganesha Rai, Anton Simeonov +4 more

ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancer

Cell Reports(2024)10.1016/j.celrep.2024.114991

N/A

0.362DataRank · unranked

9 citations

Marco Seehawer, Zheqi Li, Andriana Patmanidis, Triet M. Bui, Pierre Foidart +19 more

Small Molecule Antiviral Compound Collection (SMACC): a database to support the discovery of broad-spectrum antiviral drug molecules

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.09.499397

Top 52%

0.333DataRank

Top 52%5 citations

Cleber C. Melo‐Filho, Daniel Korn, Richard T. Eastman, Ganesha Rai, Anton Simeonov +4 more

A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers

Toxicology Letters(2020)10.1016/j.toxlet.2020.12.002

N/A

0DataRank · unranked

15 citations

Yuhong Fang, Maya L. Gosztyla, Andrew J. Li, Wenwei Huang, Christopher A. LeClair +4 more

Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences

SLAS DISCOVERY(2020)10.1177/2472555220911451

N/A

0DataRank · unranked

10 citations

Tobie D. Lee, Dorian M. Cheff, Maya L. Gosztyla, Rosita R. Asawa, Carina Danchik +6 more

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2005463117

N/A

0DataRank · unranked

47 citations

Adam Yasgar, T Teramoto, Myoung‐Hwa Lee, Dorjbal Dorjsuren, Richard T. Eastman +13 more

Predictive Models for Human Organ Toxicity Based on In Vitro Bioactivity Data and Chemical Structure

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.9b00305

N/A

0DataRank · unranked

39 citations

Deborah K. Ngan, Lin Ye, Menghang Xia, Heidi Q. Xie, Bin Zhao +3 more

A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells

Scientific Reports(2020)10.1038/s41598-020-61082-3

N/A

0DataRank · unranked

36 citations

Carina Danchik, Alexey Zakharov, Yu‐Chi Chen, Ty C. Voss, Ajit Jadhav +6 more

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

Cancer Research(2020)10.1158/0008-5472.can-19-2207

N/A

0DataRank · unranked

31 citations

Manikandan Periyasamy, Ajit Jadhav, Dorjbal Dorjsuren, Joseph C. Siefert, Theresa E. Hickey +17 more

Systematic Identification of Molecular Targets and Pathways Related to Human Organ Level Toxicity

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.0c00305

N/A

0DataRank · unranked

25 citations

Weida Tong, Menghang Xia, Anton Simeonov, Ruili Huang, Tuan Xu

Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.

INDIGO (University of Illinois at Chicago)(2020)10.17615/0ecj-ye88

N/A

0DataRank · unranked

5 citations

C.H. Arrowsmith, Irene Chau, Guillermo Senisterra, Masoud Vedadi, Jian Jin +16 more

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.18.255877

N/A

0DataRank · unranked

30 citations

Paul Shinn, Zina Itkin, Richard T. Eastman, Robert Bostwick, Lynn Rasmussen +14 more

Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19

Preprints.org(2020)10.20944/preprints202004.0299.v1

N/A

0DataRank · unranked

18 citations

Jacob S. Roth, Kyle R. Brimacombe, Anton Simeonov, Min Shen, Samarjit Patnaik +2 more

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.29.178889

N/A

0DataRank · unranked

15 citations

Lu Chen, Richard T. Eastman, Zina Itkin, Paul Shinn, Catherine Chen +8 more

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.27.223578

N/A

0DataRank · unranked

15 citations

Miao Xu, Hu Zhu, Catherine Z. Chen, Emily M. Lee, Shihua He +11 more

Discovery of TMPRSS2 inhibitors from virtual screening

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.28.424413

N/A

0DataRank · unranked

8 citations

Jonathan H. Shrimp, Hui Guo, Miao Xu, Catherine Z. Chen, Wei Zhu +7 more

Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.03.235242

N/A

0DataRank · unranked

7 citations

Pinar Ormanoglu, Jaroslav Slamecka, Claire Malley, Pei‐Hsuan Chu, Vukasin M. Jovanovic +12 more

Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.03.187039

N/A

0DataRank · unranked

1 citations

Zina Itkin, Lu Chen, Gergely Zahoránszky-Köhalmi, Chanaki Amaratunga, Olivo Miotto +10 more

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.04.976548

N/A

0DataRank · unranked

0 citations

Emily M. Lee, Jianbo Pan, Miao Xu, Hee‐Sool Rho, Yichen Cheng +20 more

A High Throughput Fluorescence Polarization Assay for Inhibitors of the GoLoco Motif/G-alpha Interaction

UNC Libraries(2020)10.17615/g5ha-5183

N/A

0DataRank · unranked

0 citations

David P. Siderovski, Anton Simeonov, Ajit Jadhav, Mark Hughes, Adam J. Kimple +6 more

High-Throughput Screen Identifies Cyclic Nucleotide Analogs That Inhibit Prostatic Acid Phosphatase

UNC Libraries(2020)10.17615/5kdc-c884

N/A

0DataRank · unranked

0 citations

Eric S. McCoy, Ajit Jadhav, Mark J. Zylka, David J. Maloney, Anton Simeonov +2 more

A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells

Nature Methods(2021)10.1038/s41592-021-01126-2

N/A

0DataRank · unranked

186 citations

Carlos A. Tristan, Lu Chen, Vukasin M. Jovanovic, Claire Malley, Pei‐Hsuan Chu +13 more

Large-Scale Modeling of Multispecies Acute Toxicity End Points Using Consensus of Multitask Deep Learning Methods

Journal of Chemical Information and Modeling(2021)10.1021/acs.jcim.0c01164

N/A

0DataRank · unranked

103 citations

Vishal B. Siramshetty, Vinícius M. Alves, Eugene Muratov, Nicole Kleinstreuer, Alexander Tropsha +4 more

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Frontiers in Pharmacology(2021)10.3389/fphar.2020.592737

N/A

0DataRank · unranked

95 citations

Paul Shinn, Zina Itkin, Richard T. Eastman, Robert Bostwick, Lynn Rasmussen +14 more

Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells

Stem Cell Reports(2021)10.1016/j.stemcr.2021.11.004

N/A

0DataRank · unranked

69 citations

Pinar Ormanoglu, Jaroslav Slamecka, Claire Malley, Pei‐Hsuan Chu, Vukasin M. Jovanovic +13 more

Biological activity-based modeling identifies antiviral leads against SARS-CoV-2

Nature Biotechnology(2021)10.1038/s41587-021-00839-1

N/A

0DataRank · unranked

53 citations

Miao Xu, Hu Zhu, Catherine Z. Chen, Wei Zhu, Emily M. Lee +15 more

A Universal and High-Throughput Proteomics Sample Preparation Platform

Analytical Chemistry(2021)10.1021/acs.analchem.1c00265

N/A

0DataRank · unranked

47 citations

Yaqin Zhang, Tuan Xu, Zhengxi Wei, Qin Yao, Yuhong Fang +8 more

The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101191

N/A

0DataRank · unranked

40 citations

Warunee Dansithong, Stephen C. Kales, Sharan Paul, Gentrie Maag, Erika Aoyama +12 more

Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition

Drug Metabolism and Disposition(2021)10.1124/dmd.120.000320

N/A

0DataRank · unranked

40 citations

Sankalp Jain, Pranav Shah, Nao Torimoto‐Katori, Alexey Zakharov, Ðắc-Trung Nguyễn +8 more

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

Scientific Reports(2021)10.1038/s41598-021-86110-8

N/A

0DataRank · unranked

31 citations

Catherine Z. Chen, Srilatha Sakamuru, Jinghua Zhao, Deborah K. Ngan, Anton Simeonov +5 more

Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00019

N/A

0DataRank · unranked

29 citations

Karavadhi Surendra, Rajan Pragani, Li Liu, Yuhong Fang, Weihe Zhang +28 more

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

Cell Reports(2021)10.1016/j.celrep.2021.109040

N/A

0DataRank · unranked

29 citations

Kathleen A. Trychta, Shyh‐Ming Yang, Susanne Bäck, Adam Yasgar, Emily S. Wires +21 more

Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2

Bioorganic & Medicinal Chemistry(2021)10.1016/j.bmc.2021.116349

N/A

0DataRank · unranked

28 citations

Nathaniel C. Gilbert, Amanda Ohler, Michelle Armstrong, Steve Perry, Chakrapani Kalyanaraman +14 more

Predictive Models to Identify Small Molecule Activators and Inhibitors of Opioid Receptors

Journal of Chemical Information and Modeling(2021)10.1021/acs.jcim.1c00439

N/A

0DataRank · unranked

27 citations

Jinghua Zhao, Menghang Xia, Huixiao Hong, Anton Simeonov, Iosif I. Vaisman +2 more

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites

Scientific Reports(2021)10.1038/s41598-021-81486-z

N/A

0DataRank · unranked

25 citations

Richard T. Eastman, Kathryn J. Wicht, Daniel J. Jansen, Daniel C. Talley, Benjamin A. Sigmon +25 more

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.127906

N/A

0DataRank · unranked

24 citations

Miao Xu, Xin Hu, Emily M. Lee, Xiao Lü, Ruili Huang +19 more

Hybrid In Silico Approach Reveals Novel Inhibitors of Multiple SARS-CoV-2 Variants

ACS Pharmacology & Translational Science(2021)10.1021/acsptsci.1c00176

N/A

0DataRank · unranked

16 citations

Daniel C. Talley, Bolormaa Baljinnyam, Jun Choe, Quinlin Hanson, Wei Zhu +10 more

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

Genomics Proteomics & Bioinformatics(2021)10.1016/j.gpb.2020.06.016

N/A

0DataRank · unranked

13 citations

Emily M. Lee, Jianbo Pan, Miao Xu, Hee‐Sool Rho, Yichen Cheng +20 more

Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells

ACS Pharmacology & Translational Science(2021)10.1021/acsptsci.1c00064

N/A

0DataRank · unranked

12 citations

Adam Yasgar, Robert W. Maul, Amanda E. Rieffer, Daniel Crawford, Daniel J. Salamango +10 more

High-Throughput Detection of Ligand-Protein Binding Using a SplitLuc Cellular Thermal Shift Assay

Methods in molecular biology(2021)10.1007/978-1-0716-1665-9_2

N/A

0DataRank · unranked

15 citations

Ashley E. Owens, Natalia J. Martinez, Eric Wallgren, Anton Simeonov, Mark J. Henderson +1 more

Cross-Platform Bayesian Optimization System for Autonomous Biological Assay Development

SLAS TECHNOLOGY(2021)10.1177/24726303211053782

N/A

0DataRank · unranked

11 citations

Carleen Klumpp‐Thomas, Adam Yasgar, Jameson Travers, Shayne Frebert, Kelli M. Wilson +9 more

Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules

Methods in molecular biology(2021)10.1007/7651_2021_394

N/A

0DataRank · unranked

10 citations

Pei‐Hsuan Chu, Claire Malley, John Braisted, Pinar Ormanoglu, Ruili Huang +9 more

Identification of hit compounds with anti-schistosomal activity on in vitro generated juvenile worms in cell-free medium

PLoS neglected tropical diseases(2021)10.1371/journal.pntd.0009432

N/A

0DataRank · unranked

3 citations

Ulrich Fabien Prodjinotho, Nagwa Elkhafif, Ruili Huang, Anton Simeonov, Thomas Spangenberg +2 more

Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite

Environmental Health Perspectives(2021)10.1289/ehp10369

N/A

0DataRank · unranked

31 citations

Agnes L. Karmaus, Jeremy Fitzpatrick, Grace Patlewicz, Prachi Pradeep, Domenico Alberga +95 more

Cross-platform Bayesian optimization system for autonomous biological assay development

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.23.448246

N/A

0DataRank · unranked

1 citations

Carleen Klumpp‐Thomas, Adam Yasgar, Jameson Travers, Shayne Frebert, Kelli M. Wilson +9 more

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.22.465476

N/A

0DataRank · unranked

1 citations

Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu +26 more

Correction to: Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules

Methods in molecular biology(2021)10.1007/7651_2021_458

N/A

0DataRank · unranked

1 citations

Pei‐Hsuan Chu, Claire Malley, John Braisted, Pinar Ormanoglu, Ruili Huang +9 more

