Thirumala‐Devi Kanneganti

Biochemistry, Genetics and Molecular BiologyImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 5%percentile

0.526Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.14.444026

Top 37%

0.526DataRank

Top 37%9 citations

Wojciech Rosikiewicz, Jamy C. Peng, Thirumala‐Devi Kanneganti, Yawei Hui, Hongjian Jin +6 more

Papers

Driven by 114 papers — median percentile 63. Top paper: “Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes”.

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Cell(2020)10.1016/j.cell.2020.11.025

N/A

1.1DataRank · unranked

1650 citations

Bhesh Raj Sharma, Shraddha Tuladhar, Evan P. Williams, Lillian Zalduondo, Parimal Samir +11 more

Caspases in Cell Death, Inflammation, and Pyroptosis

Annual Review of Immunology(2020)10.1146/annurev-immunol-073119-095439

N/A

1.0DataRank · unranked

902 citations

R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, Sannula Kesavardhana

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

Nature Immunology(2021)10.1038/s41590-021-00937-x

N/A

0.964DataRank · unranked

619 citations

Rajendra Karki, Evan P. Williams, Dong Yang, Elizabeth Fitzpatrick, Peter Vogel +3 more

The ‘cytokine storm’: molecular mechanisms and therapeutic prospects

Trends in Immunology(2021)10.1016/j.it.2021.06.001

N/A

0.909DataRank · unranked

428 citations

Thirumala‐Devi Kanneganti, Rajendra Karki

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.015924

N/A

0.820DataRank · unranked

236 citations

Shraddha Tuladhar, Rajendra Karki, Bhesh Raj Sharma, Benoit Briard, Sannula Kesavardhana +3 more

RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis

ImmunoHorizons(2020)10.4049/immunohorizons.2000097

N/A

0.806DataRank · unranked

214 citations

Sannula Kesavardhana, Rajendra Karki, Balabhaskararao Kancharana, Amanda R. Burton, Thirumala‐Devi Kanneganti +1 more

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.015036

N/A

0.798DataRank · unranked

204 citations

Evan P. Williams, R. K. Subbarao Malireddi, Rajendra Karki, Balaji Banoth, Amanda R. Burton +5 more

Advances in Understanding Activation and Function of the NLRC4 Inflammasome

International Journal of Molecular Sciences(2021)10.3390/ijms22031048

N/A

0.737DataRank · unranked

135 citations

Thirumala‐Devi Kanneganti, Balamurugan Sundaram

ADAR1 and ZBP1 in innate immunity, cell death, and disease

Trends in Immunology(2023)10.1016/j.it.2023.01.001

N/A

0.708DataRank · unranked

111 citations

Thirumala‐Devi Kanneganti, Rajendra Karki

Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis)

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105141

N/A

0.706DataRank · unranked

110 citations

Rajendra Karki, Y. Rajesh, Thirumala‐Devi Kanneganti, Bhesh Raj Sharma

Inflammasome signaling in colorectal cancer

Translational research(2022)10.1016/j.trsl.2022.09.002

N/A

0.670DataRank · unranked

86 citations

Thirumala‐Devi Kanneganti, Bhesh Raj Sharma

Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity

Immunity(2023)10.1016/j.immuni.2023.04.001

N/A

0.571DataRank · unranked

44 citations

Christina F. Lusi, Siavash Mashayekh, Abhinit Nagar, Malireddi Subbarao, Griffin Kane +14 more

Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection

The Journal of Immunology(2021)10.4049/jimmunol.2100757

N/A

0.557DataRank · unranked

40 citations

Rajendra Karki, Min Zheng, Balabhaskararao Kancharana, SangJoon Lee, Sannula Kesavardhana +4 more

CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.14.444026

Top 37%

0.526DataRank

Top 37%9 citations

Wojciech Rosikiewicz, Jamy C. Peng, Thirumala‐Devi Kanneganti, Yawei Hui, Hongjian Jin +6 more

ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease

The Journal of Experimental Medicine(2020)10.1084/jem.20200885

N/A

0.524DataRank · unranked

32 citations

Thirumala‐Devi Kanneganti, Sannula Kesavardhana

Inflammasomes and their role in PANoptosomes

Current Opinion in Immunology(2024)10.1016/j.coi.2024.102489

N/A

0.520DataRank · unranked

31 citations

Thirumala‐Devi Kanneganti, Vinod Nadella

A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells

PLoS ONE(2024)10.1371/journal.pone.0299577

N/A

0.505DataRank · unranked

28 citations

Roman Sarkar, Rajendra Karki, Thirumala‐Devi Kanneganti, Sk Mohiuddin Choudhury

Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis

mBio(2021)10.1128/mbio.01059-21

N/A

0.489DataRank · unranked

25 citations

Shelbi Christgen, Shraddha Tuladhar, Peter Vogel, R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti +1 more

Evolutionary and Functional Analysis of Caspase-8 and ASC Interactions to Drive Lytic Cell Death, PANoptosis

Molecular Biology and Evolution(2025)10.1093/molbev/msaf096

N/A

0.385DataRank · unranked

9 citations

Eswar Kumar Nadendla, R. K. Subbarao Malireddi, Syed Asfarul Haque, Raghvendra Mall, Andrew F. Neuwald +2 more

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

Frontiers in Immunology(2022)10.3389/fimmu.2022.1068230

N/A

0.312DataRank · unranked

7 citations

Ratnakar R. Bynigeri, Balabhaskararao Kancharana, Bhesh Raj Sharma, Amanda R. Burton, S. William Pelletier +2 more

It’s just a phase: NLRP6 phase separations drive signaling

Cell Research(2021)10.1038/s41422-021-00594-7

N/A

0.269DataRank · unranked

5 citations

Thirumala‐Devi Kanneganti, Rebecca E. Tweedell

Sensory nerves unlock the TOLL-7 gate for cancer spread

Trends in Immunology(2024)10.1016/j.it.2024.09.005

N/A

0.208DataRank · unranked

3 citations

Thirumala‐Devi Kanneganti, R. K. Subbarao Malireddi

Chromatin Regulator SMARCA4 Is Essential for MHV-Induced Inflammatory Cell Death, PANoptosis

Viruses(2024)10.3390/v16081261

N/A

0.182DataRank · unranked

2 citations

Thirumala‐Devi Kanneganti, R. K. Subbarao Malireddi

A BAF-fling connection to RIPK1

Cell Research(2022)10.1038/s41422-022-00688-w

N/A

0.165DataRank · unranked

2 citations

Thirumala‐Devi Kanneganti, Jessica M. Gullett

Methotrexate inhibition of muropeptide transporter SLC46A2 controls psoriatic skin inflammation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.29.509906

N/A

0.104DataRank · unranked

1 citations

Christina F. Lusi, Siavash Mashayekh, Abhinit Nagar, Malireddi Subbarao, Griffin Kane +14 more

Programming inflammatory cell death for therapy

Pharmacology & Therapeutics(2021)10.1016/j.pharmthera.2021.108010

N/A

0DataRank · unranked

286 citations

Rebecca E. Tweedell, Thirumala‐Devi Kanneganti, Shelbi Christgen

NLRP3 inflammasome in cancer and metabolic diseases

Nature Immunology(2021)10.1038/s41590-021-00886-5

N/A

0DataRank · unranked

1110 citations

Thirumala‐Devi Kanneganti, Bhesh Raj Sharma

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

Nature(2021)10.1038/s41586-021-03875-8

N/A

0DataRank · unranked

762 citations

Rajendra Karki, Yaqiu Wang, Lam Nhat Nguyen, Ravi Kalathur, Thirumala‐Devi Kanneganti +1 more

From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways

Computational and Structural Biotechnology Journal(2021)10.1016/j.csbj.2021.07.038

N/A

0DataRank · unranked

518 citations

Thirumala‐Devi Kanneganti, Yaqiu Wang

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

Cell Reports(2021)10.1016/j.celrep.2021.109858

N/A

0DataRank · unranked

410 citations

Balamurugan Sundaram, Bhesh Raj Sharma, SangJoon Lee, R. K. Subbarao Malireddi, Lam Nhat Nguyen +8 more

Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth

ImmunoHorizons(2021)10.4049/immunohorizons.2100059

N/A

0DataRank · unranked

191 citations

Rajendra Karki, Balamurugan Sundaram, Balabhaskararao Kancharana, SangJoon Lee, Parimal Samir +2 more

Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins

Nature Communications(2021)10.1038/s41467-020-20807-8

N/A

0DataRank · unranked

100 citations

R. K. Subbarao Malireddi, Ji-Eun Kim, Peter Vogel, Masahiro Yamamoto, Thirumala‐Devi Kanneganti +1 more

PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field

Journal of Molecular Biology(2021)10.1016/j.jmb.2021.167249

N/A

0DataRank · unranked

97 citations

Thirumala‐Devi Kanneganti, Lam Nhat Nguyen

Role of inflammasomes/pyroptosis and PANoptosis during fungal infection

PLoS Pathogens(2021)10.1371/journal.ppat.1009358

N/A

0DataRank · unranked

72 citations

R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, Benoit Briard

DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100579

N/A

0DataRank · unranked

60 citations

Parimal Samir, Min Zheng, R. K. Subbarao Malireddi, Rajendra Karki, Bhesh Raj Sharma +5 more

A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma

Cancer Research(2021)10.1158/0008-5472.can-20-3510

N/A

0DataRank · unranked

34 citations

Geoffrey Neale, Peter Vogel, R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, Sarang Tartey

Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101379

N/A

0DataRank · unranked

23 citations

Rajendra Karki, Balabhaskararao Kancharana, Hartmut Berns, Shondra M. Pruett‐Miller, Thirumala‐Devi Kanneganti +1 more

Integrated stress response restricts macrophage necroptosis

Life Science Alliance(2021)10.26508/lsa.202101260

N/A

0DataRank · unranked

12 citations

Parimal Samir, R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, David E. Place

Metabolic regulation of pyroptotic cell death expands the therapeutic landscape for treating inflammatory disease

Signal Transduction and Targeted Therapy(2021)10.1038/s41392-021-00467-w

N/A

0DataRank · unranked

9 citations

Thirumala‐Devi Kanneganti, David E. Place

The IFN‐inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice

European Journal of Immunology(2021)10.1002/eji.202149305

N/A

0DataRank · unranked

7 citations

David E. Place, Min Zheng, Benoit Briard, Masahiro Yamamoto, Thirumala‐Devi Kanneganti +1 more

TLR and IKK Complex–Mediated Innate Immune Signaling Inhibits Stress Granule Assembly

The Journal of Immunology(2021)10.4049/jimmunol.2100115

N/A

0DataRank · unranked

12 citations

David E. Place, R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, Parimal Samir

Fostering experimental and computational synergy to modulate hyperinflammation

Trends in Immunology(2021)10.1016/j.it.2021.11.004

N/A

0DataRank · unranked

12 citations

Thirumala‐Devi Kanneganti, Antonio del Sol, Ilya S. Potapov

Sepsis take-out: Inhibiting bacterial deliveries

Immunity(2021)10.1016/j.immuni.2021.02.010

N/A

0DataRank · unranked

9 citations

Thirumala‐Devi Kanneganti, Shelbi Christgen

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.06.425634

N/A

0DataRank · unranked

23 citations

Tong Yang, Jianqiu Xiao, Canxin Xu, Yael Alippe, Kai Sun +6 more

Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.28.427517

N/A

0DataRank · unranked

4 citations

Barun Poudel, Rodrigo P. Baptista, Kristen Peissig, Lisa S. Hancox, Justine C. Shiau +9 more

