Aleem Gangjee

Biochemistry, Genetics and Molecular BiologyMedicineChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 15 papers. Top paper: “Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer”.

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

Molecular Cancer Therapeutics(2020)10.1158/1535-7163.mct-20-0423

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76 citations

Zhanjun Hou, Aleem Gangjee, Larry H. Matherly, Aamod S. Dekhne

The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115887

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7 citations

Tasdique M. Quadery, Ernest Hamel, Lerin R. Luckett‐Chastain, Michael A. Ihnat, Susan L. Mooberry +2 more

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.127923

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24 citations

Tasdique M. Quadery, Ruoli Bai, Lerin R. Luckett‐Chastain, Ernest Hamel, Michael A. Ihnat +2 more

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Bioorganic & Medicinal Chemistry(2021)10.1016/j.bmc.2021.116093

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12 citations

Nian Tong, Jennifer Wong-Roushar, Carrie O’Connor, Xilin Zhou, Zhanjun Hou +8 more

Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer

Bioorganic & Medicinal Chemistry(2021)10.1016/j.bmc.2021.116061

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9 citations

Arpit Doshi, Lerin R. Luckett‐Chastain, Michael A. Ihnat, Ernest Hamel, Susan L. Mooberry +2 more

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

Scientific Reports(2022)10.1038/s41598-022-14788-5

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15 citations

Lisa Rubinsak, Agnes Malysa, Sijana H. Dzinic, Manasa Ravindra, Mathew Schneider +11 more

Microtubule Stabilizers as Modifiers of Alpha‐Synucleinopathy

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r3222

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1 citations

Tarun N. Bhatia, Kristin M. Miner, Krishna Kaku, Yesha V. Shah, Brett A. DeMarco +4 more

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00763

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17 citations

Jade M. Katinas, Tejashree Magdum, Khushbu Shah, Jennifer E. Wong, Carrie O’Connor +7 more

Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site

Bioorganic & Medicinal Chemistry(2023)10.1016/j.bmc.2023.117217

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7 citations

Krishna Kaku, Andrew J. Robles, Ernest Hamel, Susan L. Mooberry, Aleem Gangjee +1 more

Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism

ACS Pharmacology & Translational Science(2023)10.1021/acsptsci.3c00020

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6 citations

Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha V. Shah, Morgan C. Nyman, Jade M. Katinas +10 more

Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer

Molecular Cancer Therapeutics(2024)10.1158/1535-7163.mct-23-0550

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15 citations

Carrie O’Connor, Aamod S. Dekhne, Xun Bao, Md. Junayed Nayeen, Mathew Schneider +11 more

Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates

Molecular Pharmacology(2024)10.1124/molpharm.124.000912

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12 citations

Mathew Schneider, Jade M. Katinas, Md. Junayed Nayeen, Khushbu Shah, Tejashree Magdum +9 more

Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2

Biochemistry(2024)10.1021/acs.biochem.3c00613

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6 citations

Md. Junayed Nayeen, Mathew Schneider, Khushbu Shah, Alexandra N. Fifer, Lily M. Klapper +8 more

Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydroxymethyltransferase inhibition in human tumors

Drug Metabolism and Disposition(2025)10.1016/j.dmd.2025.100120

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2 citations

Carrie O’Connor, Xun Bao, Md. Junayed Nayeen, Tejashree Magdum, Abhishekh Sharma +7 more

Determination of the pyrrolo[2,3-d] pyrimidine antifolate AGF94 from a preclinical murine study using a simple UHPLC-MS/MS assay

Journal of Chromatography B(2025)10.1016/j.jchromb.2025.124833

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0 citations

Robynne Ashe, Alexander Duncan, Ethan C. Wilner, Keith T. Schmidt, Kristbjorn O. Gudmundsson +6 more