Inhibiting SARS‐CoV‐2 infection with lysosomal alkalizers

The FASEB Journal(2021)10.1096/fasebj.2021.35.s1.02122

N/A

0DataRank · unranked

0 citations

Catherine Chen, Robert Bostwick, Lynn Rasmussen, Bruce Nguyen Tran, Yu‐Shan Cheng +21 more

Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.07.467657

N/A

0DataRank · unranked

0 citations

Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris Brown, Punn Augsornworawat +12 more

Efficient and safe single-cell cloning of human pluripotent stem cells using the CEPT cocktail

Nature Protocols(2022)10.1038/s41596-022-00753-z

N/A

0DataRank · unranked

47 citations

Hyenjong Hong, Yogita Jethmalani, Yu Chen, Claire Weber, Pei‐Hsuan Chu +7 more

Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data

Toxicology and Applied Pharmacology(2022)10.1016/j.taap.2022.116250

N/A

0DataRank · unranked

44 citations

Deborah K. Ngan, Tuan Xu, Zhichao Liu, Jinghua Zhao, Srilatha Sakamuru +6 more

Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome

JCI Insight(2022)10.1172/jci.insight.156549

N/A

0DataRank · unranked

30 citations

Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris Brown, Punn Augsornworawat +12 more

Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation

Archives of Toxicology(2022)10.1007/s00204-022-03291-5

N/A

0DataRank · unranked

24 citations

Jinghua Zhao, Pranav Shah, Jameson Travers, Carleen Klumpp‐Thomas, Xin Xu +7 more

Allosteric Binders of ACE2 Are Promising Anti-SARS-CoV-2 Agents

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00049

N/A

0DataRank · unranked

23 citations

Sankalp Jain, Cleber C. Melo‐Filho, Zoe L. Sessions, Tesia Bobrowski, Jun Choe +10 more

LUHMES Dopaminergic Neurons Are Uniquely Susceptible to Ferroptosis

Neurotoxicity Research(2022)10.1007/s12640-022-00538-y

N/A

0DataRank · unranked

23 citations

Hyunhee Kim, Lara El Touny, Anton Simeonov, David Gerhold, Zhi‐Bin Tong

A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102228

N/A

0DataRank · unranked

21 citations

Mandi Gandelman, Sharan Paul, Thomas S. Dexheimer, Warunee Dansithong, Karla P. Figueroa +11 more

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

PLoS ONE(2022)10.1371/journal.pone.0272364

N/A

0DataRank · unranked

18 citations

Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu +27 more

Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor

Nature Communications(2022)10.1038/s41467-022-33762-3

N/A

0DataRank · unranked

16 citations

Stephen C. Kales, James A. Cornwell, Marwa M. Afifi, Ganesha Rai, Alexey Zakharov +3 more

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

PLoS ONE(2022)10.1371/journal.pone.0261821

N/A

0DataRank · unranked

9 citations

Richard T. Eastman, Min Jae Song, Adam Yasgar, Yuchi Chen, Kapil Bharti +6 more

Controlled Proteolysis of an Essential Virulence Determinant Dictates Infectivity of Lyme Disease Pathogens

Infection and Immunity(2022)10.1128/iai.00059-22

N/A

0DataRank · unranked

9 citations

Sandhya Bista, Shelby D. Foor, Shraboni Dutta, Xiuli Yang, Michael Ronzetti +9 more

Advances in luminescence-based technologies for drug discovery

Expert Opinion on Drug Discovery(2022)10.1080/17460441.2023.2160441

N/A

0DataRank · unranked

16 citations

Michael Ronzetti, Anton Simeonov, Bolormaa Baljinnyam

A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System

mBio(2022)10.1128/mbio.00240-22

N/A

0DataRank · unranked

8 citations

Dorjbal Dorjsuren, Stephanie S. Lehman, C. L. Larson, Steven A. Titus, Hongmao Sun +6 more

Application of temperature-responsive HIS-tag fluorophores to differential scanning fluorimetry screening of small molecule libraries