Intestinal tête-à-tête: helminths blunt immunity against flaviviruses

Cell Research(2021)10.1038/s41422-021-00505-w

N/A

0DataRank · unranked

0 citations

Thirumala‐Devi Kanneganti, David E. Place

Innate Immune Cell Death in Neuroinflammation and Alzheimer’s Disease

Cells(2022)10.3390/cells11121885

N/A

0DataRank · unranked

258 citations

Thirumala‐Devi Kanneganti, Y. Rajesh

PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality

The Journal of Immunology(2022)10.4049/jimmunol.2200508

N/A

0DataRank · unranked

257 citations

Thirumala‐Devi Kanneganti, Pandian Nagakannan

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

Journal of Translational Medicine(2022)10.1186/s12967-022-03767-z

N/A

0DataRank · unranked

122 citations

Thirumala‐Devi Kanneganti, Rajendra Karki

It’s All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects

Cells(2022)10.3390/cells11091495

N/A

0DataRank · unranked

113 citations

Rebecca E. Tweedell, Thirumala‐Devi Kanneganti, Jessica M. Gullett

Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology

NAR Cancer(2022)10.1093/narcan/zcac033

N/A

0DataRank · unranked

50 citations

Ratnakar R. Bynigeri, Rajendra Karki, R. K. Subbarao Malireddi, Bhesh Raj Sharma, Thirumala‐Devi Kanneganti +1 more

DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease

Cells(2022)10.3390/cells11101608

N/A

0DataRank · unranked

39 citations

Thirumala‐Devi Kanneganti, Parimal Samir

Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

Cell Reports(2022)10.1016/j.celrep.2022.111434

N/A

0DataRank · unranked

36 citations

Rajendra Karki, Raghvendra Mall, Bhesh Raj Sharma, Ravi Kalathur, SangJoon Lee +5 more

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines

Pathogens(2022)10.3390/pathogens11121400

N/A

0DataRank · unranked

18 citations

Jessica M. Gullett, Thirumala‐Devi Kanneganti, Jianlin Lu

Humans pIKK-up NLRP3 to skip NEK7

Trends in Immunology(2022)10.1016/j.it.2022.10.007

N/A

0DataRank · unranked

3 citations

Thirumala‐Devi Kanneganti, R. K. Subbarao Malireddi

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.21.508892

N/A

0DataRank · unranked

1 citations

Ratnakar R. Bynigeri, Balabhaskararao Kancharana, Bhesh Raj Sharma, Amanda R. Burton, S. William Pelletier +2 more

NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

Cell(2023)10.1016/j.cell.2023.05.005

N/A

0DataRank · unranked

392 citations

Pandian Nagakannan, Raghvendra Mall, Yaqiu Wang, Roman Sarkar, Hee Jin Kim +6 more

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Cell Death and Differentiation(2023)10.1038/s41418-023-01153-w

N/A

0DataRank · unranked

358 citations

Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John Abrams, Dieter Adam +95 more

Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes

Trends in Molecular Medicine(2023)10.1016/j.molmed.2023.10.001

N/A

0DataRank · unranked

259 citations

Thirumala‐Devi Kanneganti, Ankit Pandeya

Innate immune inflammatory cell death: PANoptosis and PANoptosomes in host defense and disease

European Journal of Immunology(2023)10.1002/eji.202250235

N/A

0DataRank · unranked

148 citations

Jessica M. Gullett, Rebecca E. Tweedell, Thirumala‐Devi Kanneganti, Wen Chen

PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis

Current Opinion in Immunology(2023)10.1016/j.coi.2023.102348

N/A

0DataRank · unranked

117 citations

Thirumala‐Devi Kanneganti, Rajendra Karki

ZBP1 Drives IAV-Induced NLRP3 Inflammasome Activation and Lytic Cell Death, PANoptosis, Independent of the Necroptosis Executioner MLKL

Viruses(2023)10.3390/v15112141

N/A

0DataRank · unranked

53 citations

Bhesh Raj Sharma, Ratnakar R. Bynigeri, Yaqiu Wang, Jianlin Lu, Thirumala‐Devi Kanneganti +1 more

Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosis

iScience(2023)10.1016/j.isci.2023.106938

N/A

0DataRank · unranked

41 citations

Ratnakar R. Bynigeri, Raghvendra Mall, Eswar Kumar Nadendla, Jon P. Connelly, Shondra M. Pruett‐Miller +2 more

