Benjamin P. Kleinstiver

Also affiliated with Massachusetts General Hospital

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 57 papers. Top paper: “SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia”.

SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia

Brain(2023)10.1093/brain/awac460

N/A

0.992DataRank · unranked

35 citations

Hagar Mor Shaked, Kenneth Gable, Sita D. Gupta, Xueyang Pan, Niranjanakumari Somashekarappa +93 more

Splice modulators target PMS1 to reduce somatic expansion of the Huntington’s disease-associated CAG repeat

Nature Communications(2024)10.1038/s41467-024-47485-0

N/A

0.832DataRank · unranked

40 citations

Dadi Gao, Kevin Correia, Jennie C. L. Roy, Shota Shibata, Iris N. Farnum +14 more

High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease

Science Translational Medicine(2024)10.1126/scitranslmed.adj6779

N/A

0.585DataRank · unranked

23 citations

Linyuan Ma, Siyuan Liu, Lauren R. Fox, Madelynn N. Whittaker, Ronald J. Meis +15 more

Allele-specific silencing of the gain-of-function mutation in Huntington’s disease using CRISPR/Cas9

JCI Insight(2022)10.1172/jci.insight.141042

N/A

0.533DataRank · unranked

34 citations

Eun Pyo Hong, Seri S. Park, Doo Eun Choi, Ihn Sik Seong, Madelynn N. Whittaker +4 more

Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.05.009

N/A

0.396DataRank · unranked

13 citations

Bence György, Pike-See Cheah, Benjamin P. Kleinstiver, William A. Eimer, Sara P. Garcia +8 more

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

medRxiv(2020)10.1101/2020.12.09.20246736

N/A

0.360DataRank · unranked

10 citations

Adrienne M. Stilp, Caitlin McHugh, Shuquan Rao, Deepti Jain, Xiuwen Zheng +74 more

CRISPR targeting of mmu-miR-21a through a single adeno-associated virus vector prolongs survival of glioblastoma-bearing mice

Molecular Therapy(2024)10.1016/j.ymthe.2024.11.023

N/A

0.345DataRank · unranked

9 citations

Anne B. Vrijmoet, Isabelle W Jetten, David Rufino‐Ramos, Alexandra J E M de Reus, Koen Breyne +6 more

Treatment of a severe vascular disease using a bespoke CRISPR–Cas9 base editor in mice

Nature Biomedical Engineering(2025)10.1038/s41551-025-01499-1

N/A

0.342DataRank · unranked

8 citations

Sabyasachi Das, Vijai Krishnan, Leillani L. Ha, Lauren R. Fox, Hannah E. Stutzman +28 more

Voices in methods development

Nature Methods(2019)10.1038/s41592-019-0585-6

N/A

0.269DataRank · unranked

5 citations

Rosalind Mott Firenze, Clifford Brangwynne, Ibrahim I. Cissé, Oliver Fiehn, Petra Fromme +44 more

Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.28.538700

N/A

0.241DataRank · unranked

4 citations

Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe +5 more

Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.06.447255

N/A

0DataRank · unranked

3 citations

Carlos Sánchez-Bolaños, Ismael Moreno-Sánchez, David Brena, Dmytro Kukhtar, Miguel Ruiz-López +11 more

Lack of Cas13a inhibition by anti-CRISPR proteins from Leptotrichia prophages

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.27.445852

N/A

0DataRank · unranked

1 citations

Matthew C. Johnson, Logan T. Hille, Benjamin P. Kleinstiver, Joseph Bondy‐Denomy, Alexander J. Meeske

Precise DNA cleavage using CRISPR-SpRYgests

Nature Biotechnology(2022)10.1038/s41587-022-01492-y

N/A

0DataRank · unranked

53 citations

Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman +7 more

CRISPR-Cas knockout of miR21 reduces glioma growth

Molecular Therapy — Oncolytics(2022)10.1016/j.omto.2022.04.001

N/A

0DataRank · unranked

48 citations

Thomas S. van Solinge, Pike-See Cheah, Liza Morsett, Joseph El Khoury, Joseph I. Rissman +5 more