Frontiers in Pharmacology(2022)10.3389/fphar.2022.1040039

N/A

0DataRank · unranked

4 citations

Bolormaa Baljinnyam, Zina Itkin, Sankalp Jain, Ganesha Rai, Alexey Zakharov +3 more

Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

ACS Infectious Diseases(2022)10.1021/acsinfecdis.2c00172

N/A

0DataRank · unranked

8 citations

John Janiszewski, Catherine Z. Chen, Miao Xu, Kelli M. Wilson, Stephen C. Kales +12 more

Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem Cells

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.24.485622

N/A

0DataRank · unranked

4 citations

Carlos A. Tristan, Claire Weber, Pei‐Hsuan Chu, Seungmi Ryu, Vukasin M. Jovanovic +12 more

Application of biophysical methods for improved protein production and characterization: a case study on an HtrA-family bacterial protease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.27.477556

N/A

0DataRank · unranked

1 citations

Bolormaa Baljinnyam, Ishrat Jalal, Utpal Pal, Anton Simeonov, Michael Ronzetti

A Comprehensive Roadmap of Human Placental Development in vitro

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.07.487558

N/A

0DataRank · unranked

0 citations

Carlos A. Tristan, Seungmi Ryu, Pei‐Hsuan Chu, Claire Weber, Tao Deng +7 more

High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions

The Annual Review of Pharmacology and Toxicology(2023)10.1146/annurev-pharmtox-112122-104310

N/A

0DataRank · unranked

55 citations

Srilatha Sakamuru, Masato Ooka, Ruili Huang, Carleen Klumpp‐Thomas, Paul Shinn +10 more

Dome1–JAK–STAT signaling between parasite and host integrates vector immunity and development

Science(2023)10.1126/science.abl3837

N/A

0DataRank · unranked

54 citations

Chrysoula Kitsou, Shraboni Dutta, Michael Ronzetti, Min Zhang, Quentin Bernard +20 more

Scalable generation of sensory neurons from human pluripotent stem cells

Stem Cell Reports(2023)10.1016/j.stemcr.2023.03.006

N/A

0DataRank · unranked

52 citations

Vukasin M. Jovanovic, Carlos A. Tristan, Claire Weber, Pei‐Hsuan Chu, Jason Inman +17 more

A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells

Stem Cell Reports(2023)10.1016/j.stemcr.2023.06.007

N/A

0DataRank · unranked

33 citations

Claire Weber, Jaroslav Slamecka, Seungmi Ryu, Pei‐Hsuan Chu, Chaitali Sen +15 more

Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00482

N/A

0DataRank · unranked

14 citations

Adam Yasgar, James Wellnitz, Ganesha Rai, Marielle Rath, Rodolpho C. Braga +6 more

Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2218896120

N/A

0DataRank · unranked

27 citations

Karolina Mikulska‐Ruminska, Yulia Y. Tyurina, Diane K. Luci, Adam Yasgar, Svetlana N. Samovich +23 more

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

Nature Communications(2023)10.1038/s41467-023-40537-x

N/A

0DataRank · unranked

25 citations

Yongwang Zhong, Xin Hu, Tuan Xu, Ying‐Hua Zhang, Stephen C. Kales +13 more

Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

Redox Biology(2023)10.1016/j.redox.2023.102611

N/A

0DataRank · unranked

24 citations

Ganesha Rai, A. V. Kozyr, Nathaniel De Jonge, Emily F. Gliniewicz, Lars J. Berg +16 more

Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors

ACS Chemical Biology(2023)10.1021/acschembio.3c00293

N/A

0DataRank · unranked

12 citations

Deepika R. Tripu, Samuel A. Barritt, Yihang Jing, Diamond Gallimore, Stephen C. Kales +11 more

Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates

Journal of Chemical Information and Modeling(2023)10.1021/acs.jcim.2c01516

N/A

0DataRank · unranked

13 citations

Md Kabir, Srilatha Sakamuru, Pranav Shah, Elias Carvalho Padilha, Deborah K. Ngan +5 more

In vitro profiling of pesticides within the Tox21 10K compound library for bioactivity and potential toxicity