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence

PLoS Pathogens(2023)10.1371/journal.ppat.1011003

N/A

0DataRank · unranked

26 citations

Mateo Murillo-Léon, Niklas Endres, Ailan Farid Arenas, Jorge Enrique Gómez‐Marín, Florence Melbert +7 more

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Journal of Visualized Experiments(2023)10.3791/64308

N/A

0DataRank · unranked

19 citations

Rebecca E. Tweedell, Thirumala‐Devi Kanneganti, Joo‐Hui Han

AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2210181120

N/A

0DataRank · unranked

16 citations

Barun Poudel, Rodrigo P. Baptista, Kristen Peissig, Lisa S. Hancox, Justine C. Shiau +9 more

Inflammatory cell death, PANoptosis, screen identifies host factors in coronavirus innate immune response as therapeutic targets

Communications Biology(2023)10.1038/s42003-023-05414-9

N/A

0DataRank · unranked

14 citations

Ratnakar R. Bynigeri, Raghvendra Mall, Jon P. Connelly, Shondra M. Pruett‐Miller, Thirumala‐Devi Kanneganti +1 more

Comparative analysis identifies genetic and molecular factors associated with prognostic clusters of PANoptosis in glioma, kidney and melanoma cancer

Scientific Reports(2023)10.1038/s41598-023-48098-1

N/A

0DataRank · unranked

12 citations

Thirumala‐Devi Kanneganti, Raghvendra Mall

CD47 halts Ptpn6 -deficient neutrophils from provoking lethal inflammation

Science Advances(2023)10.1126/sciadv.ade3942

N/A

0DataRank · unranked

7 citations

Matthew S. Yorek, Saurabh Saini, Peter Vogel, David K. Meyerholz, Thirumala‐Devi Kanneganti +2 more

Innate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications

PLoS Biology(2023)10.1371/journal.pbio.3002022

N/A

0DataRank · unranked

11 citations

Sivakumar Prasanth Kumar, Thirumala‐Devi Kanneganti, Rebecca E. Tweedell

Heartbreakers: innate sensors ZBP1 and cGAS linked to cardiotoxicity

Cell Research(2023)10.1038/s41422-023-00861-9

N/A

0DataRank · unranked

8 citations

Thirumala‐Devi Kanneganti, Wen Chen

Data from A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma

(2023)10.1158/0008-5472.c.6513139.v1

N/A

0DataRank · unranked

0 citations

Geoffrey Neale, Peter Vogel, R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, Sarang Tartey

NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

Cell(2024)10.1016/j.cell.2024.05.034

N/A

0DataRank · unranked

200 citations

Pandian Nagakannan, Hee Jin Kim, Hadia M. Abdelaal, Raghvendra Mall, Omkar Indari +8 more

The NLR family of innate immune and cell death sensors

Immunity(2024)10.1016/j.immuni.2024.03.012

N/A

0DataRank · unranked

190 citations

Rebecca E. Tweedell, Sivakumar Prasanth Kumar, Thirumala‐Devi Kanneganti, Balamurugan Sundaram

NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress

Nature Communications(2024)10.1038/s41467-024-45466-x

N/A

0DataRank · unranked

91 citations

Rajendra Karki, R. K. Subbarao Malireddi, Raghvendra Mall, Roman Sarkar, Bhesh Raj Sharma +7 more

Innate immune sensing of cell death in disease and therapeutics

Nature Cell Biology(2024)10.1038/s41556-024-01491-y

N/A

0DataRank · unranked

71 citations

Thirumala‐Devi Kanneganti, Si Ming Man

The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis

BMC Biology(2024)10.1186/s12915-024-01901-5

N/A

0DataRank · unranked

37 citations

R. K. Subbarao Malireddi, Raghvendra Mall, Jon P. Connelly, Shondra M. Pruett‐Miller, Thirumala‐Devi Kanneganti +1 more

Innate Immunity in Protection and Pathogenesis During Coronavirus Infections and COVID-19