Expanding the Scope of Bacterial CRISPR Activation with PAM-Flexible dCas9 Variants

ACS Synthetic Biology(2022)10.1021/acssynbio.2c00405

N/A

0DataRank · unranked

21 citations

Ava V. Karanjia, Mateusz Legut, Zharko Daniloski, Samantha E. Koplik, Joely Nelson +5 more

Recent Advances in Double-Strand Break-Free Kilobase-Scale Genome Editing Technologies

Biochemistry(2022)10.1021/acs.biochem.2c00311

N/A

0DataRank · unranked

16 citations

Benjamin P. Kleinstiver, Connor J. Tou

Lack of Cas13a inhibition by anti-CRISPR proteins from Leptotrichia prophages

Molecular Cell(2022)10.1016/j.molcel.2022.05.002

N/A

0DataRank · unranked

13 citations

Logan T. Hille, Benjamin P. Kleinstiver, Alexander J. Meeske, Joseph Bondy‐Denomy, Matthew C. Johnson

Expanding the scope of bacterial CRISPR activation with PAM-flexible dCas9 variants

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.14.500123

N/A

0DataRank · unranked

1 citations

Ava V. Karanjia, Mateusz Legut, Zharko Daniloski, Samantha E. Koplik, Joely Nelson +5 more

Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo

Research Square(2022)10.21203/rs.3.rs-1836399/v1

N/A

0DataRank · unranked

0 citations

Yong Tao, Yiran Li, Wan Du, Madelynn N. Whittaker, John A. Zuris +13 more

Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis

Immunity(2023)10.1016/j.immuni.2023.04.013

N/A

0DataRank · unranked

59 citations

John E. Mindur, Abi G. Yates, Donghoon Lee, John F. Fullard, Atsushi Anzai +23 more

PAM-flexible genome editing with an engineered chimeric Cas9

Nature Communications(2023)10.1038/s41467-023-41829-y

N/A

0DataRank · unranked

57 citations

Sabrina Koseki, Rachel A. Silverstein, Nadia Amrani, Christina Peng, Christian Kramme +17 more

Sniper2L is a high-fidelity Cas9 variant with high activity

Nature Chemical Biology(2023)10.1038/s41589-023-01279-5

N/A

0DataRank · unranked

55 citations

Nahye Kim, Ikenna C. Okafor, Sung-Chul Choi, Seonwoo Min, Joonsun Lee +9 more

Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo

Nature Communications(2023)10.1038/s41467-023-40476-7

N/A

0DataRank · unranked

48 citations

Verónica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N. Whittaker +14 more

Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy

Nature Biomedical Engineering(2023)10.1038/s41551-023-01132-z

N/A

0DataRank · unranked

43 citations

Leillani L. Ha, Rebecca Yaworski, Emma R Sutton, Cícera R. Lazzarotto, Kathleen A. Christie +10 more

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells

PLoS Genetics(2023)10.1371/journal.pgen.1010680

N/A

0DataRank · unranked

38 citations

Thierry Fotsing Tadjo, Mélissa Beaudoin, Simon Lalonde, Ken Sin Lo, Benjamin P. Kleinstiver +2 more

Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F

Molecular Therapy(2023)10.1016/j.ymthe.2023.06.007

N/A

0DataRank · unranked

37 citations

Killian S. Hanlon, Maryna V. Ivanchenko, Eric Zinn, Elizabeth Linarte, Yaqiao Li +6 more

Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins

Nature Microbiology(2023)10.1038/s41564-022-01265-y

N/A

0DataRank · unranked

32 citations

Ylenia Jabalera, Sara Samperio, Matías Morin, Almudena Fernández, Logan T. Hille +17 more

CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells

Frontiers in Immunology(2023)10.3389/fimmu.2022.1067417

N/A

0DataRank · unranked

26 citations

Taylor Liu, Siyuan Liu, Amanda Lawson, Uimook Choi, Nikita Kozhushko +16 more

Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression

The Journal of Heart and Lung Transplantation(2023)10.1016/j.healun.2023.06.001

N/A

0DataRank · unranked

23 citations

S. Juvet, Jonathan Yeung, Zehong Guan, Gavin W. Wilson, Jim Hu +6 more

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.12.557440

N/A

0DataRank · unranked

29 citations

Connor J. Tou, Emily M. King, Madeline L. Eller, Linyuan Ma, David Rufino‐Ramos +2 more

Base editing as a genetic treatment for spinal muscular atrophy

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.20.524978

N/A

0DataRank · unranked

19 citations

Leillani L. Ha, Rebecca Yaworski, Cícera R. Lazzarotto, Kathleen A. Christie, Aoife Reilly +9 more

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.16.524176

N/A

0DataRank · unranked

10 citations

Paula P. Navarro, Pusparanee Hakim, Ananda VY, Xingping Qin, Juan C. Landoni +13 more

PMS1 as a target for splice modulation to prevent somatic CAG repeat expansion in Huntington’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.25.550489

N/A

0DataRank · unranked

2 citations

Dadi Gao, Kevin Correia, Jennie C. L. Roy, Shota Shibata, Iris N. Farnum +13 more

Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease

(2023)10.7554/elife.89782.1

N/A

0DataRank · unranked

2 citations

Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe +5 more

Reviewer #2 (Public Review): Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease

(2023)10.7554/elife.89782.1.sa1

N/A

0DataRank · unranked

0 citations

Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe +5 more

Reviewer #3 (Public Review): Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease

(2023)10.7554/elife.89782.1.sa0

N/A

0DataRank · unranked

0 citations

Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe +5 more

Author response: Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease

(2023)10.7554/elife.89782.1.sa4

N/A

0DataRank · unranked

0 citations

Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe +5 more

Myocardial infarction augments sleep to limit cardiac inflammation and damage

Nature(2024)10.1038/s41586-024-08100-w

N/A

0DataRank · unranked

95 citations

Jan D. Hoffmann, Teresa Gerhardt, Máté G. Kiss, Faris M. Zuraikat, Oren Cohen +32 more

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

Nature Biotechnology(2024)10.1038/s41587-024-02324-x

N/A

0DataRank · unranked

65 citations

Connor J. Tou, Emily M. King, Madeline L. Eller, David Rufino‐Ramos, Linyuan Ma +7 more

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

The EMBO Journal(2024)10.1038/s44318-024-00027-2

N/A

0DataRank · unranked

59 citations

Paula P. Navarro, Pusparanee Hakim, Ananda VY, Xingping Qin, Juan C. Landoni +13 more

CRISPR-Cas Genome Editing in Ex Vivo Human Lungs to Rewire the Translational Path of Genome-Targeting Therapeutics

Human Gene Therapy(2024)10.1089/hum.2023.223

N/A

0DataRank · unranked

10 citations

Haruchika Yamamoto, S. Juvet, Jonathan Yeung, Zehong Guan, Akhi Akhter +13 more

Engineered CRISPR-Base Editors as a Permanent Treatment for Familial Dysautonomia

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.11.27.625322

N/A

0DataRank · unranked

3 citations

Anil Chekuri, Jennifer Art, Krishnakanth Kondabolu, Elisabetta Morini, Nadja Zeltner +3 more

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease

New England Journal of Medicine(2025)10.1056/nejmoa2504747

N/A

0DataRank · unranked

294 citations

Sarah Grandinette, Xiao Wang, Taylor R. Hudson, Kevin Briseno, Anne Marie Berry +40 more

Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery

Journal of Extracellular Vesicles(2025)10.1002/jev2.70094

N/A

0DataRank · unranked

18 citations

Ayrton Zargani‐Piccardi, Kevin Leandro, David Rufino‐Ramos, Emilio Di lanni, Dawn Madison Frederick +12 more