Toxicology and Applied Pharmacology(2023)10.1016/j.taap.2023.116600

N/A

0DataRank · unranked

9 citations

Menghang Xia, Anton Simeonov, Ruili Huang, Deborah K. Ngan

Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc

Antimicrobial Agents and Chemotherapy(2023)10.1128/aac.01465-22

N/A

0DataRank · unranked

8 citations

Jéssica E. Araújo, Bingbing Deng, Kazutoyo Miura, Xiomara A. Gaitán, Maísa da Silva Araújo +6 more

Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs

ACS Pharmacology & Translational Science(2023)10.1021/acsptsci.2c00250

N/A

0DataRank · unranked

5 citations

Hobin Lee, Paola Oliva, Klára Kirsch, Bo-Ra Kim, Jong Il Ahn +11 more

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells

Biochemical and Biophysical Research Communications(2023)10.1016/j.bbrc.2023.08.050

N/A

0DataRank · unranked

4 citations

Mindy I. Davis, Kazutaka Sumita, Yu-Xiang Zheng, Satoshi Kofuji, Mika Sasaki +9 more

RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma

Cancer Immunology Research(2023)10.1158/2326-6066.cir-22-1023

N/A

0DataRank · unranked

4 citations

Shuwen Cao, Shyh‐Ming Yang, Ganesha Rai, Natalia J. Martinez, Adam Yasgar +11 more

A unique borrelial protein facilitates microbial immune evasion

mBio(2023)10.1128/mbio.02135-23

N/A

0DataRank · unranked

2 citations

Kalvis Brangulis, Anil Kumar Shakya, Vipin Singh Rana, Sandhya Bista, Chrysoula Kitsou +12 more

Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.15.540887

N/A

0DataRank · unranked

3 citations

Deepika R. Tripu, Samuel A. Barritt, Yihang Jing, Diamond Gallimore, Stephen C. Kales +11 more

Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds.

ChemRxiv(2023)10.26434/chemrxiv-2023-r78sj

N/A

0DataRank · unranked

2 citations

Adam Yasgar, James Wellnitz, Ganesha Bantukallu, Marielle Rath, Rodolpho C. Braga +6 more

Editorial: Biophysical target engagement assays in chemical biology and pharmacological research

Frontiers in Cell and Developmental Biology(2023)10.3389/fcell.2023.1163966

N/A

0DataRank · unranked

2 citations

Nathan P. Coussens, Anton Simeonov, Bolormaa Baljinnyam

Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc

Zenodo (CERN European Organization for Nuclear Research)(2023)10.5281/zenodo.8246875

N/A

0DataRank · unranked

0 citations

Jéssica E. Araújo, Bingbing Deng, Kazutoyo Miura, Xiomara A. Gaitán, Maísa da Silva Araújo +6 more

Use of Tox21 screening data to profile PFAS bioactivities on nuclear receptors, cellular stress pathways, and cytochrome p450 enzymes

Journal of Hazardous Materials(2024)10.1016/j.jhazmat.2024.134642

N/A

0DataRank · unranked

19 citations

Srilatha Sakamuru, Jinghua Zhao, Yanyan Qu, Yuhong Fang, Dingyin Tao +6 more

Prediction of chemical-induced acute toxicity using in vitro assay data and chemical structure

Toxicology and Applied Pharmacology(2024)10.1016/j.taap.2024.117098

N/A

0DataRank · unranked

11 citations

Tuan Xu, Deborah K. Ngan, Menghang Xia, Jinghua Zhao, Srilatha Sakamuru +3 more

Pyrimidine Azepine Targets the Plasmodium bc1 Complex and Displays Multistage Antimalarial Activity

JACS Au(2024)10.1021/jacsau.4c00674

N/A

0DataRank · unranked

10 citations

Surendra K. Prajapati, Ernest Diez Benavente, Jéssica E. Araújo, Bingbing Deng, Kazutoyo Miura +14 more