Annual Review of Immunology(2024)10.1146/annurev-immunol-083122-043545

N/A

0DataRank · unranked

31 citations

Bhesh Raj Sharma, Thirumala‐Devi Kanneganti, R. K. Subbarao Malireddi

Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107676

N/A

0DataRank · unranked

26 citations

Sk Mohiuddin Choudhury, Thirumala‐Devi Kanneganti, Roman Sarkar

Defining PANoptosis: Biochemical and Mechanistic Evaluation of Innate Immune Cell Death Activation

Current Protocols(2024)10.1002/cpz1.1112

N/A

0DataRank · unranked

15 citations

Taylor Hibler, Thirumala‐Devi Kanneganti, Rebecca E. Tweedell

Yin and Yang of innate immune cell death

Cell Research(2024)10.1038/s41422-024-01007-1

N/A

0DataRank · unranked

2 citations

Thirumala‐Devi Kanneganti, Yaqiu Wang

Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease

Cell Discovery(2025)10.1038/s41421-025-00791-3

N/A

0DataRank · unranked

63 citations

Rebecca E. Tweedell, Gary Kasof, Thirumala‐Devi Kanneganti, Eswar Kumar Nadendla

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis

Cell(2025)10.1016/j.cell.2025.11.002

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43 citations

Jianlin Lu, Alexandre F. Carisey, Sangappa B. Chadchan, Ha Won Lee, R. K. Subbarao Malireddi +12 more

Innate immune sensor NLRP3 drives PANoptosome formation and PANoptosis

The Journal of Immunology(2025)10.1093/jimmun/vkaf042

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39 citations

Sk Mohiuddin Choudhury, Hadia M. Abdelaal, Yaqiu Wang, Thirumala‐Devi Kanneganti, Bhesh Raj Sharma

Identification of an IRF–ZBP1–caspase-8–NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2525296122

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10 citations

Wen Chen, Clay D. King, Sivakumar Prasanth Kumar, Chadi A. El Farran, Peter Vogel +3 more

ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs

Cell(2025)10.1016/j.cell.2025.04.033

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1 citations

Thirumala‐Devi Kanneganti, Rebecca E. Tweedell

Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death

Trends in Immunology(2025)10.1016/j.it.2025.02.004

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1 citations

Thirumala‐Devi Kanneganti, Bhesh Raj Sharma

Back from the brink: programmed cell revival for regeneration

The EMBO Journal(2025)10.1038/s44318-025-00538-6

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0 citations

Thirumala‐Devi Kanneganti, Balamurugan Sundaram

For “U” the bell tolls: Pseudouridine evades TLR detection

Molecular Cell(2025)10.1016/j.molcel.2025.08.008

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0 citations

Thirumala‐Devi Kanneganti, A. P. Young

Pediatric Acute Myeloid Leukemia-associated S100A9 Drives T Cell Dysfunction 2533

The Journal of Immunology(2025)10.1093/jimmun/vkaf283.439

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0 citations

Tyler Bruno, Tian Mi, Paulina Velasquez, Swati Naik, Shanta Alli +11 more

Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

Trends in Immunology(2020)10.1016/j.it.2020.10.005

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215 citations

Rudragouda Channappanavar, Thirumala‐Devi Kanneganti, SangJoon Lee

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.013752

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181 citations

R. K. Subbarao Malireddi, Amanda R. Burton, Shaina N. Porter, Peter Vogel, Shondra M. Pruett‐Miller +2 more

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

Immunity(2020)10.1016/j.immuni.2020.04.010

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172 citations

Luigi Mari, Clifford S. Guy, Bradlee L. Heckmann, Diego A. Rodríguez, Sebastian Rühl +9 more

NLRP12 in innate immunity and inflammation

Molecular Aspects of Medicine(2020)10.1016/j.mam.2020.100887

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149 citations

Thirumala‐Devi Kanneganti, Shraddha Tuladhar

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

Immunological Reviews(2020)10.1111/imr.12909

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576 citations

Thirumala‐Devi Kanneganti, Min Zheng

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

Frontiers in Cellular and Infection Microbiology(2020)10.3389/fcimb.2020.00237

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560 citations

Min Zheng, Sannula Kesavardhana, Rajendra Karki, R. K. Subbarao Malireddi, Balaji Banoth +8 more