GenomePAM directs PAM characterization and engineering of CRISPR-Cas nucleases using mammalian genome repeats

Nature Biomedical Engineering(2025)10.1038/s41551-025-01464-y

N/A

0DataRank · unranked

2 citations

Limei Ai, Bang Wang, Shifeng Lian, Lawrence Ip, James Liu +5 more

Non-invasive detection of allele-specific CRISPR-SaCas9-KKH disruption of TOR1A DYT1 allele in a xenograft mouse model

Molecular Therapy — Nucleic Acids(2025)10.1016/j.omtn.2025.102466

N/A

0DataRank · unranked

1 citations

Dawn Madison Frederick, Nutan Sharma, Edwina Abou Haidar, Tianhe Xiao, Justin Seungkyu Han +9 more

GenomePAM directs PAM characterization and engineering of CRISPR-Cas nucleases using mammalian genome repeats

Research Square(2025)10.21203/rs.3.rs-4552906/v1

N/A

0DataRank · unranked

0 citations

Miao Yu, Limei Ai, Bang Wang, Shifeng Lian, James Liu +5 more

Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

eLife(2025)10.1101/2025.08.31.673354

N/A

0DataRank · unranked

0 citations

Elena Hein, Beatrice Alexander-Howden, Timur von Bock und Polach, Tricia Mathieson, Benjamin P. Kleinstiver +3 more

Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer

Nature Microbiology(2020)10.1038/s41564-020-0692-2

N/A

0DataRank · unranked

125 citations

Kathleen A. Christie, Beatriz A. Osuna, Rafael Pinilla‐Redondo, Benjamin P. Kleinstiver, Joseph Bondy‐Denomy +1 more

Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes

Cell Host & Microbe(2020)10.1016/j.chom.2020.04.001

N/A

0DataRank · unranked

94 citations

Shweta Karambelkar, Caroline Mahendra, Kathleen A. Christie, Bianca Garcı́a, Alan R. Davidson +4 more

enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9

Molecular Therapy(2020)10.1016/j.ymthe.2020.09.025

N/A

0DataRank · unranked

14 citations

Maarten Jacquemyn, Tim Dierckx, Benjamin P. Kleinstiver, Hendrik Jan Thibaut, Dirk Daelemans +1 more

In vivo engineering of lymphocytes after systemic exosome-associated AAV delivery

Scientific Reports(2020)10.1038/s41598-020-61518-w

N/A

0DataRank · unranked

30 citations

Killian S. Hanlon, Jeya-shree Natasan, Adrienn Volak, Amine Meliani, Federico Mingozzi +4 more

Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources

Journal for ImmunoTherapy of Cancer(2020)10.1136/jitc-2020-000990

N/A

0DataRank · unranked

29 citations

Leah C Marsh, Ambike Aarti Srivastava, Amanda A. Bouffard, Angela C. Boroughs, Irene Scarfò +13 more

Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells

Blood(2021)10.1182/blood.2020008503

N/A

0DataRank · unranked

74 citations

Julie Brault, Ronald J. Meis, Siyuan Liu, Linhong Li, Mara Pavel-Dinu +18 more

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

Cell(2021)10.1016/j.cell.2021.06.022

N/A

0DataRank · unranked

73 citations

Inbal Rachmin, Kaustubh Adhikari, Luba M. Pardo, Ju Hee Lee, Alicia M. McConnell +48 more

Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA

Nature Protocols(2021)10.1038/s41596-020-00465-2

N/A

0DataRank · unranked

52 citations

Jonathan Y. Hsu, J. Keith Joung, Benjamin P. Kleinstiver, Russell T. Walton

CRISPR-targetedMAGT1insertion restores XMEN patient hematopoietic stem cells and lymphocytes

Blood(2021)10.1182/blood.2021011192

N/A

0DataRank · unranked

38 citations

Taylor Liu, Ezekiel Bello, Siyuan Liu, Colin L. Sweeney, Ronald J. Meis +18 more