3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons

SLAS DISCOVERY(2024)10.1016/j.slasd.2024.01.004

N/A

0DataRank · unranked

6 citations

Ruili Huang, John Braisted, Pei‐Hsuan Chu, Anton Simeonov, David Gerhold +1 more

Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

Frontiers in Toxicology(2024)10.3389/ftox.2024.1321857

N/A

0DataRank · unranked

6 citations

Tuan Xu, Judy Strickland, Li Zhang, Yuhong Fang, Dingyin Tao +5 more

Small-Molecule Disruptors of the Interaction between Calcium- and Integrin-Binding Protein 1 and Integrin αIIbβ3 as Novel Antiplatelet Agents

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.4c00026

N/A

0DataRank · unranked

4 citations

Adam Yasgar, Voddarahally N. Manjuprasanna, Meghna U. Naik, Bolormaa Baljinnyam, Alexey Zakharov +6 more

Highly efficient generation of self-renewing trophoblast from human pluripotent stem cells

iScience(2024)10.1016/j.isci.2024.110874

N/A

0DataRank · unranked

3 citations

Seungmi Ryu, Carlos A. Tristan, Pei‐Hsuan Chu, Claire Weber, Tao Deng +6 more

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion

Biochemical and Biophysical Research Communications(2024)10.1016/j.bbrc.2024.149981

N/A

0DataRank · unranked

2 citations

Kara Wolfe, Kazutaka Sumita, Shun Kageyama, Hirofumi Yoshino, Yoshihisa Hirota +18 more

Cell-Based Covalent-Capture Deubiquitinase Assay for Inhibitor Discovery

ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.4c00331

N/A

0DataRank · unranked

2 citations

Jenna Miller, Sankalp Jain, Alexey Zakharov, Ganesha Rai, Anton Simeonov +3 more

Fatty Acid Derivatization and Cyclization of the Immunomodulatory Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor Activity

Molecular Cancer Therapeutics(2024)10.1158/1535-7163.mct-23-0790

N/A

0DataRank · unranked

2 citations

Raul Calvo, Anju Kumari, Rushikesh Sable, Yuhong Fang, Dingyin Tao +17 more

Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.27.601062

N/A

0DataRank · unranked

3 citations

Narisu Narisu, Lori L. Bonnycastle, Ravi Tharakan, Kendall T. Mesch, Hannah J. Glover +22 more

AI-driven drug discovery: identification and optimization of ALDH3A1 selective inhibitors with nanomolar activity

ChemRxiv(2024)10.26434/chemrxiv-2024-5zxxm

N/A

0DataRank · unranked

2 citations

Adam Yasgar, Anu Dalal, Marissa A. Davies, Aleksandra Nilova, Natalia J. Martinez +4 more

A comprehensive update on the application of high-throughput fluorescence imaging for novel drug discovery

Expert Opinion on Drug Discovery(2025)10.1080/17460441.2025.2499123

N/A

0DataRank · unranked

15 citations

Anton Simeonov, Michael Ronzetti

Integrated Approach of Machine Learning and High-Throughput Screening to Identify Chemical Probe Candidates Targeting Aldehyde Dehydrogenases

ACS Pharmacology & Translational Science(2025)10.1021/acsptsci.5c00395

N/A

0DataRank · unranked

4 citations

Sankalp Jain, Marissa A. Davies, Carina Danchik, Taylor Niehoff, Ran Jing +6 more

Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation

Toxicology and Applied Pharmacology(2025)10.1016/j.taap.2025.117315

N/A

0DataRank · unranked

2 citations

Srilatha Sakamuru, Jinghua Zhao, Menghang Xia, Stephen Ferguson, David M. Reif +3 more

Expanded Tox21 Biological Assay Panel for the Prediction of Drug-Induced Liver Injury and Cardiotoxicity

Environmental Health Perspectives(2025)10.1021/ehp.6c00052

N/A

0DataRank · unranked

1 citations

Masato Ooka, Jinghua Zhao, Srilatha Sakamuru, Deborah K. Ngan, Li Zhang +13 more

MT1G activation in dopaminergic neurons identifies chelators and their relationships to cytotoxicity

SLAS DISCOVERY(2025)10.1016/j.slasd.2025.100244

N/A

0DataRank · unranked

2 citations

Srilatha Sakamuru, James Travers, Tuan Xu, Shu Yang, Menghang Xia +4 more

Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning

Biology(2025)10.3390/biology14050522

N/A

0DataRank · unranked

1 citations

Jingran Wen, Daniel R. Scoles, Anton Simeonov, Thomas S. Dexheimer, Ajit Jadhav +6 more

Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.17.633658

N/A

0DataRank · unranked

3 citations

Dorjbal Dorjsuren, Sankalp Jain, Marielle Rath, Ricardo Scheufen Tieghi, Alexander Tropsha +4 more

An Integrated Platform for High-Throughput Extraction and Mass Spectrometry-Based Quantification of Cholesterol and Sphingosine

Analytical Chemistry(2025)10.1021/acs.analchem.4c06628

N/A

0DataRank · unranked

0 citations

Yuhong Fang, Maya L. Gosztyla, Edward L. Zhu, Abhijeet Kapoor, Andrés E. Dulcey +12 more

Small molecule antiviral compound collection (SMACC): A comprehensive, highly curated database to support the discovery of broad-spectrum antiviral drug molecules

UNC Libraries(2025)10.17615/pwav-1m04

Top 100%

0DataRank

Top 100%0 citations

Ganesha Rai, Eugene Muratov, Alexander Tropsha, Daniel Korn, Anton Simeonov +4 more

Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds

UNC Libraries(2025)10.17615/srnb-f444

N/A

0DataRank · unranked

0 citations

Ganesha Rai, Marielle Rath, Anton Simeonov, Eugene Muratov, Alexey Zakharov +6 more

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Science Translational Medicine(2020)10.1126/scitranslmed.aax6337

N/A

0DataRank · unranked

434 citations

Rushikesh Sable, Michael Ronzetti, Wendy Bautista, Zachary Knotts, Abisola Abisoye-Ogunniyan +37 more

Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2

Trends in Pharmacological Sciences(2020)10.1016/j.tips.2020.07.004

N/A

0DataRank · unranked

127 citations

Ying Fu, Xin Hu, Matthew D. Hall, Anton Simeonov, Alex Renn

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

Molecular Therapy(2020)10.1016/j.ymthe.2020.12.016

N/A

0DataRank · unranked

126 citations

Lu Chen, Richard T. Eastman, Zina Itkin, Paul Shinn, Catherine Z. Chen +8 more

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Cell Reports(2020)10.1016/j.celrep.2020.01.039

N/A

0DataRank · unranked

125 citations

Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey Brender, Kazutoshi Yamamoto +36 more

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

ACS Infectious Diseases(2020)10.1021/acsinfecdis.0c00349

N/A

0DataRank · unranked

93 citations

Catherine Z. Chen, Robert Bostwick, Lynn Rasmussen, Bruce Nguyen Tran, Yu-Shan Cheng +21 more

Identification of a G-Protein-Independent Activator of GIRK Channels

Cell Reports(2020)10.1016/j.celrep.2020.107770

N/A

0DataRank · unranked

39 citations

Peter M.U. Ung, Gergely Zahoránszky-Köhalmi, Alexey Zakharov, Natalia J. Martinez, Anton Simeonov +6 more

Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential

Frontiers in Bioengineering and Biotechnology(2020)10.3389/fbioe.2020.00109

N/A

0DataRank · unranked

48 citations

Xue Liu, Masato Ooka, Li Zhang, Min Jae Song, Ruili Huang +5 more

Modulation of Triple Artemisinin-Based Combination Therapy Pharmacodynamics by Plasmodium falciparum Genotype

ACS Pharmacology & Translational Science(2020)10.1021/acsptsci.0c00110

N/A

0DataRank · unranked

18 citations

Zina Itkin, Lu Chen, Gergely Zahoránszky-Köhalmi, Chanaki Amaratunga, Olivo Miotto +10 more

Stem Cell-Derived Endothelial Cell Model that Responds to Tobacco Smoke Like Primary Endothelial Cells

Chemical Research in Toxicology(2020)10.1021/acs.chemrestox.9b00363

N/A

0DataRank · unranked

17 citations

Guibin Chen, David Kuo, John Braisted, Ruili Huang, Yuhong Wang +4 more

Anton Simeonov

Indexed papers

Top data-sharing exemplar

Papers