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Cell(2020)10.1016/j.cell.2020.03.040

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543 citations

Rajendra Karki, Peter Vogel, Thirumala‐Devi Kanneganti, Min Zheng

The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

Frontiers in Cellular and Infection Microbiology(2020)10.3389/fcimb.2020.00238

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535 citations

R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, Parimal Samir

Toward targeting inflammasomes: insights into their regulation and activation

Cell Research(2020)10.1038/s41422-020-0295-8

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287 citations

David E. Place, Thirumala‐Devi Kanneganti, Shelbi Christgen

Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer

JCI Insight(2020)10.1172/jci.insight.136720

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279 citations

Bhesh Raj Sharma, Ein Lee, Balaji Banoth, R. K. Subbarao Malireddi, Parimal Samir +6 more

PANoptosis in microbial infection

Current Opinion in Microbiology(2020)10.1016/j.mib.2020.07.012

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237 citations

SangJoon Lee, Thirumala‐Devi Kanneganti, David E. Place

DNA Sensing in the Innate Immune Response

Physiology(2020)10.1152/physiol.00022.2019

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216 citations

David E. Place, Thirumala‐Devi Kanneganti, Benoit Briard

Galactosaminogalactan activates the inflammasome to provide host protection

Nature(2020)10.1038/s41586-020-2996-z

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129 citations

Thierry Fontaine, Parimal Samir, David E. Place, Laetitia Muszkieta, R. K. Subbarao Malireddi +13 more

Intracellular innate immune receptors: Life inside the cell

Immunological Reviews(2020)10.1111/imr.12912

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124 citations

Thirumala‐Devi Kanneganti

The innate immune system and cell death in autoinflammatory and autoimmune disease

Current Opinion in Immunology(2020)10.1016/j.coi.2020.10.013

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81 citations

Thirumala‐Devi Kanneganti, David E. Place

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma

Developmental Cell(2020)10.1016/j.devcel.2020.05.027

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80 citations

Amir Jassim, Erica Nathan, Reuben J. Gilbertson, Daniel Tahan, Nadin Hoffmann +8 more

A comprehensive guide to studying inflammasome activation and cell death

Nature Protocols(2020)10.1038/s41596-020-0374-9

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75 citations

R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, Rebecca E. Tweedell

Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles

Trends in Molecular Medicine(2020)10.1016/j.molmed.2020.07.010

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24 citations

Thirumala‐Devi Kanneganti, Rebecca E. Tweedell

RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling

The Journal of Immunology(2020)10.4049/jimmunol.2000244

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18 citations

Ankit Malik, Arjun Balakrishnan, R. K. Subbarao Malireddi, Thirumala‐Devi Kanneganti, Deepika Sharma

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation

Cellular and Molecular Immunology(2020)10.1038/s41423-020-0398-7

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11 citations

Prajwal Gurung, Rajendra Karki, Amanda R. Burton, Paul J. Hertzog, Thirumala‐Devi Kanneganti +1 more

IRF8 Regulates Gram-Negative Bacteria–Mediated NLRP3 Inflammasome Activation and Cell Death

The Journal of Immunology(2020)10.4049/jimmunol.1901508

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31 citations

Ein Lee, Bhesh Raj Sharma, Balaji Banoth, Thirumala‐Devi Kanneganti, Rajendra Karki

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion

PLoS Pathogens(2020)10.1371/journal.ppat.1008364

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27 citations

Benoit Briard, Parimal Samir, Rajendra Karki, Anannya Bhattacharya, Clifford S. Guy +7 more

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

PubMed(2020)10.1101/2020.10.29.361048

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36 citations

Bhesh Raj Sharma, Shraddha Tuladhar, Evan P. Williams, Lillian Zalduondo, Parimal Samir +11 more

Zα2 domain of ZBP1 is a molecular switch regulating Influenza-induced PANoptosis and perinatal lethality during development

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.05.026542

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12 citations

R. K. Subbarao Malireddi, Amanda R. Burton, Shaina N. Porter, Peter Vogel, Shondra M. Pruett‐Miller +2 more

Thirumala‐Devi Kanneganti

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